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*  The Inositol-3-Phosphate Synthase Biosynthetic Enzyme Has Distinct Catalytic and Metabolic Roles. - Oxford Neuroscience
To date, most inositol studies have focused on the molecular and cellular effects of inositol depletion without considering ... Removal of inositol supplementation from the ino1(-) mutant resulted in a rapid 56% reduction in inositol levels, triggering ... Inositol depletion also caused a dramatic generalized decrease in phosphoinositide levels that was rescued by inositol ... We show that loss of Ino1 results in an inositol auxotrophy that can be rescued only partially by exogenous inositol. ...
https://www.neuroscience.ox.ac.uk/publications/609539
*  Inositol Pyrophosphate Synthesis by Inositol Hexakisphosphate Kinase 1 Is Required for Homologous Recombination Repair* -...
... are water-soluble inositol phosphates that contain high energy diphosphate moieties on the inositol ring. Inositol ... implying that inositol pyrophosphates are required for HR-mediated repair. Our study therefore highlights inositol ... hexakisphosphate kinase 1 (IP6K1) participates in inositol pyrophosphate synthesis, converting inositol hexakisphosphate (IP(6 ... are water-soluble inositol phosphates that contain high energy diphosphate moieties on the inositol ring. Inositol ...
https://www.semanticscholar.org/paper/Inositol-Pyrophosphate-Synthesis-by-Inositol-Hexak-Jadav-Chanduri/073a3b130e9172555a5c3a89f39671c08341a9cb
*  VIP1 - Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase - Saccharomyces cerevisiae (strain ATCC 204508 ...
... thereby regulating signaling of phosphate availability (PubMed:17412959). Required for the function of the cortical actin ... Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by ... Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol ... inositol metabolic process Source: GO_Central. *inositol phosphate biosynthetic process Source: SGD ,p>Inferred from Direct ...
http://www.uniprot.org/uniprot/Q06685
*  ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Iγ |...
B and C) Overexpression of membrane-targeted HA-tagged inositol 5-phosphate phosphatase domain of synaptojanin 1 (HA-IPP1-CAAX ... Phosphatidylinositol 4-phosphate 5-kinase type Iγ (PIPKIγ) and synaptojanin 1, the major brain PI(4)phosphate 5-kinase and PI(4 ... Phosphatidylinositol 4-phosphate 5-kinase α is a downstream effector of the small G protein ARF6 in membrane ruffle formation. ... Phosphatidylinositol 4-phosphate 5-kinase Iβ is essential for epidermal growth factor receptor-mediated endocytosis. J. Biol. ...
http://jcb.rupress.org/content/162/1/113
*  Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I α | JEM
BMMCs were labeled for 48 h with 10 μCi ml−1 [3H]-myo-inositol (Amersham Biosciences) in inositol-free DMEM containing dialyzed ... The phosphatidylinositol phosphate kinases (PIPKs) are enzymes important for PI(4,5)P2 synthesis. There are two types of PIPKs ... Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I α. Junko Sasaki, Takehiko Sasaki, Masakazu ... The intracellular PI(4,5)P2 content was assessed in BMMCs that had been metabolically labeled with [3H]inositol for 48 h to ...
http://jem.rupress.org/content/201/6/859
*  Inositol Phosphates and Lipids | SpringerLink
Inositol, in its native or lipid derived forms, serves as a master building block which, when phosphorylated, leads to the ... Inositol Phosphates and Lipids: Methods and Protocols compiles many of the techniques that underscore phosphorylated inositol ... In Inositol Phosphates and Lipids: Methods and Protocols, expert researchers introduce the basic methodological tools to ... Molecular Manipulation and Analysis of Inositol Phosphate and Pyrophosphate Levels in Mammalian Cells ...
https://link.springer.com/book/10.1007/978-1-60327-175-2
*  Inositol Phosphates and Derivatives - Allen B. Reitz - Oxford University Press
Two overview chapters provide comprehensive background information on stereochemistry and nomenclature of inositol phosphates, ... Novel Routes to Inositol Phosphates Using Pseudomonas putida Oxidation of Arenes. Enantiospecific Synthesis of Inositol ... Pharmacolotical Effects of D-myo-Inositol-1,2,6-Trisphosphate. Synthesis of New myo-Inositol Derivatives Containing Phosphate, ... Preparation of Optically Active myo-Inositol Derivatives as Intermediates for the Synthesis of Inositol Phosphates. ...
https://global.oup.com/academic/product/inositol-phosphates-and-derivatives-9780841220867?cc=us&lang=en
*  Reactome | Inositol phosphate metabolism
Inositol phosphates (IPs) are molecules involves in signalling processes in eukaryotes. myo-Inositol consists of a six-carbon ... Inositol phosphate synthesis and the nuclear processes they affect Monserrate, JP, York, JD ... Back in the water: the return of the inositol phosphates Irvine, RF, Schell, MJ ... and triphospho inositol phosphates aka pyrophosphates (Irvine & Schell 2001, Bunney & Katan 2010, Alcazar-Romain & Wente 2008, ...
http://www.reactome.org/content/detail/R-HSA-1483249
*  Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to...
