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*  Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis. | Scholars@Duke
Fibronectin's RGD-mediated binding to the alpha5beta1 integrin is dramatically enhanced by a synergy site within fibronectin ... The integrin-binding synergy site is a much more extensive surface than the small linear peptide sequence. ... R1379 in the peptide PHSRN, and the nearby R1374 have been shown previously to be important for alpha5beta1-mediated adhesion ( ... presumably toward the integrin, and mutated them to alanine. ...
https://scholars.duke.edu/display/pub706506
*  Reactome | Integrin alpha5beta1 binds FN1 dimer
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
http://www.reactome.org/content/detail/R-XTR-202723
*  Reactome | Integrin alpha5beta1:FN1 dimer [plasma membrane]
Integrin alpha5beta1 binds FN1 dimer (Homo sapiens) * Integrin alpha5beta1:FN1 dimer [plasma membrane] (Homo sapiens) ... Integrin alpha5beta1 binds FN1 dimer (Homo sapiens) * Integrin alpha5beta1:FN1 dimer [plasma membrane] (Homo sapiens) ... Integrin alpha5beta1:FN1 dimer [plasma membrane] (Gallus gallus) Integrin alpha5beta1:FN1 dimer [plasma membrane] (Mus musculus ... Integrin alpha5beta1:FN1 dimer [plasma membrane] (Bos taurus) Integrin alpha5beta1:FN1 dimer [plasma membrane] (Canis ...
http://www.reactome.org/content/detail/R-HSA-202708
*  Reactome | COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47
Integrin cell surface interactions (Rattus norvegicus) * COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Rattus ...
http://www.reactome.org/content/detail/R-RNO-2426259
*  3VI3: Crystal structure of alpha5beta1 integrin headpiece (ligand-free form)
Integrin alpha-5Integrin beta-1SG/19 Fab fragment (Heavy chain)SG/19 Fab fragment (Light chain)ALPHA-D-MANNOSECALCIUM ...
https://www.ncbi.nlm.nih.gov/Structure/pdb/3VI3
*  BAFF synthesis by rheumatoid synoviocytes is positively controlled by alpha5beta1 integrin stimulation and is negatively...
In contrast, we demonstrated that stimulation of alpha5beta1 integrin can induce BAFF synthesis and release per se and that ... and alpha5beta1 integrin are able to induce BAFF synthesis by RA FLS. METHODS: Quantitative reverse transcription-polymerase ... alpha5beta1 integrin (bacterial lipopeptide [BLP] palmitoyl-3-cysteine-serine-lysine-4, lipopolysaccharide [LPS], CpG, and ... In contrast, we demonstrated that stimulation of alpha5beta1 integrin can induce BAFF synthesis and release per se and that ...
https://www.ndorms.ox.ac.uk/publications/681606
*  Adeno-associated virus type 2 contains an... & related info | Mendeley
For example, adenoviruses are known to interact with alphaV integrins by virtue of a high-a... ... Integrins have been implicated as coreceptors in the infectious pathways of several nonenveloped viruses. ... Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry.. *Asokan A ... In this report, we demonstrate that integrin alpha5beta1 serves as an alternative coreceptor for AAV2 infection in human ...
https://www.mendeley.com/research-papers/adenoassociated-virus-type-2-contains-integrin-alpha5beta1-binding-domain-essential-viral-cell-entry/
*  Focal adhesion kinase modulates cell adhesion strengthening via integrin activation.
