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*  The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity (Journal Article) | SciTech Connect
Journal Article: The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity ... This parasite relies on inosine 5{prime}-monophosphate dehydrogenase (IMPDH) to obtain guanine nucleotides, and inhibition of ...
https://www.osti.gov/scitech/biblio/1002265
*  RCSB PDB - 1MEH: Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with IMP and MOA bound...
Crystal Structures of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with Substrate, Cofactor and Analogs ... Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with IMP and MOA bound. ...
http://www.rcsb.org/pdb/explore/materialsAndMethods.do?structureId=1MEH
*  Impdh2 MGI Mouse Gene Detail - MGI:109367 - inosine monophosphate dehydrogenase 2
J:11016 Tiedeman AA, et al., Isolation and sequence of a cDNA encoding mouse IMP dehydrogenase. Gene. 1991 Jan 15;97(2):289-93 ... IPR001093 IMP dehydrogenase/GMP reductase. IPR015875 IMP dehydrogenase / GMP reductase, conserved site ...
http://www.informatics.jax.org/marker/MGI:109367
*  guaB - Inosine-5'-monophosphate dehydrogenase - Yersinia pestis - guaB gene & protein
IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine ... IPR005990. IMP_DH. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. ... IPR005990. IMP_DH. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. ... IMP dehydrogenaseUniRule annotation. ,p>Manual validated information which has been generated by the UniProtKB automatic ...
http://www.uniprot.org/uniprot/Q0WD32
*  TIGR01303
This HMM represents a family of proteins, often annotated as a putative IMP dehydrogenase, related to IMP dehydrogenase and GMP ... also have IMP dehydrogenase as described by TIGRFAMs entry TIGR01302. ...
http://www.jcvi.org/cgi-bin/tigrfams/HmmReportPage.cgi?acc=TIGR01303
*  IMPDH2 Gene - GeneCards | IMDH2 Protein | IMDH2 Antibody
Inosine Monophosphate Dehydrogenase 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards ... IMP (Inosine Monophosphate) Dehydrogenase 2 3 * Inosine Monophosphate Dehydrogenase Type II 3 ... inosine 5-monophosphate dehydrogenase,type II,paralog to IMPDH1 *IMPDH2. UniProtKB/Swiss-Prot BiophysicochemicalProperties: ... Tissue specificity: IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor. ...
http://www.genecards.org/cgi-bin/carddisp.pl?gene=IMPDH2
*  Human Metabolome Database: Showing metabocard for Xanthylic acid (HMDB0001554)
Hedstrom L: IMP dehydrogenase: mechanism of action and inhibition. Curr Med Chem. 1999 Jul;6(7):545-60. [PubMed:10390600 ] ... Markland W, McQuaid TJ, Jain J, Kwong AD: Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a ... Jayaram HN, Cooney DA, Grusch M, Krupitza G: Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and ... Digits JA, Hedstrom L: Drug selectivity is determined by coupling across the NAD+ site of IMP dehydrogenase. Biochemistry. 2000 ...
http://www.hmdb.ca/metabolites/HMDB0001554
*  Inosine 5′-monophosphate dehydrogenase of Escherichia coli. Purification by affinity chromatography, subunit structure and...
Escherichia coli IMP dehydrogenase (EC 1.2.1.14) was purified by affinity chromatography on immobilized nucleotides. The enzyme ... demonstrated that IMP dehydrogenase comprises identical subunits of mol.wt. 58000. Trypsin and Pronase cleave the 58000-mol.wt ... AMP-agarose was used resulted in a homogeneous preparation of IMP dehydrogenase. The enzyme was also purified by ... GMP appears to be a competitive inhibitor with respect to IMP, with no evidence for regulatory behaviour being found. The two ...
http://www.biochemj.org/content/183/3/481
*  Inosine 5′-monophosphate dehydrogenase of Escherichia coli K12: the nature of the inhibition by guanosine 5′-monophosphate ...
When IMP is the variable substrate, IMP dehydrogenase (EC 1.2.1.14) gives non-linear Lineweaver-Burk plots in the presence of ... Inosine 5′-monophosphate dehydrogenase of Escherichia coli K12: the nature of the inhibition by guanosine 5′-monophosphate ( ... Inosine 5′-monophosphate dehydrogenase of Escherichia coli K12: the nature of the inhibition by guanosine 5′-monophosphate ( ... Inosine 5′-monophosphate dehydrogenase of Escherichia coli K12: the nature of the inhibition by guanosine 5′-monophosphate ( ...
http://www.biochemj.org/content/133/3/607
*  Merimepodib|VI-21497;VX-497;MMP|CAS 198821-22-6 Buy Merimepodib from supplier medchemexpress.com
Inosine monophosphate dehydrogenase)....Quality confirmed by NMR,HPLC & MS. ... Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of ... Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of ... Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of ...
