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*  JNK1, JNK2, and JNK3 are involved in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells.
Inhibitory Concentration 50. Liver Neoplasms / enzymology*, genetics, pathology. Mitogen-Activated Protein Kinase 10 / genetics ... was developed by exposing parental cells to gradually increasing concentrations of adriamycin. The MTT assay was used to ...
http://www.biomedsearch.com/nih/JNK1-JNK2-JNK3-are-involved/20525557.html
*  Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula.
Inhibitory Concentration 50. Mice. Molecular Structure. Nuclear Magnetic Resonance, Biomolecular. Stereoisomerism. ... Both 1 and 2 were found to have moderate inhibitory activity against the transcription factor AP-1 (IC₅₀ = 5.2 and 6.0 μM, ...
http://www.biomedsearch.com/nih/Grassypeptolides-F-G-Cyanobacterial-Peptides/21806011.html
*  Investigation on the in vitro antioxidant capacity of methanol extract, fractions and flavones from Oroxylum indicum Linn bark
The inhibitory activity of all samples was investigated at various concentrations (Figure 2). The crude extract of the plant ( ... Keywords: Oroxylum indicum; Flavones; Methanol/extract; DPPH assay; Antioxidants; Inhibitory Concentration 50; Bignoniaceae. ... the radical inhibitory activity of chrysin was undetectable at all examined concentrations, when that of oroxylin A, detectable ... FIGURE 2 DPPH free radical inhibiting activity (%) at various concentration of the total extract, hexane (HF), methanol (MF) ...
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100619&lng=en&tlng=en
*  Laboratory for Metabolism Modifying Medicine - Aalborg University's Research Portal
Inhibitory Concentration 50 Proteomic and Post-Translational Modification Profiling of Exosome-Mimetic Nanovesicles Compared to ...
https://vbn.aau.dk/en/organisations/laboratory-for-metabolism-modifying-medicine
*  Michal Krystian Egelund Oklinski - Aalborg Universitets forskningsportal
Mørkholt, A. S., Kastaniegaard, K., Trabjerg, M. S., Gopalasingam, G., Niganze, W., Oklinski, M. K., Larsen, A., Nieland, J. G. K., Stensballe, A., Nielsen, S. & Nieland, J. D., 2017, I : International Journal of MS Care. 19, Suppl. 1, s. 54 (NP01).. Publikation: Bidrag til tidsskrift › Konferenceabstrakt i tidsskrift › Forskning › peer review ...
https://vbn.aau.dk/da/persons/138071
*  Frontiers | Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System |...
... aureus demonstrated that this molecule was likely responsible for the inhibitory activity, and further proof was provided when ... aureus demonstrated that this molecule was likely responsible for the inhibitory activity, and further proof was provided when ... The dog pathogen, S. schleiferi, expressed the most potent inhibitory activity and was active against all four agr classes ... The dog pathogen, S. schleiferi, expressed the most potent inhibitory activity and was active against all four agr classes ...
https://www.frontiersin.org/articles/10.3389/fmicb.2016.01733/full
*  October 22nd, 1999 - Volume 13 - Issue 15 : AIDS
... inhibitory concentration of didanosine in HIV-infected cells. Rana, Khurram Z.; Simmons, Kelly A.; Dudley, Michael N. ...
https://journals.lww.com/aidsonline/toc/1999/10220
*  The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes...
inhibitory concentration 50 percent. CIA: collagen induced arthritis. Declarations. Acknowledgements. This work was sponsored ... Another approach was described by De Ceuninck et al [55], who noted that disruption of IGF-1 binding to the inhibitory binding ... We do propose, based on previous observations, that vincaria is effective by limiting the inhibitory actions of IL-1β or the ... 1997, 99: 643-50.View ArticlePubMedPubMed CentralGoogle Scholar. *. Ballinger AB, Azooz O, El-Haj T, Poole S, Farthing MJ: ...
https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-6-13
*  In vitro antiproliferative activity of partially purified Trigona laeviceps propolis from Thailand on human cancer cell lines |...
