Insulin receptor substrate 1 is a substrate of the Pim protein kinases. ... This analysis identified the insulin receptor substrate 1 and 2 (IRS1/2) as potential Pim substrates. Experiments were carried ... This phosphorylation was shown to have effects on the half-life of the IRS family of proteins, suggesting a role in insulin or ... To identify novel substrates, bioinformatics analysis was carried out to identify proteins containing a consensus Pim ...

IRS-1, for example, is an IRS protein that contains a phosphotyrosine binding-domain (PTB-domain). In addition, the insulin ... Thus, the insulin receptor binds IRS. IRS1 (see also Insulin receptor substrate 1) IRS2 (see also Insulin receptor substrate 2 ... Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells. ... "Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site". Oncogene. 18 (20 ...

A family of insulin receptor substrate (IRS) proteins mediates the pleiotropic effects of insulin and insulin-like growth ... IGF, insulin-like growth factor, IRS, insulin receptor substrate, PI-3K phosphoinositide 3-kinase, insulin, knockout mouse, ... Insulin receptor substrate proteins and neuroendocrine function D. J. Withers D. J. Withers 1 ... D. J. Withers; Insulin receptor substrate proteins and neuroendocrine function. Biochem Soc Trans 1 August 2001; 29 (4): 525- ...

mTORC1 contributes to insulin resistance by causing proteasomal degradation of insulin receptor substrate (IRS) proteins, such ... Human cytomegalovirus attenuates AKT activity by destabilizing insulin receptor substrate proteins. *Anthony J. Domma ... The phosphoinositide 3-kinase (PI3K)/AKT pathway plays crucial roles in cell viability and protein synthesis and is frequently ... as IRS1, which are necessary for the recruitment of PI3K to growth factor receptors. In cells infected with a recombinant HCMV ...

Abbreviations: CREB3L4-cAMP responsive element-binding protein 3 like 4; IRS-2-insulin receptor substrate-2; PDE7A- ... 11 fibronectin-binding proteins (FBPs), 10 choline-binding proteins (CBPs), and 28 mucus-binding proteins (MBPs) (Fig. 1). They ... Among the genes modulated by the ΔspaF mutant, the most notable were the genes associated with G-protein-coupled receptor ... New, D. C. & Wong, Y. H. Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression. J ...

Mice lacking insulin receptor substrate-2 (Irs2) develop beta cel … ... deficiency of insulin-producing beta cells. The mechanisms governing replication of terminally differentiated beta cells and ... Insulin / metabolism* * Insulin Receptor Substrate Proteins * Intracellular Signaling Peptides and Proteins * Islets of ... Mice lacking insulin receptor substrate-2 (Irs2) develop beta cell failure, suggesting that insulin signaling is required to ...

Insulin receptor substrate protein 53 (IRSp53) as a binding partner of anti-metasatasis molecule NESH, a member of Abelson ... Insulin receptor substrate protein 53 (IRSp53) as a binding partner of anti-metasatasis molecule NESH, a member of Abelson ...

Effects of chromium picolinate and biotin on protein expression of PPAR-γ, insulin receptor substrate 1 and NF-κB in tissues of ... PPAR-γ and insulin receptor substrate 1 (IRS-1) are important biomarkers involved in insulin signalling and resistance as well ... ChromiumBiotinGlucoseInsulinPPAR-γPhosphorylated insulin receptor substrate-1NF-κB ... Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. J Clin Invest 90, 1839- ...

Genes Involved and Proteins. Gene name. IRS4 (insulin receptor substrate 4). Location ... results in overexpression of the insulin receptor substrate 4 gene through illegitimate recombination with the T-cell receptor ... such as the insulin and insulin growth factor receptors, and a complex network of intracellular signalling molecules, resulting ... Relatively little is known about the tumorigenic potential of the IRS proteins. Expression of IRS1, IRS2 or IRS4 in the 32D ...

