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*  hom - Homoserine dehydrogenase - Mycobacterium leprae (strain TN) - hom gene & protein
Homoserine dehydrogenase (hom). This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is ... Belongs to the homoserine dehydrogenase family.Curated. Phylogenomic databases. evolutionary genealogy of genes: Non-supervised ... sp,P46806,DHOM_MYCLE Homoserine dehydrogenase OS=Mycobacterium leprae (strain TN) OX=272631 GN=hom PE=3 SV=1 ... This protein is involved in step 3 of the subpathway that synthesizes L-homoserine from L-aspartate.. Proteins known to be ...
http://www.uniprot.org/uniprot/P46806
*  Homoserine dehydrogenase - Wikipedia
... the precise mechanism of complete homoserine dehydrogenase catalysis remains unknown. The homoserine dehydrogenase-catalyzed ... In enzymology, a homoserine dehydrogenase (EC 1.1.1.3) is an enzyme that catalyzes the chemical reaction L-homoserine + NAD(P ... Homoserine dehydrogenase catalyzes the reaction of aspartate-semialdehyde (ASA) to homoserine. The overall reaction reduces the ... Homoserine dehydrogenase has an NAD(P)H cofactor, which then donates a hydrogen to the same carbon, effectively reducing the ...
https://en.wikipedia.org/wiki/Homoserine_dehydrogenase
*  Inhibition of homoserine dehydrogenase I by L-serine in Escherichia coli. - PubMed - NCBI
Inhibition of homoserine dehydrogenase I by L-serine in Escherichia coli.. Hama H1, Kayahara T, Tsuda M, Tsuchiya T. ... reported that a major cause of growth inhibition of Escherichia coli by L-serine is its inhibition of homoserine dehydrogenase ... strongly inhibited the HDH I activities in both the forward and reverse reactions between aspartate semialdehyde and homoserine ...
https://www.ncbi.nlm.nih.gov/pubmed/1907968?dopt=Abstract
*  thrA - Bifunctional aspartokinase/homoserine dehydrogenase 1 - Escherichia coli (strain K12) - thrA gene & protein
... homoserine biosynthetic process, lysine biosynthetic process via diaminopimelate ... Bifunctional aspartokinase/homoserine dehydrogenase 1. Alternative name(s):. Aspartokinase I/homoserine dehydrogenase I. Short ... Bifunctional aspartokinase/homoserine dehydrogenase 1 (thrA), Bifunctional aspartokinase/homoserine dehydrogenase 2 (metL) ... Bifunctional aspartokinase/homoserine dehydrogenase 1 (thrA), Bifunctional aspartokinase/homoserine dehydrogenase 2 (metL) ...
https://www.uniprot.org/uniprot/P00561
*  Bifunctional aspartokinase/homoserine dehydrogenase elisa and antibody
Recombinant Protein and Bifunctional aspartokinase/homoserine dehydrogenase Antibody at MyBioSource. Custom ELISA Kit, ... Bifunctional aspartokinase/homoserine dehydrogenase 1. Bifunctional aspartokinase/homoserine dehydrogenase 1 ELISA Kit. ... Bifunctional aspartokinase/homoserine dehydrogenase 2. Bifunctional aspartokinase/homoserine dehydrogenase 2 ELISA Kit. ... Bifunctional aspartokinase/homoserine dehydrogenase. Bifunctional aspartokinase/homoserine dehydrogenase ELISA Kit. ...
https://www.mybiosource.com/protein_family.php?root=bifunctional-aspartokinase-homoserine-dehydrogenase
*  Transcriptional and biochemical regulation of a novel Arabidopsis thaliana bifunctional aspartate kinase-homoserine...
"Transcriptional and biochemical regulation of a novel Arabidopsis thaliana bifunctional aspartate kinase-homoserine ... dehydrogenase gene isolated by functional complementation of a yeast hom6 mutant, Plant Molecular Biology" on DeepDyve, the ... An aspartate kinase-homoserine dehydrogenase (AK-HSDH) cDNA of Arabidopsis thaliana has been cloned by functional ... Bifunctional protein in carrot contains both aspartokinase and homoserine dehydrogenase activities. Wilson, B.J.; Gray, A.C.; ...
https://www.deepdyve.com/lp/springer_journal/transcriptional-and-biochemical-regulation-of-a-novel-arabidopsis-GSt8xx9Nx3
*  "Crystal structures of homoserine dehydrogenase suggest a novel catalyt" by B. DeLaBarre, Paul R. Thompson et al.
