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*  The DWF4 Gene of Arabidopsis Encodes a Cytochrome P450 That Mediates Multiple 22α-Hydroxylation Steps in Brassinosteroid...
Rescue of dwf4 by 22α-hydroxylated steroids confirms that the missing step in dwf4 is hydroxylation at the C-22 position. In ... As shown in Figure 1, a 6-oxolactone or 7-oxalactone in the B ring, 5α hydrogen, and multiple hydroxylations at four different ... Of the steps in BR biosynthesis in Madagascar periwinkle, the 22α-hydroxylation reaction has been suggested to be the rate- ... The DWF4 Gene of Arabidopsis Encodes a Cytochrome P450 That Mediates Multiple 22α-Hydroxylation Steps in Brassinosteroid ...
http://www.plantcell.org/content/10/2/231.long
*  Potent Inhibition of the Cytochrome P-450 3A-Mediated Human Liver Microsomal Metabolism of a Novel HIV Protease Inhibitor by...
... hydroxylation, dextromethorphanO-demethylation, chlorzoxazone 6-hydroxylation, and terfenadine oxidation (t-butyl hydroxylation ... terfenadine hydroxylation, 17α-ethynylestradiol hydroxylation; Kumar et al., 1996). HIV protease inhibitors saquinavir and ... 1990) Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1. Chem Res Toxicol 3:566-573. ... The in vitro IC50 values for the inhibition of CYP3A-mediated terfenadine hydroxylation were 1.1 and 4.6 μM for 3:1 and 29:1 ...
http://dmd.aspetjournals.org/content/27/8/902.long
*  HIF Prolyl Hydroxylases抗体|Abcam中国|Anti-HIF Prolyl Hydroxylases抗体(ab94626)
... may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. ...
http://www.abcam.cn/hif-prolyl-hydroxylases-antibody-ab94626.html
*  Peptidylglycine alpha-Amidating Monooxygenase/PAM Overexpression Lysate (Native) (NBP2-05619): Novus Biologicals
Peptidylglycine alpha-Amidating Monooxygenase/PAM Overexpression Lysate (Native). Tested Reactivity: Hu. Validated: WB. Backed by our 100% Guarantee.
https://www.novusbio.com/products/peptidylglycine-alpha-amidating-monooxygenase-pam-lysate_nbp2-05619
*  Hydroxylation | Harvard Catalyst Profiles | Harvard Catalyst
"Hydroxylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Hydroxylation" by people in Harvard Catalyst Profiles by year ... Below are the most recent publications written about "Hydroxylation" by people in Profiles. ... and whether "Hydroxylation" was a major or minor topic of these publication. ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/Hydroxylation
*  British Library EThOS: The hydroxylation of cholesterol
These observations suggested the participation of the cytochrome, P450, in the cholesterol 7α-hydroxylation reaction as the ... fraction and it is therefore unlikely that this haeinoprotein is the rate-controlling species in the 7a-hydroxylation reaction ...
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.699834
*  Biological role of prolyl 3-hydroxylation in type IV collagen | PNAS
Posttranslational modifications of collagen include prolyl 4-hydroxylation, lysyl hydroxylation and glycosylation, and prolyl 3 ... Prolyl 3-hydroxylation in type IV collagen protects it from the interaction with GPVI, and consequently ablates the ability of ... Biological role of prolyl 3-hydroxylation in type IV collagen. Elena Pokidysheva, Sergei Boudko, Janice Vranka, Keith Zientek, ... Thus, 3-hydroxylation of type IV collagen is indispensable for embryonic development in mice. We assign a molecular function ...
http://www.pnas.org/content/111/1/161
*  Catalysts | Free Full-Text | Direct Hydroxylation of Benzene to Phenol over TS-1 Catalysts
Extraframework Ti species were not selective for hydroxylation. ... Direct Hydroxylation of Benzene to Phenol over TS-1 Catalysts. ... Extraframework Ti species were not selective for hydroxylation. View Full-Text Keywords: benzene; hydroxylation; phenol; TS-1 ... Luo, Y.; Xiong, J.; Pang, C.; Li, G.; Hu, C. Direct Hydroxylation of Benzene to Phenol over TS-1 Catalysts. Catalysts 2018, 8, ... Luo Y, Xiong J, Pang C, Li G, Hu C. Direct Hydroxylation of Benzene to Phenol over TS-1 Catalysts. Catalysts. 2018; 8(2):49. ...
