The Ethical and Scientific Considerations of Human Immunodeficiency Virus Antibody Screening in Volunteers for Clinical...
The Ethical and Scientific Considerations of Human Immunodeficiency Virus Antibody Screening in Volunteers for Clinical Pharmacologic ...https://repository.library.georgetown.edu/handle/10822/820671
The C3-V4 region is a major target of autologous neutralizing antibodies in human immunodeficiency virus type 1 subtype C...
The early autologous neutralizing antibody response in human immunodeficiency virus type 1 (HIV-1) subtype C infections is often characterized by high titers, but the response is type specific with little to no cross-neutralizing activity. The specificities of these early neutralizing antibodies are not known; however, the type specificity suggests that they may target the variable regions of the envelope. Here, we show that cross-reactive anti-V3 antibodies developed within 3 to 12 weeks in six individuals but did not mediate autologous neutralization. Using a series of chimeric viruses, we found that antibodies directed at the V1V2, V4, and V5 regions contributed to autologous neutralization in some individuals, with V1V2 playing a more substantial role. However, these antibodies did not account for the total neutralizing capacity of these sera against the early autologous virus. Antibodies directed ...http://researchspace.ukzn.ac.za/handle/10413/7828
HIV Antibody Test Accuracy: Window Period, Result Interpretation
One of the tests that are most suitable for diagnosing HIV in adults is the HIV antibody test. Get information about ELISA antibody test, window period and result of the test.http://www.medicalhealthtests.com/articles/11/hiv-testing/hiv-antibody-test-accuracy.html
The experience of having a positive HIV antibody test. | Base documentaire | BDSP
Little is known about the logistics of taking an HIV antibody test and yet knowledge of people s experiences of having a test result is helpful to evolving a sensitive and client orientated service and can provide some guidelines for organisation issues around testing. This paper reports the experiences of 252 gay men who had an HIV test which...http://www.bdsp.ehesp.fr/Base/45243/
Undetectable VL and HIV Antibody Test - Forum on Choosing Your Meds -- TheBody.com
The HIV antibody test is different from the HIV viral load. A screening test called an Elisa is done first and then is confirmed by a type of assay called the Western Blot. The Western Blot can...http://www.thebody.com/Forums/AIDS/Treatment/Q46152.html
PLOS Pathogens: Broadly Neutralizing Human Anti-HIV Antibody 2G12 Is Effective in Protection against Mucosal SHIV Challenge...
Author Summary An effective HIV vaccine should elicit broadly neutralizing antibodies, i.e. antibodies that neutralize a wide spectrum of different HIVs in vitro. A number of human monoclonal antibodies have been isolated with broad neutralization and shown to protect macaques against vaginal HIV challenge. Protection is generally correlated with neutralization and requires relatively high antibody concentrations that may be difficult to achieve by vaccination. Here, we show that one monoclonal antibody (2G12) is unusually potent in protection relative to its neutralizing ability as hinted at by earlier data. Further studies eliminate an unusual ability of 2G12 to be transported to the vagina (site of infection) as a possible explanation for our observations. Although the precise mechanism is unclear, the studies have important implications for HIV vaccine design in general by suggesting ...http://journals.plos.org/plospathogens/article/comments?id=10.1371/journal.ppat.1000433&imageURI=info:doi/10.1371/journal.ppat.1000433.t001
Maternal Anti-HIV Antibodies May Enhance Transmission
Strong maternal antibodies for HIV could be ineffective for protecting infants from HIV. Maternal Anti-HIV Antibodies Associate with Enhanced Transmission.http://www.medindia.net/news/healthwatch/maternal-anti-hiv-antibodies-may-enhance-transmission-174259-1.htm
"You Bet Your Life": Rodney Richards: Evolution of a Diagnosis - How Testing HIV Antibody Positive Became Equivalent to Having...
