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*  Reactome | Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1
Integrin cell surface interactions (Bos taurus) * Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and ... Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 Stable Identifier ... Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens) ... Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Bos taurus) ...
http://www.reactome.org/content/detail/R-BTA-2327695
*  Structure Function Analysis of Integrins alpha1beta1 and alpha2beta2 - Roy Zent
Integrins are transmembrane receptors formed by non-covalently bound alpha and beta subunits. The beta-1 subunit binds 12 alpha ... Structure Function Analysis of Integrins alpha1beta1 and alpha2beta2 Zent, Roy Sanders, Charles R. Vanderbilt University ... Structure Function Analysis of Integrins alpha1beta1 and alpha2beta2. Zent, Roy; Sanders, Charles R. / Vanderbilt University ... Structure Function Analysis of Integrins alpha1beta1 and alpha2beta2. Zent, Roy; Sanders, Charles R. / Vanderbilt University ...
http://grantome.com/grant/NIH/R01-DK083187-04
*  Distinct structural forms of type I collagen modulate cell cycle regulatory proteins in mesangial cells.
Integrin alpha1beta1. Integrins / metabolism. Male. Microtubule-Associated Proteins / metabolism. Mitogen-Activated Protein ... 0/Blood Proteins; 0/Cdkn1b protein, rat; 0/Cell Cycle Proteins; 0/Cyclin E; 0/Integrin alpha1beta1; 0/Integrins; 0/Microtubule- ... changes of expression and/or activation of MAPK and G1-phase regulators and could result from the lack of alpha1beta1 integrin ... In MCs plated on monomer type I collagen, alpha1, alpha2, and beta1 integrin chains were recruited into focal contacts. However ...
http://www.biomedsearch.com/nih/Distinct-structural-forms-type-collagen/10972675.html
*  Itga1 - Integrin alpha-1 precursor - Rattus norvegicus (Rat) - Itga1 gene & protein
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in ... "Alpha1beta1-integrin is an essential signal for neurite outgrowth induced by thrombospondin type 1 repeats of SCO-spondin.". ... IPR013649 Integrin_alpha-2. IPR018184 Integrin_alpha_C_CS. IPR028994 Integrin_alpha_N. IPR032695 Integrin_dom_sf. IPR002035 VWF ... IPR013649 Integrin_alpha-2. IPR018184 Integrin_alpha_C_CS. IPR028994 Integrin_alpha_N. IPR032695 Integrin_dom_sf. IPR002035 VWF ...
https://www.uniprot.org/uniprot/P18614
*  Glucose enhances rotavirus enterotoxin-induced intestinal chloride secretion. - PubMed - NCBI
Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin. Seo NS, et al. Proc Natl Acad Sci U S A. ...
https://www.ncbi.nlm.nih.gov/m/pubmed/28488023/
*  Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics
Importance of alpha1beta1 Integrin and TGF-beta. Donald E. Staunton, ICOS Corporation, USA Regulation of Leukocyte Integrin ... Conformational Regulation of Integrin Structure and Function. Paul S. Frenette, Albert Einstein College of Medicine, USA ... JAM2 Interactions with Integrin. Beat A. Imhof, Centre Médical Universitaire, Switzerland Facilitation of Leukocyte ... Integration of Signals from G-Protein Coupled Receptors, Selectin and Integrin Engagement by Rolling Neutrophils. ...
http://keystonesymposia.org/index.cfm?e=web.meeting.program&meetingid=611
*  Reactome | GlcGalHyl-COL1A2 [extracellular region]
Integrins alpha1beta1, alpha2beta1:Collagen type I fibril:Mg2+ [plasma membrane] (Homo sapiens) * Collagen type I fibril [ ... Integrins alpha1beta1, alpha2beta1:Collagen type I fibril:Mg2+ [plasma membrane] (Homo sapiens) * Collagen type I fibril [ ... Integrin cell surface interactions (Homo sapiens) * Collagen type I binds integrin alpha11beta1 (Homo sapiens) * Collagen type ... Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens) * Collagen type I fibril [extracellular ...
https://reactome.org/content/detail/R-HSA-2089984
*  Gilbert Moeckel, MD, PhD, FASN | Yale School of Medicine
Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration. Moeckel GW, Zhang L, Chen X, Rossini ... Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration. American Journal Of Physiology. Renal ...
