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*  "Two cases of monoclonal nodular pulmonary amyloidosis and review of th" by Kendal Endicott, Conor Hynes et al.
Herein we present two cases of NPA of the rarely reported monoclonal (light-chain restricted) form with review of the ... This localized pulmonary form of amyloidosis is most often found to contain combinations of kappa and lambda immunoglobulin ... light chain and immunoglobulin heavy chain proteins with a polyclonal lymphoplasmacystic infiltrate. ... is most often found to contain combinations of kappa and lambda immunoglobulin light chain and immunoglobulin heavy chain ...
https://hsrc.himmelfarb.gwu.edu/smhs_surgery_facpubs/440/
*  RheumaKnowledgy » Amyloidosis
Immunoglobulin (AL). Primary, Myeloma- associated amyloidosis. lg light chains. Hereditary. Familial. Various non-lg proteins. ... Under the light microscope, amyloid deposits are visualized by staining with Congo red. When viewed under polarized light, the ... The tissues are stained with Congo red and viewed under polarized light. Kidney and peripheral nerve biopsy specimens can be ...
http://www.rheumaknowledgy.com/amyloidosis/
*  Anti-Rat immunoglobulin light chain-like antibody [KT100] (ab95376) Protocols
Abcam provides specific protocols for Anti-Rat immunoglobulin light chain-like antibody [KT100] (ab95376) : Western blot ...
http://www.abcam.com/rat-immunoglobulin-light-chain-like-antibody-kt100-ab95376-protocols.html
*  Immunoglobulin Light Chains Generate Hydrogen Peroxide | American Society of Nephrology
Ig Light Chains Generate H2O2 in HK-2 Cells. Overnight incubation of HK-2 cells with each of the light chains (5 mg/ml) ... For light chains, this process has been characterized in some detail. Proximal tubular reabsorption of light chains sparks the ... Because there were limited amounts of some of the light chains, two light chains (κ1 and κ2) were used to demonstrate a dosage- ... For example, light chains that promote light chain deposition disease and amyloidosis undergo endocytosis into mesangial cells ...
https://jasn.asnjournals.org/content/18/4/1239
*  Risk factors for venous thromboembolism in immunoglobulin light chain amyloidosis | Haematologica
Risk factors for venous thromboembolism in immunoglobulin light chain amyloidosis. Katherine M. Bever, Luke I. Masha, Fangui ... Risk factors for venous thromboembolism in immunoglobulin light chain amyloidosis. Katherine M. Bever, Luke I. Masha, Fangui ... Patients with immunoglobulin light chain amyloidosis are at risk for both thrombotic and bleeding complications. While the ... Immunoglobulin light chain amyloidosis (AL) is a rare systemic disorder resulting from organ deposition of amyloid fibrils ...
http://www.haematologica.org/content/101/1/86
*  High sensitivity cardiac troponin T in patients with immunoglobulin light chain amyloidosis | Heart
High sensitivity cardiac troponin T in patients with immunoglobulin light chain amyloidosis ... High sensitivity cardiac troponin T in patients with immunoglobulin light chain amyloidosis ... assay in patients with immunoglobulin light chain amyloidosis (AL) improves risk prediction. ...
http://heart.bmj.com/content/100/5/383
*  Immunoglobulin light chain - Wikipedia
... heavy chains and two Ig light chains. There are two types of light chain in humans: kappa (κ) chain, encoded by the ... thus the two light chains of an individual antibody are identical. Each light chain is composed of two tandem immunoglobulin ... The immunoglobulin light chain is the small polypeptide subunit of an antibody (immunoglobulin). A typical antibody is composed ... Other types of light chains can be found in lower vertebrates, such as the Ig-Light-Iota chain of Chondrichthyes and Teleostei ...