NMDA Receptor-Dependent Synaptic Translocation of Insulin Receptor Substrate p53 via Protein Kinase C Signaling Kei Hori, ... The Scaffold Protein Homer1b/c Links Metabotropic Glutamate Receptor 5 to Extracellular Signal-Regulated Protein Kinase ... Differential Localization of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 and CD47 and Its ... Canonical Transient Receptor Potential 1 Plays a Role in Basic Fibroblast Growth Factor (bFGF)/FGF Receptor-1-Induced Ca2+ ...

... also known as mitogen-activated protein (MAP) kinases] is mediated by Ras. Insulin activates Ras primarily by increasing the ... Here, we show that insulin-induced activation of ERK … ... insulin receptor substrate-1) and Shc. In contrast to the ... Insulin-induced activation of extracellular signal-regulated kinases [ERKs, ... activation of the insulin receptor results in the interaction of GRB2-Sos with IRS-1 and Shc, thus linking the insulin receptor ...

PTP1B dephosphorylates the insulin receptor and its substrates, thereby inhibiting the effect of insulin. The potential of ... 2003). Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice. Diabetes 52, 21-28. ... We also evaluated the capability of extracts to inhibit the protein tyrosine phosphatase 1B, a negative regulator of insulin ... Protein Tyrosine Phosphatase 1B (PTP1B) Inhibition Assay. Protein thyrosine phosphatase 1B (PTP1B) is an enzyme that is ...

Insulin Receptor Substrate 1 (IRS-1).. *Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF ... Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. ... Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma ... Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 ...

Insulin Receptor Substrate 1 (IRS-1).. *Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF ... Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. ... Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma ... Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 ...

We have had a longstanding interest in the Insulin Receptor Substrate (IRS) proteins and the mechanism by which these essential ... Chen et al (2009) Differential Roles of Insulin-like Growth Factor Receptor- and Insulin Receptor-Mediated Signaling in the ... 2018) Identification of a novel invasion-promoting region in Insulin Receptor Substrate 2 (IRS2). Mol. Cell. Biol. 38(14): ... 2017) Differential involvement of the microtubule cytoskeleton in Insulin Receptor Substrate-1 (IRS-1) and IRS-2 signaling to ...

"Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible ... catalyzes the dephosphorylation of cellular substrates of the insulin receptor kinase results in the downregulation of insulin ... PTP1B inhibitors could increase insulin receptor tyrosine phosphorylation and mimic the cellular and in vivo actions of insulin ... has been implicated as a negative regulator of insulin action. Overexpression of PTP1B protein has been observed in insulin- ...

Protein Aliases: Insulin receptor substrate 1; IRS-1 Gene Aliases: HIRS-1; IRS1 ... IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin- ... insulin receptor binding insulin-like growth factor receptor binding protein binding 1-phosphatidylinositol-3-kinase activity ... negative regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway negative ...

Metabolic syndrome is a multiplex risk factor that arises from insulin resistance accompanying abnormal adipose deposition and ... Cellular dysfunction by protein kinases and phoshatases * Suppression of insulin receptor substrate-1 and 2 (IRS1/IRS2) gene ... Additional contributors to insulin resistance include abnormalities in insulin secretion and insulin receptor signaling, ... Insulin resistance appears to be the primary mediator of metabolic syndrome. [24] Insulin promotes glucose uptake in muscle, ...

... regulation of adenosine monophosphate-activated protein kinase (AMPK) pathway, improvement of mitochondrial function, ... Insulin receptor substrate-2 (IRS-2) is another target of BBR. Treatment with BBR in rats upregulates IRS-2 messenger RNA (mRNA ... Berberine reduces insulin resistance through protein kinase c-dependent up-regulation of insulin. Receptor expression. Metab. ... Treatment with BBR increases expression of insulin receptor (InsR) mRNA and protein both in rat L6 cells and human hepatocytes ...

Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in ... Lifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations ... immunoblot analysis showed that serum protein levels of IGF binding protein 3 (IGFBP-3), another GH-regulated protein, were not ... The impact of obesity, fat distribution, and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3 ...

... recent studies have revealed distinct functions for these adaptor proteins in regulating breast cancer progression. Thus far, ... Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in breast cancer cells *Authors: * ... Wu S, Zhou B, Xu L and Sun H: Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response in ... Wu, S., Zhou, B., Xu, L., Sun, H.Interaction between nuclear insulin receptor substrate-2 and NF-κB in IGF-1 induces response ...

IRS2 (insulin receptor substrate 2) is a 180-190 kDa substrate intermediate that lies between various cytokine receptors and ... It is the primary IRS protein found in hematopoietic cells. Depending upon the receptor, IRS2 undergoes phosphorylation, either ...

Diindolylmethane Enhances Glucose Uptake Through Activation of Insulin Signaling in 3T3‐L1 Adipocytes , Objective Indole‐3‐ ... For the insulin receptor, this does not occur; rather, it phosphorylates a large substrate protein that, in turn, engages ... In all cases but the insulin receptor (and 2 closely related receptors), these dimers are noncovalent, but insulin receptors ... insulin receptor substrate‐1, and insulin receptor early in differentiation. Conclusions Our findings suggest that DIM may ...

... normal mice and mice made insulin-resistant by heterozygous deletion of the Insulin receptor and/or insulin receptor substrate- ... and the IRS proteins. Thus, despite the decrease in p85α, PI 3-kinase activation is normal, insulin-stimulated Akt activity is ... A critical component of insulin action is the enzyme phosphoinositide (PI) 3-kinase. The major regulatory subunits of PI 3- ... Reduced expression of p85 modulates the molecular balance between this protein, the p110 catalytic subunit of PI 3-kinase, ...

... as revealed by significant reductions in insulin receptor substrate-2 protein levels (0.77-fold, p , 0.05) and Akt ... Zhao L (2004) Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for ... mice induces liver inflammation and fibrogenesis markers without disrupting insulin receptor signalling after an insulin ... deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition. J Physiol 590(10):2485- ...

2001) Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292: 104-106 Google ... In Drosophila, chico1, a mutant of the insulin receptor substrate Chico, extends lifespan up to 141% (Clancy et al., 2001). As ... a transducer of insulin signaling (Britton et al., 2002). In fact, we confirmed that the tGPH protein is localized to the ... such as insulin, were not involved in these senescence regulations. Therefore, we examined the relationship between the insulin ...

... of which 118 proteins were significantly up-regulated and 160 proteins were significantly down-regulated in myocardial tissue. ... of which 118 proteins were significantly upregulated and 160 proteins were significantly downregulated in myocardial tissue. In ... Cytc and AK4 proteins lead to oxidative stress. Therefore, we think that PTP1B may play an important role in the development of ... The results showed that a total of 278 proteins with significant changes were identified by quantitative proteomic analysis, ...

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 ... Insulin-responsive protein phosphorylation (p) measured by Simple Western in ex vivo basal and insulin-stimulated soleus. IRS1 ... Insulin-responsive protein phosphorylation (p) measured by Simple Western in ex vivo basal and insulin-stimulated soleus. IRS1 ... Consistent with reduced insulin signaling activation, insulin-stimulated phosphorylation of Akt and substrates of Akt was ...

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein ... Protein estimation. Protein estimation was carried out using the BCA method (Smith et al., 1985) with bovine serum albumin as a ... Equal amounts of protein were loaded in a 10% SDS-PAGE and transferred to the nitrocellulose membrane (Biorad, 1620112). The ... An increase in absorbance at 340 nm with the addition of enzymes was measured for 5 min and was normalized to the total protein ...

SIK2 is found in adipocytes and phosphorylates a specific serine residue in insulin receptor substrate-1. This finding, along ...