Loading...
*  Plus it
HDAC6 is known to deacetylate histone and nonhistone proteins including molecular chaperone heat shock protein 90 (Hsp90). ... Since Hsp90 has an active conformation with its client protein in cancerous cells, targeting this conformation destabilizes the ... where HDAC6 inhibitor can slow down metabolism while Hsp90 inhibitor makes the client protein prone to degradation. At the same ... As such, using a low dose of HDAC6 inhibitor in combination with Hsp90 inhibitor can be a potential therapeutic approach, ...
http://diabetes.diabetesjournals.org/content/61/7/e10
*  Intraspecific variation in thermal tolerance and heat shock protein gene expression in common killifish, Fundulus heteroclitus ...
Basal levels of heat shock proteins, particularly Hsp90, can also affect the induction of heat shock protein genes (for a ... Interspecific and acclimationinduced variation in levels of heat shock proteins 70 (hsp70) and 90 (hsp90) and heat shock ... Heat shock experiment. To determine the threshold induction temperature of heat shock proteins in killifish, we acclimated ... The magnitude of the heat shock protein response is typically proportional to the severity of the heat shock and associated ...
http://jeb.biologists.org/content/209/15/2859
*  HSP90 Heat-Shock Proteins | Profiles RNS
"HSP90 Heat-Shock Proteins" by people in this website by year, and whether "HSP90 Heat-Shock Proteins" was a major or minor ... HSP90 Heat-Shock Proteins*HSP90 Heat-Shock Proteins. *HSP90 Heat Shock Proteins ... "HSP90 Heat-Shock Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "HSP90 Heat-Shock Proteins" by people in Profiles. ...
https://profiles.umassmed.edu/display/116039
*  Phylogenetic analysis based on Hsp90 heat-shock protein sequences
p> Ubiquitous, conserved heat-shock proteins (chaperones) such as most well characterized Hsp70 and chaperonin Cpn60 are widely ... Phylogenetic analysis based on Hsp90 heat-shock protein sequences. Ubiquitous, conserved heat-shock proteins (chaperones) such ... Like Hsp70, eukaryotic Hsp90 also exists in two (cytosolic and ER) forms [3, 8]. In addition to Hsp90 of chloroplasts, Hsp90 ... we used the Hsp90 protein sequences available in databases to see whether the genes for organellar proteins have originated ...
http://www.jbsdonline.com/phylogenetic-analysis-based-hsp90-heat-shock-protein-sequences-p10279.html
*  Heat shock protein hsp90 regulates dioxin receptor function in vivo | PNAS
Heat shock protein hsp90 regulates dioxin receptor function in vivo. M L Whitelaw, J McGuire, D Picard, J A Gustafsson, L ... Heat shock protein hsp90 regulates dioxin receptor function in vivo. M L Whitelaw, J McGuire, D Picard, J A Gustafsson, L ... Heat shock protein hsp90 regulates dioxin receptor function in vivo. M L Whitelaw, J McGuire, D Picard, J A Gustafsson, and L ... Heat shock protein hsp90 regulates dioxin receptor function in vivo Message Subject (Your Name) has sent you a message from ...
https://www.pnas.org/content/92/10/4437?ijkey=1e884c4403bfe19ee7d537234260f5e3a6b5fcf2&keytype2=tf_ipsecsha
*  HSP90 / Heat Shock Protein 90 Antibody (aa1-732, clone 4F10) - Mouse Monoclonal Antibody WB, IHC-P, E - Buy Now! |Abgent
Heat Shock Protein 90 Antibody (aa1-732, clone 4F10), Mouse Monoclonal Antibody validated in WB, IHC-P, E (ALS12550), Abgent ... Heat Shock Protein 90 Antibody (aa1-732, clone 4F10) HSP90 / Heat Shock Protein 90 Antibody (aa1-732, clone 4F10). Mouse ... HSP90 / Heat Shock Protein 90 Antibody (aa1-732, clone 4F10) is for research use only and not for use in diagnostic or ... Anti-HSP90 / Heat Shock Protein 90 antibody IHC of human brain, cerebellum. ...
