WikiGenes - Vhl - von Hippel-Lindau tumor suppressor
Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Maltepe, E., ... Hypoxia-inducible factor 1 proteomics and diving adaptations in ringed seal. Johnson, P., Elsner, R., Zenteno-Savín, T. Free ... mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor ... solid tumors by engineered overexpression of von Hippel-Lindau tumor suppressor protein and antisense hypoxia-inducible factor- ...https://www.wikigenes.org/e/gene/e/22346.html
Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death. - The Christie Research...
Hypoxia inducible factors (HIFs) are responsible for the majority of gene expression changes under hypoxia, and are themselves ... Hypoxia inducible factors (HIFs) are responsible for the majority of gene expression changes under hypoxia, and are themselves ... Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.Authors: Chowdhury R, ... Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by ...http://christie.openrepository.com/christie/handle/10541/91488
"Expression of Vascular Endothelial Growth Factor Subtypes in Mammary I" by Katherine F. Maloney
Vascular endothelial growth factor (VEGF) subtypes have been shown to be associated with lympho-vascular invasion, lymph node ... Expression of vascular endothelial growth factor (VEGF) family members in breast cancer. ... VEGF-C and VEGF-R protein expression was associated with adverse prognostic factors, including lymph node metastases, higher ... Nature Clinical Practice Oncology 2006; 1: 24-40. Jeltsch, Michael et al. Hyperplasia of lymphatic vessels in VEGF-C transgenic ...https://escholarship.umassmed.edu/ssp/45/
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) ... Hypoxia Inducible Factor-1) is one of the key regulators of the transcriptional response to oxygen deprivation (1). HIF-1 is ... The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor ... The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal ...http://invivosaglik.com/nanobodies_63_en.html
HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation...
PHD2 mRNA was induced by hypoxia in the liver and PHD3 mRNA in liver, testis and heart. Overall our results show that PHD2 mRNA ... We have investigated the organ distribution of the PHDs in the rat, their regulation by hypoxia and changes in local expression ... Inducibility of PHD2 and 3 by hypoxia and ischemia in vivo has important implications both for the pathophysiology of ... regulates expression of genes involved in adaptation to hypoxia and ischemia. Three prolyl hydroxylases (PHD1-3) underlie ...https://www.rdm.ox.ac.uk/publications/19484
Anti Human Prolyl Hydroxylase 1 Antibody, clone PHD112/G7 - Mouse Anti-Human Monoclonal Antibody WB, IHC-P - Buy Now! |Abgent
Anti Human Prolyl Hydroxylase 1 Antibody, clone PHD112/G7 , Mouse Anti-Human Monoclonal Antibody validated in WB, IHC-P ( ... Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key ... Egl nine homolog 2, 18.104.22.168, Estrogen-induced tag 6, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 1, HIF-PH1, HIF- ... however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for ...http://www.abgent.com/products/ABD12496-Anti-Human-Prolyl-Hydroxylase-1-Antibody-clone-PHD112G7-
Roles of facilitative glucose transporter GLUT1 in [18F]FDG positron emission tomography (PET) imaging of human diseases - Open...
Oxidized low-density lipoprotein stimulates macrophage 18F-FDG uptake via hypoxia-inducible factor-1α activation through Nox2- ... Resveratrol suppresses cancer cell glucose uptake by targeting reactive oxygen species-mediated hypoxia-inducible factor-1α ... more established there is a movement towards hypoxic conditions under which the transcription factor hypoxia-inducible factor-1 ... Factors that have a major influence on [18F]FDG uptake in breast cancers include expression of GLUT1 and hexokinase I and also ...https://openmedscience.com/article/roles-of-facilitative-glucose-transporter-glut1-in-18ffdg-positron-emission-tomography-pet-imaging-of-human-diseases/
Hypoxia-Inducible Factor-1 | SpringerLink
Hypoxia-inducible factor 1 HIF-1, which is expressed in all metazoan organisms and serves as a transcriptional factor that ... Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. 2010;40(2):294-309.PubMedPubMedCentralCrossRefGoogle ... Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell. 2011;146:772-84.PubMedPubMedCentralCrossRefGoogle Scholar ... Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen. Nat Immunol. 2013;14:1173-82. ...https://link.springer.com/referenceworkentry/10.1007/978-3-319-67199-4_101697
'hypoxia inducible factor 1' Protocols and Video...
... hypoxia inducible factor 1' include 'Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation ... Induction of Hypoxia in Living Frog and Zebrafish Embryos', 'A Mouse Distraction Osteogenesis Model', 'Human Primary ... Induction and Testing of Hypoxia in Cell Culture', 'Use of a Hanging Weight System for Coronary Artery Occlusion in Mice', ' ... Creating Defined Gaseous Environments to Study the Effects of Hypoxia on C. elegans', 'In vivo Bioluminescence Imaging of Tumor ...https://www.jove.com/keyword/hypoxia+inducible+factor+1
WikiGenes - HIF1A - hypoxia inducible factor 1, alpha subunit...
Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, ... The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau ... Bimodal effect of hypoxia in cancer: role of hypoxia inducible factor in apoptosis. Wang, Y., Pakunlu, R.I., Tsao, W., Pozharov ... Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia. Suzuki, H., Tomida, A ...https://www.wikigenes.org/e/gene/e/3091.html
Hif1a - Hypoxia-inducible factor 1-alpha - Rattus norvegicus (Rat) - Hif1a gene & protein
Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of ... Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity). ... vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate ... metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology ...https://www.uniprot.org/uniprot/O35800
Xenon Upregulates Hypoxia Inducible Factor 1 Alpha in Neonatal Rat Brain under Normoxic Conditions
Hypoxia inducible factor 1 alpha (HIF-1α) is regulated by cellular oxygen tension  and is important in neuronal protection ... G. L. Semenza, "Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1," Annual Review of Cell and Developmental ... N. Pore, Z. Jiang, H. K. Shu, E. Bernhard, G. D. Kao, and A. Maity, "Akt1 activation can augment hypoxia-inducible factor-1α ... Xenon Upregulates Hypoxia Inducible Factor 1 Alpha in Neonatal Rat Brain under Normoxic Conditions. Simona Valleggi,1 Chirag B ...https://www.hindawi.com/journals/isrn/2011/510297/
Natural antisense transcript of hypoxia-inducible factor 1 regulates h | OTT
Hypoxia is a key stress that triggers apoptosis in various tumors, including epithelial ovarian cancer (EOC). Previous ... Natural antisense transcript of hypoxia-inducible factor 1 regulates hypoxic cell apoptosis in epithelial ovarian cancer Jun- ... jun Qiu,1-3 Xiao-jing Lin,1-3 Ting-ting Zheng,1-3 Xiao-yan Tang,1-3 Ke-qin Hua1-3 1Department of Gynecology, Obstetrics and ... Natural antisense transcript of hypoxia-inducible factor 1 regulates hypoxic cell apoptosis in epithelial ovarian cancer. ...https://www.dovepress.com/natural-antisense-transcript-of-hypoxia-inducible-factor-1-regulates-h-peer-reviewed-article-OTT
What does hypoxia-inducible factor 1, alpha subunit mean?
Meaning of hypoxia-inducible factor 1, alpha subunit. What does hypoxia-inducible factor 1, alpha subunit mean? Information and ... translations of hypoxia-inducible factor 1, alpha subunit in the most comprehensive dictionary definitions resource on the web. ... Definition of hypoxia-inducible factor 1, alpha subunit in the Definitions.net dictionary. ... What does hypoxia-inducible factor 1, alpha subunit mean?. Definitions for hypoxia-inducible factor 1, alpha subunit. Here are ...http://www.definitions.net/definition/hypoxia-inducible%20factor%201,%20alpha%20subunit
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. | Sigma-Aldrich
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.. [Weibo Luo, Hongxia Hu, Ryan Chang, Jun ... We show that PKM2 gene transcription is activated by hypoxia-inducible factor 1 (HIF-1). PKM2 interacts directly with the HIF-1 ... Interaction of PKM2 with prolyl hydroxylase 3 (PHD3) enhances PKM2 binding to HIF-1α and PKM2 coactivator function. Mass ... Thus, PKM2 participates in a positive feedback loop that promotes HIF-1 transactivation and reprograms glucose metabolism in ...https://www.sigmaaldrich.com/catalog/papers/21620138
Expression of Hypoxia-inducible Factor 1α in Epithelial Ovarian Tumors | Clinical Cancer Research
... hypoxia-inducible factor; bHLH, basic helix-loop-helix; PAS, PER-ARNT-SIM; VEGF, vascular endothelial growth factor; MVD, ... Expression of Hypoxia-inducible Factor 1α in Epithelial Ovarian Tumors. Peter Birner, Monika Schindl, Andreas Obermair, Gerhard ... Expression of Hypoxia-inducible Factor 1α in Epithelial Ovarian Tumors. Peter Birner, Monika Schindl, Andreas Obermair, Gerhard ... Expression of Hypoxia-inducible Factor 1α in Epithelial Ovarian Tumors Message Subject (Your Name) has forwarded a page to you ...http://clincancerres.aacrjournals.org/content/7/6/1661?ijkey=40c20237e69f9339a0ee4f6d21fcdb1e2e34822a&keytype2=tf_ipsecsha
Manganese Superoxide Dismutase Modulates Hypoxia-Inducible Factor-1α Induction via Superoxide | Cancer Research
The transcription factor hypoxia-inducible factor (HIF) is a key regulator of the cellular response to O2 homeostasis. HIF up- ... Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S ... Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays an important role in O2 homeostasis. Numerous ... Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 1999; 15: 551-78. ...http://cancerres.aacrjournals.org/content/68/8/2781
The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis. - PubMed -...
