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*  anti-Insulin antibody | GeneTex
... insulin) for ICC/IF, IHC-Fr, IHC-P. Anti-Insulin pAb (GTX27842) is tested in Human, Mouse samples. 100% Ab-Assurance. ... insulin. Background. Insulin is a hormone that is synthesized, stored and secreted by beta islets of Langerhans cells of the ... Masjkur J et al. Hes3 is Expressed in the Adult Pancreatic Islet and Regulates Gene Expression, Cell Growth, and Insulin ... Masjkur J et al. Hes3 is Expressed in the Adult Pancreatic Islet and Regulates Gene Expression, Cell Growth, and Insulin ...
http://www.genetex.com/Insulin-antibody-GTX27842.html
*  Glucagon:Role of Glucagon & Glucagon Injection Kit » How To Relief
Glucagon is a hormone, secreted into the bloodstream by the alpha cells, found in the Islets of Langerhans, in the pancreas. It ... In each of these processes, glucagon, and insulin work together. Insulin will prevent glucose levels from increasing too high, ... Although secreted by the pancreas, glucagon directly impacts the liver as it works to control blood sugar levels and fats. ... In people with diabetes, blood glucose levels too high.The cause for this is either because not enough insulin is present or, ...
http://howtorelief.com/glucagon-role-glucagon-glucagon-injection-kit/
*  Lab-Made Insulin-Secreting Cells | The Scientist Magazine®
... paving the way for a cell therapy to treat diabetes. ... Researchers craft hormone-producing pancreas cells from human ... beta cells. cell & molecular biology. diabetes. human embryonic stem cells. insulin. pancreas. stem cell research. stem cells. ... Lab-Made Insulin-Secreting Cells. Researchers craft hormone-producing pancreas cells from human embryonic stem cells, paving ... And the process yielded billions of the insulin-secreting cells. "You'll be able to create buckets and buckets of cells," ...
https://www.the-scientist.com/the-nutshell/lab-made-insulin-secreting-cells-36598
*  Activation of insulin-secreting cells by pyruvate and halogenated derivatives | Biochemical Journal
Activation of insulin-secreting cells by pyruvate and halogenated derivatives. A P Yates, A M Lynch, L Best ... Activation of insulin-secreting cells by pyruvate and halogenated derivatives Message Subject (Your Name) has forwarded a page ... It is proposed that oxidative metabolism of pyruvate is not a prerequisite for its stimulatory actions on pancreatic beta-cells ... A marked stimulation of insulin secretion and 45Ca2+ efflux rate was observed in response to 3-fluoropyruvate and 3- ...
http://www.biochemj.org/content/265/1/283
*  Frequency Therapeutics Awarded Grant from JDRF to Generate Glucose-Responsive Insulin-Secreting Cells for Type 1 Diabetes...
Frequency Therapeutics awarded grant from JDRF International to pursue small molecule approach for beta cell replacement to ... intestinal stem cells into functional insulin-secreting cells using small molecule drugs, which could be a key step in ... Frequency Therapeutics Awarded Grant from JDRF to Generate Glucose-Responsive Insulin-Secreting Cells for Type 1 Diabetes ... gastrointestinal stem cells to differentiate into insulin-producing beta cells, in an effort to discover and develop new ...
https://www.businesswire.com/news/home/20180222005310/en/Frequency-Therapeutics-Awarded-Grant-JDRF-Generate-Glucose-Responsive
*  Stem cells from diabetic patients coaxed to become insulin-secreting cells | Veterinary Sciences Tomorrow
Stem cells from diabetic patients coaxed to become insulin-secreting cells. Posted on June 1, 2016. by Vetscite ... "The cells we've manufactured sense the presence of glucose and secrete insulin in response. And beta cells do a much better job ... own stem cells to manufacture new cells that make insulin.. The researchers showed that the new cells could produce insulin ... The scientists tested the cells in culture and in mice, and in both cases found that the cells secreted insulin in response to ...
http://vetscite.org/2016/06/stem-cells-from-diabetic-patients-coaxed-to-become-insulin-secreting-cells/
*  Engineered Commensal Bacteria Reprogram Intestinal Cells Into Glucose-Responsive Insulin-Secreting Cells for the Treatment of...
