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北京大学医学部机构知识库(IR@PKUHSC): Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells from tumors in...  北京大学医学部机构知识库([email protected]): Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells from tumors in...
Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells from tumors in association with ... Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells from tumors in association with ... Wang, Jing,et al."Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells from tumors in association ... Wang, Jing,Bu, Dingfang,&Zhu, Xuejun.(2007).Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells ...
more infohttp://ir.bjmu.edu.cn/handle/400002259/50993
  "Antibodies to immunoglobulin heavy chain variable regions protect help" by J Puri, neriah Y. Ben et al.
Antibodies to immunoglobulin heavy chain variable regions protect helper cells from specific suicide by radiolabeled antigen. ... Puri, J; Ben, neriah Y.; Givol, D; and Lonai, P, "Antibodies to immunoglobulin heavy chain variable regions protect helper ...
more infohttps://mouseion.jax.org/ssbb1980/1413/
  "Does activation-induced deaminase initiate antibody diversification by" by Janet Stavnezer and Sean P. Bradley
There, it is required for somatic hypermutation, gene conversion and class switch recombination of antibody variable region ... Immunoglobulin M; Immunoglobulin Variable Region ... and class switch recombination of antibody variable region ... Antibody Diversity; B-Lymphocytes; Cytidine Deaminase; *Gene Conversion; *Genes, Immunoglobulin; Humans; ...
more infohttps://escholarship.umassmed.edu/wfc_pp/183/
Chronic lymphocytic leukemia/small cell lymphoma (CLL/SLL) | Flow Cytometry  Chronic lymphocytic leukemia/small cell lymphoma (CLL/SLL) | Flow Cytometry
This distinction is based on the maturity of the lymphocytes as discerned by the immunoglobulin variable-region heavy chain ( ... in the IgVH antibody gene region whereas low risk patients show considerable mutations of the DNA in the antibody gene region ... These cells are positioned in the same region as normal lymphocytes (red). ...
more infohttp://clinicalflow.com/chronic-lymphocytic-leukemiasmall-cell-lymphoma-cllsll
Primary structure of a deleted human lambda type immunoglobulin light chain containing carbohydrate: protein Sm lambda  Primary structure of a deleted human lambda type immunoglobulin light chain containing carbohydrate: protein Sm lambda
The constant (C) region is fully intact, comprising 105 residues, whereas the variable region (V) has only 30 residues. The V- ... such as the hinge regions of heavy (H) and light (L) chains and the hypervariable regions, are particularly susceptible to ... An internal molecular deletion occurring in a human lambda type immunoglobulin light (L)-chain (Sm lambda) has been defined by ... Carbohydrate is attached to an Asx residue at position 25, in the first hypervariable region, associated with the sequence ...
more infohttps://eurekamag.com/research/041/068/041068912.php
Somatic hypermutation of immunoglobulin  variable region genes: focus on follicular lymphoma and multiple myeloma  Somatic hypermutation of immunoglobulin variable region genes: focus on follicular lymphoma and multiple myeloma
Somatic hypermutation of immunoglobulin variable region genes: focus on follicular lymphoma and multiple myeloma. ... Analysis of the rearranged immunoglobulin variable region gene hypermutation has provided important information concerning the ... Additionally, abortive κ light chain variable region genes in λ-expressing myelomas carried a significant number of somatic ... Despite the already acknowledged evidence for a selectable distribution of mutations within the clonal immunoglobulin variable ...
more infohttps://insights.ovid.com/imrv/199804000/00004210-199804000-00025
Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type. - Semantic Scholar  Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type. - Semantic Scholar
The region comprises five V kappa sequences of subgroup I and one interspersed V kappa pseudogene of subgroup II. The six genes ... An 80,000 base-pair region from the gene locus encoding the variable regions of the human immunoglobulins of the kappa type (V ... An 80,000 base-pair region from the gene locus encoding the variable regions of the human immunoglobulins of the kappa type (V ... Evolutionary relationship between human and mouse immunoglobulin kappa light chain variable region genes. *Guido Kroemer, Arno ...
more infohttps://www.semanticscholar.org/paper/Organization-and-evolution-of-a-gene-cluster-for-of-Pech-Jaenichen/a36d3dca34894c26f4e5ae08a1cf93d75a9995b4
Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions | PNAS  Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions | PNAS
Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. N Hozumi and S Tonegawa ... Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions ... Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions ... Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions ...
more infohttp://www.pnas.org/content/73/10/3628
Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in mucosa...  Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in mucosa...
