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*  Global Histone Deacetylase Inhibitors Industry 2016 Market Research Report : ReportsnReports
The Global Histone Deacetylase Inhibitors Industry 2016 Market Research Report... ... 152 Pages Report] Check for Discount on Global Histone Deacetylase Inhibitors Industry 2016 Market Research Report report by ... Global Histone Deacetylase Inhibitors Industry 2016 Market Research Report Table of Contents 1 Industry Overview of Histone ... 1.3 Applications of Histone Deacetylase Inhibitors 1.4 Industry Chain Structure of Histone Deacetylase Inhibitors 1.5 Industry ...
http://www.reportsnreports.com/reports/590469-global-histone-deacetylase-inhibitors-industry-2016-market-research-report.html
*  Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils
However, TSA did not increase the acetylation of a non-histone target NF-κB p65. c-jun-N-terminal kinase and caspases 3 and 6 ... Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils. Kankaanranta, Hannu; Janka-Junttila, ... Apoptosis in malignant cells is induced by histone deacetylase (HDAC) inhibitors, whereas HDAC inhibitors do not usually induce ... TSA reduced eosinophil and neutrophil nuclear HDAC activities by ~50-60%, suggesting a non-histone target. ...
http://tampub.uta.fi/handle/10024/66272
*  Expression analysis of histone acetyltransferases in rice under drought stress. - Agriculture and Agri-Food Canada (AAFC)
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) maintain the homeostasis of histone acetylation. Studies in ... Expression analysis of histone acetyltransferases in rice under drought stress.. Fang, H., Liu, X., Thorn, R.G., Duan, J., and ... The significant increase in the transcript levels of OsHATs and the acetylation level of lysine residues on Histone H3 and H4 ... Histone acetylation is one of the vital reversible modifications of chromatin structure that regulates gene expression in ...
http://www.agr.gc.ca/eng/abstract/publication?id=35910000000605
*  Changed Histone Acetylation Patterns in Normal-Appearing White Matter and Early Multiple Sclerosis Lesions | Journal of...
Acetylation of histone H3 results from the balance between the activity of histone acetyltransferases (HATs) and histone ... Histone H3 acetylation in the frontal cortex of MS and normal brains. A, Immunocytochemical analysis of histone H3 acetylation ... High levels of acetylation of histone H3 were found in oligodendrocytes within the PPWM, whereas reduced histone H3 acetylation ... In this study, we analyzed the equilibrium between histone acetylation, mediated by HATs, and histone deacetylation, mediated ...
http://www.jneurosci.org/content/31/9/3435.long
*  Transcriptional Regulation of Endothelial Arginase 2 by Histone Deacetylase 2 | Arteriosclerosis, Thrombosis, and Vascular...
Transcriptional Regulation of Endothelial Arginase 2 by Histone Deacetylase 2. Deepesh Pandey, Gautam Sikka, Yehudit Bergman, ... The goal of the current study is to determine the role of specific histone deacetylases (HDACs) in the regulation of ... Transcriptional Regulation of Endothelial Arginase 2 by Histone Deacetylase 2. Deepesh Pandey, Gautam Sikka, Yehudit Bergman, ... Transcriptional Regulation of Endothelial Arginase 2 by Histone Deacetylase 2. Deepesh Pandey, Gautam Sikka, Yehudit Bergman, ...
http://atvb.ahajournals.org/content/early/2014/05/15/ATVBAHA.114.303685
*  The Role of NAD+ Dependent Histone Deacetylases (sirtuins) in Ageing | BenthamScience
Histone deacetylases (HDACs) are enzymes that are able to deacetylate lysine side chains in histones and certain non-histone ... Abstract: Histone deacetylases (HDACs) are enzymes that are able to deacetylate lysine side chains in histones and certain non- ... The Role of NAD+ Dependent Histone Deacetylases (sirtuins) in Ageing. Author(s): Johannes Trapp. Affiliation: ... Three classes of histone deacetylases have been recognized in humans. Class I and II are zinc-dependent amidohydrolases and ...
http://www.eurekaselect.com/58149/article
*  Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance
Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas. Histopathology. 2009;54:688-98 ... Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell ... Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma. Expert Opin Ther Targets. 2010;14 ... Targeting histone deacetyalses in the treatment of B- and T-cell malignancies. Invest New Drugs. 2010;28(Suppl 1):S58-78 ...
http://www.medsci.org/v11p0994.htm
*  Histone modification, gene regulation and epigenetic memory in embryonic stem cells - eTheses Repository
In order to explore this, the histone deacetylase inhibitor valproic acid (VPA) was used to induce hyperacetylation of histones ... Histone modifications are thought to act as a layer of epigenetic information, because of their strong association with gene ... However, although specific histone modifications correlate with transcriptional status, whether they play a causative role or ... It was concluded that histone acetylation plays an important role in transcription but additional signals are required for ...
