High prevalence of metallo-beta-lactamase producing Acinetobacter baumannii isolated from two hospitals in Tehran, Iran. ... which detects the probability of isolates being able to produce carbapenemases enzyme and out of the isolates, 11 (33.3%) were ... AL-Muhannak FH, Al-Mohana A. Spread of Some Extended-spectrum Beta-lactamases: In Clinical Isolates of Gram-negative Bacilli in ... Moland, E. S., Kim, S. Y., Hong, S. G., & Thomson, K. S. Newer β-Lactamases: clinical and laboratory implications, Part I. ...
For multidrug resistance studies, she perform and evaluate PCR and real-time PCR for extended spectrum of beta-lactamase ... carrying at least one extended spectrum β-lactamase (ESBL) gene (blaCTX-M-14,-15, -27, -55, or blaVER-5). The carbapenemases ... Also, 190 (95%) said they will go to the hospital if they have symptoms while, all of them agreed it is good to wash hands ... Blood cultures reported positive and the isolate was reported as R. planticola on the third hospital day. The isolate was ...
... extended spectrum beta-lactamase (ESBL) production (n = 4), or multidrug resistance (n = 4). This review highlights significant ... Extended spectrum beta-lactamase (ESBL) producing E. coli were detected in one of the three hospital sewage samples and in 26% ... focus on extended spectrum β-lactamases and carbapenemases). Expert Opin. Pharmacother. 2013, 14, 199-210. [Google Scholar] [ ... extended spectrum beta-lactamase (ESBL) production (n = 4), or multidrug resistance (n = 4). This review highlights significant ...
In the last two decades multi drug resistant microorganisms (both hospital- and community-acquired) challenged the scientific ... Bacterial resistance to antibiotics is growing up day by day in both community and hospital setting, with a significant impact ... metallobeta-lactamases, including the New Delhi metallo-beta-lactamase 1 (NDM-1), and the class D carbapenemases, mostly found ... Ceftobiprole was refractory to hydrolysis by the common staphylococcal PC1 beta-lactamase, the class A TEM-1 beta-lactamase, ...
... including extended-spectrum beta-lactamase genes, but Snesrud emphasized that it was not a pan-resistant strain. The plasmid ... "Different hospitals tend to pick different machines, so in order for our results to be universal and comparable to everybody ... But if the mcr-1 gene is transferred and ends up on a resistance plasmid that contained genes encoding carbapenemases or 16s ... "Any antibiotic-resistant bacteria that show up in a clinical laboratory at any of the militarys hospitals or clinics come to ...
These species may gain extended-spectrum beta-lactamase (ESBL) enzymes, which confer resistance to almost all beta-lactams ... aureus isolates identified from inpatient and outpatient settings in a large childrens hospital demonstrated resistance to ... except carbapenems, or carbapenemases, which make them resistant to carbapenems. Antibiotic exposure allows these highly ... Extended-Spectrum β-Lactamase-Producing and Third-Generation Cephalosporin-Resistant Enterobacteriaceae in Children: Trends in ...
... carbapenemases, plasmid-mediated AmpC β-lactamases and OXA β-lactamases. International Journal of Antimicrobial Agents, 2011, ... Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique ... Variety of TEM-, SHV-, and CTX-M-type beta-lactamases present in recent clinical isolates of Escherichia coli, Klebsiella ... The investigated isolates were obtained from four local hospitals and did not include the hospital of the initial report. ...
... initial screening of the most frequent carbapenemases with one single test. Single detection of 13 different carbapenem ... For initial screening for the most common carbapenemases. The emergence and spread of carbapenem-hydrolysing ß-lactamases ... the New Dheli metallo beta lactamase (NDM) and OXA-48. In Germany, OXA-48 is the most predominant carbapenemase followed by KPC ... amongst gram-negative bacteria over the past decade represents a serious issue in the hospital environment. This fact is ...
How common are carbapenemases?. *How common are metallo-beta-lactamase genes, like NDM and VIM, in CRE in the United States? ... Antibiotic Resistant Germs in Hospitals. *Outpatient Settings. *Laboratory Resourcesplus icon *Reference AST Data ... of carbapenemases identified have been metallo-β-lactamases (MBLs). Preventing the spread of these carbapenemases is critical, ... How common are metallo-beta-lactamase genes, like NDM and VIM, in CRE in the United States?. NDM, VIM, and IMP are less ...
... such as spectrum extended spectrum beta lactamase Enterbacteriaceae, several phenotypic techniques have been proposed for the ... In this work we will establish a comparaison of the performances of the two phenotypic methods of detection of carbapenemases: ... at Childrens Abderrahim El Harouchi hospital of Casablanca. The examination in the admission showed a feverish infant, with ... such as spectrum extended spectrum beta lactamase Enterbacteriaceae, several phenotypic techniques have been proposed for the ...