Here we report that inositol phosphates (InsPs) and phosphatdidylinositol phosphates (PtdInsPs) serve as activators of IDE. ... Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to ... Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to ... Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to ...
https://www.ncbi.nlm.nih.gov/pubmed/28325868?dopt=Abstract
*  Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid...
Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid ... Chemogenetic characterization of inositol phosphate metabolic pathway reveals druggable enzymes for targeting kinetoplastid ... Chemogenetic characterization of inositol phosphate metabolic pathway reveals druggable enzymes for targeting kinetoplastid ... Chemogenetic characterization of inositol phosphate metabolic pathway reveals druggable enzymes for targeting kinetoplastid ...
https://www.ncbi.nlm.nih.gov/pubmed/27133314
*  Inositol-phosphate phosphatase - Wikipedia
... inositol 1-phosphatase, L-myo-inositol-1-phosphate phosphatase, myo-inositol 1-phosphatase, inositol phosphatase, inositol ... phosphate Thus, the two substrates of this enzyme are myo-inositol phosphate and H2O, whereas its two products are myo-inositol ... an inositol-phosphate phosphatase (EC 3.1.3.25) is an enzyme that catalyzes the chemical reaction myo-inositol phosphate + H2O ... myo-inositol-1(or 4)-phosphate phosphohydrolase, myo-inositol monophosphatase, and myo-inositol-1-phosphatase. Eisenberg F Jr ( ...
https://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase
*  Conserved binding positions of inositol phosphates to P | Open-i
Superimposed inositol phosphates in complex with PH domains from five different proteins: DAPP ... Conserved binding positions of inositol phosphates to PH domains. ... Figure 5: Conserved binding positions of inositol phosphates to PH domains. Superimposed inositol phosphates in complex with PH ... Figure 5: Conserved binding positions of inositol phosphates to PH domains. Superimposed inositol phosphates in complex with PH ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2200656_1472-6807-7-80-5&req=4
*  Inositol phosphate - Wikipedia
The group comprises: inositol monophosphate (IP) inositol bisphosphate (IP2) inositol trisphosphate (IP3) inositol ... Inositol phosphates are a group of mono- to polyphosphorylated inositols. They play crucial roles in diverse cellular functions ... Further reading: Function of calcium in humans Inositol tetra-, penta-, and hexa-phosphates have been implicated in gene ... Inositol trisphosphates act on the inositol triphosphate receptor to release calcium into the cytoplasm. ...
https://en.wikipedia.org/wiki/Inositol_phosphate
*  Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes | Biochemical Journal
Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes. G M Burgess, R F Irvine, M J Berridge, J S McKinney, J ... In permeabilized hepatocytes, inositol 1,4,5-trisphosphate, inositol 2,4,5-trisphosphate and inositol 4,5-bisphosphate induced ... The order of potency was inositol 1,4,5-trisphosphate greater than inositol 2,4,5-trisphosphate greater than inositol 4,5- ... Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes Message Subject (Your Name) has forwarded a page to you ...
http://www.biochemj.org/content/224/3/741
*  Inositol Phosphate Production in the Left Ventricle following Induction of Acute Hypertension | Clinical Science
Inositol Phosphate Production in the Left Ventricle following Induction of Acute Hypertension. DH MacIver, AM Heagerty, JD ... Inositol Phosphate Production in the Left Ventricle following Induction of Acute Hypertension ... Inositol Phosphate Production in the Left Ventricle following Induction of Acute Hypertension ... Inositol Phosphate Production in the Left Ventricle following Induction of Acute Hypertension ...
http://www.clinsci.org/content/76/s20/52P.3
*  Frontiers | The Binding Mechanism Between Inositol Phosphate (InsP) and the Jasmonate Receptor Complex: A Computational Study |...