Engineered Commensal Bacteria Reprogram Intestinal Cells Into Glucose-Responsive Insulin-Secreting Cells for the Treatment of ... Engineered Commensal Bacteria Reprogram Intestinal Cells Into Glucose-Responsive Insulin-Secreting Cells for the Treatment of ... Engineered Commensal Bacteria Reprogram Intestinal Cells Into Glucose-Responsive Insulin-Secreting Cells for the Treatment of ... Engineered Commensal Bacteria Reprogram Intestinal Cells Into Glucose-Responsive Insulin-Secreting Cells for the Treatment of ...
http://diabetes.diabetesjournals.org/content/early/2015/01/27/db14-0635
*  Selective nucleotide-release from dense-core granules in insulin-secreting cells | Journal of Cell Science
Selective nucleotide-release from dense-core granules in insulin-secreting cells Message Subject (Your Name) has sent you a ... Selective nucleotide-release from dense-core granules in insulin-secreting cells. Stefanie Obermüller, Anders Lindqvist, Jovita ... Selective nucleotide-release from dense-core granules in insulin-secreting cells. Stefanie Obermüller, Anders Lindqvist, Jovita ... Selective nucleotide-release from dense-core granules in insulin-secreting cells. Stefanie Obermüller, Anders Lindqvist, Jovita ...
http://jcs.biologists.org/content/early/2005/09/01/jcs.02549
*  Cytoadherence of Lymphocytes From Type I Diabetic Subjects to Insulin-Secreting Cells: Marker of Anti-β-Cell Cellular Immunity ...
Cytoadherence of Lymphocytes From Type I Diabetic Subjects to Insulin-Secreting Cells: Marker of Anti-β-Cell Cellular Immunity ... Cytoadherence of Lymphocytes From Type I Diabetic Subjects to Insulin-Secreting Cells: Marker of Anti-β-Cell Cellular Immunity ... Cytoadherence of Lymphocytes From Type I Diabetic Subjects to Insulin-Secreting Cells: Marker of Anti-β-Cell Cellular Immunity ... Cytoadherence of Lymphocytes From Type I Diabetic Subjects to Insulin-Secreting Cells: Marker of Anti-β-Cell Cellular Immunity ...
http://diabetes.diabetesjournals.org/content/36/12/1356
*  Development of an optimized 5-stage protocol for the in vitro preparation of insulin-secreting cells from mouse ES cells |...
... from mouse embryonic stem cells, we have developed an optimized 5-stage protocol by... ... In order to produce insulin-secreting cells with a high value of glucose-stimulated insulin secretion (GSIS) ... Glucose-stimulated insulin secretion Insulin-secreting cells Mouse ES cells Pre-diabetes model mice ... Development of an optimized 5-stage protocol for the in vitro preparation of insulin-secreting cells from mouse ES cells. ...
https://link.springer.com/article/10.1007%2Fs10616-015-9853-1
*  Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival -...
... adenoviral REST transduction in INS-1E cells led to increased cell death under control conditions, and sensitized cells to ... Using siRNA-mediated knockdown in INS-1E cells, we showed that Cdk5r2 protects beta cells against cytokines and palmitate- ... Decreased levels of Cdk5r2 in beta cells of RIP-REST mice further confirmed that it is controlled by REST, in vivo. ... In diabetic RIP-REST mice, high levels of REST were associated with postnatal beta cell apoptosis, which resulted in gradual ...
https://infoscience.epfl.ch/record/184307
*  Insulin-secreting cells derived from stem cells: Clinical perspectives, hypes and hopes | ScholarBank@NUS
Insulin-secreting cells derived from stem cells: Clinical perspectives, hypes and hopes. ... Insulin-secreting cells derived from stem cells: Clinical perspectives, hypes and hopes. Transplant Immunology 15 (2) : 113-129 ... The first one is to develop a protocol that may allow obtaining a pure population of functional insulin-secreting cells as ... In order to become a realistic clinical issue transplantation of insulin-producing cells derived from stem cells, it needs to ...