2017). Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in ... Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in mucosa ... Humans, Neoplasms, Adnexal and Skin Appendage, Eye Neoplasms, Genetic Predisposition to Disease, Immunoglobulin Variable Region ... DNA Mutational Analysis, Gene Silencing, Gene Rearrangement, Phenotype, Mutation, Genes, Immunoglobulin Heavy Chain, Lymphoma, ...
more infohttps://www.repository.cam.ac.uk/handle/1810/269885
Rearrangement of immunoglobulin heavy chain variableregion genes - Haemolytic Anaemia  Rearrangement of immunoglobulin heavy chain variableregion genes - Haemolytic Anaemia
The central process in B-cell formation is the rearrangement of Ig variable-region genes. For rearrangement of V-region genes ... The CDR1 and CDR2 regions encode two out of the three parts of the variable region that determine the antigenic specificity of ... The variableregion component of the immunoglobulin heavy chain gene is divided into three types of gene segment. V segments, D ... The V gene segments are longer than J or D segments and encode much of the framework of the variable-region domain, together ...
more infohttps://www.europeanmedical.info/haemolytic-anaemia/rearrangement-of-immunoglobulin-heavy-chain-variableregion-genes.html
Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversity. - Radcliffe Department of Medicine  Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversity. - Radcliffe Department of Medicine
... region belonging to the VHIII subgroup has been used in filter hybridisations to estimate the number of heavy-chain V-genes in ... A mouse cloned cDNA probe containing a variable (V) ... A mouse cloned cDNA probe containing a variable (V) region ... Immunoglobulin Variable Region, Immunoglobulin kappa-Chains, Mice, Nucleic Acid Hybridization, Structure-Activity Relationship ... Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversity. Rabbitts TH., Matthyssens G., Hamlyn PH ...
more infohttps://www.rdm.ox.ac.uk/publications/601749
immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus] 5mg A1072-5 | Gentaursearch  immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus] 5mg A1072-5 | Gentaursearch
immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus] 5mg datasheet and description hight quality ... immunoglobulin light chain variable region [ ]/[Mus musculus] 5mg. Short name: immunoglobulin light chain variable region [Homo ... immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus] 5mg. Contact us. ... immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus] 5 milligrams of pure chemical substance for ...
more infohttp://gentaursearch.com/product/human/33337/immunoglobulin-light-chain-variable-region-fragment-homo-sapiens-mus-musculus-5mg.html
CD27 | Cancer Genetics Web  CD27 | Cancer Genetics Web
extracellular region - immunoglobulin mediated immune response - induction of apoptosis - integral to plasma membrane - ... less Immunoglobulin Heavy Chain Variable gene (IGHV) somatic hypermutation (57 vs 97%, P=0.012) and less IGHV3-23 gene ... Single-cell immunoglobulin gene sequencing showed polyclonality, indicating that these cells are not precursors to the myeloma ... The goal of this study was to characterize the B-cell populations and immunoglobulin genetics in TM patients. We found a unique ...
more infohttp://www.cancerindex.org/geneweb/CD27.htm
CD1D | Cancer Genetics Web  CD1D | Cancer Genetics Web
... no association was found between NKT-like cell frequency and immunoglobulin heavy chain variable region gene (IGHV) mutation or ... Identical immunoglobulin gene rearrangements were identified in both the hairy cell leukemia and Langerhans cell sarcoma ... Bisulfite sequencing and MSP revealed that GpG islands in the promoter regions of KDR and FLT4 were unmethylated in HUVECs, ... Both Ki7LI and MS were able to split luminal tumors into subgroups with significantly variable outcomes, independent of other ...
more infohttp://www.cancerindex.org/geneweb/CD1D.htm
Obtention and engineering of non-human primate (NHP) antibodies for therapeutics.  Obtention and engineering of non-human primate (NHP) antibodies for therapeutics.
Immunoglobulin Variable Region / genetics. Peptide Library. Primates / immunology*. Recombinant Proteins / genetics, immunology ... 0/Antibodies; 0/Immunoglobulin Variable Region; 0/Peptide Library; 0/Recombinant Proteins ... The framework regions (FR) - the regions most implicated in tolerance - of these NHP antibody fragments were shown to be very ...
more infohttp://www.biomedsearch.com/nih/Obtention-Engineering-Non-Human-Primate/20105119.html
Modulation of Epstein-Barr virus latent membrane protein 1 activity by intrabodies.  Modulation of Epstein-Barr virus latent membrane protein 1 activity by intrabodies.
Immunoglobulin Variable Region / chemistry, genetics, immunology*. Molecular Sequence Data. Peptide Library. Recombinant ... 0/Antibodies, Viral; 0/EBV-associated membrane antigen, Epstein-Barr virus; 0/Immunoglobulin Variable Region; 0/Peptide Library ... METHODS: This study uses a phage display single-chain variable fragments (scFvs) library to screen recombinant antibodies ... specific to the LMP1 C terminal region. A total of 45 individual clones were obtained, and these scFvs were cloned as ...
