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*  15-Hydroxyeicosatetraenoic acid - Wikipedia
15S-dihydroxy-eicosatetraenoic acid (5(S),15(S)-diHETE), 5-oxo-15(S)-hydroxyeicosatetraenoic acid (5-oxo-15(S)-HETE, a subset ... 15Z-eicosatetraenoic acid (12(S)-hydroxyeicosatetraenoic acid), (i.e. 12(S)-HETE), respectively, or further metabolized through ... hydroperoxyeicosatetraenoic acid and (15S)-hydroxyeicosatetraenoic acid on the acute- lymphoblastic-leukaemia cell line Jurkat ... 13E-eicosatetraenoic acid (15(R)-HpETE). Human cells release arachidonic acid (i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid) from ...
https://en.wikipedia.org/wiki/15-Hydroxyeicosatetraenoic_acid
*  12-Hydroxyeicosatetraenoic acid - Wikipedia
12-Hydroxyeicosatetraenoic acid (12-HETE) is a derivative of the 20 carbon polyunsaturated fatty acid, arachidonic acid, ... 5-Hydroxyeicosatetraenoic acid 15-Hydroxyeicosatetraenoic acid Hamberg, M; Samuelsson, B (1974). "Prostaglandin endoperoxides. ... and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid ... Herbertsson H, Kühme T, Hammarström S (Jul 1999). "The 650-kDa 12(S)-hydroxyeicosatetraenoic acid binding complex: occurrence ...
https://en.wikipedia.org/wiki/12-Hydroxyeicosatetraenoic_acid
*  Hydroxyeicosatetraenoic acid - Wikipedia
5-Hydroxyeicosatetraenoic acid 12-Hydroxyeicosatetraenoic acid 15-Hydroxyeicosatetraenoic acid 20-Hydroxyeicosatetraenoic acid ... 19-Hydroxyeicosatetraenoic acid (see 20-Hydroxyeicosatetraenoic acid). ...
https://en.wikipedia.org/wiki/Hydroxyeicosatetraenoic_acid
*  5-Hydroxyeicosatetraenoic acid - Wikipedia
5-Hydroxyeicosatetraenoic acid (5-HETE, 5(S)-HETE, or 5S-HETE) is an eicosanoid, i.e. a metabolite of arachidonic acid. It is ... 5-Hydroxyeicosatetraenoic acid is more properly termed 5(S)-hydroxyicosatetraenoic acid or 5(S)-HETE) to signify the (S) ... dihydroxyeicosatetraenoic acid (5(S),15(S)-diHETE), or 5-oxo-15-hydroxyeicosatetraenoic acid (5-oxo-15(S)-HETE). 5(S)-HETE, 5- ... arachidonic acid 5-hydroperoxide i.e. 5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HpETE). 5-(S)-HpETE may then be ...
https://en.wikipedia.org/wiki/5-Hydroxyeicosatetraenoic_acid
*  20-Hydroxyeicosatetraenoic acid - Wikipedia
20-Hydroxyeicosatetraenoic acid, also known as 20-HETE or 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid, is an eicosanoid ... lauric acid) and/or longer chain (e.g. docosahexaenoic acid) fatty acids. They can also ω-hydroxylate and thereby reduce the ... 14Z-eicosatetraenoic acid, then to 18-carboxy-5Z,8Z,10Z,14Z-octadecatetraenoic acid, and then to the further chain-shortened ... 14Z-eicosatetraenoic acid which is rapidly reduced to 11,20-dihydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid; they also metabolize ...
https://en.wikipedia.org/wiki/20-Hydroxyeicosatetraenoic_acid
*  A 12(S)-hydroxyeicosatetraenoic acid receptor interacts with steroid receptor coactivator-1 | PNAS
12(S)-hydroxyeicosatetraenoic acid;. LLC,. Lewis lung carcinoma;. LXD,. domain having one LXXLL motif (X meaning any amino acid ... The eicosanoid 12(S)-hydroxy-5,8,10,14-(Z,Z,E,Z)-eicosatetraenoic acid [12(S)-HETE] is formed from arachidonic acid by the ... A 12(S)-hydroxyeicosatetraenoic acid receptor interacts with steroid receptor coactivator-1. Yuko Kurahashi, Helena Herbertsson ... 4C). Three C-terminal deletion mutants [SRC-1/AatII (amino acids 1-1,393), SRC-1/NheI (amino acids 1-947), and SRC-1/BamHI ( ...
