JCI - Might β3-adrenergic receptor agonists be useful in disorders of glucose homeostasis?
Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology. 1996 ...
JCI - Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels
Treatment of severe hyperlipidemia in apolipoprotein E-deficient mice by bone marrow transplantation. J Clin Invest 1995. 96: ...
JCI - Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of...
... hyperlipidemia, and hyperglycemia, may also produce ROS that could further disrupt protein folding in the ER lumen. We propose ...
JCI Insight -
Oral nitrite restores age-dependent phenotypes in eNOS-null mice
Systemic hyperlipidemia and diminished long-chain fatty acid oxidation capacity in ad libitum-fed 4-month-old eNOS-/- mice. (A ... Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase. Circulation. 2001;104(3 ... Treatment of 4-month-old eNOS-/- mice with nitrite for 10 days corrected the hypertension and serum hyperlipidemia and ... NO deficiency in the eNOS-/- mice leads to systemic hypertension, hyperlipidemia, hepatic steatosis, reduced skeletal muscle ...
JCI Insight -
Dual PPARα/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction
Dual PPARα/γ agonists that were developed to target hyperlipidemia and hyperglycemia in patients with type 2 diabetes caused ...
JCI Insight -
Suppression of pullulanase-induced cytotoxic T cell response with a dual promoter in GSD IIIa mice
... and hyperlipidemia as well as elevated hepatic transaminases and elevated creatine kinase (CK). Long-term complications include ...