Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide...
... that are specific inhibitors of heat shock protein 90 (Hsp90) (9, 10). Inhibition of Hsp90 promotes the degradation of ... 2012) Using the heat-shock response to discover anticancer compounds that target protein homeostasis. ACS Chem Biol 7(2):340- ... inhibit Hsp90 (10, 37), the mechanism of heat shock modulation by the DAL12 7 has not been clarified (36). The two additional ... 1) is a DAL with a 12-membered ring (DAL12) that modulates the heat shock response and the immune system (8, 9). ...