http://www.pnas.org/content/97/11/5779
*  Functional Variant of CYP4A11 20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension | Circulation
The CYP4A11 arachidonic acid monooxygenase oxidizes endogenous arachidonic acid (AA) to 20-hydroxyeicosatetraenoic acid (20- ... The CYP4A arachidonic acid (AA) monooxygenases oxidize endogenous AA to 20-hydroxyeicosatetraenoic acid (20-HETE). The 20-HETE ... McGiff JC, Quilley J. 20-Hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids and blood pressure. Curr Opin Nephrol ... Functional Variant of CYP4A11 20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension. James V. ...
http://circ.ahajournals.org/content/111/1/63
*  The release of 15-hydroxyeicosatetraenoic acid by human placental trophoblast is increased in preeclampsia.
We tested the hypothesis that trophoblast produces 15-hydroxyeicosatetraenoic acid, and its level is elevated in trophoblast ... and aspirin reduces 15-hydroxyeicosatetraenoic acid secretion. We suggest 15-hydroxyeicosatetraenoic acid plays a role in the ... 0/Hydroxyeicosatetraenoic Acids; 0/Isoenzymes; 0/Lipoxygenase Inhibitors; 50-78-2/Aspirin; 500-38-9/Nordihydroguaiaretic Acid; ... Hydroxyeicosatetraenoic Acids / metabolism*. Isoenzymes / antagonists & inhibitors, physiology. Lipoxygenase / physiology. ...
http://www.biomedsearch.com/nih/release-15-hydroxyeicosatetraenoic-acid-by/9465803.html
*  20-Hydroxyeicosatetraenoic Acid Mediates Angiotensin Ii-Induced Phospholipase D Activation in Vascular Smooth Muscle Cells |...
20-Hydroxyeicosatetraenoic Acid Mediates Angiotensin Ii-Induced Phospholipase D Activation in Vascular Smooth Muscle Cells. ... The increase in Ras/MAP kinase activity elicited by Ang II in VSMC is mediated by 20-hydroxyeicosatetraenoic acid (HETE) and to ... 20-Hydroxyeicosatetraenoic Acid Mediates Angiotensin Ii-Induced Phospholipase D Activation in Vascular Smooth Muscle Cells ... 20-Hydroxyeicosatetraenoic Acid Mediates Angiotensin Ii-Induced Phospholipase D Activation in Vascular Smooth Muscle Cells ...
http://hyper.ahajournals.org/content/36/Suppl_1/723.1
*  Synthesis and Function of Cytochrome P450 4A1-Derived 20-Hydroxyeicosatetraenoic Acid in Rat Renal Arteries | Hypertension
20-hydroxyeicosatetraenoic acid (20-HETE) is the principal arachidonic acid metabolite in tubular and vascular structures of ... Synthesis and Function of Cytochrome P450 4A1-Derived 20-Hydroxyeicosatetraenoic Acid in Rat Renal Arteries. Michal Laniado- ... Synthesis and Function of Cytochrome P450 4A1-Derived 20-Hydroxyeicosatetraenoic Acid in Rat Renal Arteries ... Synthesis and Function of Cytochrome P450 4A1-Derived 20-Hydroxyeicosatetraenoic Acid in Rat Renal Arteries ...
http://hyper.ahajournals.org/content/36/Suppl_1/681.6
*  20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. | Circulation Research
20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries.. Y H Ma, D Gebremedhin, M L ... 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. ... 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. ... 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. ...
http://circres.ahajournals.org/content/72/1/126
*  Identification of a G-Protein coupled receptor for esterified 15(S)hydroxyeicosatetraenoic acid on human primary bronchial...
Identification of a G-Protein coupled receptor for esterified 15(S)hydroxyeicosatetraenoic acid on human primary bronchial ... Identification of a G-Protein coupled receptor for esterified 15(S)hydroxyeicosatetraenoic acid on human primary bronchial ... Identification of a G-Protein coupled receptor for esterified 15(S)hydroxyeicosatetraenoic acid on human primary bronchial ... Identification of a G-Protein coupled receptor for esterified 15(S)hydroxyeicosatetraenoic acid on human primary bronchial ...
http://www.jimmunol.org/content/190/1_Supplement/181.10
*  CREB-Mediated IL-6 Expression Is Required for 15(S)-Hydroxyeicosatetraenoic Acid-Induced Vascular Smooth Muscle Cell Migration ...