... inositol phosphate (InsP), and jasmonate ZIM-domain protein (JAZ). COI1 acts as multi-component signaling hub that binds with ... inositol phosphate (InsP), and jasmonate ZIM-domain protein (JAZ). COI1 acts as multi-component signaling hub that binds with ... The carbon atom and oxygen atoms of inositol phosphates and JA-Ile are colored in green and red, phosphorus atoms of inositol ... InsP, inositol phosphate. E2, RBX1, CULLIN1 (CUL1), ASK1, and the F-box protein COI1 are components of the SCF-complex. MED25, ...
https://www.frontiersin.org/articles/10.3389/fpls.2018.00963/full
*  Inositol Phosphate Release and Metabolism During Myocardial Ischemia and Reperfusion in Rat Heart | Circulation Research
Ischemia for longer than 5 minutes caused a cessation of inositol phosphate production, with inositol phosphates initially ... First, total release of inositol phosphates was greater (466±37 compared with 345±29 cpm/mg protein, P,.05). Second, inositol 1 ... Inositol Phosphate Release and Metabolism During Myocardial Ischemia and Reperfusion in Rat Heart. Karen E. Anderson, Anthony M ... Inositol phosphate release and metabolism in rat left atria. Circ Res. 1995;76:252-260. ...
http://circres.ahajournals.org/content/76/2/261
*  Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3 |...
Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3. S ... Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3 ... Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3 ... Generation of inositol phosphates, diacylglycerol and calcium fluxes in myoblasts treated with 1,25-dihydroxyvitamin D3 ...
http://www.biochemj.org/content/289/3/675
*  The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization |...
... inositol phosphate; IP3K, Ins(1,4,5)P3 3-kinase; IP6K, InsP6 kinase; (Hs or Rn)IPMK, (human or rat) inositol phosphate ... Functionally important motifs [inositol phosphate-binding site, ATP-binding site, catalytically important SSLL (Ser-Ser-Leu-Leu ... It was previously reported that it is also an inositol phosphate multikinase and an important factor of the mRNA export pathway ... The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. ...
http://www.biochemj.org/content/366/2/549
*  Inhibition of carbachol-induced inositol phosphate accumulation by phencyclidine, phencyclidine-like ligands and sigma agonists...
It is concluded that PCP, PCP-like compounds and sigma agonists block carbachol-induced inositol-phosphate accumulation by ... In all three regions studied, PCP significantly inhibited carbachol-induced [3H]inositol phosphate accumulation working as low ... Inhibition of carbachol-induced inositol phosphate accumulation by phencyclidine, phencyclidine-like ligands and sigma agonists ... Inhibition of carbachol-induced inositol phosphate accumulation by phencyclidine, phencyclidine-like ligands and sigma agonists ...
http://jpet.aspetjournals.org/content/254/3/952
*  Stimulation of generation of inositol phosphates by carbamoylcholine and its inhibition by phorbol esters and iodide in dog...
The action of carbamoylcholine (Cchol), NaF and other agonists on the generation of inositol phosphates (IPs) was studied in ... Stimulation of generation of inositol phosphates by carbamoylcholine and its inhibition by phorbol esters and iodide in dog ... Stimulation of generation of inositol phosphates by carbamoylcholine and its inhibition by phorbol esters and iodide in dog ... Stimulation of generation of inositol phosphates by carbamoylcholine and its inhibition by phorbol esters and iodide in dog ...
http://www.biochemj.org/content/263/3/795
*  Impacts of dietary calcium, phytate, and phytase on inositol hexakisphosphate degradation and inositol phosphate release in...
Impacts of dietary calcium, phytate, and phytase on inositol hexakisphosphate degradation and inositol phosphate release in ... and phytase concentrations on inositol phosphate (IP3-6) profile in different digestive tract (GI) segments. The experiment was ...
https://insights.ovid.com/pousci/201796100/00006610-201796100-00014
*  1-phosphatidyl-1D-myo-inositol 4-phosphate(3-) (CHEBI:58178)
1-phosphatidyl-1D-myo-inositol 4-phosphate(3−) (CHEBI:58178) is conjugate base of 1-phosphatidyl-1D-myo-inositol 4-phosphate ( ... 1-phosphatidyl-1D-myo-inositol 4-phosphate (CHEBI:17526) is conjugate acid of 1-phosphatidyl-1D-myo-inositol 4-phosphate(3−) ( ... myo-inositol 4-phosphate(3−) (CHEBI:58178). 1-stearoyl-2-oleoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate(3−) (CHEBI: ... myo-inositol 4-phosphate(3−) (CHEBI:58178). 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate)(3−) (CHEBI:85468 ...
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=61083
*  Inositol phosphate metabolism | LAMP
1-phosphatidylinositol-4-phosphate 5-kinase. 2.7.1.68. TA19180. CDP diacylglycerol-inositol 3-phosphatidyltransferase. 2.7.8.11 ... 1-phosphatidylinositol-4-phosphate 5-kinase. 2.7.1.68. TA11845. 1-phosphatidylinositol-4-phosphate 5-kinase. 2.7.1.68. TA13405 ...
http://www.llamp.net/?q=Ta%20Inositol%20phosphate%20metabolism