Sirtuin Type 1 Mediates the Retinal Protective Effect of Hydrogen-Rich Saline Against Light-Induced Damage in Rats | IOVS |...
Rats received intravitreal injections of 10 μg EX-527 or the same volume of vehicle, as previously reported.35 Transresveratrol ... Gong Y, Qiu Y, Song Z, Gu Q, Wu X, Sun X. Effects of single intravitreal rhEPO injection on light-induced retinal injury in ... Sirt1 expression was detected from day 1 to 6 after injection (n = 3, *P , 0.05, versus the 0 day group). (B) Representative ... Sirt1 expression was detected from day 1 to 6 after injection (n = 3, *P , 0.05, versus the 0 day group). (B) Representative ...
A1120, a Nonretinoid RBP4 Antagonist, Inhibits Formation of Cytotoxic Bisretinoids in the Animal Model of Enhanced Retinal...
The injection volume was 10 μL. Extraction and injection for HPLC were performed under dim red light. Levels of bisretinoid ...
Amphiregulin and Ocular Axial Length | IOVS | ARVO Journals
... and the right eyes with amphiregulin injections experienced an increased (P=0.02) axial elongation in a dose-dependent manner ( ...
Complications of Botulinum Toxin-A for Treatment of Esotropia in Children | IOVS | ARVO Journals
... had prior BTX-A injection. Mean age at injection was 3.9 ± 3.3 years (9 months to 13.8 years). BTX-A injection was unilateral ( ... Demographic, historical, and pre-injection clinical data as well as details of the BTX-A injection and perioperative ... However, there are few reports of tonic pupil after BTX-A injection. The mechanism of action is unknown, but it may be direct ... Subjects ,17 years of age with esotropia were enrolled in a 9-month data-collection study following BTX-A injection of one or ...
Chronic Ocular Hypertension Induced by Circumlimbal Suture in Rats | IOVS | ARVO Journals
A new experimental model of glaucoma in rats through intracameral injections of hyaluronic acid. Exp Eye Res. 2005; 81: 71-80. ... Unpublished work in our laboratory suggests that during intracameral injection of microbeads into rat eyes, IOP can spike well ... including hypertonic saline injection into episcleral veins,15-17 laser application to the trabecular meshwork or the ... were euthanized by intracardiac injection of pentobarbital (Lethabarb; Virbac Pty Ltd., Crookwell, NSW, Australia). Eyes were ...
Targeted Delivery of Anti-Angiogenic Agent TNP-470 Using Water-Soluble Polymer in the Treatment of Choroidal Neovascularization...
To evaluate the effects of treatment, all angiographic negatives taken 7 to 9 minutes after injection to document the degree of ... In this study, the conjugates remained in the subretinal space 24 hours after intravenous injection. It was reported that PVA, ... with different molecular weights after intravenous injection. Drug Delivery. 1997;4:23-31. [CrossRef] ... Experimental CNV was induced by subretinal injection of gelatin microspheres containing basic fibroblast growth factor, into ...
N-Chlorotaurine Is an Effective Antiviral Agent against Adenovirus In Vitro and in the Ad5/NZW Rabbit Ocular Model | IOVS |...
... the NCT solutions were prepared in Sterile Water for Injection, USP (Abbott Laboratories, North Chicago, IL). NCT and control ... the NCT solutions were prepared at the desired concentrations in Sterile Water for Injection (Abbott Laboratories). The ...
BMSC-derived exosomes promote retinal ganglion cell survival in multiple rodent models of glaucoma | IOVS | ARVO Journals
To experimentally induce glaucoma, we used DBA/2J mice or rats receiving either an intracameral injection of microbeads or a ... Long-term neuroprotective effects (one year) of monthly BMSC exosome injections are currently being tested in the DBA/2J model. ...
An engineered porous silica particle for sustained intravitreal delivery of mycophenolic acid | IOVS | ARVO Journals
After the injection, slit-lamp, tonometry, indirect ophthalmoscopy, and ERG were performed for two weeks. ... The loaded particles finally were briefly washed before drying for in vitro release and in vivo intravitreal injection. In ... Conclusions : MPA can be successfully loaded into C8 grafted pSiO2 particles and the intravitreal injection was well tolerated ...
Autoimmunity Contributes To The Mechanism Of Optic Nerve Degeneration And Rgc Neuropathy Following Elevation Of Intraocular...
At 2 to 8 weeks after microbead injection, the degrees of RGC and axon degeneration were assessed quantitatively using electron ... Results: : All mice that received anterior chamber injection of microbeads exhibited transient IOP elevation for approximately ... mice exhibited significant less axon and RGC loss than that of C57BL/6J mice at both 2 and 8 weeks post injection of microbeads ...
Angiotensin II selectively activates retinal microglia in mice | IOVS | ARVO Journals
The injection of AngII resulted in altered microglial morphology consistent with activation, characterised by increased soma ... GFP mice received 1µl intravitreal injections of 10mM AngII, with the fellow eye receiving 1µl saline. Retinae were collected ...