http://scholarbank.nus.edu.sg/handle/10635/107969
*  Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells. - Semantic Scholar
... in response to IL-1beta in clonal insulin-secreting cells. Moreover, IL-1beta activates a short isoform of STAT-3 that potently ... may be a novel point of transduction cross talk and an additional mechanism utilised by IL-1beta in the pancreatic beta-cell ... Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells.. @article{Morton1999Interleukin1betaAA, ... Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells.}, author={Nicholas M Morton and R.A.C. de ...
https://www.semanticscholar.org/paper/Interleukin-1beta-activates-a-short-STAT-3-isoform-Morton-Groot/69966fe82b59a21eb3171fc5680c36a7d1ff827b
*  Geron Obtains Insulin-Secreting Cell Patent
... cells [] in a second medium comprising nicotinamide; thereby obtaining a population comprising human insulin secreting cells." ... patent regarding several methods to obtain insulin-secreting cells. U.S. Patent No. 7,033,831 ("Islet cells from human ... embryonic stem cells"), issued on April 25th, claims methods "for obtaining human insulin secreting cells." This patent states ... "a system for efficient production of primate cells that have differentiated from pluripotent cells into cells of the islet cell ...
http://dailydoseofip.blogspot.com/2006/05/geron-obtains-insulin-secreting-cell.html
*  OSA | Intrinsic optical signal imaging of glucose-stimulated insulin secreting β-cells
Intrinsic optical signal imaging of glucose-stimulated insulin secreting β-cells Yi-Chao Li, Wan-Xing Cui, Xu-Jing Wang, ... In this paper, we demonstrate the feasibility of using IOS imaging for functional examination of insulin secreting INS-1 cells ... "Intrinsic optical signal imaging of glucose-stimulated insulin secreting β-cells," Opt. Express 19, 99-106 (2011) ... 4 (A) Enlarged image of cell 4 in Fig. 3A. The enclosed red line around the cell represents the boundary calculated by the ...
https://www.osapublishing.org/oe/abstract.cfm?uri=oe-19-1-99
*  No rebirth for insulin secreting pancreatic beta cells
The number of beta cells in the pancreas increases in response to greater demand for insulin or ... ... the hormone responsible for stimulating cells to convert glucose to energy. ... No rebirth for insulin secreting pancreatic beta cells. April 24, 2013, Journal of Clinical Investigation Pancreatic beta cells ... Researchers discover mechanism that could convert certain cells into insulin-making cells. April 29, 2011 Simply put, people ...
https://medicalxpress.com/news/2013-04-rebirth-insulin-secreting-pancreatic-beta.html
*  Characterization of insulin glycation in insulin-secreting cells maintained in tissue culture - Ulster Institutional Repository
These observations indicate that insulin is readily glycated and secreted from insulin-secreting cells under hyperglycaemic ... Characterization of insulin glycation in insulin-secreting cells maintained in tissue culture ... Characterization of insulin glycation in insulin-secreting cells maintained in tissue culture. JOURNAL OF ENDOCRINOLOGY, 152 (1 ... Glycated insulin was readily secreted by BRIN-BD11 cells upon active stimulation with glucose and other secretagogues. Cellular ...
http://uir.ulster.ac.uk/3146/
*  Ca(2+)-activated K+ channels from an insulin-secreting cell line incorporated into planar lipid bilayers. - Oxford Neuroscience
Ca(2+)-activated K+ channels from the plasma membrane of an insulin-secreting hamster Beta-cell line (HIT T15) were ... At a membrane potential of + 20 mV, which is close to the peak of the Beta-cell action potential, channel activity was half- ... These results resemble those found for Ca(2+)-activated K+ channels in native Beta cell membranes and indicate that the channel ... Ca(2+)-activated K+ channels from an insulin-secreting cell line incorporated into planar lipid bilayers. ...
https://www.neuroscience.ox.ac.uk/publications/113455
*  Calcium currents in insulin-secreting beta-cells. - Radcliffe Department of Medicine
Islets of Langerhans, Animals, Humans, Insulin, Calcium Channels, Calcium Channel Blockers, Electric Conductivity ...
https://www.rdm.ox.ac.uk/publications/9608
*  Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of...