http://etheses.bham.ac.uk/3160/
*  Conformationally rigid histone deacetylase inhibitors correct DF508-CFTR protein function - DTU Orbit
Conformationally rigid histone deacetylase inhibitors correct DF508-CFTR protein function. Publication: Research - peer-review ... Histone deacetylase (HDAC) inhibitors have shown partial efficacy toward correcting cystic fibrosis transmembrane conductance ...
http://orbit.dtu.dk/en/publications/conformationally-rigid-histone-deacetylase-inhibitors-correct-df508cftr-protein-function
*  Dynamic histone marks in the hippocampus and cortex facilitate memory consolidation - Zurich Open Repository and Archive
Gräff, Johannes; Woldemichael, Bisrat T; Berchtold, Dominik; Dewarrat, Grégoire; Mansuy, Isabelle M (2012). Dynamic histone ... These histone PTMs are further associated with the expression of the immediate early gene zif268, a transcription factor that ... These histone PTMs are further associated with the expression of the immediate early gene zif268, a transcription factor that ... When these histone PTMs are increased in vivo by transgenic intervention or intense training, they facilitate memory ...
http://www.zora.uzh.ch/id/eprint/74039/
*  Epigenetic Regulation of Vascular Smooth Muscle Cell Proliferation and Neointima Formation by Histone Deacetylase Inhibition |...
Epigenetic Regulation of Vascular Smooth Muscle Cell Proliferation and Neointima Formation by Histone Deacetylase Inhibition. ... Methods and Results-In the present study, we investigated the role of histone deacetylase (HDAC) inhibition in SMC ... Epigenetic Regulation of Vascular Smooth Muscle Cell Proliferation and Neointima Formation by Histone Deacetylase Inhibition ... There is accumulating evidence that histone acetylation constitutes a major epigenetic modification for the transcriptional ...
http://atvb.ahajournals.org/content/early/2011/01/13/ATVBAHA.110.221952
*  Finding combinatorial histone code by semi-supervised biclustering | BMC Genomics | Full Text
Combinatorial histone modifications identified by tandem mass spectrometry. Histone modifications within a single histone tail ... Asterisk, histone states shared by all three cell types and cover at least 1% of the enhancers. B) Histone mark occurrence ... Histone marks of each state is indicated at the bottom of the histogram. Each column represents a histone state with the filled ... With m histone modifications there is an m × m similarity matrix C representing the correlations among the set of histone ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-301
*  Contribution of non-histone proteins to chromatin structure and stability
... dc.contributor.advisor. Flaus, Andrew. ... Isotope labeled recombinant histone H2AX was also used in quantitative mass spectrometry to determine in vivo abundance.. en_IE ... Histones are responsible for packaging the genomes of almost all eukaryotes into fundamental repeating nucleosome units. The ... They behave aberrantly in histone complex formation, possibly due to extended H2A and H4 tails, but can be assembled into ...
https://aran.library.nuigalway.ie/handle/10379/5543?show=full
*  Histone Methyltransferase (Inhibitors Agonists Modulators Antagonists)-MedChemExpress.com
Methylation on histones H3K4, H3K36 and H3K79 is generally associated with gene activation, whereas methylation on histones ... Crucial to PRC2 activity, the histone methyltransferase enhancer of zeste homolog 2 (EZH2) tri-methylates lysine 27 of histone ... Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC50 of 0.6 μM for SU(VAR)3-9. It ... EPZ-5676 is a potent and selective aminonucleoside inhibitor of DOT1L histone methyltransferase with Ki of < 80 pM, ...
http://update.medchemexpress.com/Targets/Histone%20Methyltransferase.html
*  RCPA - Histone Ab
Histone antibodies are of limited value in distinguishing between SLE and drug-induced lupus. Although present in 100% of ...
https://www.rcpa.edu.au/Library/Practising-Pathology/RCPA-Manual/Items/Pathology-Tests/H/Histone-Ab
*  RCSB PDB - Gene View - HDAC4 - histone deacetylase 4
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
http://www.rcsb.org/pdb/gene/HDAC4?chromosome=chr2&range=240033408&v=hg19
*  Histone H3-K9 methyltransferase, plant (IPR025794) | InterPro | EMBL-EBI
In general, members of this family methylate 'Lys-9' of histone H3. It also methylates 'Lys-27' of histone H3 [PMID: 15546353] ... Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3.. EMBO J. 23 4286-96 2004 ... Histone H3-K9 methyltransferase, plant (IPR025794). Short name: Hist-Lys_N-MeTrfase_plant ... Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis.. EMBO J. 24 1418-29 2005 ...