Integrin alpha5beta1 / metabolism*. Integrins / metabolism*. Kinetics. Mice. Phosphorylation / drug effects. Phosphotyrosine / ... 0/Fibronectins; 0/Integrin alpha5beta1; 0/Integrins; 0/Talin; 125361-02-6/Vinculin; 21820-51-9/Phosphotyrosine; EC 2.7.10.2/ ... During the early stages of adhesion, FAK expression in FAK-null cells enhances integrin activation to promote integrin binding ... This work demonstrates a novel role for FAK in integrin activation and the time-dependent generation of cell-ECM forces.. ...
http://www.biomedsearch.com/nih/Focal-adhesion-kinase-modulates-cell/19297531.html
*  Browse our ANGPTL2 ELISA Kits
Results reveal a novel cascade comprising sequential P. gingivalis lipopolysaccharide --> ANGPTL2 --> integrin alpha5beta1 --> ...
http://www.antibodies-online.com/abstract/Angiopoietin-Like+2+
*  Homeobox - Wikipedia
Boudreau NJ, Varner JA (Feb 2004). "The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and ... HoxD3 and HoxB3 are proinvasive, angiogenic genes that upregulate b3 and a5 integrins and Efna1 in ECs, respectively. HoxA3 ... integrins, and components of the ECM. HoxA5 is implicated in atherosclerosis. ...
https://en.wikipedia.org/wiki/Homeobox
*  HOXD3 - Wikipedia
Boudreau NJ, Varner JA (Feb 2004). "The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and ...
https://en.wikipedia.org/wiki/HOXD3
*  Alpha-5 beta-1 - Wikipedia
Integrin alpha5beta1 at the US National Library of Medicine Medical Subject Headings (MeSH) ITGA5 ITGB1 Info with links in the ... Boudreau NJ, Varner JA (February 2004). "The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and ... α5β1 is an integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis. It is composed of ... α5β1-integrin is transported inside the cell by the kinesin KIF1C, a kinesin-3 organelle transporter that walks along ...
https://en.wikipedia.org/wiki/Alpha-5_beta-1
*  KAKEN - Research Projects | Study on interaction of integrins with extracellular matrix in proliferation of chondrocytes ...
... anti-alpha5beta1 integrin or anti-fibronectin antibody, indicating that attachment involved alpha5beta1 integrin. In contrast, ... To analyze the role of alpha5beta1 integrin in chondrocyte proliferation, we used agar suspension cultures in which the ... The results of the study indicate that alpha5beta1 integrin plays multiple roles in chondrocyte behavior and function, and ... Publications] D.Boettiger: 'Regulation of integrin alpha5beta1 affinity during myogenic differentiation.' Dev.Biol.169. 261-272 ...
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06671853/
*  Fibronectin binding protein A - Wikipedia
Huveneers S, Truong H, Fässler R, Sonnenberg A, Danen EH (2008). "Binding of soluble fibronectin to integrin alpha5 beta1 - ... Similarly, the α5β1 integrin present on host cells also binds fibronectin to create a link to its actin cytoskeleton, binding ...
https://en.wikipedia.org/wiki/Fibronectin_binding_protein_A
*  JCI - Biomarkers for epithelial-mesenchymal transitions
Integrin alpha5beta1 and fibronectin regulate polarized cell protrusions required for Xenopus convergence and extension. Curr. ... In addition, integrin signaling facilitates EMT (68, 69), and various integrins are expressed on both epithelial and ... A change in the level of expression of different integrins (an integrin switch) often reflects alterations in cell-ECM ... The characterization of alpha5-integrin expression on tubular epithelium during renal injury. Am. J. Physiol. Renal Physiol. ...
https://www.jci.org/articles/view/36183
*  Frontiers | Biology of Vascular Endothelial Growth Factor C in the Morphogenesis of Lymphatic Vessels | Bioengineering and...
