Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death. - The Christie Research...
Hypoxia inducible factors (HIFs) are responsible for the majority of gene expression changes under hypoxia, and are themselves ... alpha Subunit. -. dc.subject.mesh. Ketoglutaric Acids. -. dc.subject.mesh. Metabolic Networks and Pathways. - ... Hypoxia inducible factors (HIFs) are responsible for the majority of gene expression changes under hypoxia, and are themselves ... Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.Authors: Chowdhury R, ...http://christie.openrepository.com/christie/handle/10541/91488
Prolyl hydroxylase domain enzyme 2 is the major player in regulating hypoxic responses in rheumatoid arthritis. - Nuffield...
... enzymes and factor-inhibiting HIF-1α (FIH-1), which regulate cellular HIF levels, and to study the roles of these enzymes in RA ... which coordinate cellular responses to hypoxia. The objective of this study was to analyze the expression and regulation of ... highlighting the major importance of this enzyme in hypoxia- and angiogenesis-dependent inflammatory diseases such as RA. ... RESULTS: In human RA FLS, knockdown of PHD-2, but not knockdown of PHD-1 or FIH-1, dramatically augmented HIF-1α expression, ...https://www.ndorms.ox.ac.uk/publications/323032
... alpha subunit (basic helix-loop-helix transcription factor). Background. Hypoxia, a condition of low tissue O2 concentration, ... Hypoxia Inducible Factor-1) is one of the key regulators of the transcriptional response to oxygen deprivation (1). HIF-1 is ... TNF-alpha, NOS-2, and chemokines resulting in inflammation. Knockout mice deficient in either p40 or p19, or in either subunit ... the IL-23 alpha subunit). IL-23 is an important part of the inflammatory response against infection. It promotes upregulation ...http://invivosaglik.com/nanobodies_63_en.html
Anti Human Prolyl Hydroxylase 1 Antibody, clone PHD112/G7 - Mouse Anti-Human Monoclonal Antibody WB, IHC-P - Buy Now! |Abgent
Anti Human Prolyl Hydroxylase 1 Antibody, clone PHD112/G7 , Mouse Anti-Human Monoclonal Antibody validated in WB, IHC-P ( ... Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key ... role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly ... Egl nine homolog 2, 126.96.36.199, Estrogen-induced tag 6, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 1, HIF-PH1, HIF- ...http://www.abgent.com/products/ABD12496-Anti-Human-Prolyl-Hydroxylase-1-Antibody-clone-PHD112G7-
WikiGenes - HIF1A - hypoxia inducible factor 1, alpha subunit...
Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, ... The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau ... pVHL functions in a multi-subunit E3 ubiquitin ligase that targets the hypoxia-inducible transcription factor Hif1 alpha for ... Bimodal effect of hypoxia in cancer: role of hypoxia inducible factor in apoptosis. Wang, Y., Pakunlu, R.I., Tsao, W., Pozharov ...https://www.wikigenes.org/e/gene/e/3091.html
What does hypoxia-inducible factor 1, alpha subunit mean?
... alpha subunit in the Definitions.net dictionary. Meaning of hypoxia-inducible factor 1, alpha subunit. What does hypoxia- ... alpha subunit mean? Information and translations of hypoxia-inducible factor 1, alpha subunit in the most comprehensive ... alpha subunit. Here are all the possible meanings and translations of the word hypoxia-inducible factor 1, alpha subunit.. ... alpha Subunit. Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by ...http://www.definitions.net/definition/hypoxia-inducible%20factor%201,%20alpha%20subunit
HIF1A - Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor) - Bos taurus (Bovine) - HIF1A...
R-BTA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha. R-BTA-5689880. Ub-specific processing ... R-BTA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha. R-BTA-5689880. Ub-specific processing ... R-BTA-1234162. Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha. ... R-BTA-1234162. Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha. ...http://www.uniprot.org/uniprot/A0JND0
HIF1A Gene - GeneCards | HIF1A Protein | HIF1A Antibody
Hypoxia Inducible Factor 1 Alpha Subunit, including: function, proteins, disorders, pathways, orthologs, and expression. ... This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed ... Hypoxia Inducible Factors (HIFs) are transcription factors that are activated in response to decreased oxygen availability in ... Hypoxia Inducible Factor 1 Alpha Subunit 2 3 5 * Hypoxia Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=HIF1A
007561 - B6.129-Hif1a|tm3Rsjo|/J
... to strains expressing Cre recombinase in various tissues and may be useful for studies of the role of HIF transcription factors ... The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest 117( ... alpha subunit. Gene Synonym(s). AA959795; HIF-1-alpha; HIF-1A; HIF-1alpha; HIF1; HIF1-ALPHA; HIF1alpha; MOP1; PASD8; bHLHe78; ... Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res 60(15):4010-5. PubMed: 10945599MGI: J: ...https://www.jax.org/strain/007561
Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α...
