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*  Changes in phosphoinositide turnover in isolated guinea pig hearts stimulated with isoproterenol. | Circulation Research
Examination of 32P labeling of inositol trisphosphates in the same hearts revealed that the radioactivity associated with these ... and they were completely abolished by the beta-receptor blocker propranolol. Examination of the phosphoinositide-specific ... The incorporation of 32Pi into phospholamban, troponin I, phosphatidylinositols, and inositol trisphosphates was studied in ... The tissue levels of the inositol 1,4,5-trisphosphate isoform were also measured in hearts perfused with isoproterenol for 3 ...
http://circres.ahajournals.org/content/65/4/989
*  Selected Studies on the Toxicity of Thimerosal Published in Peer Reviewed Scientific and Medical Journals
Sperm, inositol trisphosphate, and thimerosal-induced intracellular Ca2+ elevations in rabbit eggs. Fissore RA, Robl JM (1993 ... Cardiac ryanodine receptor activity is altered by oxidizing reagents in either the luminal or cytoplasmic solution. Eager and ... Modulation of inositol 1,4,5-trisphosphate binding to the various inositol 1,4,5-trisphosphate receptor isoforms by thimerosal ... The effects of thimerosal on the purified InsP3 receptor. Mezna M, Longland CL, Michelangeli F. Biochem Soc Trans (1998). Aug; ...
http://www.whale.to/vaccine/thim.html
*  Subtype-selective regulation of IP(3) receptors by thimerosal via cysteine residues within the IP(3)-binding core and...
... receptors) and ryanodine receptors are the most widely expressed intracellular Ca(2+) channels and both are regulated by thiol ... Chimaeric proteins in which the SD of the IP(3)R was replaced by the structurally related A domain of a ryanodine receptor were ... by modifying cysteine residues within both the SD and IBC and thereby stabilizing an active conformation of the receptor. ... residues 1-604) of IP(3)R1 and IP(3)R2, but not to that of IP(3)R3. Binding of a competitive antagonist (heparin) or partial ...
https://pharm.ox.ac.uk/publications/640294
*  Inositol 1,4,5-trisphosphate receptor (IPR000493) | InterPro | EMBL-EBI
Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.. J. Biol. Chem. 285 ... GO:0070679 inositol 1,4,5 trisphosphate binding GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel ... The inositol 1,4,5-trisphosphate (IP3)3 receptor (IP3R) are tetrameric intracellular Ca2+ release channels on the endoplasmic ... Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and ...
https://www.ebi.ac.uk/interpro/entry/IPR000493
*  Inositol 1,4,5-trisphosphate receptor (IPR000493) | InterPro | EMBL-EBI
Inositol 1,4,5-trisphosphate receptor (IPR000493). Short name: InsP3_rcpt Family relationships *Ryanodine receptor-related ( ... Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.. J. Biol. Chem. 285 ... GO:0070679 inositol 1,4,5 trisphosphate binding GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel ... The inositol 1,4,5-trisphosphate (IP3)3 receptor (IP3R) are tetrameric intracellular Ca2+ release channels on the endoplasmic ...
http://www.ebi.ac.uk/interpro/entry/IPR000493
*  Itpr2 - Inositol 1,4,5-trisphosphate receptor type 2 - Mus musculus (Mouse) - Itpr2 gene & protein
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release ... Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release ... Inositol 1,4,5-trisphosphate receptor type 2Add BLAST. 2701. Amino acid modifications. Feature key. Position(s). Description ... Inositol 1,4,5-trisphosphate bindingBy similarity. 5. ,p>This subsection of the 'Family and Domains' section describes a region ...
http://www.uniprot.org/uniprot/Q9Z329
*  ITPR1 - Inositol 1,4,5-trisphosphate receptor type 1 - Bos taurus (Bovine) - ITPR1 gene & protein
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- ... trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 ... Inositol 1,4,5-trisphosphate receptor type 1Add BLAST. 2709. Amino acid modifications. Feature key. Position(s). Description ... Inositol 1,4,5-trisphosphate bindingBy similarity. 5. ,p>This subsection of the 'Family and Domains' section describes a region ...
http://www.uniprot.org/uniprot/Q9TU34
*  Itpr2 - Inositol 1,4,5-trisphosphate receptor type 2 - Mus musculus (Mouse) - Itpr2 gene & protein
Inositol 1,4,5-trisphosphate receptor type 2Imported. ,p>Information which has been imported from another database using ... tr,B2KF89,B2KF89_MOUSE Inositol 1,4,5-trisphosphate receptor type 2 (Fragment) OS=Mus musculus GN=Itpr2 PE=1 SV=1 ... 1. Imported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href="/manual/ ... Annotation score:1 out of 5. ,p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB ...