https://en.wikipedia.org/wiki/Immunoglobulin_light_chain
*  Analysis of the Immunoglobulin Light Chain Genes in Zebra Finch: Evolutionary Implications
Evidence for one immunoglobulin light-chain type in chickens: absence of a blocked N-terminal light-chain type. Biochem Genet. ... and two identical light chains (IGL). Most tetrapod species encode more than one isotype of light chains. Chicken is the only ... Analysis of the Immunoglobulin Light Chain Genes in Zebra Finch: Evolutionary Implications. Sabyasachi Das,*,1,2 Uzra Mohamedy, ... Organization of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2. Hum Mol Genet. 1995;4:983-991. [PubMed ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2877555/
*  Variability of the immunoglobulin light chain in the Siberian sturgeon, Acipenser baeri
immunoglobulin; light chain; VL gene; diversity; evolution; Siberian sturgeon; Acipenser baeri; HEAVY-CHAIN; SOMATIC MUTATION; ... Variability of the immunoglobulin light chain in the Siberian sturgeon, Acipenser baeri. Lundqvist, ML Uppsala University. ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:105872
*  Cerebrospinal fluid immunoglobulin light chain ratios predict disease progression in multiple sclerosis | Journal of Neurology,...
Highly related immunoglobulin light chain sequences in different multiple sclerosis patients. J Neuroimmunol 1999;100:98-101. ... Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine. Clin Chem 2001;47:673-80. ... Multiple sclerosis: assay of free immunoglobulin light chains. Ann Clin Biochem 2017;54:5-13.doi:10.1177/0004563216652175 ... Objective To determine whether the ratio of cerebrospinal fluid (CSF) immunoglobulin kappa to lambda light chains at time of ...
https://jnnp.bmj.com/content/89/10/1044
*  Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts : Comparison with myeloma
Immunoglobulin light chain (AL) amyloidosis is characterized by tissue deposition of amyloid fibers derived from immunoglobulin ... Immunoglobulin light chain (AL) amyloidosis is characterized by tissue deposition of amyloid fibers derived from immunoglobulin ... Immunoglobulin light chain (AL) amyloidosis is characterized by tissue deposition of amyloid fibers derived from immunoglobulin ... Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts : Comparison with myeloma. Da ...
https://lup.lub.lu.se/search/publication/467dc134-08d1-481d-8041-4e576bf4283e
*  Frontiers | Diversity of Immunoglobulin Light Chain Genes in Non-Teleost Ray-Finned Fish Uncovers IgL Subdivision into Five...
... encoding homogeneous lambda-like light chain. In addition, sterlet possesses sigma-like VL and J-CL genes, which are ... encoding homogeneous lambda-like light chain. In addition, sterlet possesses sigma-like VL and J-CL genes, which are ... The isotype described previously as the teleostean IgL lambda turned out to be a kappa and lambda chain paralog that emerged ... The isotype described previously as the teleostean IgL lambda turned out to be a kappa and lambda chain paralog that emerged ...
https://www.frontiersin.org/articles/10.3389/fimmu.2018.01079/full
*  Primary structure of a deleted human lambda type immunoglobulin light chain containing carbohydrate: protein Sm lambda
An internal molecular deletion occurring in a human lambda type immunoglobulin light (L)-chain (Sm lambda) has been defined by ... Primary structure of a deleted human lambda type immunoglobulin light chain containing carbohydrate: protein Sm lambda. ... Primary structure of a deleted human lambda type immunoglobulin light chain containing carbohydrate: protein Sm lambda. ... and light (L) chains and the hypervariable regions, are particularly susceptible to breakage and reunion. We postulate that the ...
https://eurekamag.com/research/041/068/041068912.php
*  Systemic immunoglobulin light chain amyloidosis - UCL Discovery
... immunoglobulin light chain amyloidosis is a protein misfolding disease caused by the conversion of immunoglobulin light chains ... Systemic immunoglobulin light chain amyloidosis. Nature Reviews Disease Primers , 4 , Article 38. 10.1038/s41572-018-0034-3. ... Systemic immunoglobulin light chain amyloidosis - pre-styled.pdf - ["content_typename_Accepted version" not defined] Access ... have led to rapid and deep suppression of amyloid light chain production in the majority of patients. However, effective ...
http://discovery.ucl.ac.uk/10065475/
*  Melphalan, lenalidomide and dexamethasone for the treatment of immunoglobulin light chain amyloidosis: results of a phase II...
