Cytoskeleton reorganization mediates alpha6beta1 integrin-associated actions of laminin on proliferation and survival, but not...
This study aimed to assess the importance of the cytoskeleton in the alpha6beta1 integrin-mediated actions of laminin on ... Previous investigations have shown that these effects are mostly mediated by the alpha6beta1 integrin, but its signalization ... It could enhance proliferation and survival of GC through its alpha6beta1 integrin-mediated actions on cytoskeleton. In ... a specific function-blocking antibody raised against alpha6 integrin subunit (anti-alpha6 IgG), and (3) an inhibitor of the ...https://rbej.biomedcentral.com/articles/10.1186/1477-7827-3-19
Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion | Development
Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for ... Chen, H. and Sampson, N. S. (1999). Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor ... Normal fertilization occurs with eggs lacking the integrin alpha6beta1 and is CD9-dependent. J. Cell Biol. 149, 1289-1296. ... Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting ...http://dev.biologists.org/content/129/8/1995
Reactome | Laminin-211 [extracellular region]
Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Homo sapiens) * Integrin alpha6beta1:Laminin-211, 221, 332, ... Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Homo sapiens) * Integrin alpha7beta1:Laminin-211, 221, 411, 512, ... Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Homo sapiens) * Integrin alpha3beta1, alpha6beta4: ... Non-integrin membrane-ECM interactions (Homo sapiens) * Dystroglycan binds Laminins and Dystrophin (Homo sapiens) * ...https://reactome.org/content/detail/R-HSA-216003
Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics
CCN1 and Its Receptor Integrin alpha6beta1 Instigate a Vicious Circle to Accelerate Disturbed Flow-Induced Atherosclerosis. ...https://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1523
2006) Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. Blood 107:1405-1412. ... Lack of Smad4 Affects Platelet Integrin αIIbβ3-Mediated Inside-Out Signaling.. Integrin αIIbβ3-mediated bidirectional signaling ... 2010) G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling. Science 327:340- ... The levels of integrin β1 and ROCK1 in Smad4−/− platelets dropped to about half of the levels observed in the Smad4f/f controls ...http://molpharm.aspetjournals.org/content/92/3/285
Ligation of alpha6beta1 integrin by laminin G peptides. J Biol Chem 1996;271:27221-27224pmid:8910291. ... 1D and E). Combining varied concentrations of AG73 with AG32 (CGGTWYKIAFQRNRK), another α6β1 integrin-engaging ligand (25), we ... Augmentation of integrin-mediated mechanotransduction by hyaluronic acid. Biomaterials 2014;35:71-82pmid:24120037. ... An angiogenic laminin site and its antagonist bind through the alpha(v)beta3 and alpha5beta1 integrins. FASEB J 2001;15:1389- ...http://diabetes.diabetesjournals.org/content/64/11/3713
2003) alpha6beta1 integrin directs migration of neuronal precursors in adult mouse forebrain. Exp Neurol 183:273-285, doi: ... S1P1 deletion in the RMS downregulates the cell adhesion molecule NCAM1 and β1 integrin. A, NCAM1 and β1 integrin (Itgb1) ... 2007) Beta1 integrins control the formation of cell chains in the adult rostral migratory stream. J Neurosci 27:2704-2717, doi: ... A, Neuroblasts (green cells) migrating in chains in the RMS express high levels of S1P1, PSA-NCAM, and β1 integrin. S1P is ...http://www.jneurosci.org/content/35/40/13659
Laminina, alfa 3 - Viquipèdia, l'enciclopèdia lliure
Laminin-8 stimulates cell adhesion and migration through alpha3beta1 and alpha6beta1 integrins.». J. Biol. Chem., vol. 276, 20 ... Gonzales M, Haan K, Baker SE, et al. «A cell signal pathway involving laminin-5, alpha3beta1 integrin, and mitogen-activated ...https://ca.wikipedia.org/wiki/Laminina,_alfa_3
Multiple Sclerosis; Sclerosis, Disseminated; Multiple Sclerosis, Acute Fulminating; MS (Multiple Sclerosis)
Integrin alpha6beta1. 1. + +. 414. Carbon Monoxide. 1. + +. 415. Sertraline. 1. + +. 416. Fibrillar Collagens. 1. + +. ...https://lookfordiagnosis.com/results.php?symptoms=Multiple+Sclerosis%3B%20Sclerosis%2C%20Disseminated%3B%20Multiple%20Sclerosis%2C%20Acute%20Fulminating%3B%20MS%20%28Multiple%20Sclerosis%29&lang=1&parent=%2F&mode=F&therapy_ap=1
Regulation of mitogen-activated protein kinase activation by the cytoplasmic domain of the alpha6 integrin subunit. - Semantic...