... suggest that HSD exhibits a new variation on dehydrogenase chemistry. ... The structure of the antifungal drug target homoserine dehydrogenase (HSD) was determined from Saccharomyces cerevisiae in apo ... DeLaBarre, B.; Thompson, Paul R.; Wright, G. D.; and Berghuis, A. M., "Crystal structures of homoserine dehydrogenase suggest a ... The structure of the antifungal drug target homoserine dehydrogenase (HSD) was determined from Saccharomyces cerevisiae in apo ...
https://escholarship.umassmed.edu/thompson/91/
*  IUCr) Acta Crystallographica Section D Volume 71, Part 5, May 2015
The structure of S. aureus homoserine dehydrogenase at different pH conditions provides a basis for understanding the role of a ... Structural and functional analysis of betaine aldehyde de-hydrogenase from Staphylococcus aureus. A. S. Halavaty, R. L. Rich, C ... aureus COL has betaine aldehyde dehydrogenase activity and is structurally similar to aldehyde dehydrogenases. ... PDB references: betaine aldehyde dehydrogenase, 4mpb; complex with NAD+, 4mpy; complex with NAD+ with BME-free Cys289, 4nea; ...
http://journals.iucr.org/d/issues/2015/05/00/index.html
*  ACT domain (IPR002912) | InterPro | EMBL-EBI
homoserine dehydrogenases. *malate dehydrogenases. *phosphoglycerate dehydrogenases. * phenylalanine and tryptophan-4- ... The archetypical ACT domain is the C-terminal regulatory domain of 3-phosphoglycerate dehydrogenase (3PGDH), which folds with a ...
http://www.ebi.ac.uk/interpro/entry/IPR002912
*  Methionine - New World Encyclopedia
β-aspartate semialdehyde dehydrogenase. *homoserine dehydrogenase. *homoserine acyltransferase. *cystathionine-γ-synthase. * ... Homoserine converts to O-succinyl homoserine, which then reacts with cysteine to produce cystathionine, which is cleaved to ... 7) α-ketoacid dehydrogenase converts α-ketobutyrate to propionyl-CoA, which is metabolized to succinyl-CoA in a three-step ... First, aspartic acid is converted via β-aspartyl-semialdehyde into homoserine, introducing the pair of contiguous methylene ...
https://www.newworldencyclopedia.org/entry/Methionine
*  Threonine - New World Encyclopedia
α-aspartate semialdehyde dehydrogenase. *homoserine dehydrogenase. *homoserine kinase. *threonine synthase. Threonine ... Homoserine undergoes O-phosphorylation; this phosphate ester undergoes hydrolysis concomitant with relocation of the OH group ( ... In plants and microorganisms, threonine is synthesized from aspartic acid via α-aspartyl-semialdehyde and homoserine. ...
http://www.newworldencyclopedia.org/entry/Threonine
*  BRENDA - Reference to 1.1.1.3; Id = 246401
Homoserine dehydrogenase from Saccharomyces cerevisiae: kinetic mechanism and stereochemistry of hydride transfer. Jacques, S.L ...
http://www.brenda-enzymes.org/literature.php?e=1.1.1.3&r=246401
*  Threonine
α-aspartate semialdehyde dehydrogenase * homoserine dehydrogenase * homoserine kinase * threonine synthase. Metabolism. ... Homoserine undergoes O-phosphorylation; this phosphate ester undergoes hydrolysis concomitant with relocation of the OH group.[ ... It is converted to pyruvate via Threonine Dehydrogenase. An intermediate in this pathway can undergo thiolysis with CoA to ... In plants and microorganisms, threonine is synthesized from aspartic acid via α-aspartyl-semialdehyde and homoserine. ...
https://www.bionity.com/en/encyclopedia/Threonine.html
*  UniProt: I0JSX8 HALH3
DE RecName: Full=Homoserine dehydrogenase {ECO:0000256,RuleBase:RU000579}; DE EC=1.1.1.3 {ECO:0000256,RuleBase:RU000579}; GN ... DR GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC. DR GO; GO:0050661; F:NADP binding; IEA:InterPro. DR ... Belongs to the homoserine dehydrogenase family. CC {ECO:0000256,RuleBase:RU004171}. CC ... DR Pfam; PF00742; Homoserine_dh; 1. DR Pfam; PF03447; NAD_binding_3; 1. DR PIRSF; PIRSF036497; HDH_short; 1. DR SUPFAM; ...
https://www.genome.jp/dbget-bin/www_bget?uniprot:I0JSX8_HALH3
*  A functional update of the Escherichia coliK-12 genome | Genome Biology | Full Text
... aspartokinase I and homoserine dehydrogenase I) and MetL (aspartokinase II and homoserine dehydrogenase II) where only the ... Truffa-Bachi P, Van Rapenbusch R, Gros C, Cohen GN, Janin J: The threonine-sensitive homoserine dehydrogenase and aspartokinase ... Vickers LP, Ackers GK, Ogilvie JW: Aspartokinase I-homoserine dehydrogenase I of Escherichia coli K12. Concentration-dependent ... Saccharomyces cerevisiae, however, does contain a unimodular sequence-similar homoserine dehydrogenase (DhoM, SWISS-PROT P31116 ...
https://genomebiology.biomedcentral.com/articles/10.1186/gb-2001-2-9-research0035
*  BRENDA - Reference to 1.1.1.3; Id = 246403
Role of serine 352 in the allosteric response of Serratia marcescens aspartokinase I-homoserine dehydrogenase I analyzed by ...
http://www.brenda-enzymes.org/literature.php?e=1.1.1.3&r=246403
*  On the origin and evolution of biosynthetic pathways: integrating microarray data with structure and organization of the Common...
