HMGB1 AND ANTI-HMGB1 ANTIBODIES FOR THE PROGNOSTIC OF NEUROLOGICAL DISORDERS - Patent application
... with the protein HMGB). The term "circulating" also applies to the residual HMGB1 protein quantitated without treatment.  ... 0005] The high mobility group box 1 (HMGB1) protein is a non-histone chromosomal protein that acts as a potent proinflammatory ... 0143] The concentration of HMGB1 protein (i.e., residual circulating HMGB1 protein) in sample from HIV-infected patients was ... fluid sample with native HMGB1 protein or derivatives thereof; and b) quantitating the antibodies specific for HMGB1.. ...http://www.patentsencyclopedia.com/app/20130065221
High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity - Bianchi - 2007 -...
Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1, Brain, Behavior, and ... Many of these events involve high-mobility group box 1 protein (HMGB1), a nuclear protein that is released passively when ... High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Authors. *. Marco E. Bianchi, ... Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats ...http://onlinelibrary.wiley.com/doi/10.1111/j.1600-065X.2007.00574.x/full
Frontiers | Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats | Immunology
... and anxiety in aged rats by preventing surgery-induced reduction of phosphorylated cyclic AMP response element-binding protein ... and anxiety in aged rats by preventing surgery-induced reduction of phosphorylated cyclic AMP response element-binding protein ... High mobility group box 1 protein (HMGB1) is rapidly released after tissue trauma and critically involved in response to ... High mobility group box 1 protein (HMGB1) is rapidly released after tissue trauma and critically involved in response to ...https://www.frontiersin.org/articles/10.3389/fimmu.2016.00441/full
Mini-review: The nuclear protein HMGB1 as a proinflammatory mediator - Erlandsson Harris - 2004 - European Journal of...
Agresti, A. and Bianchi, M. E., HMGB proteins and gene expression. Curr. Opin. Genet. Dev. 2003.13: 170-178. *CrossRef, ... Falciola, L., Spada, F., Calogero, S., Langst, G., Voit, R., Grummt, I. and Bianchi, M. E., High mobility group 1 protein is ... Gardella, S., Andrei, C., Ferrera, D., Lotti, L. V., Torrisi, M. R., Bianchi, M. E. and Rubartelli, A., The nuclear protein ... Jayaraman, L., Moorthy, N. C., Murthy, K. G., Manley, J. L., Bustin, M. and Prives, C., High mobility group protein-1 (HMG-1) ...http://onlinelibrary.wiley.com/doi/10.1002/eji.200424916/references
Anti-HMGB1 antibody [HAP46.5] (ab12029) | Abcam
HMGB 1 antibody. *HMGB1 antibody. *HMGB1_HUMAN antibody. *NONHISTONE CHROMOSOMAL PROTEIN HMG1 antibody ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ... Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the ... The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res. 38:D142-D148 (2010) . ...http://www.abcam.com/hmgb1-antibody-hap465-ab12029.html
HMGB-1 elisa kit | Rat High mobility group protein B1 (HMGB-1) ELISA Kit-NP 002119.1
Rat High mobility group protein B1 (HMGB-1) ELISA Kit-NP_002119.1 (MBS265968) product datasheet at MyBioSource, ELISA Kits ... High mobility group protein B1 (HMGB-1), ELISA Kit. ★Popular Item★ Also Known As Rat High mobility group protein B1 (HMGB-1) ... Recombinant Protein. • BCL2-adenovirus E1B 19 kDa protein-interacting protein 3 (Bn... Recombinant Protein. more .... ... HMGB-1 elisa kit :: Rat High mobility group protein B1 (HMGB-1) ELISA Kit. ...https://www.mybiosource.com/prods/ELISA-Kit/Rat/High-mobility-group-protein-B1-HMGB-1/HMGB-1/datasheet.php?products_id=265968
Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE | JEM
HMGB proteins are required for the proinflammatory activity of apoptotic nucleosomes. To further test whether HMGB1 contributes ... We then refer to them as HMGBlow, and the WT counterparts are referred to as HMGB+. Human monocyte-derived macrophages were ... Nucleosomes were prepared from Jurkat cells (5 × 108 cells per preparation) and HMGB WT and HMGBlow MEF (2 × 108 cells per ... The adaptor protein MyD88 (myeloid differentiation primary response protein 88) is critical for signal transduction leading to ...http://jem.rupress.org/content/205/13/3007?ijkey=4558731fd5764008496e712bec54e8a236f83470&keytype2=tf_ipsecsha
Tissue specific expression of ar, sox9a, dmrt1, fig α, | Open-i
HMGB Proteins/genetics. *Male. *Organ Specificity. *Receptors, Androgen/genetics. *SOX9 Transcription Factor ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2500022_1477-7827-6-25-8&req=4
Chromatin - Wikipedia
HMO1 an HMGB protein helps in stabilizing nucleosomes-free chromatin. The packaging of eukaryotic DNA into chromatin presents a ... Chromatin is a macromolecular complex of a DNA macromolecule and protein macromolecules (and RNA). The proteins package and ... The primary protein components of chromatin are histones that compact the DNA. Chromatin is only found in eukaryotic cells ( ... These play a dual role of a site of recognition by many proteins and as a sink for torsional stress from RNA polymerase or ...https://en.wikipedia.org/wiki/Chromatin
RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation | Journal of...