... urine free light chain excretion and serum free light chain ratio).. Hematologic responses were measured at three, six, nine ... Immunoglobulin light chain amyloidosis (AL) is a plasma cell dyscrasia characterized by deposition of amyloid fibrils in ... Melphalan, lenalidomide and dexamethasone for the treatment of immunoglobulin light chain amyloidosis: results of a phase II ... Melphalan, lenalidomide and dexamethasone for the treatment of immunoglobulin light chain amyloidosis: results of a phase II ...
http://www.haematologica.org/content/98/5/789
*  Novel Analysis of Clonal Diversification in Blood B Cell and Bone Marrow Plasma Cell Clones in Immunoglobulin Light Chain...
Immunoglobulin light chain amyloidosis (AL) is characterized by a limited clonal expansion of plasma cells and amyloid ... Human B cells cell differentiation repertoire development plasma cells light chain amyloidosis immunoglobulin light chain ... Immunoglobulin light chain variable (V) region genes influence clinical presentation and outcome in light chain-associated ... Immunoglobulin light chain amyloidosis (AL) is characterized by a limited clonal expansion of plasma cells and amyloid ...
https://link.springer.com/article/10.1007%2Fs10875-006-9056-9
*  AL-Base: a visual platform analysis tool for the study of amyloidogenic immunoglobulin light chain sequences. - Semantic Scholar
... light chain (LC) sequences derived from patients with AL amyloidosis and controls, is described, along with a collection of ... Clarifying immunoglobulin gene usage in systemic and localized immunoglobulin light-chain amyloidosis by mass spectrometry.. * ... Inhibition of Light Chain 6aJL2-R24G Amyloid Fiber Formation Associated with Light Chain Amyloidosis.. *Angel E Pelaez-Aguilar ... Structure and energetic basis of overrepresented λ light chain in systemic light chain amyloidosis patients.. *Jun Zhao, ...
https://www.semanticscholar.org/paper/AL-Base%3A-a-visual-platform-analysis-tool-for-the-of-Bodi-Prokaeva/228679f00366cedcedf60c8fcd6b797093bfb322
*  Serological Immunoglobulin-Free Light Chain Profile in Myasthenia Gravis Patients
Serological levels of free immunoglobulin light chains (FLCs), produced in excess of heavy chains during synthesis of ... Serological Immunoglobulin-Free Light Chain Profile in Myasthenia Gravis Patients. Umberto Basile,1 Mariapaola Marino,2 Cecilia ... We found a statistically significant increase in free κ chains in both AChR- and MuSK-MG patients, while free λ chain levels ... We also observed a significant reduction of both free κ and λ chains in 1/4 MuSK-MG patients along with specific abs titer, two ...
https://www.hindawi.com/journals/jir/2018/9646209/abs/
*  Immunoglobulin light chain gene translocations in non-Hodgkin'...
Immunoglobulin light chain gene translocations in non-Hodgkin's lymphoma as assessed by fluorescence in situ hybridisation.: In ... while a few involve the immunoglobulin light chain gene (IGL) locus, consisting of the kappa light chain gene (IGkappa) and the ... Immunoglobulin light chain gene translocations in non-Hodgkin's lymphoma as assessed by fluorescence in situ hybridisation.. ... In non-Hodgkin's lymphoma (NHL), the majority of translocations involve the immunoglobulin heavy chain gene (IGH) locus, ...