https://www.ebi.ac.uk/interpro/entry/IPR025794
*  Histone H2A - Agaricus bisporus (White button mushroom)
DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and ... Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. ... IPR009072. Histone-fold. IPR002119. Histone_H2A. IPR007125. Histone_H2A/H2B/H3. IPR032454. Histone_H2A_C. IPR032458. Histone_ ... IPR009072. Histone-fold. IPR002119. Histone_H2A. IPR007125. Histone_H2A/H2B/H3. IPR032454. Histone_H2A_C. IPR032458. Histone_ ...
http://www.uniprot.org/uniprot/Q9HGX4
*  Histone Deacetylase Inhibitors and Anticancer Therapy: Ingenta Connect
Alterations in histone acetylation may lead to changes in chromatin structure and transcriptional dysregulation of genes that ... First clinical studies have shown that histone hyperacetylation can be achieved safely in humans and that treatment of cancer ... Recent reports have shown that pharmacological manipulation of chromatin remodeling by histone deacetylase (HDAC) inhibitors, ...
https://www.ingentaconnect.com/content/ben/cmcaca/2002/00000002/00000004/art00003
*  BigH1 -- The key histone for male fertility
The role of histone H1 in male infertility. ... more about:. »Drosophila »Drosophila melanogaster »IRB »fertility »germ »male ... have identified the histone BigH1 as a key protein in stem cell differentiation to male sex cells. Histones are basic proteins ... All animals have histones that are specific to the germ line. In Drosophila, BigH1 is expressed in the male and female germ ... BigH1 -- The key histone for male fertility. 14.12.2017. Researchers in the Chromatin Structure and Function Lab at the ...
https://www.innovations-report.com/html/reports/life-sciences/bigh1-the-key-histone-for-male-fertility.html
*  Regulation of Immune Responses by Histone Deacetylase Inhibitors
C. Monneret, "Histone deacetylase inhibitors," European Journal of Medicinal Chemistry, vol. 40, no. 1, pp. 1-13, 2005. View at ... E. F. de Zoeten, L. Wang, K. Butler et al., "Histone deacetylase 6 and heat shock protein 90 control the functions of FOXP3+ T- ... B. A. Garcia, S. A. Busby, J. Shabanowitz, D. F. Hunt, and N. Mishra, "Resetting the epigenetic histone code in the MRL-lpr/lpr ... I. M. Chung, M. Y. Kim, W. H. Park, and H. I. Moon, "Histone deacetylase inhibitors from the rhizomes of Zingiber zerumbet," ...
https://www.hindawi.com/journals/isrn/2012/690901/ref/
*  Anti-Histone H2A antibody (ab93460) | Abcam
Rabbit polyclonal Histone H2A antibody validated for WB, IHC, Flow Cyt and tested in Human. Immunogen corresponding to ... DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and ... All lanes : Anti-Histone H2A antibody (ab93460) at 1/1000 dilution. Lane 1 : A2058. Lane 2 : A375. Lane 3 : K562. Lane 4 : HeLa ... Anti-Histone H2A antibody (ab93460) at 1/100 dilution + K562 cell line lysates at 35 µg. Predicted band size: 14 kDa. ...
https://www.abcam.com/histone-h2a-antibody-ab93460.html
*  Cocaine Addiction and Histone Methylation | Science Signaling
Maze et al. observed that histone lysine methylation in the nucleus accumbens plays a critical role in mediating the regulation ... Cocaine suppression of histone methylation in the nucleus accumbens mediates the drug's ability to enhance reward. ... Cocaine suppression of histone methylation in the nucleus accumbens mediates the drug's ability to enhance reward. ... Chronic cocaine was linked to overall reductions in dimethylation of lysine 9 of histone 3 (H3K9) in this brain region. ...
https://stke.sciencemag.org/content/3/104/ec12
*  Promoter Region-Specific Histone ... preview & related info | Mendeley
... and histone chaperones. Specific regulation of histone incorporation/evictio... ... Regulation of chromatin in eukaryotic transcription requires histone-modifying enzymes, nucleosome remodeling complexes, ... and histone chaperones. Specific regulation of histone incorporation/eviction by histone chaperones on the promoter (e.g., ... Promoter Region-Specific Histone Incorporation by the Novel Histone Chaperone ANP32B and DNA-Binding Factor KLF5. *Munemasa Y ...
https://www.mendeley.com/research-papers/promoter-regionspecific-histone-incorporation-novel-histone-chaperone-anp32b-dnabinding-factor-klf5/