https://www.mdpi.com/2073-4344/8/2/49
*  Abstract] Active Learning for the Prediction of Asparagine/Aspartate Hydroxylation Sites on Proteins
... hydroxylation sites on proteins. The verification of hydroxylation sites on human proteins in wet-lab experiments is very ... Active Learning for the Prediction of Asparagine/Aspartate Hydroxylation Sites on Proteins Festus O. Iyuke, James R. Green, and ... Active learning, support vector machines, hydroxylation site prediction, class imbalance Abstract. In this paper, we propose ... Using a dataset of N/D sites with known hydroxylation state, we here demonstrate through simulations that active learning query ...
http://actapress.com/Abstract.aspx?paperId=452880
*  Hydroxylation - Wikipedia
The hydroxylation process involves conversion of a CH group into a COH group. Hydroxylation is an oxidative process. The oxygen ... In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Hydroxylation is the first step ... Proline hydroxylation is also a vital component of hypoxia response via hypoxia inducible factors. In some cases, proline may ... Hydroxylation occurs at the γ-C atom, forming hydroxyproline (Hyp), which stabilizes the secondary structure of collagen due to ...
https://en.wikipedia.org/wiki/Hydroxylation
*  Biphenyl hydroxylation enhanced by an engineered o-xylene dioxygenase from Rhodococcus sp. strain DK17. - PubMed - NCBI
Biphenyl hydroxylation enhanced by an engineered o-xylene dioxygenase from Rhodococcus sp. strain DK17.. Yoo M1, Kim D, Zylstra ... Hydroxylation of the non-growth substrate biphenyl by recombinant o-xylene dioxygenases from Rhodococcus sp. strain DK17 was ... The metabolites from the biphenyl hydroxylation by each enzyme were identified and quantified by gas chromatography-mass ... analyses indicated that hydrophobic interactions and shielding effects against water are important factors in the hydroxylation ...
https://www.ncbi.nlm.nih.gov/pubmed/21575716?dopt=Abstract
*  Regulation of Axonal Midline Guidance by Prolyl 4-Hydroxylation in Caenorhabditis elegans | Journal of Neuroscience
Regulation of Axonal Midline Guidance by Prolyl 4-Hydroxylation in Caenorhabditis elegans. Nanna Torpe and Roger Pocock ... The most common modification of the ECM is prolyl 4-hydroxylation. However, little is known of its importance in the control of ... Our study has identified a requirement for proline hydroxylation in neuronal guidance that is supplied by a specific P4H α- ... To date, however, the importance of prolyl 4-hydroxylation in the control of neuronal development is not well understood. ...
http://www.jneurosci.org/content/34/49/16348
*  Milas hydroxylation - Wikipedia
The Milas hydroxylation is an organic reaction converting an alkene to a vicinal diol, and was developed by Nicholas A. Milas ... The Use of Vanadium Pentoxide and Chromium Trioxide as Catalysts of Hydroxylation". Journal of the American Chemical Society. ... Milas, Nicholas A.; Sussman, Sidney (July 1936). "The Hydroxylation of the Double Bond". Journal of the American Chemical ... "Milas Hydroxylation". Comprehensive Organic Name Reactions and Reagents. 437: 1948-1951. 2010. doi:10.1002/9780470638859. ...
https://en.wikipedia.org/wiki/Milas_hydroxylation
*  Hypoxia Prevents AKT Hydroxylation and Promotes AKT Hyperactivation | Cancer Discovery
Hypoxia Prevents AKT Hydroxylation and Promotes AKT Hyperactivation Message Subject (Your Name) has forwarded a page to you ... Hydroxylation-deficient AKT mutants induced enhanced anchorage-independent growth in vitro and tumor formation in vivo compared ... Moreover, two cancer-associated mutations, AKT1G311D and AKT2 P127N, were identified that reduce AKT hydroxylation, disrupt the ... EGLN1-mediated prolyl-hydroxylation suppresses activity of AKT by promoting its recognition by VHL. ...
http://cancerdiscovery.aacrjournals.org/content/6/10/1078.1
*  Hydroxylation of estradiol - Wikipedia
The hydroxylation of estradiol is one of the major routes of metabolism of the estrogen steroid hormone estradiol. It is ... Whereas 4-hydroxylation constitutes the minor pathway in the liver, the greater proportion of CYP1B1 expression in extrahepatic ... Extrahepatic 2-hydroxylation is chiefly mediated by CYP1A1 and CYP3A4. 2-Hydroxyestradiol (2-OHE2) can experience three ... The enzyme most responsible for estradiol 4-hydroxylation is CYP1B1. In humans, CYP1B1 mRNA and protein exhibit constitutive ...
https://en.wikipedia.org/wiki/Hydroxylation_of_estradiol
*  Woodward cis-hydroxylation - Wikipedia
The Woodward cis-hydroxylation (also known as the Woodward reaction) is the chemical reaction of alkenes with iodine and silver ... Mangoni, L.; Dovinola, V. (1969). "The stereochemistry of woodward cis-hydroxylation in some steroidal olefins". Tetrahedron ... "cis-Hydroxylation of a Synthetic Steroid Intermediate with Iodine, Silver Acetate and Wet Acetic Acid". J. Am. Chem. Soc. 80 (1 ...
https://en.wikipedia.org/wiki/Woodward_cis-hydroxylation
*  RCSB PDB - 6F0B: Cytochrome P450 TxtC employs substrate conformational switching for sequential aliphatic and aromatic...