http://www.abgent.com/products/ALS12550-Anti-HSP90--Heat-Shock-Protein-90-Antibody-aa1-732-clone-4F10-ALS12550
*  Heat shock protein HSP 90-alpha - DrugBank
Heat shock protein HSP 90-alpha. Details. Name. Heat shock protein HSP 90-alpha. Kind. protein. Organism. Human. Polypeptides. ... Heat shock protein HSP 90-alpha. P07900. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. ...
https://www.drugbank.ca/biodb/bio_entities/BE0001120
*  Cellular team players: New insights into energy generation by heat shock protein Hsp90
Proteins like the so-called heat shock protein Hsp90 play an important role in almost all processes within human cells. They ... A typical example for this kind of cooperation can be seen in the heat shock protein Hsp90, which controls the proper folding ... Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease. June 22, 2009 Dissecting how heat ... Cellular team players: New insights into energy generation by heat shock protein Hsp90. June 30, 2014, Technical University ...
https://phys.org/news/2014-06-cellular-team-players-insights-energy.html
*  BDPI USP - Detalhe do registro: Transcription of the Hsp30, Hsp70, and Hsp90 heat shock protein genes is modulated by the PalA...
Transcription of the Hsp30, Hsp70, and Hsp90 heat shock protein genes is modulated by the PalA protein in response to acid pH- ... Transcription of the Hsp30, Hsp70, and Hsp90 heat shock protein genes is modulated by the PalA protein in response to acid pH- ... Transcription of the Hsp30, Hsp70, and Hsp90 heat shock protein genes is modulated by the PalA protein in response to acid pH- ... 2011). Transcription of the Hsp30, Hsp70, and Hsp90 heat shock protein genes is modulated by the PalA protein in response to ...
https://bdpi.usp.br/item/002214395
*  Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for...
Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrest ... In a range of cell lines, immobilized geldanamycin bound elements of a major class of heat shock protein (HSP90) in a stable ... Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for ... Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for ...
https://www.pnas.org/content/91/18/8324?ijkey=a0183d77a9e5a0e314bd94e96039ee63464a717c&keytype2=tf_ipsecsha
*  Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers. - PubMed - NCBI
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers.. Jhaveri K1, Taldone T, Modi S, ... This article is part of a Special Issue entitled: Heat Shock Protein 90 (HSP90). ... Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers ... Hsp90 is an ATP dependent molecular chaperone protein which integrates multiple oncogenic pathways. As such, Hsp90 inhibition ...
https://www.ncbi.nlm.nih.gov/pubmed/22062686?dopt=Abstract
*  Abstract C196: Co‐treatment with NVP‐BEZ235 and heat shock protein (hsp) 90 or pan‐deacetylase (DAC) inhibitor is...
Abstract C196: Co‐treatment with NVP‐BEZ235 and heat shock protein (hsp) 90 or pan‐deacetylase (DAC) inhibitor is ... Abstract C196: Co‐treatment with NVP‐BEZ235 and heat shock protein (hsp) 90 or pan‐deacetylase (DAC) inhibitor is ... Abstract C196: Co‐treatment with NVP‐BEZ235 and heat shock protein (hsp) 90 or pan‐deacetylase (DAC) inhibitor is ... Abstract C196: Co‐treatment with NVP‐BEZ235 and heat shock protein (hsp) 90 or pan‐deacetylase (DAC) inhibitor is ...
http://mct.aacrjournals.org/content/8/12_Supplement/C196
*  HSP90AA1 recombinant protein | Heat shock protein HSP 90-alpha (HSP90AA1) Recombinant Protein-NP 001012688.1
Heat shock protein HSP 90-alpha (HSP90AA1) Recombinant Protein-NP_001012688.1 (MBS1472904) product datasheet at MyBioSource, ... Heat shock protein HSP 90-alpha (HSP90AA1), Recombinant Protein. Also Known As Recombinant Bovine Heat shock protein HSP 90- ... HSP90AA1 recombinant protein :: Heat shock protein HSP 90-alpha (HSP90AA1) Recombinant Protein. ... NCBI Protein Information heat shock protein HSP 90-alpha UniProt Protein Name Heat shock protein HSP 90-alpha ...
https://www.mybiosource.com/prods/Recombinant-Protein/Heat-shock-protein-HSP-90-alpha-HSP90AA1/HSP90AA1/datasheet.php?products_id=1472904
*  Involvement of the 90-kDa Heat Shock Protein (Hsp-90) in CB2 Cannabinoid Receptor-Mediated Cell Migration: A New Role of Hsp-90...