It is found either as a membrane-bound or soluble protein that is markedly upregulated by stress in epithelial cells, thereby ... The HMGB proteins have a long C-terminal acidic tail except for HMGB4, which recently has been detected at the protein level in ... None of the other nuclear HMG proteins have been shown to activate RAGE. The HMGB proteins can complex CpG DNA, and highly bent ... HMGN proteins (formerly HMG14 and HMG17) have nucleosomal binding domains. HMGB proteins (formerly HMG1 through HMG4) are ...https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-7-17
HMGB1 in Cancer: Good, Bad, or Both? | Clinical Cancer Research
Priming the nucleosome: a role for HMGB proteins? EMBO Rep 2003;4:131-6. ... High mobility group protein B1 is an activator of apoptotic response to antimetabolite drugs. Mol Pharmacol 2008;73:260-9. ... The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway. EMBO Rep 2002;3:995 ... HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha. Nucleic Acids Res 2009;37:2070-86. ...http://clincancerres.aacrjournals.org/content/19/15/4046.full
Characterization of an Entamoeba histolytica High-Mobility-Group Box Protein Induced during Intestinal Infection
HMGB) protein, EhHMGB1. We tested if EhHMGB1 encoded a functional HMGB protein and determined its role in control of parasite ... a characteristic of HMGB proteins. Core conserved residues required for DNA bending activity in other HMGB proteins were ... However, only one other protein (XP_653586) shared significant sequence similarity with EhHMGB1. Two HMGB proteins which were ... contain only one HMGB domain (13). In contrast, the six HMGB proteins that have been identified in S. mansoni and Schistosoma ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2547075/?lang=en-ca
High Mobility Group Box Protein 1 (HMGB1)-Partner Molecule Complexes Enhance Cytokine Production by Signaling Through the...
The nuclear protein high mobility group box protein 1 (HMGB1) promotes inflammation upon extracellular release. HMGB1 induces ... 2009) HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature. 462:99-103. ... The nuclear protein high mobility group box protein 1 (HMGB1) promotes inflammation upon extracellular release. HMGB1 induces ... High mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein that binds and bends DNA and facilitates ...https://link.springer.com/article/10.2119%2Fmolmed.2011.00327
Early detection of prostate carcinogens by immunohistochemistry of HMGB2
HMGB proteins are reported to inhibit DNA repair in vivo, which may be intimately involved with the accumulation of genetic ... Agresti, A. and Bianchi, M.E. (2003): HMGB proteins and gene expression. Curr. Opin. Genet. Dev., 13, 170-178.. ... Protein tyrosine phosphatase, receptor type M -1.9. Cytoskeleton associated protein 2. 1.9. Phosphoserine aminotransferase 1 - ... Reeves, R. and Adair, J.E. (2005): Role of high mobility group (HMG) chromatin proteins in DNA repair. DNA Repair (Amst.), 4, ...https://www.jstage.jst.go.jp/article/jts/43/6/43_359/_html/-char/en
2003) Phosphorylation of maize and Arabidopsis HMGB proteins by protein kinase CK2alpha. Biochemistry 42, 3503-3508. ... mitogen-activated protein kinase kinase kinase. PIP. plasma membrane intrinsic protein. PPI. protein-protein interaction. PP2A ... plasma membrane intrinsic protein 2A, light harvesting chlorophyll A/B binding protein 1.1, and flowering bHLH 3 proteins in a ... and calmodulin-domain protein kinase 9 (kinase of FBH3) are enhanced by ethylene, and protein kinase superfamily protein ...https://www.mcponline.org/content/12/12/3559
The American Journal of Tropical Medicine and Hygiene | Human Schistosomiasis Is Associated with Endotoxemia and Toll-Like...
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature 462: 99-103.[Crossref] ... Serum lipopolysaccharide-binding protein in endotoxemic patients with inflammatory bowel disease. Inflamm Bowel Dis 13: 269-277 ... Uncoupling of induced protein processing from maturation in dendritic cells exposed to a highly antigenic preparation from a ... Endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase. J Biol ...http://www.ajtmh.org/content/journals/10.4269/ajtmh.2011.10-0397
DSpace@MIT: Browsing Department of Chemistry by Title
High mobility group box (HMGB) proteins are DNA-binding proteins that regulate many important DNA-related processes. They are ... Understanding the functions of HMGB proteins in the mechanism of action of cisplatin ...https://dspace.mit.edu/handle/1721.1/7792/browse?rpp=20&order=ASC&sort_by=1&etal=-1&type=title&starts_with=U
Frontiers | Comprehensive Transcriptome Analyses Reveal Differential Gene Expression Profiles of Camellia sinensis Axillary...