Beta-lactam/beta-lactamase inhibitor therapy for potential AmpC-producing organisms: a systematic review and meta-analysis. ... However, in recent years, the introduction of community clones in hospitals and the spread of hospital clones to the community ... cAztreonam may be used against GNB that produce MBLs (VIM, NDM or IMP) or OXA-48-type carbapenemases, if coproduction of ESBL ... Current options for the treatment of infections due to extended-spectrum beta-lactamase-producing Enterobacteriaceae in ...
... it lacks activity against metallo-beta-lactamase (MBL) producing carbapenemases. Aztreonam is known to be stable against ... blinded noninferiority study comparing sulbactam-durlobactam to colistin in the treatment of hospital-acquired and ventilator ... a novel beta-lactamase inhibitor with potent activity against class A serine beta-lactamases (specifically ESBLs), is also ... a new cyclic boronate beta-lactamase inhibitor, is being developed with cefepime for the treatment of beta-lactamase producing ...
... with genotype VII circulating in both hospitals. The presence of blaOXA-23 in 13% (11/83) and IS Aba1 linked blaOXA-66 in 79.5 ... This study underscores the major role of carbapenem-hydrolyzing class D β-lactamases, and in particular the acquired OXA-23, in ... A. baumannii isolates (n = 83) originated from two hospital settings in central Ohio were used in this study. Pulsed-field gel ... Bratu S, Landman D, Martin DA, Georgescu C, Quale J: Correlation of antimicrobial resistance with beta-lactamases, the OmpA- ...
Hospital outbreak caused by Klebsiella pnumoniae producing KPC-2 beta -lactamase resistant to colistin. J Hosp Infect 2010; 76( ... 12-Cuzon G, Nass T , Nordmann p. KPC carbapenemases: what is at stake in clinical microbiology? Pathol Biol(Paris) 2010; 58(1 ... 4-Vatopoulos A. High rates of metallo-beta-lactamase-producing Klebsiella pneumoniae in Greece--a review of the current ... Detection of Klebsiella pneumoniae and Escherichia coli strains producing extended-spectrum beta-lactamases. Journal of ...
Worldwide dissemination of the Klebsiella pneumoniae , VIM, OXA, and New Delhi metallo-Beta-lactamase type carbapenemases among ... Hospital acquired Infection News, Research - Page 3. Synthetic, Enterome partner to study effects of beta-lactam antibiotics on ... The beta-lactam and beta-lactamase inhibitors market is expected to exhib... ... Beta-lactam and beta-lactamase inhibitors are ... Beta-Lactamases Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, ... ...
Detection of extended spectrum beta lactamases, ampc beta lactamases and metallobetalactamases in clinical isolates of ... Joseph NM, Elan S, Vadivu S, Kanungo R. Needlestick injuries among healthcare workers of a tertiary care hospital in South ... Simple screening tests for detection of carbapenemases in clinical isolates of nonfermentative Gram-negative bacteria. Indian J ... Joseph NM, Mathias S. Challenges in detection of AmpC β-lactamases among Enterobacteriaceae. Indian J Med Res. 2013;137:216-7. ...
... the enterobacteria producing extended spectrum beta-lactamases (ESBL) or carbapenemases (CARB), Pseudomonas aeruginosa (ESBL or ... In comparison to the University Clinical Centre of Serbia, the hospital stays at Zemun and Zvezdara University Medical Centres ... Intestinal Carriage among High-Risk Patients in University Hospitals in Serbia by Ana Janjusevic ... Data on patient demographics and clinical characteristics, length of hospital stay, therapy, and procedures were obtained from ...
... carbapenemases, plasmid-mediated AmpC beta-lactamases and OXA Oxacilline hydrolyserend metallo beta lactamase (Oxacilline ... Clinical impact of antimicrobial resistance in European hospitals: Excess mortality and length of hospital stay related to ... retail chicken meat and poultry share the same ESBL Extended spectrum beta-lactamases (Extended spectrum beta-lactamases) genes ... hydrolyserend metallo beta lactamase) beta-lactamases. Voets G.M., Fluit A.C., Scharringa J., Cohen Stuart J., Leverstein-van ...
Yong D, Toleman MA, Giske CG, Cho HS, Sundman K et al. Characterization of a new metallo-beta-lactamase gene, blaNDM-1, and a ... Zou H, Jia X, Liu H, Li S, Wu X et al. Emergence of NDM-5-producing Escherichia coli in a teaching hteaching hospital in ... Pedersen T, Sekyere JO, Govinden U, Moodley K, Sivertsen A et al. Spread of plasmid-encoded NDM-1 and GES-5 carbapenemases ... Wu W, Feng Y, Tang G, Qiao F, McNally A et al. NDM metallo-β-lactamases and their bacterial producers in health care settings. ...