Hydroxyeicosatetraenoic Acids Stimulate VSMC Migration. Toward understanding the role of eicosanoids in the pathophysiology of ... Formation of 15-hydroxyeicosatetraenoic acid (15-HETE) as the predominant eicosanoid in aortas from Watanabe Heritable ... A novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis. J Lipid Res. ... CREB-Mediated IL-6 Expression Is Required for 15(S)-Hydroxyeicosatetraenoic Acid-Induced Vascular Smooth Muscle Cell Migration ...
http://atvb.ahajournals.org/content/29/6/809
*  Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates...
Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates ... Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates ... 20-hydroxyeicosatetraenoic acid) and the vasodilator EETs (epoxyeicosatrienoic acids), play an important role in the ... Recent studies have shown that the renal CYP450 (cytochrome P450) metabolites of AA (arachidonic acid), the vasoconstrictor 20- ...
http://www.curehunter.com/public/pubmed20050826.do
*  Nitric Oxide-20-Hydroxyeicosatetraenoic Acid Interaction in the Regulation of K+ Channel Activity and Vascular Tone in Renal...
20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. Circ Res. 1993;72:126-136. ... Nitric Oxide-20-Hydroxyeicosatetraenoic Acid Interaction in the Regulation of K+ Channel Activity and Vascular Tone in Renal ... Nitric Oxide-20-Hydroxyeicosatetraenoic Acid Interaction in the Regulation of K+ Channel Activity and Vascular Tone in Renal ... Nitric Oxide-20-Hydroxyeicosatetraenoic Acid Interaction in the Regulation of K+ Channel Activity and Vascular Tone in Renal ...
http://circres.ahajournals.org/content/83/11/1069?ijkey=b0f93a0fea4c2f220b8d225615b48d616c5fc78b&keytype2=tf_ipsecsha
*  Measurement of vasoactive metabolites (hydroxyeicosatetraenoic and epoxyeicosatrienoic acids) in uterine tissues of normal and...
Mounting evidence implicates nonprostanoid eicosanoids, epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids ( ... Measurement of vasoactive metabolites (hydroxyeicosatetraenoic and epoxyeicosatrienoic acids) in uterine tissues of normal and ...
http://www.biomedsearch.com/nih/Measurement-vasoactive-metabolites-hydroxyeicosatetraenoic-epoxyeicosatrienoic/20852449.html
*  "CYP4A2-Induced Hypertension Is 20-Hydroxyeicosatetraenoic Acid- and An" by Komal Sodhi, Cheng-Chia Wu et al.
Treatment with lisinopril, losartan, or the 20-HETE antagonist 20-hydroxyeicosa-6(Z), 15(Z)-dienoic acid decreased blood ... dienoic acid. In cultured endothelial cells, 20-HETE specifically and potently induced ACE expression without altering the ... We have shown previously that increased vascular endothelial expression of CYP4A2 leads to 20-hydroxyeicosatetraenoic (20-HETE ... CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid-and angiotensin II-dependent. Hypertension. 2010;56(5):871-8. ...
https://mds.marshall.edu/sm_bm/158/
*  New analogues of 13-hydroxyocatdecadienoic acid and 12-hydroxyeicosatetraenoic acid block human blood platelet aggregation and...
Analogues of 12-hydroxyeicosatetraenoic acid and 13-hydroxyocatdecadienoic acid were shown previously to modulate platelet ... We synthesized 10 compounds based on the structures of analogues of 12-hydroxyeicosatetraenoic acid and 13- ... hydroxyocatdecadienoic acid and evaluated their effect on platelet aggregation triggered by arachidonic acid. The structure ... Thromboxane A2 is derived from arachidonic acid through the action of cyclooxygenases and thromboxane synthase. It is mainly ...
https://bmcchem.biomedcentral.com/articles/10.1186/1752-153X-6-152
*  Role of arachidonic acid metabolites on the control of non-differentiated intestinal epithelial cell growth. - PubMed - NCBI
... epoxyeicosatrienoic acid; hydroxyeicosatetraenoic acid; leukotriene; lipoxygenase; nordihydroguaiaretic acid; phospholipase A(2 ... 12 and 15-hydroxyeicosatetraenoic acid (HETE) but not LTD4, 20-HETE and epoxyeicosatrienoic acids. We also found that ... Hydroxyeicosatetraenoic acid; LOX; LT; Leukotriene; NDGA; PG; PLA(2); Prostaglandin; arachidonic acid; cyclooxygenase; ... Role of arachidonic acid metabolites on the control of non-differentiated intestinal epithelial cell growth.. Cabral M1, Martín ...
https://www.ncbi.nlm.nih.gov/pubmed/23685077
*  Metabolites | Free Full-Text | Targeted Chiral Analysis of Bioactive Arachidonic Acid Metabolites Using Liquid-Chromatography...