Compared with other heat shock proteins, Hsp90 is distinguished by its specific interactions with various signaling proteins ... Involvement of the 90-kDa Heat Shock Protein (Hsp-90) in CB2 Cannabinoid Receptor-Mediated Cell Migration: A New Role of Hsp-90 ... Involvement of the 90-kDa Heat Shock Protein (Hsp-90) in CB2 Cannabinoid Receptor-Mediated Cell Migration: A New Role of Hsp-90 ... Involvement of the 90-kDa Heat Shock Protein (Hsp-90) in CB2 Cannabinoid Receptor-Mediated Cell Migration: A New Role of Hsp-90 ...
http://molpharm.aspetjournals.org/content/72/5/1289
*  Gene expression profiles of cytosolic heat shock proteins Hsp70 and Hsp90 from symbiotic dinoflagellates in response to thermal...
In this study, we identified members of two major heat shock proteins (HSPs) families, Hsp70 and Hsp90, in Symbiodinium sp. ( ... Reduced expression of the Hsp90 gene under heat stress can indicate a reduced role in inhibiting the heat shock transcription ... Elevated temperatures decreased an Hsp90 expression under both rapid and gradual heat stress scenarios. Comparable Hsp70 and ... gene expression profiles observed for Hsp70 and Hsp90 suggests diverse roles of these molecular chaperones during heat stress ...
https://infoscience.epfl.ch/record/176205
*  Gentaur Molecular :Prospecbio \ Mouse Anti Human Heat shock protein HSP 90-alpha HSP90 Alpaha \ ant-398
Mouse Anti Human Heat shock protein HSP 90-alpha HSP90 Alpaha \ ant-398 for more molecular products just contact us ... Mouse Anti Human Heat shock protein HSP 90-alpha HSP90 Alpaha. Related products : Mouse Anti Human Heat shock protein HSP 90- ... Mouse Anti Human Heat shock protein HSP 90-alpha HSP90 Alpaha / Product Detail : ant-398 Mouse Anti Human Heat shock protein ... Mouse Anti Human Heat shock protein HSP 90-alpha HSP90 Alpaha Human samples 80 % of the research is conducted on human samples ...
http://www.antibody-antibodies.com/product_det.php?id=2787359&supplier=search&name=Mouse%20Anti%20Human%20Heat%20shock%20protein%20HSP%2090_alpha%20HSP90%20Alpaha
*  Targeting Heat-Shock Protein 90 (HSP90) as a Complementary Strategy to Immune Checkpoint Blockade for Cancer Therapy | Cancer...
Targeting Heat-Shock Protein 90 (HSP90) as a Complementary Strategy to Immune Checkpoint Blockade for Cancer Therapy. David A. ... In this regard, heat-shock protein 90 (HSP90) represents an important emerging target for cancer therapy because its ... Targeting Heat-Shock Protein 90 (HSP90) as a Complementary Strategy to Immune Checkpoint Blockade for Cancer Therapy ... Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for ...
http://cancerimmunolres.aacrjournals.org/content/3/6/583
*  HSP90 inhibition: two-pronged exploitation of cancer dependencies. - PubMed - NCBI
... central components of which are HSP90 and other heat shock proteins. We evaluate the evidence that inhibiting HSP90 in cancer ... The early clinical hypothesis for inhibiting HSP90 in cancers was based on the dependence of certain key client proteins in ... HSP90 inhibition: two-pronged exploitation of cancer dependencies.. Travers J1, Sharp S, Workman P. ... we review the current status of the discovery and development of HSP90 inhibitors and we identify routes to improve their ...