https://www.medchemexpress.com/Merimepodib.html
*  Inosine Monophosphate Dehydrogenase. A Major Therapeutic by Krzysztof W. Pankiewicz, Barry M. Goldstein - Stowarzyszenie Library
... phosphate dehydrogenase (IMP D H ) activity in extracts of ovarian carcinomas. Gynecol. Oncol. 1992, 47, 66-70. 44. ; Look, K ... Inosine Monophosphate Dehydrogenase. A Major Therapeutic by Krzysztof W. Pankiewicz, Barry M. Goldstein. Posted on March 8, ... Inosine Monophosphate Dehydrogenase: a huge healing Target presents a complete examine the chemotherapeutic aim inosine ... Inosine Monophosphate Dehydrogenase: a massive Therpeutic Target presents a comphrensive examine the chemotherapeutic inosine ...
http://opole-skwp.iq.pl/library/inosine-monophosphate-dehydrogenase-a-major-therapeutic-target
*  GMP reductase 2
A single crystal structure of human GMPR type 2 with IMP and NADPH fortuitously captures three different states, each of which ... Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside ...
https://pharos.nih.gov/idg/targets/Q9P2T1
*  IMP Dehydrogenase Mutants: Cell Culture Model for Hyperuricemia | SpringerLink
The second regulatory domain occurs subsequent to IMP synthesis, where both adenylosuccinate synthetase and IMP dehydrogenase, ... Ullman B. (1984) IMP Dehydrogenase Mutants: Cell Culture Model for Hyperuricemia. In: De Bruyn C.H.M.M., Simmonds H.A., Müller ... The first occurs before the IMP branchpoint in which both PRPP synthetase and PRPP-glutamine amidotransferase are subject to ...
https://link.springer.com/chapter/10.1007/978-1-4684-4553-4_74
*  IMP dehydrogenase - Wikipedia
There are two IMP dehydrogenase isozymes in humans. IMP dehydrogenase nearly always contains a long insertion that has two CBS ... IMP dehydrogenase EC 1.1.1.205 (Inosine-5'-monophosphate dehydrogenase) (Inosinic acid dehydrogenaseis) (IMPDH) an enzyme that ... IMP dehydrogenase is associated with cell proliferation and is a possible target for cancer chemotherapy. Mammalian and ... Natsumeda Y, Ohno S, Kawasaki H, Konno Y, Weber G, Suzuki K (March 1990). "Two distinct cDNAs for human IMP dehydrogenase". J. ...
https://en.wikipedia.org/wiki/IMP_dehydrogenase
*  somatostatin | Broad-Spectrum Antiviral Activity of the IMP Dehydrogenase Inhibitor
History: In adults with sickle cell disease (SCD), an elevated tricuspid regurgitant velocity (TRV) measured by Doppler echocardiography, an improved serum N-terminal proCbrain natriuretic peptide (NT-pro-BNP) level, and pulmonary hypertension (PH) diagnosed by ideal center catheterization (RHC) are independent risk elements for mortality. level add up to or higher than 160 pg/ml, or RHC-confirmed PH. For individuals informed they have improved mortality risk, we make a solid suggestion for hydroxyurea as first-line therapy and a fragile suggestion for chronic transfusions alternatively therapy. For those individuals with SCD with raised TRV only or raised NT-pro-BNP alone, as well as for individuals with SCD with RHC-confirmed PH with raised pulmonary artery wedge pressure and low pulmonary vascular level of resistance, we make a solid suggestion against PAH-specific therapy. Nevertheless, for select individuals with SCD with RHC-confirmed PH who've raised pulmonary vascular level of resistance ...
http://hr010.net/tag/somatostatin/
*  Tozasertib | Broad-Spectrum Antiviral Activity of the IMP Dehydrogenase Inhibitor
Vasoactive intestinal peptide (VIP) has diverse and essential part in human being physiology and physiopathology and their receptors constitute potential targets for the treating several diseases such as for example neurodegenerative disorder, asthma, diabetes, and inflammatory diseases. go through conformational changes leading to key sequences situated in intracellular loops to become exposed also to connect to the G protein. Tozasertib For the time being, the connection network concerning N229 and Q380 maintains TM7 inside a conformation essential for appropriate activation of G proteins. The three-dimensional model also recommended that Q380 could work as a floating ferry-boat, switching between R188 and N229 residues side-chains therefore contributing to sign transduction propagation and Tozasertib activation of G proteins (Chugunov et al., 2010). Open up in another window Number 3 Three-dimensional style of the transmembrane domains from the VPAC1 receptor. Lateral (A). and best (B). watch ...
http://hr010.net/tag/tozasertib/
*  Recombinant Human IMP (Inosine 5'-Monophosphate) Dehydrogenase 2, His-tagged IMPDH2-1274H - Creative BioMart
... inosine monophosphate dehydrogenase type II; IMP dehydrogenase 2; inosine-5"-monophosphate dehydrogenase 2; IMP dehydrogenase 2 ... dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMPDH-II; IMP oxireductase 2; inosine 5" phosphate dehydrogenase ... Recombinant Human IMP (Inosine 5'-Monophosphate) Dehydrogenase 2, His-tagged. Download Datasheet See All IMPDH2 Products. Bring ... IMP dehydrogenase activity; metal ion binding; nucleotide binding; oxidoreductase activity; protein binding. ...