In order to investigate the metabolism of arachidonic acid in vitro or in vivo, targeted methods are advantageous in order to ... This review article provides an overview of arachidonic acid metabolism and targeted chiral methods that have been utilized for ... A complex structurally diverse series of eicosanoids arises from the metabolism of arachidonic acid. The metabolic profile is ... hydroxyeicosatetraenoic acid; HPETE, hydroperoxyeicosatetraenoic acid; HX, hepoxillin; LOX, lipoxygenase; LT, leukotriene; LX, ...
http://www.mdpi.com/2218-1989/2/2/337/htm
*  Nutrients | Free Full-Text | Effects of Long-Term Oral Administration of Arachidonic Acid and Docosahexaenoic Acid on the...
... acid. In this study, we investigated the effects of long-term therapy with ARA or docosahexaenoic acid (DHA) on the cytotoxic ... NK cell activity is regulated partly by eicosanoids, which are produced from arachidonic acid (ARA) and eicosapentaenoic (EPA) ... hydroxyeicosatetraenoic acid; HEPE, hydroxyeicosapentaenoic acids; RvE2, ResolvinE2; HDoHE, hydroxydocosahexaenoic acid; PD1, ... Note: PLA, palmitic acid; STA, stearic acid, OLA, oleic acid; LA, linolenic acid; ARA, arachidonic acid; EPA, eicosapentaenoic ...
http://mdpi.com/2072-6643/5/6/1949/htm
*  BLT2 Is Upregulated in Allergen-Stimulated Mast Cells and Mediates the Synthesis of Th2 Cytokines | The Journal of Immunology
hydroxyeicosatetraenoic acid. LTB4. leukotriene B4. NAC. N-acetylcysteine. NS. nonstimulated. RL. lung resistance. ROS. ... Louis, MO). LTB4, 12(S)-hydroxyeicosatetraenoic acid (HETE), U75302, and LY255283 (25) were purchased from Cayman Chemical (Ann ... Leukotriene B4 (LTB4) is a potent lipid mediator derived from arachidonic acid by the action of 5-lipoxygenase; it is one of ... nonessential amino acids, 50 μM 2-ME, sodium pyruvate, and HEPES buffer containing 20 ng/ml stem cell factor and 10 ng/ml IL-3 ...
http://www.jimmunol.org/content/185/10/6329?ijkey=555cb6f4562ebd40bd500cc4fbde183e52a70ff6&keytype2=tf_ipsecsha
*  II - Acute and Chronic Inflammation Flashcards by Raymond Yu | Brainscape
Leukotriene B4 (LTB4) and hydroxyeicosatetraenoic acid (HETE). (TOPNOTCH) Robbins Basic Pathology, 9th ed. p. 84 ... Central amorphous granular debris, loss of all cellular detail, acid-fast bacilli ...
https://www.brainscape.com/flashcards/ii-acute-and-chronic-inflammation-3991081/packs/5858956
*  12-Hydroxyeicosatetraenoic acid
... (12-HETE) is a derivative of the 20 carbon polyunsaturated fatty acid, arachidonic acid, ... and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid ... 15-Hydroxyeicosatetraenoic acid. References. *↑ Hamberg, M; Samuelsson, B (1974). "Prostaglandin endoperoxides. Novel ... ALOX12 metabolizes arachidonic acid almost exclusively to 12(S)-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12(S)-HpETE or ...
https://ipfs.io/ipfs/QmXoypizjW3WknFiJnKLwHCnL72vedxjQkDDP1mXWo6uco/wiki/12-HETE.html
*  Showing Health Effect 5-hydroxyeicosatetraenoic-acid inhibitor - FooDB
Showing Health Effect 5-hydroxyeicosatetraenoic-acid inhibitor. Identification. Name. 5-hydroxyeicosatetraenoic-acid inhibitor ...
http://foodb.ca/health_effects/8