If it is indeed the case, as the FDA and manufacturers of HIV antibody tests contend, that the significance of a positive Western Blot (WB) in healthy blood donors (or anyone without symptoms of AIDS) is not known, then what...http://barnesworld.blogs.com/barnes_world/2007/02/rodney_richards.html
The Facts About Rapid HIV Antibody Tests
Rapid HIV tests can produce results in as little as 20 minutes, reducing the anxieties that can often prevent people from returning for their results.https://www.verywell.com/understand-your-hiv-testing-options-49153
4. IMMUNOLOGY. - :: BIOTED
This experiment's aim is to provide students the molecular biology and pathogenesis basics of acquired immunodeficiency syndrome (AIDS).. An HIV test detects HIV infection indirectly using an ELISA test against HIV antibodies in the blood. The test works by taking antibodies from the patient's blood and adding them to a microtiter plate coated with HIV antigen. If HIV antibodies are present in the blood, they will bind to the antigens on the plate. This binding is detected with an enzyme-linked secondary antibody that causes a color change upon addition of substrate. In this experiment, students will perform an ELISA test by coating microtiter plate wells with simulated HIV antigen and then test simulated donor serum for anti-HIV antibodies.. , Kit includes: ...http://bioted.es/4-immunology/?lang=en/
Building Better HIV Antibodies - Redorbit
Caltech biologists create neutralizing antibody that shows increased potency. Using highly potent antibodies isolated from HIV-positive people, researchers have recently begun to identify ways to broadly neutralize the many possible subtypes of HIV. Now, a team led by biologists at the California Institute of Technology (Caltech) has built upon one of these naturally occurring antibodies to create a stronger version they believe is a better candidate for clinical applications.. Current advances in isolating antibodies from HIV-infected individuals have allowed for the discovery of a large number of new, broadly neutralizing anti-HIV antibodies directed against the host receptor (CD4) binding site-a functional site on the surface of the virus that allows for cell entry and infection. Using a technique known as structure-based rational design, the team modified one ...http://www.redorbit.com/news/health/1112410405/building-better-hiv-antibodies/
Powerful HIV-Neutralizing Antibody s Pictures Revealed By Scripps Researchers
Researchers at The Scripps Research Institute have uncovered the surprising details of how a powerful anti-HIV antibody grabs hold of the virus.http://www.medindia.net/news/Powerful-HIV-Neutralizing-Antibodys-Pictures-Revealed-By-Scripps-Researchers-92031-1.htm
Anti-HIV Antibodies May Spur AIDS Vaccine Development | TIME.com
Researchers report a breakthrough in generating powerful antibodies that can neutralize HIV. An HIV infection is really an intensive molecular arms race launched from the minute the virus infects a new host. AIDS progresses not because the body isn't capable of fighting off HIV - it is.http://healthland.time.com/2013/04/04/anti-hiv-antibodies-may-spur-aids-vaccine-development/?iid=tl-article-mostpop2
Anti-Mouse (Murine) Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like antibody for Western Blotting (WB)
Compare & find the top performing anti-Mouse (Murine) Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like antibody for Western Blotting (WB).http://www.antibodies-online.com/negative-regulation-of-transporter-activity-pathway-113/nedd4l-antibody-4328/mouse-wb-314318/
Design of gp41 directed anti-HIV antibodies - G. Clore
Research is focused on studying the events involved in HIV-1 fusion, the development of fusion inhibitors directed against gp41 and the development of monoclona...http://grantome.com/grant/NIH/ZIA-DK029038-07
Structure Cluster - 2F5B: CRYSTAL STRUCTURE OF FAB' FROM THE HIV-1 NEUTRALIZING ANTIBODY 2F5 IN COMPLEX WITH ITS GP41...
2F5B: Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications.http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=2F5B
Remediated Sequence - 2F5B: CRYSTAL STRUCTURE OF FAB' FROM THE HIV-1 NEUTRALIZING ANTIBODY 2F5 IN COMPLEX WITH ITS...
2F5B: Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications.http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=2F5B
Structure Cluster - 1TJI: Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a...
1TJI: Structure and mechanistic analysis of the Anti-Human Immunodeficiency Virus type 1 antibody 2F5 in complex with its gp41 epitopehttp://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1TJI
Sequence Similarity - 1TJH: Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a...
1TJH: Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitopehttp://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1TJH&entity=2&seqid=100
Remediated Sequence - 1TJG: Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a...
1TJG: Structure and mechanistic analysis of the Anti-Human Immunodeficiency Virus Type 1 antibody 2F5 in complex with its gp41 epitopehttp://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=1TJG&bionumber=1
RCSB PDB for 1TJH
1TJH: Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitopehttp://www.rcsb.org/pdb/explore/images.do?structureId=1TJH
RCSB PDB for 1TJH
1TJH: Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitopehttp://www.rcsb.org/pdb/explore/quickPDB.do?structureId=1TJH
Cows produce powerful HIV antibodies | Science News
For the first time in any animal, researchers elicit broadly neutralizing antibodies against HIV. Cows' antibodies could help with drug development.https://www.sciencenews.org/article/cows-produce-powerful-hiv-antibodies?mode=topic&context=133
Scientists identify broad and potent HIV antibodies that mimic CD4 binding
In a finding that may be good news for scientists developing HIV vaccines and therapies, a team of researchers at The Rockefeller University and the Howard Hughes Medical Institute have found a way to investigate the broadly ...https://medicalxpress.com/news/2011-07-scientists-broad-potent-hiv-antibodies.html
Monkeys Suppress HIV-Like Virus for Extended Period After Dual-Antibody Treatment - TheBodyPRO.com
Giving monkeys two powerful anti-HIV antibodies immediately after infection with an HIV-like virus enabled the immune systems of some of the animals to ...http://www.thebodypro.com/content/79543/monkeys-suppress-hiv-like-virus-for-extended-perio.html?ic=wnhp