https://www.creativebiomart.net/description_20640_8.htm
*  usmle 2: block 1 Flashcards by Nashid Chaudhury | Brainscape
mutation in branched-chain alpha-keto acid dehydrogenase. can't decarboxylate the alpha-keto acid derivatives of leucine, ...
https://www.brainscape.com/flashcards/usmle-2-block-1-2307996/packs/3729903
*  Leber Congenital Amaurosis - GeneReviews® - NCBI Bookshelf
Abnormal gene product. Inhibition of cellular IMP dehydrogenase activity results in an abrupt cessation of DNA synthesis and a ... In the purine de novo synthetic pathway, IMP dehydrogenase is positioned at the branch point in the synthesis of adenine and ... Retinol dehydrogenase 12. RDH12 @ LOVD. RDH12. RDH12. LCA14. LRAT. 4q32. ​.1. Lecithin retinol acyltransferase. Retina ... Normal gene product. Retinol dehydrogenase 12 (RDH12) is a photoreceptor-specific enzyme involved in all-trans- and cis-retinol ...
https://www.ncbi.nlm.nih.gov/books/NBK1298/
*  test #36 4.27 Flashcards by Nashid Chaudhury | Brainscape
3. ribavarin monophosphate inhibits cellular monophosphate dehydrogenase (depleting GTP pools) [needed to convert IMP to GMP). ... lethal hypermutation, inhibiting RNA pol and inosine monophosphate dehydrogenase (depleting GTP), causing defective 5' cap ...
https://www.brainscape.com/flashcards/test-36-427-2264031/packs/3729903
*  Search: All Pfam signatures | InterPro | EMBL-EBI
IMP dehydrogenase/GMP reductase (IPR001093) Pfam signature: PF00478 Glucose-6-phosphate dehydrogenase, NAD-binding (IPR022674) ... Short-chain dehydrogenase/reductase SDR (IPR002347) Pfam signature: PF00106 Alcohol dehydrogenase, C-terminal (IPR013149) Pfam ... Alcohol dehydrogenase, iron-type/glycerol dehydrogenase GldA (IPR001670) Pfam signature: PF00465 Ribosomal protein L10P ( ... Proline dehydrogenase domain (IPR002872) Pfam signature: PF01619 Pollen allergen Poa p IX/Phl p VI (IPR002914) Pfam signature: ...
http://www.ebi.ac.uk/interpro/member-database/Pfam
*  Principles of Biochemistry/Nucleic acid III: Sythesis of nucleotides - Wikibooks, open books for an open world
IMP dehydrogenase converts IMP into XMP. *GMP synthase converts XMP into GMP ... dihydroorotate dehydrogenase[19] (the only mitochondrial enzyme). orotate. Dihydroorotate then enters the mitochondria where it ... Both adenine and guanine are derived from the nucleotide inosine monophosphate (IMP), which is synthesised on a pre-existing ... Enzymes taking part in IMP synthesis constitute a multienzyme complex in the cell. Evidences demonstrate that there are ...
https://en.wikibooks.org/wiki/Principles_of_Biochemistry/Nucleic_acid_III:_Sythesis_of_nucleotides
*  Impdh2 - Inosine-5'-monophosphate dehydrogenase 2 - Mus musculus (Mouse) - Impdh2 gene & protein
IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine ... IPR005990 IMP_DH. IPR015875 IMP_DH/GMP_Rdtase_CS. IPR001093 IMP_DH_GMPRt. ... IPR005990 IMP_DH. IPR015875 IMP_DH/GMP_Rdtase_CS. IPR001093 IMP_DH_GMPRt. ... IMP dehydrogenase activity Source: MGI ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for the function, ...
https://www.uniprot.org/uniprot/P24547
*  Differential Sensitivities of Fast- and Slow-Cycling Cancer Cells to Inosine Monophosphate Dehydrogenase 2 Inhibition by...
Natsumeda Y, et al. (1990) Two distinct cDNAs for human IMP dehydrogenase. J. Biol. Chem. 265:5292-5.PubMedGoogle Scholar ... Carr SF, Papp E, Wu JC, Natsumeda Y. (1993) Characterization of human type I and type II IMP dehydrogenases. J. Biol. Chem. 268 ... Takebe N, et al. (2006) IMP dehydrogenase inhibitor mycophenolate mofetil induces caspase-dependent apoptosis and cell cycle ... The product of this construct has normal IMP dehydrogenase activity but lacks the binding site for MPA and thus confers MPA ...
https://link.springer.com/article/10.2119%2Fmolmed.2015.00126
*  Mead J[au] - PubMed - NCBI
Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis.. Gorla SK, McNair NN, Yang G, Gao S, Hu M, ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Mead+J%5Bau%5D&dispmax=50