Hospitals , beta-Lactamases/genetics , Klebsiella pneumoniae/genetics , Microbial Sensitivity Tests ... patient demographics and clinical condition was collated from the Hospital Information System and detection of carbapenemases ... beta-Lactamases/genetics , Carbapenems/pharmacology , Carbapenems/therapeutic use , Gram-Negative Bacteria , Klebsiella ... beta-Lactamases/genetics , Escherichia coli/genetics , Klebsiella pneumoniae/genetics ...
Only four clinical isolates with OmpK35 and OmpK36 porin defects and carrying multiple beta lactamases and carbapenemases had ... Gastrointestinal Klebsiella pneumoniae accounts for around a third of all Gram-negative infections, which can be hospital ... Avibactam improved antibiotic potency in strains carrying extended spectrum beta lactamase enzymes, however the presence of ... expands its spectrum of activity to cover the highly resistant organisms with multiple β-lactamases and serine carbapenemases ...
We also show the presence of several genes encoding MBLs (metallo-β-lactamases), carbapenemases, and the mcr (mobile colistin ... Also, the treatment of drinking water aims to reduce the microbial load, which explains why alpha and beta diversities of the ... Resistance to antimicrobials, initially confined to hospitals, has also been observed in the natural environment, which raises ... The genes encoding metallo-β-lactamase enzymes (blaAIM, blaGIM, blaIMP, and blaVIM) were detected in the two watersheds and in ...
Prevalence of extended-spectrum beta-lactamases in isolates of the Enterobacter cloacae complex from German hospitals. Clinical ... Characterization of carbapenemases, extended spectrum β-lactamases and molecular epidemiology of carbapenem-non- susceptible ... Clonal relation and antimicrobial resistance pattern of extended-spectrum β-lactamase- and AmpC β-lactamase-producing ... and CTX-M-extended spectrum β-lactamases and class 1 integron among Enterobacter cloacae isolates collected from hospitals of ...
... extended-spectrum beta-lactamases, and penicillin-binding protein 2a. It was designed to detect nosocomial pneumonia pathogens ... susceptible isolates among β-lactamase-negative ampicillin-resistant Haemophilus influenzae in a tertiary care hospital in ... species identification and detection of resistance genes associated with beta-lactam resistance encoding carbapenemases, ... Medicine Hospital Center, Charity Hospital and Medical Center of Louisiana at New Orleans; Consulting Staff, Ochsner Medical ...
Relative Abundance of Extended-Spectrum-Beta-Lactamase-Producing Escherichia coli in the Gut of Patients Admitted to Hospitals. ... Rapid Detection and Characterization of Carbapenemases in Enterobacterales with a New Modified Carbapenem Inactivation Method, ... Capturing the mutational landscape of the beta-lactamase TEM-1.. Proceedings of the National Academy of Sciences of the United ... Capturing the mutational landscape of the beta-lactamase TEM-1.. Proceedings of the National Academy of Sciences of the United ...
... including novel beta lactam-beta lactamase inhibitor combinations. This study provides a contemporary global view of OmpK36- ... Abstract: Carbapenem-resistance in Klebsiella pneumoniae (KP) sequence type ST258 is mediated by carbapenemases (e.g. KPC-2) ... Our data suggests that the continuous selective pressure imposed by widespread Carbapenem utilisation in hospital settings ...
Rapid molecular tests could accelerate the control of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) and ... Rapid molecular tests could accelerate the control of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) and ... for rapid detection of carbapenemases and ESBLs in clinical Enterobacteriaceae isolates recovered at two Spanish hospitals. J ... Efficacy of admission screening for extended-spectrum beta-lactamase producing Enterobacteriaceae. PLoS ONE. 2013;8(4):e62678. ...
Novel Carbapenem-Hydrolyzing Beta-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae. Antimicrobial ... Different organisms/species/carbapenemases are counted as separate events from other organisms/species/carbapenemases. ... Infection Control and Hospital Epidemiology, 2008. 29(12): 1099 -1106. DOI: 10.1086/592412 ... New Delhi metallo-β-lactamase [NDM], oxacillinase-48 [OXA-48], Verona integron-encoded metallo-β-lactamase [VIM], imipenemase [ ...
... coli isolates harboring New Delhi metallo-beta-lactamase 5 (NDM-5) showed high levels of cefiderocol resistance, of which ... we detected intra-hospital transmission of ST11 and ST45 strains in single and multiple wards in several hospitals, whereas ... TL;DR: The results support the use of either test in routine laboratories for the rapid detection of common carbapenemases and ... suggesting intra-hospital transmission within single and multiple wards. Reducing intra-hospital transmission remains to be the ...