https://www.ncbi.nlm.nih.gov/pubmed/22245656?dopt=Abstract
*  Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90 | Biochemical Society Transactions
heat-shock organizing protein; HSE, heat-shock responsive element; HSF, heat-shock factor; HSP, heat-shock protein; HSR-1, heat ... heat-shock protein 90 (Hsp90), is a refined sensor of protein function facilitating the biological activity of properly folded ... Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90. Gisela I. Mazaira, Cristina Daneri- ... Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90 ...
http://www.biochemsoctrans.org/content/46/1/51
*  Study of AUY922 and Cetuximab in Patients With KRAS Wild-Type Metastatic Colorectal Cancer - Full Text View - ClinicalTrials.gov
HSP90 Heat-Shock Proteins. EGFR protein, human. Additional relevant MeSH terms: Colorectal Neoplasms. Adenocarcinoma. Rectal ... Prior treatment with any Hsp90 inhibitor compounds. * Patients who received systemic anti-cancer treatment prior to the first ...
https://clinicaltrials.gov/ct2/show/NCT01294826?recr=Open&cond=%22Rectal+Diseases%22&rank=11
*  Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K...
0/HSP90 Heat-Shock Proteins; 0/Recombinant Proteins; 0/Tetrazolium Salts; 0/Thiazoles; 298-93-1/thiazolyl blue; EC 2.7.1.-/ ... HSP90 Heat-Shock Proteins / metabolism*. Male. Mesenchymal Stromal Cells / cytology*. Phosphatidylinositol 3-Kinases / ... The aim of this study is to explore the cytoprotection of heat shock protein 90 (Hsp90) against hypoxia and serum deprivation- ... Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/ ...
http://www.biomedsearch.com/nih/Heat-shock-protein-90-protects/20669351.html
*  Wee1-Hsp90 inhibitor combination treatment: molecular therapy with potentially broad applicability.
0/Cell Cycle Proteins; 0/HSP90 Heat-Shock Proteins; 0/Nuclear Proteins; EC 2.7.10.1/Protein-Tyrosine Kinases ... Cell Cycle Proteins / antagonists & inhibitors*. HSP90 Heat-Shock Proteins / antagonists & inhibitors*. Humans. Male. Nuclear ... The list of Hsp90 client proteins is always expanding and includes transcription factors, steroid hormone receptors, protein ... Y38 in human Hsp90α; Y24 in yeast Hsp90).4,5 Wee1 targets and phosphorylates Hsp90 while it is in an "open" conformation, and ...
http://www.biomedsearch.com/nih/Wee1-Hsp90-inhibitor-combination-treatment/22983000.html
*  Effects of CTT on stimulation of MEK-ERK1/2 and Akt pat | Open-i
HSP90 Heat-Shock Proteins/metabolism*. *Human Umbilical Vein Endothelial Cells/metabolism*. *Immunoglobulin G/metabolism* ... and Akt proteins (B). Membranes were then probed for β actin for normalization of protein content. A representative Western ... and Akt proteins (B). Membranes were then probed for β actin for normalization of protein content. A representative Western ... like effect of Grp94-IgG by increasing the rate of secretion of both HSP90 and MMP-9.Results reveal a fundamental role of HSP90 ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4373444_jcmm0015-2768-f2&req=4
*  CTT does not antagonize the Grp94-IgG complex-dependent | Open-i
HSP90 Heat-Shock Proteins/metabolism*. *Human Umbilical Vein Endothelial Cells/metabolism*. *Immunoglobulin G/metabolism* ... like effect of Grp94-IgG by increasing the rate of secretion of both HSP90 and MMP-9.Results reveal a fundamental role of HSP90 ... like effect of Grp94-IgG by increasing the rate of secretion of both HSP90 and MMP-9.Results reveal a fundamental role of HSP90 ... Crucial role of HSP90 in the Akt-dependent promotion of angiogenic-like effect of glucose-regulated protein94 (Grp94)-IgG ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4373444_jcmm0015-2768-f5&req=4
*  Institute of Cancer Research Repository - Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma
Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma ... Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma. LEUKEMIA, 24 (10). pp. 1804-1807. ISSN ... MOLECULAR CHAPERONE; HSP70; HEAT-SHOCK-PROTEIN-70. Research teams:. ICR divisions , Cancer Therapeutics , Signal Transduction ...
http://publications.icr.ac.uk/9987/