https://medicine.yale.edu/research/gilbert_moeckel.profile
*  Very Late Antigen-1 Mediates Corneal Lymphangiogenesis | IOVS | ARVO Journals
Pozzi A Wary KK Giancotti FG Gardner HA . Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in ... 18 The specific roles of integrins in LG are still largely unknown. VLA-1 (very late antigen-1), also known as integrin α1β1, ... Stepp MA . Corneal integrins and their functions. Exp Eye Res. 2006;83:3-15. [CrossRef] [PubMed] ... Integrins are known to have an essential role in the LG process by mediating cell interactions with the extracellular matrix. ...
https://iovs.arvojournals.org/article.aspx?articleid=2188573
*  Frontiers | Soft TCPTP Agonism-Novel Target to Rescue Airway Epithelial Integrity by Exogenous Spermidine | Pharmacology
Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP. ... 2012). Integrin alpha9beta1 in airway smooth muscle suppresses exaggerated airway narrowing. J. Clin. Invest. 122, 2916-2927. ... The hypothesis that envisages a pathogenic role for PA is also supported by the findings of a study describing the integrin- ... It has been shown that proper assembly of the integrin-SSAT-PIP5K1γ complex results in efficient PA catabolism and airways ...
https://www.frontiersin.org/articles/10.3389/fphar.2016.00147/full
*  COL16A1 Gene - GeneCards | COGA1 Protein | COGA1 Antibody
Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains. (PMID: 16754661) Eble JA … Grässel S ... Interacts with FBN1, fibronectin and integrins ITGA1/ITGB1 and ITGA2/ITGB1. Integrin ITGA1/ITGB1 binds to a unique site within ... GO annotations related to this gene include integrin binding. An important paralog of this gene is COL22A1. ... Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations ...
http://www.genecards.org/cgi-bin/carddisp.pl?gene=COL16A1&keywords=GH01H031707&prefilter=genomic_location
*  Reactome | GalHyl-COL4A1(173-1669) [extracellular region]
Integrins alpha1beta1, alpha2beta1:Collagen type IV networks:Mg2+ [plasma membrane] (Homo sapiens) * Collagen type IV networks ... Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens) * Collagen types III, IV ... Integrin cell surface interactions (Homo sapiens) * Collagen type IV binds integrin alpha10beta1 (Homo sapiens) * Collagen type ... Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 (Homo sapiens) * Collagen type IV networks [extracellular ...
https://reactome.org/content/detail/R-HSA-2127432
*  SMART: VWA domain annotation
THE CRYSTAL STRUCTURE OF THE I-DOMAIN OF HUMAN INTEGRIN ALPHA1BETA1. 1rd4. An allosteric inhibitor of LFA-1 bound to its I- ... INTEGRIN ALPHA M I DOMAIN. 1mhp. Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a ... Integrin I domain of complement receptor 3 in complex with C3d. 4mmx. Integrin AlphaVBeta3 ectodomain bound to the tenth domain ... Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist L-739758. 2vdk. Re-refinement of Integrin AlphaIIbBeta3 ...
http://smart.embl.de/smart/do_annotation.pl?DOMAIN=VWA&START=126&END=357&E_VALUE=1.25e-1&TYPE=SMART&BLAST=PIDLYYLMDLSYSMLDDLNNVKKLGGDLLQALNEITESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKACQPPFAFRHVLKLTDNSNQFQTEVGKQLISGNLDAPEGGLDAIMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNMYKRSNEFDYPSVGQLAHKLSESNIQPIFAVTKKMVKTYEKLTEIIPKSAVGELSDDSSNVVQLIK
*  Review. The lens as a model for fibrotic disease | Philosophical Transactions of the Royal Society B: Biological Sciences
2004 Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am. J. Pathol. 165, 617-630. ... β1 integrin is the most diverse integrin subunit as it can associate with 12 different α integrin chains [131], thus is the ... A gene expression profile of integrins in FHL 124 cells. (a) The baseline signal of integrin gene expression detected in non- ... Similarly, in non-ocular fibrotic diseases αVβ6 integrin is increased following acute biliary injury [145]. αVβ6 integrin ...
http://rstb.royalsocietypublishing.org/content/366/1568/1301
*  Immune Semaphorins: Novel Features of Neural Guidance Molecules | SpringerLink
Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature 2007;446:680-4. doi: ... Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature 2003;424:398-405. doi: 10.1038/nature01790.PubMed ... Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins. J Invest Dermatol. 2008;128:151- ... C1 engagement on mouse dendritic cells by viral semaphorin A39R induces actin cytoskeleton rearrangement and inhibits integrin- ...
