In this study, we investigated the role of the NF-κB signaling pathway and inflammation in the amelioration of renal IRI using ... In this study, we investigated the role of the NF-κB signaling pathway and inflammation in the amelioration of renal IRI using ... Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. ... Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. ...
Inhibition of C5 strongly inhibited late inflammation, as measured by neutrophil influx and induction of the murine CXC ... BACKGROUND: Complement has been implicated in the pathophysiology of renal ischemia-reperfusion (I/R) injury. However, the ... METHODS: Mice were subjected to 45 min of unilateral ischemia and subsequent contralateral nephrectomy and reperfusion for 2, ... METHODS: Mice were subjected to 45 min of unilateral ischemia and subsequent contralateral nephrectomy and reperfusion for 2, ...
Effects of Coriandrum sativum on distant organ inflammation and apoptosis due to liver ischemia/reperfusion injury. Vol. 64 No ... Download PDF Effects of Coriandrum sativum on distant organ inflammation and apoptosis due to liver ischemia/reperfusion injury ... Liver ischemia/reperfusion (IR) often affects distant organs, such as small intestine, kidney, and lung. Coriandrum sativum (CS ... Damaging effects of IR as well as apoptosis and inflammation were found to be decreased in the groups treated with CS. ...
Early exposure to germs modifies kidney damage and inflammation after experimental ischemia-reperfusion injury. ... Early exposure to germs modifies kidney damage and inflammation after experimental ischemia-reperfusion injury. Together they ...
... collateral myocardial ischemia-reperfusion injury (MIRI) and pertinent cardioprotection are still challenging to address and ... While effective early reperfusion of the criminal coronary artery after a confirmed AMI is the typical treatment at present, ... "Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the ... "NOD2 contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and inflammation," Life ...
As such, inhibiting proline hydroxylation of RIPK1 promotes RIPK1 activation to trigger cell death and inflammation. Hepatocyte ... which is disrupted upon prolonged hypoxia that activates RIPK1 activity to promote cell death and inflammation. ... by which hypoxia promotes RIPK1 activation through modulating its proline hydroxylation to mediate cell death and inflammation ... Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc. Natl Acad. Sci. USA 110, 12024-12029 ...
Reperfusion following ischemia causes acute inflammation within the microvasculature, leading to neutrophilic proliferation. ... Prolonged ischemia impairs perfusion to the endothelial cells that line the walls of the microvasculature. Impaired perfusion ... or reperfusion injury, ultimately leading to MVO. Functional no reflow phenomenon is largely reversible due to the fact that ... with longer periods of ischemia related to greater damage to the arterial microvasculature. Venous ulcer Caiazzo, Gianluca; ...
They include ischemia and reperfusion injury, systemic inflammation, and vascular dysfunction.. The most relevant goal, they ... Cardiogenic shock in the MI setting was usually fatal until the advent of acute reperfusion therapy with balloon angioplasty, ...
Finally, the ischemia reperfusion (I/R) injury model was used in C57BL/6J mice to induce retinal inflammation and investigate ... Finally, the ischemia reperfusion (I/R) injury model was used in C57BL/6J mice to induce retinal inflammation and investigate ... We tested caffeine by using in vitro and in vivo paradigms of retinal inflammation. Human retinal pigment epithelial cells ( ... In conclusion, these findings suggest that caffeine is a good candidate to counteract inflammation in retinal diseases. ...
... cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation. Biochim. Biophys. Acta 1817, 598-609 ( ...
Bergsbaken T, Fink SL and Cookson BT: Pyroptosis: Host cell death and inflammation. Nat Rev Microbiol. 7:99-109. 2009. View ... Pan Z, Sun X, Ren J, Li X, Gao X, Lu C, Zhang Y, Sun H, Wang Y, Wang H, et al: miR-1 exacerbates cardiac ischemia-reperfusion ... Ding M, Lei J, Han H, Li W, Qu Y, Fu E, Fu F and Wang X: SIRT1 protects against myocardial ischemia-reperfusion injury via ... Ischaemia-reperfusion (I/R) injury is the most important and common cause of myocardial damage and subsequent heart failure ...