Grasser, K. D. (2003). Chromatin-associated HMGA and HMGB proteins: versatile co-regulators of DNA-dependent processes. Plant ... By BlastX analysis (BLAST 2.2.30+) with the NR database4 and protein databases of Populus (Ptrichocarpa_210_v3.0.protein.fa and ... AGO proteins are key players in RNA silencing and can bind small non-coding RNAs, control protein synthesis, and affect ... All transcripts were annotated by BlastX using the NR database, Arabidopsis protein database and Populus protein database with ...https://www.frontiersin.org/articles/10.3389/fpls.2017.00553/full
Biochemical characterizations of the ROQ domain-RNA int | Open-i
Mentions: The Hmg19 and TNF23 RNAs were incubated with the wild-type and mutant ROQ domain proteins in the presence of 200 mM ... Mentions: The Hmg19 and TNF23 RNAs were incubated with the wild-type and mutant ROQ domain proteins in the presence of 200 mM ... HMGB Proteins/genetics/metabolism. *Humans. *Hydrogen Bonding. *Interleukin-6/genetics/metabolism. *Models, Molecular ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4125485_nihms-605410-f0004&req=4
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature 2009; 462: 99-103. ... and the B-lymphocyte-specific adaptor protein B-cell linker (BLNK) and B-cell adaptor protein (BCAP). Activation of the BCR- ... melanoma differentiation-associated protein (MDA)-5 or nucleotide-binding oligomerisation domain-containing protein (NOD)-2, ... and involves a number of lysosome-related organelle trafficking and biogenesis proteins including adapter-related protein ...http://erj.ersjournals.com/content/43/1/264
Comparative transcript analyses of the ovule, microspore, and mature pollen in Brassica napus, Plant Molecular Biology | 10...
Chromatin-associated HMGA and HMGB proteins: versatile co-regulators of DNA-dependent processes ... Arabidopsis ribosomal proteins RPL23aA and RPL23aB are differentially targeted to the nucleolus and are disparately required ... MIPS: a database for genomes and protein sequences. Mewes, HW; Frishman, D; Guldener, U; Mannhaupt, G; Mayer, K; Mokrejs, M; ... TGA1 and G-Box binding factors: two distinct classes of Arabidopsis leucine zipper proteins compete for the G-box-like element ...https://www.deepdyve.com/lp/springer_journal/comparative-transcript-analyses-of-the-ovule-microspore-and-mature-N8dnESUNjL
US20120076804A1 - Cancer targeted innate immunity - Google Patents
Inhibitor of hmgb protein-mediated immune response activation, and screening method CN103566377A (en) 2012-07-18. 2014-02-12. 上 ... Cancer targeting molecules can be a protein or peptide. "Polypeptide", "peptide," and "protein" are used interchangeably to ... Protein Design Labs, Inc.. Humanized immunoglobulins DK527798T3 (en) * 1990-04-06. 1997-12-15. Jolla Cancer Res Found. A method ... protein-bound radioactivity is measured in a gamma counter in order to calculate the percentage of intact fusion protein. In ...https://patents.google.com/patent/US20120076804A1/en
Zsuzsanna Hamari - ODT Personal data sheet
1. Role of HMGB proteins in chromatin organization and physiology of Aspergillus nidulans. 2. Revealing the first eukaryotic ... Karacsony Z, Gacser A, Vagvolgyi C, Scazzocchio C, Hamari Z: A dually located multi-HMG-box protein of Aspergillus nidulans has ... Further characterization of the role of the mitochondrial high-mobility group box protein in the intracellular redox ...https://doktori.hu/index.php?menuid=192&lang=EN&sz_ID=4546
High-mobility group box (HMGB) proteins are ubiquitous, abundant nuclear proteins and have diverse functions in the cell. HMGB1 ... Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes. Mol Biol Cell 2003;14: ... Therefore, HMGB proteins merit further study with respect to the molecular pathogenesis and control of HCC. ... Recently, the overexpression of HMGB proteins in rat and human HCC tissues was reported, and knockdown of HMGB2 expression in a ...http://clincancerres.aacrjournals.org/content/16/22/5511
Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food...
12126646 - Hmgb-1, a dna-binding protein with cytokine activity, induces brain tnf and il-6 produc.... 17521686 - Cannabinoid ...http://www.biomedsearch.com/nih/Cannabinoid-CB1-receptor-inverse-agonists/17521686.html