Half maximal inhibitory concentration (IC50). The obtained absorbance at 540 nm was used to determine the percentage of cell ... Three replications of each experiment were performed and the half maximal inhibitory concentration (IC50) of each extract was ... the fractional inhibitory concentration index (FICI) method should be performed in order to determine the level, if any, of ... Aso K, Kanno S, Tadano T, Satoh S, Ishikawa M: Inhibitory effect of propolis on the growth of human leukemia U937. Biol ...
https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-11-37
*  Gap junctions contribute to anchorage-independent clustering of breast cancer cells | BMC Cancer | Full Text
Inhibitory Concentration 50%. Declarations. Acknowledgements. We are grateful to the members of our group for their interest to ... 3). This inhibitory effect was obvious and maximum around 2-3 h after seeding (i.e., the very early stage of GJIC formation), ... a Representative in-focus bright-field images are shown for each brefeldin A concentration and at the indicated time points. b ... The screening strategy was to search for compounds that inhibit cell aggregation at the unique concentration of 1.25 μM. EDTA ...
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4148-5
*  Influence of DNMT inhibitors on radiation-induced γH2A | Open-i
Inhibitory Concentration 50. *Lung Neoplasms/pathology. *Tumor Stem Cell Assay. *Tyrosine/analogs & derivatives/pharmacology ... Foci were evaluated in 50 nuclei. Bars, SE. *p , 0.01 as determined by a logistic regression compared with radiation alone (6 ... Foci were evaluated in 50 nuclei. Bars, SE. *p , 0.01 as determined by a logistic regression compared with radiation alone (6 ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC3375186_1748-717X-7-39-7&req=4
*  Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal...
... inhibitory concentration (IC50) values of THC for each ESCC cell are shown in Supplementary Table 1. We selected 3 cell lines, ... Plasma concentration of curcumin was measured (**P , 0.01, vs curcumin diet; n = 5). b Xenografted-tumor growth: TE-11R cells ( ... Plasma concentration of curcumin was measured (**P , 0.01, vs control; n = 5). b PDX tumor growth: Growth kinetics of ... a Plasma concentration of curcumin: C57BL/6 mice received control, curcumin (0.6 g/kg) or Theracurmin® (THC) (2 g/kg: ...
https://link.springer.com/article/10.1007%2Fs00535-019-01549-x
*  In Vivo Antimalarial Activity of the 80 Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. &...
... inhibitory concentration. LD50:. Median lethal dose. PCV:. Packed cell volume. ... This pronounced antimalarial activity observed in the established infection test may be due to inhibitory effect of the extract ... 45-50, 2010. View at Publisher · View at Google Scholar · View at Scopus ... This suggests that LD50 of the extract is greater than 2000 mg/kg. ...
https://www.hindawi.com/journals/ecam/2018/9217835/
*  Plus it
... inhibitory concentration. IPA. Ingenuity Pathway Analysis. ISR. integrated stress response. LC50. 50% lethal concentration. ... inhibitory concentration) was calculated from three independent experiments using SigmaPlot (version 12.5) software (Systat ... being the latter accumulated in a concentration-dependent fashion (Table I). In contrast, only the highest concentration of CA ... 3D). Compared with the stronger inhibitory activity of MG-132 (IC50∼70 nm, Fig. 3E), CS was ∼200-fold less potent, suggesting ...
http://www.mcponline.org/content/16/1/8
*  Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization | JEM
... inhibitory concentration. nAb. neutralizing Ab. NHP. nonhuman primate. RLU. relative light unit. sCD4. soluble CD4. SHIV. ... inhibitory concentration (IC50) values were calculated as 6.5 µg/ml and ,0.023 µg/ml, respectively (Table S2). Furthermore, all ... 4, A and B). Sigmoidal concentration-dependent binding was observed in a similar fashion to that seen with the previously ... Initially, VHH J3 was titrated from a starting concentration of 50 µg/ml against the pseudoviruses used in the direct ...
http://jem.rupress.org/content/early/2012/05/22/jem.20112655
*  Phylogenetic tree of 10 strains of scab-causing and rel | Open-i
... biosynthesized gold nanoparticles exhibited a dose-dependent cytotoxicity against HeLa cells and the inhibitory concentration ( ... biosynthesized gold nanoparticles exhibited a dose-dependent cytotoxicity against HeLa cells and the inhibitory concentration ( ... biosynthesized gold nanoparticles exhibited a dose-dependent cytotoxicity against HeLa cells and the inhibitory concentration ( ... biosynthesized gold nanoparticles exhibited a dose-dependent cytotoxicity against HeLa cells and the inhibitory concentration ( ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4663555_marinedrugs-13-06818-g001&req=4
*  Full text] Hemagglutinin-based polyanhydride nanovaccines against H5N1 influenza | IJN
The percentage neutralization at each protein concentration was plotted and the half maximal inhibitory concentration (IC50) ... Total RNA concentration for each sample was adjusted to 40 μg/μL, and 5 μL was used as the template for the PCR reaction. PCR ... Finally, a multiplexed assay was used to quantitate the concentrations of inflammatory cytokines (IL-6, IP-10, G-CSF, IFN-γ, ... Samples containing the extracted RNA were thawed, mixed well, and the total RNA concentration was determined, in duplicate ...
