Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine | IRIS Università degli Studi di Catania
... integrin by reducing infiltrated eosinophils. We propose that blockade of integrin-mediated cell adhesion might be a target of ... integrin by reducing infiltrated eosinophils. We propose that blockade of integrin-mediated cell adhesion might be a target of ... The adhesion molecule integrin alpha(4)beta(1) is expressed in eosinophils; it interacts with the vascular cell adhesion ... The adhesion molecule integrin alpha(4)beta(1) is expressed in eosinophils; it interacts with the vascular cell adhesion ...https://www.iris.unict.it/handle/20.500.11769/51349
Reactome | VCAM1 binds Integrin alpha4beta1
Integrin cell surface interactions (Bos taurus) * VCAM1 binds Integrin alpha4beta1 (Bos taurus) ...http://www.reactome.org/content/detail/R-BTA-198941
AID 303242 - Inhibition of integrin alpha4beta1 receptor-mediated human Molt-4 cell adhesion to CS1 peptide - PubChem
Inhibition of integrin alpha4beta1 receptor-mediated human Molt-4 cell adhesion to CS1 peptide. ...https://pubchem.ncbi.nlm.nih.gov/bioassay/303242
Reactome | Integrin alpha4beta1 binds JAM2:JAM3
Integrin cell surface interactions (Gallus gallus) * Integrin alpha4beta1 binds JAM2:JAM3 (Gallus gallus) ...http://www.reactome.org/content/detail/R-GGA-202706
Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging. -...
Here we report on the identification of a high-affinity peptidomimetic ligand (LLP2A; IC50 = 2 pM) against alpha4beta1 integrin ... Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imaging.. Peng ... We further demonstrate that LLP2A can be used to image alpha4beta1-expressing lymphomas with high sensitivity and specificity ... Thus, LLP2A provides an important tool for noninvasive monitoring of alpha4beta1 expression and activity during tumor ...https://www.ncbi.nlm.nih.gov/pubmed/16767086
Details and Download Full Text PDF: Alpha4beta1 integrin blockade after spinal cord injury decreases damage and improves...
Alpha4beta1 integrin blockade after spinal cord injury decreases damage and improves neurological function.. Authors:. ... The integrin alpha4beta1, expressed by these leukocytes, is a key to their activation and migration into/within tissue. ... The leukocyte integrin alpha4beta1 is crucial for their entry. The authors previously demonstrated that an anti-alpha4 ... Timing and duration of anti-alpha4beta1 integrin treatment after spinal cord injury: effect on therapeutic efficacy.. Authors: ...https://www.pubfacts.com/detail/19038604/Alpha4beta1-integrin-blockade-after-spinal-cord-injury-decreases-damage-and-improves-neurological-fu
Distribution of α4 on multiple K562-α4wt and K562 | Open-i
Previous studies have shown that integrin alpha chain tails make strong positive contributions to integrin-mediated cell ... Furthermore, alpha4 tail deletion also significantly decreased the membrane diffusivity of alpha4beta1, as determined by a ... Previous studies have shown that integrin alpha chain tails make strong positive contributions to integrin-mediated cell ... We now show here that integrin alpha4 tail deletion markedly impairs static cell adhesion by a mechanism that does not involve ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2199079_JEM.962074f5&req=4
Immunohistochemical analysis of c-kit receptor express | Open-i
Cell adhesion to FN40 was completely inhibited with antibodies against the alpha4 and beta1 integrin subunits, revealing that ... Cell adhesion to FN40 was completely inhibited with antibodies against the alpha4 and beta1 integrin subunits, revealing that ... The SCF-stimulated adhesion occurred without concomitant changes in surface integrin expression, thereby indicating an avidity- ... The SCF-stimulated adhesion occurred without concomitant changes in surface integrin expression, thereby indicating an avidity- ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2198988_JEM.970564f2&req=4
NCAM1 Gene - GeneCards | NCAM1 Protein | NCAM1 Antibody
Integrin α4β1 inhibitor, Highly potent and selective inhibitor of integrin alpha4beta1. 0. ... Highly potent and selective inhibitor of integrin alpha4beta1. 327613-57-0. Echistatin, alpha1 isoform. alphaVbeta3 and ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=NCAM1
SELE Gene - GeneCards | LYAM2 Protein | LYAM2 Antibody
Highly potent and selective inhibitor of integrin alpha4beta1. 327613-57-0. Echistatin, alpha1 isoform. alphaVbeta3 and ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=SELE
den Hertog group
Integrin alpha4beta1 promotes FAK-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Hsia, D ... Laminin alpha 4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and ...https://www.hubrecht.eu/research-groups/den-hertog-group/
CD169 mediates the capture of exosomes in spleen and lymph node | Blood Journal
Exosomes released during reticulocyte maturation bind to fibronectin via integrin alpha4beta1. Eur J Biochem. 2000;267(2):583- ... DC-derived exosomes abundantly express the ligand milk-fat globule lactadherin, a potential ligand for the αvβ3/β5 integrins.38 ... Adhesion and signaling by B cell-derived exosomes: the role of integrins. FASEB J. 2004;18(9):977-979. ...http://www.bloodjournal.org/content/123/2/208?sso-checked=true
Dock2 - Wikipedia
"DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin alpha4beta1". ...https://en.wikipedia.org/wiki/Dock2
Produktübersicht anti-CD69 Antikörper
CD69 is induced by integrin alpha4beta1 outside-in signalling and T-cell receptor signalling. ...https://www.antikoerper-online.de/abstract/CD69+
CD106 (VCAM-1) Antibody (Monoclonal, STA)
CD106 binds to Integrin alpha4beta1 (VLA-4, CD49d/CD29) and Integrin alpha4beta7 (LPAM-1). Cytokine-mediated upregulation of ...https://www.thermofisher.com/antibody/product/CD106-VCAM-1-Antibody-clone-STA-Monoclonal/14-1069-82
Overlapping Roles of CXCL13, Interleukin 7 Receptor α, and CCR7 Ligands in Lymph Node Development | JEM
Role of alpha4beta1 integrin activation by CXCR5. Immunity. 17:363-373.. OpenUrlCrossRefPubMed ... the integrin α4β7, and the CXCL13 (BLC) receptor, CXCR5 (2, 6). When these cells are identified by their expression of IL-7Rα ...http://jem.rupress.org/content/197/9/1191?ijkey=546326b6b2774eb9677430edf0412cd1abaa1bca&keytype2=tf_ipsecsha
IGSF8 - Wikipedia
2004). "EWI-2 modulates lymphocyte integrin alpha4beta1 functions". Blood. 103 (8): 3013-9. doi:10.1182/blood-2003-07-2201. ... Stipp CS, Kolesnikova TV, Hemler ME (2004). "EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5". J. ... 2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization". J. Biol. ...https://en.wikipedia.org/wiki/IGSF8
Rap1: Selective activator of β2 integrins?<...