Evaluation of Intravitreal Application of Pegaptanib Sodium (Macugen®) on Laser-Induced CNV in Cynomolgus Monkeys | IOVS |...
One week post-injection, 12 laser burns (4 central and 8 peripheral) were applied to the retina of both eyes to induce CNV. ... was applied to the central vitreous via inferior-temporal injection in one eye. Equivalent volume of balanced salt solution ( ...
Does repeated intravitreal injections impact the quality of life of patients, about 40 patients? | IOVS | ARVO Journals
Patients report symptoms (ocular pain and burning) that appear within hours of injection, which have an impact on their daily ... Does repeated intravitreal injections impact the quality of life of patients, about 40 patients? ... Does repeated intravitreal injections impact the quality of life of patients, about 40 patients? ... Purpose : Intravitreal injections (IVT) are used worldwide to treat age-related macular degeneration, and macular oedema. IVT ...
The Effect of Resection on Satellite Cell Activity in Rabbit Extraocular Muscle | IOVS | ARVO Journals
One week after surgery, eight rabbits received intraperitoneal injections of BrdU in sterile saline at a dose of 50 mg/kg body ... The rabbits received an injection every 2 hours for 12 hours, followed by a 24 hour BrdU-free period. Two weeks after surgery, ... The rabbits were anesthetized with an intramuscular injection of ketamine and xylazine (1:1; 10 mg/kg to 2 mg/kg, respectively ... an additional four rabbits received the same series of BrdU injections. The muscles from four additional normal rabbits labeled ...
Combination of Ranibizumab and Navigated Retinal Photocoagulation in Diabetic Macular Edema, compared to Ranibizumab Mono...
3.2 injections. In contrast, group 2 and 3 nedded significantly less ranibizumab injections (0.5 ± 0.8 and 0.8 ± 1.1, p,0.001). ... Conclusions: In this study, additional navigated laser therapy applied after 3 initial anti-VEGF injections in DME patients was ... In addition, navigated macular laser reduced the number of injections needed significantly. ... Monthly ranibizumab injection until central retinal thickness (CRT) was reduced to 450µm (Spectralis OCT) then navigated laser ...
Precision and Reliability of Retinal Thickness Measurements in Foveal and Extrafoveal Areas of Healthy and Diabetic Eyes | IOVS...
Other forms, such as surgical vitrectomy or intravitreous triamcinolone injection may be beneficial in selected cases. A third ...
Epiretinal Membranes and Incomplete Posterior Vitreous Detachment in Diabetic Macular Edema, Detected by Spectral-Domain...
Stalmans P Delaey C de Smet MD van Dijkman E Pakola S . Intravitreal injection of microplasmin for treatment of vitreomacular ...
Low Dose or Transient Administration of VEGF Trap Suppresses Corneal Neovascularization and Inflammation | IOVS | ARVO Journals
For both studies, the vasculature was labeled by intravenous injection of fluorescein-conjugated lectin (lycopersicon ... significantly decreased corneal neovascularization for at least 30 days following the last injection (p,0.01, compared to ...
The Antiangiogenic Effects of Integrin α5β1 Inhibitor (ATN-161) In Vitro and In Vivo | IOVS | ARVO Journals
5C, 5K). Similarly, at 14 days, leakage was less evident in the laser-induced lesions that received ATN-16110mg/mL injection ( ... In vivo, injection of ATN-161 after laser photocoagulation inhibited CNV leakage and neovascularization to an extent similar to ... 5A, 5I), and in the late phase (5 minutes after injection of FA), a uniformed hyperfluorescent area appeared in both groups ( ... Eyes were examined by SD-OCT and fluorescein angiography on days 1, 7, and 14 after injection, and the areas of CNV were ...
Evaluation of a telemedicine model for exudative age related macular degeneration follow-up | IOVS | ARVO Journals
During office examination in 76 cases (41%) the decision was to repeat the injection while in 109 cases (59%) it was decided ... telemedicine evaluation at the time of deciding if patients with exudative AMD treated with at least three anti-VEGF injections ...
Iron-Mediated Retinal Degeneration: Evidence for Cone Selectivity | IOVS | ARVO Journals
Real time PCR: Twelve days after injection of 0.25mM FeSO4, there was a 6.65-fold reduction in expression of M-cone opsin (p= ... TUNEL: Numerous positive nuclei were seen in the outermost portion of the ONL at 1 and 2 days after injection of 0.25mM FeSO4. ... Methods: : Adult C57BL/6 mice were given an intravitreous injection of saline or 0.10, 0.25, or 0.50mM FeSO4. Scotopic ERGs ... Results: : Oxidative stress histological markers: Three days after FeSO4 injections, there was increased staining for HNE in ...
Acute Toxic Effects of Chloroquine on the Cat Retina: Ultrastructural Changes | IOVS | ARVO Journals
Within 96 hours after an intravitreal injection of chloroquine, many outer segments were reduced to less than 20 per cent of ...