... is known to impair hemostasis when used for the prevention of perioperative inflammation and ischemia-reperfusion injury. ...
... warm ischemia and reperfusion injury with emphasis on cryonics technology ... have been shown to not only reduce ischemia-associated inflammation [PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (USA); ... BRAIN DAMAGE DUE TO ISCHEMIA/REPERFUSION *PREVENTING ISCHEMIC/REPERFUSION INJURY IN CRYONICS *PRE-TREATMENT FOR CRYONICS ... Endothelial cells are significantly more damaged by reperfusion following cold ischemia than following warm ischemia [ ...
... oxidative stress and mitigate inflammation by suppressing NOX4 and NLRP3/caspase-1 in myocardial ischaemia-reperfusion injury. ... Shen Y, Liu X, Shi J and Wu X: Involvement of Nrf2 in myocardial ischemia and reperfusion injury. Int J Biol Macromol. 125:496- ... Sun W, Wang Z, Sun M, Huang W and Wang Y and Wang Y: Aloin antagonizes stimulated ischemia/reperfusion-induced damage and ... Shi X, Tao G, Ji L and Tian G: Sappanone a protects against myocardial ischemia reperfusion injury by modulation of Nrf2. Drug ...
... chinensis exerted the protective effects on cerebral ischemia-reperfusion injury by inhibiting inflammation in brain tissue [18 ... Effects of Cuscuta chinensis flavonoids on inflammatory response of brain tissue in rats with cerebral ischemia-reperfusion ... Demirci, K.; Naziroglu, M.; Ovey, I.S.; Balaban, H. Selenium attenuates apoptosis, inflammation and oxidative stress in the ... cerebral ischemia, or d-galactose-induced mice [22,23,24]. Due to the important role of the cerebral cholinergic system in ...
The second model is a surgical model that induces ischemia/reperfusion injury and subsequent local and systemic inflammation ... The second model induced ischemia/reperfusion injury and subsequent local and systemic inflammation by surgically reducing ... The second model induced ischemia/reperfusion injury and subsequent local and systemic inflammation by surgically reducing ... The second model induced ischemia/reperfusion injury and subsequent local and systemic inflammation by surgically reducing ...
F. Arslan, M. B. Smeets, L. A. J. ONeill et al., "Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like ... K. S. Midwood and A. M. Piccinini, "DAMPening inflammation by modulating TLR signalling," Mediators of Inflammation, vol. 2010 ... It is considered to develop due to a massive alarmin release in response to ischemia reperfusion, mechanical injury, and ... Those factors include mechanical and reperfusion injuries, ischemia, various burns, UV rays, and radiation [4-6]. Adverse ...
Protective effects of glucagon-like peptide 2 on intestinal ischemia-reperfusion rats. Microsurgery 2008;28:285-90. ... that a chronic treatment with GLP-2 protects rats against the ischaemia-reperfusion-induced endotoxaemia and inflammation, by ... adipose tissue inflammation and metabolic disorders.6-9 The link between high-fat diet-induced inflammation, oxidative stress, ... Hepatic inflammation in rats with experimental small intestinal bacterial overgrowth. Gastroenterology 1990;98:414-23. ...
Protective effects of glucagon-like peptide 2 on intestinal ischemia-reperfusion rats. Microsurgery 2008;28:285-90. ... that a chronic treatment with GLP-2 protects rats against the ischaemia-reperfusion-induced endotoxaemia and inflammation, by ... adipose tissue inflammation and metabolic disorders.6-9 The link between high-fat diet-induced inflammation, oxidative stress, ... Hepatic inflammation in rats with experimental small intestinal bacterial overgrowth. Gastroenterology 1990;98:414-23. ...
Neuroprotective effect of curcumin against cerebral ischemia-reperfusion via mediating autophagy and inflammation. J. Mol. ... Newton, K.; Dixit, V.M. Signaling in innate immunity and inflammation. Cold Spring Harb. Perspect. Biol., 2012, 4(3)a006049. [ ... Liu, Y.C.; Gao, X.X.; Chen, L.; You, X.Q. Rapamycin suppresses Aβ25-35- or LPS-induced neuronal inflammation via modulation of ... Glass, C.K.; Saijo, K.; Winner, B.; Marchetto, M.C.; Gage, F.H. Mechanisms underlying inflammation in neurodegeneration. Cell, ...