Rap1 : Selective activator of β2 integrins? / Stork, Philip.. In: Blood, Vol. 110, No. 10, 15.11.2007, p. 3496-3497.. Research ... title = "Rap1: Selective activator of β2 integrins?",. abstract = "In T cells, Rap1 is well-recognized as a major mediator of ... In T cells, Rap1 is well-recognized as a major mediator of inside-out signaling to integrins following stimulation by antigen ... N2 - In T cells, Rap1 is well-recognized as a major mediator of inside-out signaling to integrins following stimulation by ...https://ohsu.pure.elsevier.com/en/publications/rap1-selective-activator-of-%CE%B22-integrins-2
Natalizumab treatment reduces fatigue in multiple sclerosis. Results from the TYNERGY trial; a study in the real life setting -...
Integrin alpha4beta1; Male; Middle Aged; Multiple Sclerosis; Quality of Life; Questionnaires; Walking Main Research Area: ...https://www.forskningsdatabasen.dk/en/catalog/240422234
LPS-Induced TLR4 Signaling in Human Colorectal Cancer Cells Increases β1 Integrin-Mediated Cell Adhesion and Liver Metastasis |...
Integrin alpha4beta1/VCAM-1 pathway mediates primary adhesion of RAW117 lymphoma cells to hepatic sinusoidal endothelial cells ... For β1 integrin blockade, β1 integrin functional blocking antibody (2.0 μg/mL) or isotype control IgG1 (2.0 μg/mL) were ... Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at ... Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly. J Biol Chem 2007;282:22964-76. ...http://cancerres.aacrjournals.org/content/71/5/1989
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size | JEM
Osteopontin is a ligand for the alpha4beta1 integrin. J. Cell Sci. 111:1165-1174. ... Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand ... Stem cells are known to express CD44 and α4 integrin, both of which are receptors capable of interacting with OPN (12, 13). ... Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing. Mol. Cell. ...http://jem.rupress.org/content/201/11/1781
Erythroid cells generated in the absence of specific β1-integrin heterodimers accumulate reactive oxygen species at homeostasis...
Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development ... Proteomic analysis of alpha4beta1 integrin adhesion complexes reveals alpha-subunit-dependent protein recruitment. Proteomics. ... Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation ... Integrin-dependent signaling in erythroid cells. How are the phenotypic differences between α4- and α 5-integrins molecularly ...http://www.haematologica.org/content/98/11/1769
The effect of anti-integrin monoclonal antibodies on antigen-induced pulmonary inflammation in allergic rabbits. - Semantic...
... integrin), CD18 (beta(2) integrin) and the alpha sub-units of beta(2) integrin CD11a (LFA-1 integrin) and CD11b (Mac-1 integrin ... Treatment with the other anti-integrin mAbs had no effect on the acute bronchoconstriction after inhaled Ag challenge.Pre- ... treatment with the anti-integrin mAbs had differential effects in blocking the recruitment of inflammatory cells 24 h after ... The integrin adhesion molecules are involved in the recruitment and activation of inflammatory cells at sites of inflammation ...https://www.semanticscholar.org/paper/The-effect-of-anti-integrin-monoclonal-antibodies-Gascoigne-Holland/835de195266434990ac0574291b231f6938e9321
Table of Contents | Journal of Cell Science
Osteopontin is a ligand for the alpha4beta1 integrin K.J. Bayless, G.A. Meininger, J.M. Scholtz, G.E. Davis ... Vitronectin regulates smooth muscle contractility via alphav and beta1 integrin L.M. Dahm, C.W. Bowers ...http://jcs.biologists.org/content/111/9.most-read
US6103522A - Human marrow stromal cell lines which sustain hematopoiesis - Google Patents
108010008212 Integrin alpha4beta1 Proteins 0 description 1 * 229940047124 Interferons Drugs 0 description 1 ...https://patents.google.com/patent/US6103522A/en