http://www.uniprot.org/uniprot/B2KF89
*  Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones | Science
The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) acts as a Ca2+ release channel on internal Ca2+ stores. Type 1 IP3R (IP3 ... Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones ... Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones ... Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones ...
http://science.sciencemag.org/content/282/5394/1705
*  Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm. | JCB
Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm.. L D Walensky, S H Snyder ... We have characterized inositol 1,4,5-trisphosphate (IP3)-gated calcium channels and upstream components of the phosphoinositide ... Western blotting using a polyclonal antibody directed against purified brain IP3 receptor (IP3R) identified a specific 260 kD ... Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm. ...
http://jcb.rupress.org/content/130/4/857
*  Down-regulation of the inositol 1,4,5-trisphosphate receptor in mouse eggs following fertilization or parthenogenetic...
In mouse eggs, these oscillations cease after a variable period of time and this is accompanied by a decrease in inositol 1,4,5 ... trisphosphate receptor (IP3R) responsiveness and down-regulation of the IP3R type 1 (IP3R-1). To investigate the signaling ... Down-regulation of the inositol 1,4,5-trisphosphate receptor in mouse eggs following fertilization or parthenogenetic ... Jellerette T1, He CL, Wu H, Parys JB, Fissore RA.. Author information. 1. Department of Veterinary and Animal Sciences, ...
https://www.ncbi.nlm.nih.gov/pubmed/10882513?access_num=10882513&link_type=MED&dopt=Abstract
*  Type 2 inositol 1,4,5-trisphosphate receptor inhibits the progression of pulmonary arterial hypertension via calcium signaling...
Narayanan D, Adebiyi A, Jaggar JH (2012) Inositol trisphosphate receptors in smooth muscle cells. Am J Physiol Heart Circ ... Berridge MJ (2016) The inositol trisphosphate/calcium signaling pathway in health and disease. Physiol Rev 96:1261-1296CrossRef ... Lencesova L, Krizanova O (2012) IP(3) receptors, stress and apoptosis. Gen Physiol Biophys 31:119-130CrossRefGoogle Scholar ... Mikoshiba K (2015) Role of IP3 receptor signaling in cell functions and diseases. Adv Biol Regul 57:217-227CrossRefGoogle ...
https://link.springer.com/article/10.1007%2Fs00380-018-1304-4
*  Inositol 1,4,5-trisphosphate receptor-interacting protein elisa and antibody
Recombinant Protein and Inositol 1,4,5-trisphosphate receptor-interacting protein Antibody at MyBioSource. Custom ELISA Kit, ... Shop Inositol 1,4,5-trisphosphate receptor-interacting protein ELISA Kit, ... Inositol 1,4,5-trisphosphate receptor-interacting protein. LOG IN MY ACCOUNT CART CONTENTS CHECKOUT ... Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 Antibody. Itpripl1 ELISA Kit. Itpripl1 Recombinant. Itpripl1 ...
https://www.mybiosource.com/protein_family.php?root=inositol-1-4-5-trisphosphate-receptor-interacting-protein
*  Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors | Biochemical Journal
P3-binding site of hepatocytes is likely to be the receptor that mediates Ca2+ mobilization, and that this receptor is at ... Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors. D L Nunn, C W Taylor ... Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors ... Liver inositol, 1,4,5-trisphosphate-binding sites are the Ca2(+)-mobilizing receptors ...
http://www.biochemj.org/content/270/1/227
*  Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2...
... functional IP3 receptors (IP3Rs) and the human homologue of the Drosophila transient receptor potential (Trp) channel, human ... Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular ... Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular ... Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular ...
http://www.biochemj.org/content/350/3/631
*  Increased expression of the inositol 1,4,5-trisphosphate receptor in human leukaemic (HL-60) cells differentiated with retinoic...
... mobilizing inositol phosphates and other inositol phosphates which also bind to the purified InsP3 receptor, suggesting that ... The results suggest that there is an absolute increase in the level of the InsP3 receptor during HL-60 cell differentiation and ... Increased expression of the inositol 1,4,5-trisphosphate receptor in human leukaemic (HL-60) cells differentiated with retinoic ... Increased expression of the inositol 1,4,5-trisphosphate receptor in human leukaemic (HL-60) cells differentiated with retinoic ...
http://www.biochemj.org/content/280/1/205
*  Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release...
Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release ... Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release ... Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release ... Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release ...
http://www.biochemj.org/content/327/1/251
*  Inositol 1,4,5-trisphosphate receptors (InsP3R) | Pancreapedia
... correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ... Inositol trisphosphate receptor Ca2+ release channels. Physiol Rev 87(2): 593-658,2007. PMID: 17429043. ... Surface accessibility and conformational changes in the N-terminal domain of type I inositol trisphosphate receptors: studies ... Calcium-dependent conformational changes in inositol trisphosphate receptors. J Biol Chem 285(32): 25085-25093,2010. PMID: ...
https://www.pancreapedia.org/molecules/inositol-145-trisphosphate-receptors-insp3r
*  Gene Knock-Outs of Inositol 1,4,5-Trisphosphate Receptors Types 1 and 2 Result in Perturbation of Cardiogenesis - Semantic...
Although the ryanodine receptor type 2, another type of intracellular Ca2+ release channel, has been shown to play a role in ... BACKGROUND Inositol 1,4,5-trisphosphate receptors (IP3R1, 2, and 3) are intracellular Ca2+ release channels that regulate ... trisphosphate receptors and their protein partners as signalling hubs. *David L Prole, Colin W Taylor ... Regulation of hair shedding by the type 3 IP3 receptor.. *Mai Sato-Miyaoka, Chihiro Hisatsune, Etsuko Ebisui, Naoko Ogawa, ...
https://www.semanticscholar.org/paper/Gene-Knock-Outs-of-Inositol-1%2C4%2C5-Trisphosphate-1-2-Uchida-Aramaki/dde8a0e680ce640aa8e686320e60a12ff95e60d8
*  Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy |...
Przyklenk K, Maynard M, Whittaker P. First molecular evidence that inositol trisphosphate signaling contributes to infarct size ... anti-GAGAB receptors, anti-LGI1, anti-CASPR2, anti-glycine receptors, anti-ganglioside antibodies) was negative. ... T-cell receptor analysis in anti-Hu associated paraneoplastic encephalomyelitis. Neurology. 1998;51:1146-50.View ArticlePubMed ... Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes. Circulation. 2013;128:1286-97.View ArticlePubMed ...
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0737-x
*  Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs. -...
A monoclonal antibody to the IP3 receptor inhibited both IICR and CICR upon injection of IP3 and Ca2+ into hamster eggs, ... The results indicate that Ca2+ release in fertilized hamster eggs is mediated solely by the IP3 receptor, and Ca(2+)-sensitized ... These phenomena are explained by inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release (IICR) and Ca(2+)-induced Ca2+ release ... Regulation of calcium spiking in mammalian oocytes through a combination of inositol trisphosphate-dependent entry and release. ...
https://www.semanticscholar.org/paper/Block-of-Ca2%2B-wave-and-Ca2%2B-oscillation-by-antibody-Miyazaki-Yuzaki/83acfdbb74a191725a08009fbee9460190eb0644
*  Inositol 1,4,5-trisphosphate receptor type 1
This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate ... Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 95 ... Ryanodine-inositol 1,4,5-triphosphate receptor calcium channel (rir-cac) family ... Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- ...
https://pharos.nih.gov/idg/targets/ITPR1
*  Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2
HCA RNA Cell Line for Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2. ...
https://pharos.nih.gov/idg/targets/ITPRIPL2
*  Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1
HCA RNA Cell Line for Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1. ... Generation and annotation of the DNA sequences of human chromosomes 2 and 4.. ...
https://pharos.nih.gov/idg/targets/Q6GPH6
*  Rapid ligand‐regulated gating kinetics of single inositol 1,4,5trisphosphate receptor Ca2+ release channels | EMBO Reports
Rapid activation and partial inactivation of inositol trisphosphate receptors by inositol trisphosphate. Biochemistry 37: 11524 ... Foskett JK, White C, Cheung KH, Mak D‐OD (2007) Inositol trisphosphate receptor Ca2+ release channels. Physiol Rev 87: 593-658 ... Mak D‐OD, White C, Ionescu L, Foskett JK (2005) Nuclear patch clamp electrophysiology of inositol trisphosphate receptor Ca2+ ... Sneyd J, Falcke M (2005) Models of the inositol trisphosphate receptor. Prog Biophys Mol Biol 89: 207-245. ...
http://embor.embopress.org/content/8/11/1044