Hypoxia-Inducible Factor 1, alpha Subunit / antagonists & inhibitors*, metabolism. Liver Neoplasms / drug therapy*, metabolism ... alpha Subunit; 0/NF-kappa B; 0/Phenylurea Compounds; 0/Piperidones; 0/sorafenib; 25X51I8RD4/Niacinamide; EC 188.8.131.52/Von Hippel ... Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α ... CONCLUSION: Hypoxia induced by sustained sorafenib treatment confers sorafenib resistance to HCC through HIF-1α and NF-κB ...http://www.biomedsearch.com/nih/Hypoxia-mediated-sorafenib-resistance-can/23299930.html
Reversal of experimental renovascular hypertension restores coronary microvascular function and architecture.
... which are independent factors for adverse cardiovascular outcomes. We hypothesized that decreased blood pressure by ... Hypoxia-Inducible Factor 1, alpha Subunit / biosynthesis. Kidney / blood supply. Microvessels / pathology, physiology*. ... alpha Subunit; EC 184.108.40.206/Procollagen-Proline Dioxygenase; EC 220.127.116.11/Von Hippel-Lindau Tumor Suppressor Protein ... These were accompanied by increased myocardial expression of hypoxia-inducible factor (HIF)-1α, inflammation, and microvascular ...http://www.biomedsearch.com/nih/Reversal-Experimental-Renovascular-Hypertension-Restores/21233798.html
Mitochondrial Function of Immune Cells in Sepsis
Tumor Necrosis Factor-alpha. *Hypoxia-Inducible Factor 1, alpha Subunit. *Shock. *Shock, Septic ... During hypoxia, the low availability of oxygen limits the reaction; HIF-1α is no. longer degraded and rapidly accumulates and ... growth factor (VEGF) and erythropoietin. Under hypoxic conditions, HIF mediates also a. decrease in mRNA levels of the ... ATP due to impaired mitochondrial function may be a factor in modulating the immune response. in sepsis. Alterations in ...http://www.knowcancer.com/cancer-trials/NCT01600989/
Academic Programs Faculty - Last Initial L - Wake Forest School of Medicine
S-Phase Kinase-Associated Proteins; TNF Receptor-Associated Factor 6; Hypoxia-Inducible Factor 1, alpha Subunit; Liver ... Receptor, Epidermal Growth Factor; Glioblastoma; Brain Neoplasms; Transcription Factors; Receptor, erbB-2 ... Muscular Dystrophies; Muscular Dystrophy, Duchenne; Marfan Syndrome; Losartan; Transforming Growth Factor beta ... Diphtheria Toxin; Sirtuin 1; Sepsis; Recombinant Fusion Proteins; Glioblastoma Academic: 336-716-8607. Department: 336-716-8607 ...http://www.wakehealth.edu/School/FacultySR.htm?st=L&li=L&ft=R
HIF1AN - Вікіпедія
Dann C.E. III, Bruick R.K., Deisenhofer J. (2002). Structure of factor-inhibiting hypoxia-inducible factor 1: an asparaginyl ... Webb J.D., Muranyi A., Pugh C.W., Ratcliffe P.J., Coleman M.L. (2009). MYPT1, the targeting subunit of smooth-muscle myosin ... is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).. Biochem. J. 420. с. 327 - 333 ... HIF1AN, FIH1, hypoxia inducible factor 1 alpha subunit inhibitor. Зовнішні ІД. MGI: 2442345 HomoloGene: 9906 GeneCards: HIF1AN ...https://uk.wikipedia.org/wiki/HIF1AN
ENSDARG00000034293 - Zebrafish Mutation Project - Wellcome Sanger Institute
... alpha subunit (basic helix-loop-helix transcription factor) [Source:HGNC. Mouse Orthologue:. Hif1a. Mouse Description:. hypoxia ... hypoxia-inducible factor 1-alpha [Source:RefSeq peptide;Acc:NP_956527]. Human Orthologue:. HIF1A. Human Description:. hypoxia ... alpha subunit Gene [Source:MGI Symbol;Acc:MGI:106918]. ...http://www.sanger.ac.uk/sanger/Zebrafish_Zmpgene/ENSDARG00000034293
HIF1AN - PrimePCR Assay and Template | Life Science | Bio-Rad
Hypoxia inducible factor 1, alpha subunit inhibitor Assay Type: SYBR® Green Assay Design: Intron-spanning Application: Gene ... alpha subunit inhibitor Assay Type: Probe Assay Design: Intron-spanning Application: Gene Expression Unique Assay ID: ... Control assays and synthetic DNA templates were designed to facilitate the assessment of the key experimental factors impacting ... Hypoxia inducible factor 1, ...http://www.bio-rad.com/en-us/prime-pcr-assays/gene/hif1an-rabbit
Tissue expression of HIF1A - Summary - The Human Protein Atlas
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed ... alpha subunit (Basic helix-loop-helix transcription factor), isoform CRA_b; Hypoxia-inducible factor 1, alpha subunit, variant ... alpha subunit (Basic helix-loop-helix transcription factor), isoform CRA_a; Hypoxia-inducible factor 1-alpha ... GO:0090575 [RNA polymerase II transcription factor complex]. GO:0097411 [hypoxia-inducible factor-1alpha signaling pathway]. GO ...http://www.proteinatlas.org/ENSG00000100644-HIF1A/tissue
HIF-1 alpha Antibody (241809) [Unconjugated] (MAB1536): Novus Biologicals
Mouse Monoclonal Anti-HIF-1 alpha Antibody (241809) [Unconjugated] cited in 25 publications. Validated: WB, Simple Western, IHC ... By: Subhash GangarHIF-3 alpha (hypoxia-inducible factor 3-alpha/ HIF3A) represents an isoform of HIF-alpha subunits which ... Hypoxia-Inducible Factors and Homeostasis. Hypoxia-Inducible Factor-1 (HIF-1) is a highly conserved heterodimeric transcription ... mediate oxygen-dependent degradation of hypoxia-inducible factor (HIF) alpha subunits. Suppression of PHD enzymes leads to ...https://www.novusbio.com/products/hif-1-alpha-antibody-241809_mab1536
Modulation of growth and angiogenic potential of oral squamous carcinoma cells in vitro using salvianolic acid B | BMC...