Ischemia-reperfusion injury - Ischemia of the nonventilated lung contributes to inflammation, microvascular permeability, and ... both inflammation and ischemia-reperfusion injury may contribute to glyocalyx damage [10] ... Biotrauma and inflammation are largely unavoidable, but minimizing fluid administration may help minimize pulmonary edema. ... with the degree of inflammation being linearly related to the longevity of lung collapse; in addition, prolonged high-pressure ...
Ischemia . Reperfusion . Baseline . Pre-ischemic treatment . Ischemia . Reperfusion . Heart rate (min−1) 125 ± 2 126 ± 2 126 ± ... Murphy GJ, Holder JC: PPAR-γ agonists: therapeutic role in diabetes, inflammation, and cancer. Trends Pharmacol Sci ... Ischemia . Reperfusion . Baseline . Pre-ischemic treatment . Ischemia . Reperfusion . Heart rate (min−1) 125 ± 2 126 ± 2 126 ± ... Ischemia. . . Reperfusion. . . . Vehicle . Troglitazone . Vehicle . Troglitazone . Vehicle . Troglitazone . Vehicle . ...
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends in Pharmacological Sciences. 19: 287-98. ... Neuroprotective FK506 does not alter in vivo nitric oxide production during ischemia and early reperfusion in rats. Stroke; a ... Nitric oxide synthase in models of focal ischemia. Stroke; a Journal of Cerebral Circulation. 28: 1283-8. PMID 9183363 DOI: ... Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemia. Journal of Cerebral Blood Flow ...
DC-mediated NKT cell activation is critical in initiating the immune response following kidney ischemia/reperfusion injury (IRI ... which mimics human acute kidney injury (AKI). Adenosine is an important antiinflammatory molecule in tissue inflammation, and ... Following 26 minutes of kidney ischemia and 24 hours of kidney reperfusion, plasma creatinine levels were measured from vehicle ...
Signaling through the chemokine SDF-1α and its receptor CXCR4 plays a critical role in the homing of stem cells to ischemia for ... Inflammation and the innate immune system, including macrophages, play crucial roles in the differentiation and activation of ... and accelerated blood reperfusion. These effects, unexpectedly, led to complete limb salvage and skeletal muscle repair, ... Chronic inflammation-associated bone diseases involve continuous destruction and impaired regeneration of bone. Mesenchymal ...
Ischemia-Reperfusion and Neonatal Intestinal Injury journal, February 2011 * Young, Christopher M.; Kingma, Sandra D. K.; Neu, ... The role of hyperosmotic stress in inflammation and disease journal, August 2012 * Brocker, Chad; Thompson, David C.; Vasiliou ... Ischemia-Reperfusion and Neonatal Intestinal Injury journal, February 2011 * Young, Christopher M.; Kingma, Sandra D. K.; Neu, ... The role of ischemia in necrotizing enterocolitis journal, August 2016 * Chen, Yong; Chang, Kenneth Tou En; Lian, Derrick Wen ...
Recombinant Klotho Protein Ameliorates Myocardial Ischemia/Reperfusion Injury by Attenuating Sterile Inflammation Authors: J ... EphrinA1-Fc attenuates myocardial ischemia/reperfusion injury in mice Authors: A DuSablon, J Parks, K Whitehurst, H Estes, R ... The Protective Effect of Anthocyanins Extracted from Aronia Melanocarpa Berry in Renal Ischemia-Reperfusion Injury in Mice ... MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and ...
Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury. Am J Physiol ... Inflammation. 2016;39:123-8 52. Freitas-Andrade M, Bechberger JF, MacVicar BA, Viau V, Naus CC. Pannexin1 knockout and blockade ... Hainz N, Wolf S, Tschernig T, Meier C. Probenecid Application Prevents Clinical Symptoms and Inflammation in Experimental ... For example, blocking the phosphorylation and activation of PANX1 by Src during ischemia through administration of the ...