https://link.springer.com/article/10.1007%2Fs10875-008-9263-7
*  Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities
Regulation of inflammation by collagen-binding integrins alpha1beta1 and alpha2beta1 in models of hypersensitivity and ... von Andrian UH, Engelhardt B. Alpha4 integrins as therapeutic targets in autoimmune disease. N. Engl. J. Med. 2003;348:68-72. [ ... Briefly, trafficking targets may include very late antigen-1 (VLA-1, or α1β1-integrin) expressed by T cells, which mediates ... Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat. Med. 2001;7:687- ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC420513/?lang=en-ca
*  ELM - Detail for LIG IBS 1
Multiple binding sites in collagen type I for the integrins alpha1beta1 and alpha2beta1.. Xu Y, Gurusiddappa S, Rich RL, Owens ... LIG_IBS_1 LIG_Integrin_isoDGR_1 LIG_RGD ELM Description:. Integrins are major collagen receptors on the surface of eukaryotic ... Integrin proteins are present only in Metazoa with no integrins found in Fungi, Viridiplantae, or TAXON:2. The structure of ... Integrins are used by viruses to gain entry into the host. Example is adeno-associated type II virus which binds to integrin ...
http://elm.eu.org/elms/elmPages/LIG_IBS_1.html
*  Reactome | 3Hyp-4Hyp-5Hyl-COL6A5 [extracellular region]
Integrin cell surface interactions (Homo sapiens) * Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and ... Collagen types VI, IX bind integrin alpha10beta1 (Homo sapiens) * Collagen tupe VI network, Collagen type IX:Integrin ... Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Homo sapiens) * Collagen ...
http://www.reactome.org/content/detail/R-HSA-2127520
*  Vanderbilt Center for Kidney Disease
Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells.. Abair TD, Sundaramoorthy M, Chen D, Heino ... Upregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) mice ... Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen ... Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin ...
http://www.vckd.org/vckd-members/billy-hudson
*  Dr. Dwight Bissell, Internal Medicine, San Francisco, CA
The role of alpha1beta1 integrin in wound contraction. A quantitative analysis of liver myofibroblasts in vivo and in primary ...
https://www.healthtap.com/experts/7680429-dr-dwight-bissell
*  Identification of Response Elements on Promoters Using Site-Directed Mutagenesis and Chromatin Immunoprecipitation | Springer...
Boudjadi S, Carrier JC, Groulx JF, Beaulieu JF (2016) Integrin alpha1beta1 expression is controlled by c-MYC in colorectal ... Boudjadi S, Carrier JC, Beaulieu JF (2013) Integrin alpha 1 subunit is up-regulated in colorectal cancer. Biomarker Res 1(16):1 ... Boudjadi S, Beaulieu JF (2016) MYC and integrins interplay in colorectal cancer. Oncoscience 3(2):50-51. https://doi.org/ ... methodology used previously for the identification and functional characterization of MYC-responsive elements in the integrin ...
https://rd.springer.com/protocol/10.1007/978-1-4939-7765-9_3
*  Collagen, type XVI, alpha 1 - Wikipedia
Eble JA, Kassner A, Niland S, Mörgelin M, Grifka J, Grässel S (2006). "Collagen XVI harbors an integrin alpha1 beta1 ...
https://en.wikipedia.org/wiki/Collagen,_type_XVI,_alpha_1
*  Angiopoietin-Like 1 (ANGPTL1) ELISA Kits
ANGPTL1 inhibited angiogenesis by interacting with integrin alpha1beta1 receptor to suppress the downstreamJAK2-STAT3 (zeige ...
https://www.antikoerper-online.de/abstract/Angiopoietin-Like+1+
*  ZMB Member Barbara Saccà, Publications
Binding and docking of synthetic heterotrimeric collagen type IV peptides with alpha1beta1 integrin. Chembiochem 2002, 3, 904- ... Synthesis of heterotrimeric collagen peptides containing the 11 integrin recognition site of collagen type IV. J. Pept. Sci. ... Incorporation of integrins into artificial planar lipid membranes: characterization by plasmon-enhanced fluorescence ...
https://www.uni-due.de/zmb/members/sacca/publications.shtml
*  Functional diversity and mechanisms of action of the semaphorins | Development
Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature 446,680 -684. ... Kikutani demonstrates further that α1 integrin-deficient macrophages exhibit reduced responses to Sema7A, and that Sema7A-/- ... less-characterised semaphorin that has previously been found to promote axon outgrowth through β1 integrin receptors ( ... Pasterkamp et al., 2003). Through functional α1/β1 integrins, Sema7A functions as a potent stimulator of monocytes and ...
http://dev.biologists.org/content/135/16/2689.long