Among these genes, HIF-1α, TNFα and MMP9 are specifically inhibited, expression of THBS2 was up-regulated. Sal B has inhibitory ... Wenger RH, Gassmann M: Oxygen(es) and the hypoxia-inducible factor-1. Biol Chem. 1997, 378 (7): 609-616.PubMedGoogle Scholar. ... alpha subunit. TNFα: tumor necrosis factor-α ... Overexpression of hypoxia-inducible factor 1α in common human ... Semenza GL: Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol. 1999, 15: 551-578. ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-11-54
Application of Nasal Cannula With Oxygen Versus Air During Eye Surgery Under Local Anaesthetic
Alpha Subunit. Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by ... Hypoxia-inducible Factor-proline Dioxygenases. Dioxygenase enzymes that specifically hydroxylate a PROLINE residue on the ... HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. They are OXYGEN-dependent enzymes that play an important role in mediating cellular ... Flaxseed Can Reduce Hypoxia-Induced Damages in Rat Testes.. Hypoxia causes detrimental effects on the structure and function of ...https://www.bioportfolio.com/resources/trial/63122/Application-of-Nasal-Cannula-With-Oxygen-Versus-Air-During-Eye-Surgery-Under.html
neoplasm of muscle of neck drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
Hypoxia-Inducible Factor 1. Hypoxia-Inducible Factor 1, alpha Subunit. Immunohistochemistry. Lymphatic Metastasis. Male. Middle ... alpha Subunit; 0 / Isoenzymes; 0 / Nuclear Proteins; 0 / Trans-Activators; 0 / Transcription Factors; 0 / endothelial PAS ... overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor ... Risk Factors. Sex Distribution. Thyroidectomy. Tomography, X-Ray Computed. *Genetic Alliance. consumer health - Thyroid cancer ...http://www.bmlsearch.com/?kwr=neoplasm+of+muscle+of+neck+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1
ELISA quantification of VEGF protein levels in the cult | Open-i
... a hypoxia-inducible transcription factor that subsequently acts to stimulate blood vessel formation and promote survival. ... alpha Subunit/biosynthesis. *Mice. *Signal Transduction/drug effects ... a hypoxia-inducible transcription factor that subsequently acts to stimulate blood vessel formation and promote survival. ... a hypoxia-inducible transcription factor that subsequently acts to stimulate blood vessel formation and promote survival. ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4129965_BMRI2014-285752.007&req=4
Proposed signaling pathways underlying the effects of S | Open-i
Proposed signaling pathways underlying the effects of SA on the suppression of HIF-1α and the induction of cell death in human ... Hypoxia inducible factor-1α (HIF-1α) is an essential regulator of the cellular response to low oxygen concentrations, ... alpha Subunit/metabolism*. *Polyenes/administration & dosage/isolation & purification/pharmacology*. *Polyunsaturated Alkamides ... Hypoxia inducible factor-1α (HIF-1α) is an essential regulator of the cellular response to low oxygen concentrations, ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4663561_marinedrugs-13-06962-g006&req=4
basal cell neoplasm of skin of eyelid diagnosis 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Neovascularization, Pathologic / metabolism. Skin Neoplasms / ... alpha Subunit. * 7. Ntomouchtsis A, Vahtsevanos K, Patrikidou A, Andreadis C, Tsobanidou C, Antoniades K: Adnexal skin ... Title] Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1alpha: a histologic and immunohistochemical ... Chemical-registry-number] 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, ...http://www.bmlsearch.com/?kwr=basal+cell+neoplasm+of+skin+of+eyelid+diagnosis+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Addgene: pcDNA3 mHIF-1α MYC (P402A/P577A/N813A)
Plasmid pcDNA3 mHIF-1α MYC (P402A/P577A/N813A) from Dr. Celeste Simon's lab contains the insert mHIF-1α (P402A/P577A/N813A) and ... The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. ... alpha subunit * Alt name. HIF1alpha * Species. M. musculus (mouse) ... A 10-amino-acid c-myc tag was further inserted at the C terminus of the HIF-1α cDNAs by using a Pfu-PCR-based protocol. The ...https://www.addgene.org/44028/