https://www.mysciencework.com/publication/show/immunoglobulin-light-chain-gene-translocations-non-hodgkin-s-lymphoma-assessed-fluorescence-situ-hybridisation-6aeb6d05
*  Immunoglobulins devoid of light chains - Vrije, Universiteit Brussel
There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete ... light chain in the four-chain model immunoglobulins is that of a committed heavy chain chaperon and that the emergence of light ... As all three immunoglobulins bind to Protein A we refer to them as IgG: namely IgG1 (light chain and heavy chain γ1 (50 Kd) ... The immunoglobulins of the invention, which are devoid of light chains are such that the variable domains of their heavy chains ...
http://www.freepatentsonline.com/5759808.html
*  Treatment Tolerability in Patients with Immunoglobulin Light-Chain Amyloidosis
... is a rare and typically fatal disease caused by misfolded light chains-protein chains formed by plasma cells that misfold into ... Immunoglobulin light-chain amyloidosis (AL amyloid-osis), one of the most common forms of amyloidosis, ... Immunoglobulin light-chain amyloidosis (AL amyloid-osis), one of the most common forms of amyloidosis, is a rare and typically ... BACKGROUND: Immunoglobulin light-chain amyloidosis (AL amyloidosis) is a rare and often fatal disease for which there is ...
http://tlgqr.com/issues/2018/november-2018-vol-11-no-8/2666-treatment-tolerability-in-patients-with-immunoglobulin-light-chain-amyloidosis
*  Comparative hybridization studies iwth an immunoglobulin light chain mRNA fraction and non-immunoglobulin mRNA of mouse. -...
Comparative hybridization studies iwth an immunoglobulin light chain mRNA fraction and non-immunoglobulin mRNA of mouse. ... Comparative hybridization studies iwth an immunoglobulin light chain mRNA fraction and non-immunoglobulin mRNA of mouse. ... Comparative hybridization studies iwth an immunoglobulin light chain mRNA fraction and non-immunoglobulin mRNA of mouse. ... Immunoglobulin Fragments, Liver, Mice, Mice, Inbred BALB C, Myeloma Proteins, Nucleic Acid Conformation, Nucleic Acid ...
https://www.rdm.ox.ac.uk/publications/601870
*  "Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocy" by Janet Stavnezer and R. C. Huang
An RNA fraction isolated from a mouse myeloma functions as template for the synthesis of a mouse Ig light chain in a cell free ... Stavnezer, Janet and Huang, R. C., "Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system ... Synthesis of a mouse immunoglobulin light chain in a rabbit reticulocyte cell-free system ... An RNA fraction isolated from a mouse myeloma functions as template for the synthesis of a mouse Ig light chain in a cell free ...
https://escholarship.umassmed.edu/wfc_pp/253/
*  High sensitivity cardiac troponin T in patients with immunoglobulin light chain amyloidosis
Home » High sensitivity cardiac troponin T in patients with immunoglobulin light chain amyloidosis ... High sensitivity cardiac troponin T in patients with immunoglobulin light chain amyloidosis. ... assay in patients with immunoglobulin light chain amyloidosis (AL) improves risk prediction. Background: Cardiac involvement is ...
http://pdc-connection.ebscohost.com/c/articles/95595898/high-sensitivity-cardiac-troponin-t-patients-immunoglobulin-light-chain-amyloidosis
*  Immunoglobulin Free Light Chains Kappa and Lambda - Immunoassays | BioVendor Research and Diagnostics Products
Immunoglobulin Free Light Chains Kappa and Lambda - Immunoassays. Product filter Immunoglobulin Free Light Chains Kappa and ... Immunoglobulin A Immunoglobulin E Immunoglobulin Free Light Chains Kappa and Lambda Insulin Insulin Receptor Interleukin-1 ... Immunoglobulin Free Light Chains Kappa and Lambda Human ELISA Type: Sandwich ELISA, Biotin-labelled antibody. ...
https://www.biovendor.com/immunoassays?molecule=Immunoglobulin%20Free%20Light%20Chains%20Kappa%20and%20Lambda