https://www.dovepress.com/hemagglutinin-based-polyanhydride-nanovaccines-against-h5n1-influenza--peer-reviewed-fulltext-article-IJN
*  Plus it
... inhibitory concentration; MRP, multidrug resistance protein; MX, mitoxantrone; MXR, mitoxantrone resistance; P-gp, P- ... These cells were further exposed to stepwise increased concentrations of TPT, up to 950 nm TPT. From this time point on, the ... The T8 cell line was developed by continuous exposure to stepwise increased TPT concentrations, ranging from 24 to 240 nm. ... Directly after incubation and at several time points after ending incubation, intracellular concentrations of TPT were ...
http://cancerres.aacrjournals.org/content/59/18/4559
*  Plus it
... inhibitory concentration; GST, glutathione S-transferase.. *Received October 19, 2000.. *Accepted March 1, 2001. ... E2 still activated TGF-α gene expression in a concentration-dependent manner; however, a higher concentration (1 nm) of E2 was ... 3) ⇓ . E2 induced TGF-α mRNA levels in a concentration-dependent manner with wild-type ERα (Fig. 3) ⇓ . E2 induced TGF-α gene ... 6) ⇓ , 4-OHT, and Ral (data not shown) induced TGF-α mRNA level in a concentration-dependent manner with D351YERα. 4-OHT was an ...
http://cancerres.aacrjournals.org/content/61/9/3632
*  In vitro antineoplastic effects of auranofin in canine lymphoma cells | BMC Cancer | Full Text
... appears to inhibit the growth and initiate apoptosis in canine lymphoma cells in vitro at clinically achievable concentrations ... At concentrations that appear clinically achievable in humans, AF demonstrated potent antiproliferative and proapoptotic ... 5, the concentration of CCNU could be markedly decreased to obtain similar inhibitory effects as a single-agent after combining ... inhibitory concentration (IC50) for growth inhibition was calculated by fitting to a sigmoidal dose-response curve using Prism ...
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4450-2
*  ORBi: Browsing ORBi
seemed to be very promising (inhibitory concentration 50% (IC50) , 5 microg/ml) whereas two other species, Strychnos ... Inhibitory Effects of Proanthocyanidins from Ribes Nigrum Leaves on Carrageenin Acute Inflammatory Reactions Induced in Rats. ... all compounds interact with a very poor efficacy and only at concentrations , I mu M with both [H-3]strychnine binding and ... The ED (50) in vivo was about 30 mg/kg/day by the intraperitoneal route (after 4 days treatment). [less ▲] ...
http://orbi.ulg.ac.be/browse?type=author&sort_by=1&order=DESC&rpp=20&etal=3&value=Tits%2C+Monique+p001322&offset=60
*  Synergy of BCL2 and histone deacetylase inhibition against leukemic cells from cutaneous T-cell lymphoma patients | Blood...
These values far exceeded the in vitro mean inhibitory concentrations observed in our study. We are further encouraged as the ... inhibitory concentrations (IC50) ranging from picomolar (85 pM) to micromolar (6.6 µM) levels. The observed heterogeneity in ... inhibitory concentration values. Furthermore, this anti-BCL2 effect was markedly potentiated by concurrent HDAC inhibition with ... we compared the mean inhibitory concentration of venetoclax between patients classified as B1 vs B2 (ISCL classification),43 as ...
http://www.bloodjournal.org/content/130/19/2073?sso-checked=true
*  Prothioconazole and Prothioconazole-Desthio Activities against Candida albicans Sterol 14-α-Demethylase | Applied and...
... inhibitory concentration; IPTG, isopropyl-β-d-thiogalactopyranoside; MCP, microchannel plate detector; NTA, nitrilotriacetic ... concentrations ranged from 0 to 100 μM, with the DMF concentration kept constant at 0.5% (vol/vol). Mean values from three ... inhibiting activity at concentrations similar to the CaCYP51 concentration. This was as expected for tight-binding CYP51 ... We compared the inhibitory properties of voriconazole, used to treat both Aspergillus and Candida infections (10), to those of ...
https://aem.asm.org/content/79/5/1639?ijkey=05f00f5a6dc5c26989f330b78a9e709023afab96&keytype2=tf_ipsecsha