... insulin content, insulin accumulation and insulin secretory function of a insulin-secreting cell line cultured for 3 days with ... Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of ... insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1, Diabetes, Obesity and Metabolism, ... The results indicate that prevention of DPP IV action is necessary for beneficial effects of GLP-1 on pancreatic beta cells and ...
https://eresearch.qmu.ac.uk/handle/20.500.12289/4495
*  Hormonal Manipulation Induces Differentiation Of Pancreatic Progenitor Cells Into Insulin-secreting Islet β-cells | 72551
In conclusion, the pancreatic progenitor cells could be differentiated to insulin-secreting islet β-cells by the pregnant serum ... Hormonal manipulation induces differentiation of pancreatic progenitor cells into insulin-secreting islet β-cells. ... also known as pancreatic progenitor cells, could be differentiated into insulin-secreting islet β-cells. In this study, we ... no matter the aggregated cells or the sphere-shaped ones are capable of secreting insulin. ...
https://www.omicsonline.org/proceedings/hormonal-manipulation-induces-differentiation-of-pancreatic-progenitor-cells-into-insulinsecreting-islet-cells-72551.html
*  Cotransplantation of Adipose Tissue-Derived Insulin-Secreting Mesenchymal Stem Cells and Hematopoietic Stem Cells: A Novel...
... and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and ... Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... Cotransplantation of Adipose Tissue-Derived Insulin-Secreting Mesenchymal Stem Cells and Hematopoietic Stem Cells: A Novel ... "Human adipose-tissue derived mesenchymal stem cells differentiate in to insulin, somatostatin and glucagons expressing cells," ...
https://www.hindawi.com/journals/sci/2010/582382/ref/
*  The secret life of insulin-producing cells - Information Centre - Research & Innovation - European Commission
... non-invasive methods for the characterisation and quantification of beta-cell mass would greatly enhance our means for gaining ... The secret life of insulin-producing cells -The development of sensitive, ... The secret life of insulin-producing cells The insulin-producing cells in the pancreas play a crucial role in the management of ... The secret life of insulin-producing cells The insulin-producing cells in the pancreas play a crucial role in the management of ...
http://ec.europa.eu/research/infocentre/article_en.cfm?id=/research/star/index_en.cfm?p=ss-betaimage&calledby=infocentre&item=All&artid=31541
*  Measuring phospholipase D activity in insulin-secreting pancreatic beta-cells and insulin-responsive muscle cells and...
Measuring phospholipase D activity in insulin-secreting pancreatic beta-cells and insulin-responsive muscle cells and ... Measuring phospholipase D activity in insulin-secreting pancreatic beta-cells and insulin-responsive muscle cells and ... Measuring phospholipase D activity in insulin-secreting pancreatic beta-cells and insulin-responsive muscle cells and ... in secretagogue-stimulated insulin-secreting pancreatic beta-cells and also insulin-stimulated adipocyte and muscle cells, two ...
https://www.garvan.org.au/research/publications/10204
*  The roles of Rac1 and syncollin in regulated exocytosis: Insulin-secreting INS-1 cells as a model | ScholarBank@NUS
By expressing mutated forms of Rac1 in insulin-secreting INS-1 cells that altered the nature of insulin secretion and ... in insulin-secreting INS-1 cells, indicated that complete, not truncated form syncollin, can be sorted into insulin secretory ... Insulin-secreting INS-1 cells as a model. ScholarBank@NUS Repository.. Abstract: Regulated exocytosis, modelled by insulin ... The roles of Rac1 and syncollin in regulated exocytosis: Insulin-secreting INS-1 cells as a model. ...
http://scholarbank.nus.edu.sg/handle/10635/14140