These data were confirmed by antibody clustering of the alpha6beta1 integrins. Both the alpha6Abeta1 and alpha6Bbeta1 integrins ... Our findings demonstrate that the alpha6beta1 integrin can activate MAP kinase, that this activation is regulated by the ... Adhesion to laminin-1 mediated by the alpha6Abeta1 integrin triggered activation of a substantial fraction of total p42 and p44 ... Activation of MAP kinase by alpha6beta1 requires both Ras and protein kinase C activity. A functional correlate for ...https://www.semanticscholar.org/paper/Regulation-of-mitogen-activated-protein-kinase-by-Wei-Shaw/b052d8a906505575590391b974f7db1892bbeb8f
WPMY-1 ATCC ® CRL-2854™ Homo sapiens prostate/stroma normal
Laminin-1 and alpha6beta1 integrin regulate acinar morphogenesis of normal and malignant human prostate epithelial cells. ... Laminin-1 and alpha6beta1 integrin regulate acinar morphogenesis of normal and malignant human prostate epithelial cells. ... The role of alpha 6 beta 1 integrin and EGF in normal and malignant acinar morphogenesis of human prostatic epithelial cells. ... The role of alpha 6 beta 1 integrin and EGF in normal and malignant acinar morphogenesis of human prostatic epithelial cells. ...https://www.atcc.org/products/all/CRL-2854.aspx
WPE-int ATCC ® CRL-2888™ Homo sapiens prostate, normal, peri
Laminin-1 and alpha6beta1 integrin regulate acinar morphogenesis of normal and malignant human prostate epithelial cells. ... Laminin-1 and alpha6beta1 integrin regulate acinar morphogenesis of normal and malignant human prostate epithelial cells. ... The role of alpha 6 beta 1 integrin and EGF in normal and malignant acinar morphogenesis of human prostatic epithelial cells. ... The role of alpha 6 beta 1 integrin and EGF in normal and malignant acinar morphogenesis of human prostatic epithelial cells. ...https://www.atcc.org/Global/Products/C/1/B/F/CRL-2888.aspx
Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase...
Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: role of alpha6beta1 integrin. Diabetes 2000; ... Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol 1995;131:791-805pmid:7593197. ... Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol Biol Cell 1995;6: ... Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992;69:11-25pmid:1555235. ...http://diabetes.diabetesjournals.org/content/60/4/1146.full.print
"Dissection of α6β4 Integrin-Dependent Signaling and Breast Carcinoma I" by Xiaoqing Yang
The α6β4 integrin can stimulate SFK activation and promote cancer invasion, however the mechanism by which it does so is not ... The α6β4 integrin, a transmembrane heterodimeric laminin receptor is associated with poor prognosis in many tumor types, ... In the current study, I provide novel mechanistic insight into how the α6β4 integrin selectively activates the Src family ... Breast Neoplasms, Integrin alpha6beta1, src-Family Kinases, Proto-Oncogene Proteins c-fyn, Neoplasm Invasiveness ...https://escholarship.umassmed.edu/gsbs_diss/563/
Patent US20020160497 - Suppressors of human breast cancer cell growth - Google Patents
Inhibition of pathogenic agents including alpha6beta1 integrin receptor of alpha6beta4 integrin receptor at a surface. ... Inhibition of pathogenic agents including α6β1 integrin receptor or α6β4 integrin receptor at a surface. ... 1995) The alpha 6 beta 1 and alpha 6 beta 4 integrins in human prostate cancer progression. Cancer Metastasis Rev. 14: 219-228 ... a, in vitro translated and [35S]methionine-labeled Integrin β4 Receptor or Laminin Binding Protein were incubated with GST ...http://www.google.co.uk/patents/US20020160497
In vivo Postnatal Electroporation and Time-lapse Imaging of Neuroblast Migration in Mouse Acute Brain Slices | Protocol ...