Extracellular matrix regulates endothelial functions through interaction of VEGFR-3 and integrin alpha5beta1. J. Cell. Physiol. ... Soldi, R., Mitola, S., Strasly, M., Defilippi, P., Tarone, G., and Bussolino, F. (1999). Role of alphavbeta3 integrin in the ... integrins (Soldi et al., 1999), or syndecans (Johns et al., 2016). However, these interactions are typically of lower affinity ... interstitial pressure that builds up during development in blood-vascularized but lymphatic-free tissues leads via β1-integrin- ...
https://www.frontiersin.org/articles/10.3389/fbioe.2018.00007/full
*  Collagen I fiber density increases in lymph node positive breast cancers: pilot study
C. T. Mierkeet al., "Integrin alpha5beta1 facilitates cancer cell invasion through enhanced contractile forces," J. Cell. Sci. ... 6 Breast cancer cells invade into Col1 matrices by overexpressing integrins on their cell surface, which enable these cells to ...
https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-17/issue-11/116017/Collagen-I-fiber-density-increases-in-lymph-node-positive-breast/10.1117/1.JBO.17.11.116017.full
*  MGAT3 - Wikipedia
2004). "Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and ...
https://en.wikipedia.org/wiki/MGAT3
*  C3G | SpringerLink
Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin alpha5beta1. ... The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. J Cell ...
https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_101544
*  Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis | Molecular...
Integrin alpha5beta1, the fibronectin receptor, as a pertinent therapeutic target in solid tumors. Cancers 2013;5:27-47. ... Integrin alpha5beta1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade ... We showed that compared with other integrin-targeting agents, 2.5F binds with high affinity to α5β1 integrin and integrins ... which instead only bind αv-containing integrins or α5β1 integrin. Targeting multiple integrin receptors is potentially ...
http://mct.aacrjournals.org/content/15/6/1291
*  Plus it
Distinct roles of talin and kindlin in regulating integrin alpha5beta1 function and trafficking. Curr Biol 2012;22:1554-63. ... The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph ...
http://cancerres.aacrjournals.org/content/75/19/4153
*  KAKEN - Research Projects | ErbBファミリーの二量体形成におけるN型糖鎖の機能 (KAKENHI-
Journal Article] Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell ... III down-regulates neurite outgrowth induced by co-stimulation of epidermal growth factor and integrins through the Ras/ERK ...
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16790167/
*  Endostatin - Wikipedia
Wickstrom, S.A.; Alitalo, K.; Keski-Oja, J. (2002). "Endostatin associates with integrin alpha5beta1 and caveolin-1, and ... By binding integrin α5β1 on endothelia cells it inhibits the signaling pathways of Ras and Raf kinases and decreases ERK-1 and ... Endostatin binding and clustering of integrins causes co-localization with caveolin-1 and activates non-receptor tyrosine ... The result is possible because pathogenic-derived angiogenesis usually involves signaling through integrins, which are directly ...
https://en.wikipedia.org/wiki/Endostatin
*  Cell movements of the deep layer of non-neural ectoderm underlie complete neural tube closure in Xenopus | Development
2006). Integrin alpha5beta1 and fibronectin regulate polarized cell protrusions required for Xenopus convergence and extension ... In a previous study, it has been reported that integrin-α6, which forms heterodimer with integrin-β1, plays essential role in ... integrin-β1-res) was generated by changing the nucleotides (indicated by lower letters) of integrin-β1B by PCR: (-4) 5′- ... 2002). Integrins in development: moving on, responding to, and sticking to the extracellular matrix. Dev. Cell 3, 311-321. ...
http://dev.biologists.org/content/139/8/1417
*  Fn1 fibronectin 1 [Rattus norvegicus (Norway rat)] - Gene - NCBI
... iabetes interferes with the osseointegration of implants by deferring expression of fibronectin and integrin alpha5beta1 Title ... Integrin alphaIIb beta3 signaling, organism-specific biosystem (from REACTOME) Integrin alphaIIb beta3 signaling, organism- ... Integrin cell surface interactions, organism-specific biosystem (from REACTOME) Integrin cell surface interactions, organism- ... GRB2:SOS provides linkage to MAPK signaling for Integrins, organism-specific biosystem (from REACTOME) GRB2:SOS provides ...
https://www.ncbi.nlm.nih.gov/gene/?term=25661