Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina | Journal of...
Excitotoxic retinal damage was induced via intraocular injections of NMDA. Microglial phenotype and neuronal survival were ... Intraocular injections. Mice were anesthetized by using an isoflurane/oxygen non-rebreathing inhaler; 98% oxygen and 2% ... We found that a single intraocular injection of IL1β prior to NMDA-treatment resulted in a significant decrease in the number ... Two consecutive daily intraocular injections of clodronate-liposomes depleted nearly 70% of the Iba1-positive microglia/ ...