Emsley, J. G., Hagg, T. alpha6beta1 integrin directs migration of neuronal precursors in adult mouse forebrain. Exp. Neurol. ...https://www.jove.com/video/50905/?language=Chinese
Peritoneal fluid stimulates neoplastic transformation of normal HEK 293 cells by high expression of pluripotent genes
Ascites induces modulation of alpha6beta1 integrin and urokinase plasminogen activator receptor expression and associated ... Loss of E-Cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target. Cancer Res 2008; 68 ...https://www.termedia.pl/Peritoneal-fluid-stimulates-neoplastic-transformation-of-normal-HEK-293-cells-by-high-expression-of-pluripotent-genes,55,34120,1,1.html
Product Overview anti-Laminin beta 1 Antibodies
Laminins 411 and 421 differentially promote tumor cell migration via alpha6beta1 integrin and MCAM (CD146 (show MCAM Antibodies ... beta1 integrin, ICAM-1 (show ICAM1 Antibodies) and VCAM-1 (show VCAM1 Antibodies). ... and laminin via the integrin, ERK (show EPHB2 Antibodies), and NF-kappaB (show NFKB1 Antibodies) dependent pathway. ... integrin expression in mouse and DMD (show DMD Antibodies) patient myoblasts ...http://www.antibodies-online.com/abstract/Laminin%2C+beta+1+
Gene Report for G00002407 - Genes2Cognition Neuroscience Research Programme
... cell adhesion and promote pancreatic cancer cell migration by decreasing the adhesive interactions between integrin alpha6beta1 ... Soluble integrin-AP chimeras should be generally useful for identifying and characterizing integrin interactions with ligands. ... Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions ... and beta6 integrins, and annexin II. Beta6 integrin mRNA levels were assessed by semiquantitative reverse transcription- ...http://www.genes2cognition.org/db/Gene/G00002407
CD151 - Wikipedia
Zhang XA, Kazarov AR, Yang X, Bontrager AL, Stipp CS, Hemler ME (2002). "Function of the tetraspanin CD151-alpha6beta1 integrin ... Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E (1999). "Selective tetraspan-integrin complexes ( ... This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 ... It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This ...https://en.wikipedia.org/wiki/CD151
CiNii 論文 - Cryptic fragment α4 LG4-5 derived from laminin α4 chain inhibits de novo...
... of laminin alpha5 harbors the binding sites of Lutheran/basal cell adhesion molecule and alpha3beta1/alpha6beta1 integrins ... Molecular dissection of the alpha-dystroglycan- and integrin-binding sites within the globular domain of human laminin-10 IDO H ... Alpha (v) beta3 and alpha (v) beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) ... Complex interactions between the laminin alpha 4 subunit and integrins regulate endothelial cell behavior in vitro and ...https://ci.nii.ac.jp/naid/10021095600
ADAM2 - Wikipedia
"Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for ... Chen H, Sampson NS (January 1999). "Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor ... "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg ...https://en.wikipedia.org/wiki/ADAM2
Important Functional Roles of Basigin in Thymocyte Development and T cell Activation
The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma ...http://www.ijbs.com/v10p0043.htm
The integrin, alpha6beta1, is necessary for the matrix-dependent activation of FAK and MAP kinase and the migration of human ... The integrin alpha 6 beta 4 and the biology of carcinoma. Biochem Cell Biol 1996;74:811-21. ... It is noteworthy that the ITGA6 gene encoding integrin α6 plays a role in the tumorigenic process of many cancers including HCC ...http://cancerres.aacrjournals.org/content/75/3/532
Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes...
The integrin, alpha6beta1, is necessary for the matrix-dependent activation of FAK and MAP kinase and the migration of human ... Expression and cytoskeletal association of integrin subunits is selectively increased in rat perivenous hepatocytes after ... integrin, beta 4. ▲ 2.61. protein binding. NM_000213. 204226_at. STAU2. staufen, RNA binding protein, homolog 2 (Drosophila). ... Integrins act as signal transducing molecules trough mitogen-activated protein (MAP) kinase like extracellular-regulated kinase ...http://www.medsci.org/v04p0028.htm