RCSB PDB - 1D5X: X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH DIPEPTIDE MIMETIC AND SEB
X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH DIPEPTIDE MIMETIC AND SEB ... Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity ... and structure-based drug design in the discovery of inhibitors of antigen presentation by MHC class II HLA-DR molecules. ... Molecular features of ligand binding to MHC class II HLA-DR molecules have been elucidated through a combination of peptide ...
RCSB PDB - 3BO8: The High Resolution Crystal Structure of HLA-A1 Complexed with the MAGE-A1 Peptide
The High Resolution Crystal Structure of HLA-A1 Complexed with the MAGE-A1 Peptide ... We have previously determined the structure of the MHC class I molecule HLA-A1 bound to a melanoma antigen-encoding gene (MAGE ... Here, we compare the X-ray structure of HLA-A1:MAGE-A1 with that complexed with Fab-Hyb3 to gain insight into structural ... Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like ...
RCSB PDB - 4G8G: Crystal Structure of C12C TCR-HA B2705-KK10
... presented by human leukocyte antigen (HLA)-B∗2705. We found that cross-reactive CD8+ T cell clonotypes were mobilized to ... These newly recruited clonotypes expressed TCRs that engaged wild-type and mutant KK10 antigens with similar affinities and ... presented by human leukocyte antigen (HLA)-B∗2705 ... ... HLA class I histocompatibility antigen, B-27 alpha chain. A. ... ultimately driving the development of more complex viral escape variants that disrupt antigen presentation. ...
RCSB PDB - 4MD0: Immune Receptor
Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared ... Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared ... Using HLA-II tetramers, we observed citrullinated vimentin- and aggrecan-specific CD4(+) T cells in the peripheral blood of HLA ... Peptide elution studies revealed P4 arginine-containing peptides from HLA-DRB1*04:02, but not from HLA-DRB1*04:01/04. ...
RCSB PDB Group Summary: P01889
... on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed ... UniProtKB description: Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 ... the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of ... microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T ...
RCSB PDB - 1A9B: DECAMER-LIKE CONFORMATION OF A NANO-PEPTIDE BOUND TO HLA-B3501 DUE TO NONSTANDARD POSITIONING OF THE C-TERMINUS
DECAMER-LIKE CONFORMATION OF A NANO-PEPTIDE BOUND TO HLA-B3501 DUE TO NONSTANDARD POSITIONING OF THE C-TERMINUS ... HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-35 B*3501 (ALPHA CHAIN). A, D ... A comparison of HLA-B*3501/peptide complexes with structures of other HLA molecules exhibits allele-specific properties of HLA- ... DECAMER-LIKE CONFORMATION OF A NANO-PEPTIDE BOUND TO HLA-B3501 DUE TO NONSTANDARD POSITIONING OF THE C-TERMINUS. *PDB DOI: ...
RCSB PDB - 6D7G: Structure of 5F3 TCR in complex with HLA-A2/MART-1
Structure of 5F3 TCR in complex with HLA-A2/MART-1 ... recognizing MART-1 on HLA-A*0201. Our work shows that antigen- ... we took advantage of an in vitro system to generate antigen-specific human T cells and show that melanoma-associated antigens, ... MART1 PEPTIDE-BETA-2-MICROGLOBULIN-HLA-A*02 CHIMERA. A. 427. Homo sapiens. Mutation(s): 0 Gene Names: B2M, CDABP0092, HDCMA22P ... Antigen recognition by T cells bearing αβ T cell receptors (TCRs) is restricted by major histocompatibility complex (MHC). ...