2003 Feb;13(1):83-9. Research Support, Non-U.S. Gov't; Review ... Hypoxia-Inducible Factor 1. *Hypoxia-Inducible Factor 1, alpha ... The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.. Pugh CW1, ... pVHL is the recognition component of the E3-ubiquitin ligase complex involved in the degradation of hypoxia-inducible factor-1 ... 1. Oxygen-sensing Group, Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Headington, ...https://www.ncbi.nlm.nih.gov/pubmed/12507560?dopt=Abstract
Hypoxia-Inducible Factor 1α Mediates Anoikis Resistance via Suppression of α5 Integrin | Cancer Research
The transcription factor hypoxia-inducible factor 1 (HIF-1) α is abundantly expressed in the majority of human carcinomas and ... The transcription factor hypoxia-inducible factor 1 (HIF-1) constitutes the principal mediator of cellular adaptation to ... Hypoxia-Inducible Factor 1α Mediates Anoikis Resistance via Suppression of α5 Integrin. Nadine Rohwer, Martina Welzel, Katjana ... Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res ...http://cancerres.aacrjournals.org/content/68/24/10113.full
Mechanical Activation of Hypoxia-Inducible Factor 1 alpha Drives Endothelial Dysfunction at Atheroprone Sites
The transcription factor HIF1 alpha (hypoxia-inducible factor 1 alpha) is canonically activated by hypoxia and has a role in ... Mechanical Activation of Hypoxia-Inducible Factor 1 alpha Drives Endothelial Dysfunction at Atheroprone Sites. In: ... The mechanism involves the transcription factor nuclear factor-kappa B that induced HIF1 alpha transcripts and induction of the ... Conclusions-Mechanical low shear stress activates HIF1 alpha at atheroprone regions of arteries via nuclear factor-kappa B and ...https://epub.ub.uni-muenchen.de/55339/
NIOSHTIC-2 Publications Search - 20022382 - p38 signaling-mediated hypoxia-inducible factor 1 alpha and vascular endothelial...
... induces hypoxia-inducible factor 1 (HIF-1) activity through the specific expression of HIF-1alpha but not HIF-1beta subunit and ... increases the level of vascular endothelial growth factor (VEGF) expression in DU145 human prostate carcinoma cells. To dissect ... p38 signaling-mediated hypoxia-inducible factor 1 alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 ... The present study demonstrates that Cr(VI) induces hypoxia-inducible factor 1 (HIF-1) activity through the specific expression ...https://www.cdc.gov/niosh/nioshtic-2/20022382.html
The role of hypoxia-inducible factor 1 in atherosclerosis | Journal of Clinical Pathology
The key regulator of hypoxia, hypoxia-inducible factor 1 (HIF-1), plays a key role in the progression of atherosclerosis by ... 1Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing, China. ... The objective of this review is to summarise the pathological role of HIF-1 in the progression of atherosclerosis. ...http://jcp.bmj.com/content/early/2012/05/07/jclinpath-2012-200828
Atorvastatin attenuates paraquat poisoning-induced epithelial-mesenchymal transition via downregulating hypoxia-inducible...
... and the potential mechanism through hypoxia-inducible factor-1 alpha (HIF-1α). ... attenuates paraquat poisoning-induced epithelial-mesenchymal transition via downregulating hypoxia-inducible factor-1 alpha. ... The mechanism may involve the downregulation of the HIF-1α/β-catenin pathway and the inhibition of the PQ-induced EMT by ATS. ... ATS treatment attenuated the EMT by increasing the levels of the epithelial markers E-cadherin and ZO-1 and by decreasing the ...https://insights.ovid.com/lisci/201811150/00076800-201811150-00016
Down-regulation of survivin and hypoxia-inducible factor-1 α by β-elemene enhances the radiosensitivity of lung adenocarcinoma...
2012 Feb;27(1):56-64. doi: 10.1089/cbr.2011.1003. Epub 2012 Jan 16. Randomized Controlled Trial; Research Support, Non-U.S. ... Down-regulation of survivin and hypoxia-inducible factor-1 α by β-elemene enhances the radiosensitivity of lung adenocarcinoma ... significantly inhibited radiation-induced expression of survivin and hypoxia-inducible factor (HIF)-1 α proteins. Because HIF-1 ... Li G1, Xie B, Li X, Chen Y, Wang Q, Xu Y, Xu-Welliver M, Zou L. ... Hypoxia-Inducible Factor 1, alpha Subunit/genetics. *Hypoxia- ...https://www.ncbi.nlm.nih.gov/pubmed/22248028
Hypoxia-inducible factor-1α mRNA: a new target for destabilization by tristetraprolin in endothelial cells. | Sigma-Aldrich
They use the hypoxia-sensitive stabilization of the hypoxia-inducible factor-1α (HIF-1α) transcription factor to engage ... Hypoxia-inducible factor-1α mRNA: a new target for destabilization by tristetraprolin in endothelial cells.. [Sandrine ... Finally, we bring evidence that silencing TTP expression enhances hypoxia-induced increase in HIF-1α protein levels with a ... in ECs reverses hypoxia-induced down-regulation of HIF-1α mRNA; 3) the decrease in the half-life of Luciferase-HIF-1α-3'UTR ...https://www.sigmaaldrich.com/catalog/papers/21775632