more infohttp://www.biomedsearch.com/nih/Modulation-Epstein-Barr-virus-latent/17460414.html
https://www.cancer.gov/types/leukemia/hp/cll-treatment-pdq  https://www.cancer.gov/types/leukemia/hp/cll-treatment-pdq
Immunoglobulin variable region heavy chain gene (IgVH) mutation.[9-13] The finding of significant numbers of mutations in this ... the immunoglobulin variable region heavy-chain (IgVH) mutational status, and the presence of 11q- or 17p- deletion established ... including the immunoglobulin variable region heavy-chain (IgVH) gene mutation, chromosomal abnormalities by fluorescent in situ ... identified four prognostic subgroups based on immunoglobulin variable region heavy-chain gene mutation (IgVH), clinical stage, ...
more infohttps://www.cancer.gov/types/leukemia/hp/cll-treatment-pdq
Chapman CJ[au] - PubMed - NCBI  Chapman CJ[au] - PubMed - NCBI
Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis.. Chapman CJ, Wright D, Stevenson FK. ... Immunogenetic analysis of the heavy chain variable regions of IgE from patients allergic to peanuts. ... Tracking of the V4-34 (VH4-21) gene in human tonsil reveals clonal isotype switch events and a highly variable degree of ... Use of phage surface expression to analyze regions of human V4-34(VH4-21)-encoded IgG autoantibody required for recognition of ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Chapman+CJ%5Bau%5D&dispmax=50
Southern blot analysis and quantitation of PCR amplifie | Open-i  Southern blot analysis and quantitation of PCR amplifie | Open-i
Immunoglobulin Variable Region/genetics*. *Immunoglobulin kappa-Chains/genetics*. *Multigene Family*. *Recombination, Genetic* ... Mentions: The human Igκ locus contains 76 Vκ and 5 Jκ gene segments located in a distal and a proximal region, carrying 36 and ... Mentions: The human Igκ locus contains 76 Vκ and 5 Jκ gene segments located in a distal and a proximal region, carrying 36 and ... Accessibility of immunoglobulin (Ig) gene segments to V(D)J recombination is highly regulated and is normally only achieved in ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2195934_JEM010340.f1b&req=4
Connection | Harvard Catalyst Profiles | Harvard Catalyst  Connection | Harvard Catalyst Profiles | Harvard Catalyst
Regulation of immunoglobulin variable-region gene assembly. Academic Article T helper cell membranes promote IL-4-independent ... Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Academic Article The molecular ... Control of immunoglobulin heavy chain constant region gene expression. Academic Article An expressed neo(r) cassette provides ... Mechanisms that control antigen receptor variable region gene assembly. Academic Article Mechanism of endogenous myc gene down- ...
more infohttps://connects.catalyst.harvard.edu/Profiles/search/default.aspx?searchtype=whypeople&nodeuri=https://connects.catalyst.harvard.edu/Profiles/profile/1252168&searchfor=Transcription,%20Genetic&exactphrase=&perpage=15&offset=0&page=1&totalpages=161&searchrequest=&sortby=&sortdirection=&showcolumns=1
Lupus eritematoso diseminado | Portsmouth Regional Hospital  Lupus eritematoso diseminado | Portsmouth Regional Hospital
Immunoglobulin variable-region gene usage in systemic autoimmune diseases. Arthritis Rheum . 2001;44:2715-2727. ...
more infohttps://portsmouthhospital.com/hl/?/11698/lupus/sp&com.dotmarketing.htmlpage.language=1
Lupus eritematoso diseminado | Medical City Dallas  Lupus eritematoso diseminado | Medical City Dallas
Immunoglobulin variable-region gene usage in systemic autoimmune diseases. Arthritis Rheum . 2001;44:2715-2727. ...
more infohttps://medicalcityhospital.com/hl/?/11698/lupus-eritematoso-sist%C3%A9mico/sp&com.dotmarketing.htmlpage.language=1
The Microenvironment of Germ Cell Tumors Harbors a Prominent Antigen-Driven Humoral Response | The Journal of Immunology  The Microenvironment of Germ Cell Tumors Harbors a Prominent Antigen-Driven Humoral Response | The Journal of Immunology
Human immunoglobulin variable region gene analysis by single cell RT-PCR. J. Immunol. Methods 244: 217-225. ... Ig variable region cloning. B cell Ig variable region libraries were built from tissue sections prepared on a cryostat, from ... Variable region sequences were analyzed using software available from the human variable region database on the ImMunoGeneTics ... The variable region cloning procedure (8) also captures the 5′ end of the Ig constant region, allowing the Ig isotype to be ...
more infohttp://www.jimmunol.org/content/182/5/3310
Table of Contents - June 04, 2012, 209 (6) | JEM  Table of Contents - June 04, 2012, 209 (6) | JEM
DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions Genetic inactivation of the genes encoding ... DNA polymerases indicates that DNA polymerase ζ inserts tandem double-base substitutions in the immunoglobulin variable region ... In the mouse lung, dendritic cells in the alveolar region but not the airway extend dendrites and take up antigen; antigen- ...
more infohttp://jem.rupress.org/content/209/6