Cytochrome P450 TxtC employs substrate conformational switching for sequential aliphatic and aromatic thaxtomin hydroxylation ... Cytochrome P450 TxtC employs substrate conformational switching for sequential aliphatic and aromatic thaxtomin hydroxylation. ... Cytochrome P450 TxtC employs substrate conformational switching for sequential aliphatic and aromatic thaxtomin hydroxylation. ...
https://www.rcsb.org/structure/6F0B
*  Prediction of phenotype for acetylation and for debrisoquine hydroxylation by DNA-tests in healthy human volunteers |...
The phenotypes for hydroxylation and acetylation can be predicted be newly developed methods based on mutation-specific ... Mahgoub A, Idle J, Dring LG, Lancester R, Smith RL (1977) Polymorphic hydroxylation of debrisoquine in man. Lancet II: 584-586 ... Broly F, Gaedigk A, Heim M, Eichelbaum M, Morike K, Meyer UA (1991) Debrisoquine/sparteine hydroxylation genotype and phenotype ... Alvan G, Bechtel E, Iselius L, Gundert-Remy U (1990) Hydroxylation polymorphisms of debrisoquine and mephenytoin in European ...
https://link.springer.com/article/10.1007/BF02220616
*  FIH-catalysed His hydroxylation of ARDs may be common. | Open-i
FIH-catalysed His hydroxylation of ARDs may be common. (A) clustalw nongapped multiple sequence alignment of ankyrin repeat ... GABPB2 and TRPV4 demonstrate FIH-dependent hydroxylation. (B-D) LC/MS analyses demonstrating FIH-catalysed His hydroxylation of ... GABPB2 and TRPV4 demonstrate FIH-dependent hydroxylation. (B-D) LC/MS analyses demonstrating FIH-catalysed His hydroxylation of ... Bottom Line: However, there are few reports on the selectivity of FIH for the hydroxylation of specific residues.NMR and ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC3569879_febs0278-1086-f6&req=4
*  I2-Catalyzed Direct α-Hydroxylation of β-Dicarbonyl Compounds with Atmospheric Oxygen under Photoirradiation
An I2-catalyzed hydroxylation of β-dicarbonyl moieties using air as the oxidant under photoirradiation gives α-hydroxy-β- ... I2-Catalyzed Direct α-Hydroxylation of β-Dicarbonyl Compounds with Atmospheric Oxygen under Photoirradiation. Chun-Bao Miao*, ...
http://www.organic-chemistry.org/abstracts/lit4/251.shtm
*  Performance of edges on carbon for the catalytic hydroxylation of benzene to phenol - Catalysis Science & Technology (RSC...
Performance of edges on carbon for the catalytic hydroxylation of benzene to phenol Y. Lyu, T. Qi, H. Yang and C. Hu, Catal. ... The present study could shed some light on the essence and function of active sites on carbon for the benzene hydroxylation to ... In the present study, the role of typical defect sites on carbon for benzene hydroxylation to phenol with hydrogen peroxide as ... Performance of edges on carbon for the catalytic hydroxylation of benzene to phenol ...
https://pubs.rsc.org/en/Content/ArticleLanding/CY/2018/C7CY01648D
*  4-Hydroxylation of oestrogens as a marker for mammary tumours | Biochemical Society Transactions
4-Hydroxylation of oestrogens as a marker for mammary tumours Message Subject (Your Name) has forwarded a page to you from ... 4-Hydroxylation of oestrogens as a marker for mammary tumours. J. G. Liehr ...
http://www.biochemsoctrans.org/content/27/2/318
*  Structural and mechanistic insight into alkane hydroxylation by Pseudomonas putida AlkB | Biochemical Journal
Structural and mechanistic insight into alkane hydroxylation by Pseudomonas putida AlkB. Hernan Alonso, Oded Kleifeld, Adva ... Structural and mechanistic insight into alkane hydroxylation by Pseudomonas putida AlkB. Hernan Alonso, Oded Kleifeld, Adva ... Structural and mechanistic insight into alkane hydroxylation by Pseudomonas putida AlkB Message Subject (Your Name) has ... Pseudomonas putida GPo1 alkane hydroxylase (AlkB) is an integral membrane protein that catalyses the hydroxylation of medium- ...
http://www.biochemj.org/content/460/2/283