The second step of the CP is catalyzed by a single aspartate semialdehyde dehydrogenase (ASDH, the product of asd). Thus, in ... Moreover, two of them (AKI and AKII) are bifunctional, carrying also homoserine dehydrogenasic activity (hom product). ... or homoserine by homoserine dehydrogenase (HD, encoded by hom). Homoserine can be then channeled towards threonine and/or ... the third step is carried out by two different homoserine dehydrogenases, referred to as HDI and HDII, which are fused to two ...
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-8-S1-S12
*  EC 1.1.1.1 to EC 1.1.1.50
EC 1.1.1.1 alcohol dehydrogenase. EC 1.1.1.2 alcohol dehydrogenase (NADP+). EC 1.1.1.3 homoserine dehydrogenase. EC 1.1.1.4 (R, ... lactate dehydrogenase; L-lactic dehydrogenase; L-lactic acid dehydrogenase; lactate dehydrogenase; lactate dehydrogenase NAD- ... Other name(s): malic dehydrogenase; L-malate dehydrogenase; NAD-L-malate dehydrogenase; malic acid dehydrogenase; NAD-dependent ... Accepted name: homoserine dehydrogenase. Reaction: L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H + H+. For ...
https://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC1/0101a.html
*  ATCC 25903 Strain Passport - StrainInfo
Homoserine dehydrogenase of Rhodospirillum rubrum. Conformational changes in the presence of substrates and modifiers ... Homoserine dehydrogenase of Rhodospirillum rubrum. II. Purification and characterization of the enzyme ...
http://www.straininfo.net/strains/21395
*  Plus it
AK, aspartate kinase; AK-HSDH, aspartate kinase/homoserine dehydrogenase; DHDPS, dihydrodipicolinate synthase; HSK, homoserine ... 2005). Identification of six novel allosteric effectors of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase ... and the bifunctional aspartate kinase/homoserine dehydrogenase I (AK-HSDH I) (de Kraker et al., 2007; Curien et al., 2005; Lee ... 2015). The impact of the branched-chain ketoacid dehydrogenase complex on amino acid homeostasis in Arabidopsis. Plant Physiol. ...
http://www.plantcell.org/content/29/6/1480
*  Zeitschrift für Naturforschung C
Expression of Aspartokinase, Dihydrodipicolinic Acid Synthase and Homoserine Dehydrogenase During Growth of Carrot Cell ...
https://www.degruyter.com/view/j/znc.1979.34.issue-12/issue-files/znc.1979.34.issue-12.xml
*  Strand-specific transcriptomes of Enterohemorrhagic Escherichia coli in response to interactions with ground beef microbiota:...
... dehydrogenase, GlpA, was also repressed in O2621765 (Table 1). Under anaerobic conditions, G3P dehydrogenase GlpA converts G3P ... Characterization of a luxI/luxR-type quorum sensing system and N-acyl-homoserine lactone-dependent regulation of exo-enzyme and ... Genes implicated in L-lactate metabolism were down-regulated in O2621765 (lldR, lldP and lldD). L-lactate dehydrogenase ( ... sn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit, FAD/NAD(P)-binding ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-3957-2
*  NCIB 10332 Strain Passport - StrainInfo
Corynebacterium glutamicum hom-thrB genes for homoserine dehydrogenase andhomoserine kinase. ATCC 13059 ...
http://www.straininfo.net/strains/8392
*  Oenococcus oeni proteome reference map | Open Biology
... aspartate-semialdehyde dehydrogenase; HSDH, homoserine dehydrogenase. ... alcohol dehydrogenase; FK, fructokinase; G6PI, glucose-6-phosphate isomerase; G6P1DH, glucose-6-phosphate 1-dehydrogenase; RPPK ... MLE, malolactic enzyme; LDH, lactate dehydrogenase; CL, citrate lyase; OAD, oxaloacetate decarboxylase; ALS, α-acetolactate ... UDP-glucose 6-dehydrogenase (OENOO_64076) and UDP-glucose 4-epimerase (OENOO_50027), which are involved in several pathways of ...
http://rsob.royalsocietypublishing.org/content/4/2/130154
*  Solow-Cordero DE[au] - PubMed - NCBI
A C-terminal deletion in Corynebacterium glutamicum homoserine dehydrogenase abolishes allosteric inhibition by L-threonine. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Solow-Cordero+DE%5Bau%5D&dispmax=50