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*  Structural and Histone Binding Ability Characterizations of Human PWWP Domains
While Tudor, chromodomain and MBT domains have long been known to bind methylated histones, PWWP was shown to exhibit histone ... Both the canonical β-barrel core and the insertion motif are directly involved in histone binding. The PWWP domain has been ... Conclusions PWWP proteins constitute a new family of methyl lysine histone binders. The PWWP domain consists of three motifs: a ... Our fluorescence polarization binding studies show that PWWP domains have weak histone binding ability, which is also confirmed ...
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018919
*  Connecting the histone acetyltransferase complex SAS-I to the centromere in S. cerevisiae
The essential histone H3 variant Cse4 plays a crucial role at the centromere in S. cerevisiae, where it replaces histone H3 in ... two histone chaperones that assemble histones H3 and H4 into nucleosomes. Our findings further suggest a role of Cac1 ... We found in our study that the histone H3 variant was able to interact over its unique N-Terminus with two subunits of the ... An important question resulted from our studies: is Sas2 able to acetylate the histone H3 variant Cse4 ? We have circumstantial ...
https://edoc.hu-berlin.de/handle/18452/15787
*  Changed Histone Acetylation Patterns in Normal-Appearing White Matter and Early Multiple Sclerosis Lesions | Journal of...
Acetylation of histone H3 results from the balance between the activity of histone acetyltransferases (HATs) and histone ... Histone H3 acetylation in the frontal cortex of MS and normal brains. A, Immunocytochemical analysis of histone H3 acetylation ... High levels of acetylation of histone H3 were found in oligodendrocytes within the PPWM, whereas reduced histone H3 acetylation ... In this study, we analyzed the equilibrium between histone acetylation, mediated by HATs, and histone deacetylation, mediated ...
http://www.jneurosci.org/content/31/9/3435.long
*  Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance
Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas. Histopathology. 2009;54:688-98 ... Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell ... Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma. Expert Opin Ther Targets. 2010;14 ... Targeting histone deacetyalses in the treatment of B- and T-cell malignancies. Invest New Drugs. 2010;28(Suppl 1):S58-78 ...
http://www.medsci.org/v11p0994.htm
*  Histone Methyltransferase (Inhibitors Agonists Modulators Antagonists)-MedChemExpress.com
Methylation on histones H3K4, H3K36 and H3K79 is generally associated with gene activation, whereas methylation on histones ... Crucial to PRC2 activity, the histone methyltransferase enhancer of zeste homolog 2 (EZH2) tri-methylates lysine 27 of histone ... Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC50 of 0.6 μM for SU(VAR)3-9. It ... EPZ-5676 is a potent and selective aminonucleoside inhibitor of DOT1L histone methyltransferase with Ki of < 80 pM, ...
http://update.medchemexpress.com/Targets/Histone%20Methyltransferase.html
*  METHOD OF SUPPRESSING GENE TRANSCRIPTION THROUGH HISTONE LYSINE METHYLATION - Patent application
DNA Cloning, Protein Purification, and Histone Methyltransferase Assay [0156] Full-length histone H3 DNA from Chlorella NC64A ... 0009] In non-limiting embodiments, the chromatin histone protein is the histone 3 protein (H3). In a specific non-limiting ... 6a-6f show effects of vSET histone H3-K27 methylation on transcription repression. a, Optimization of concentration of histone ... 0098] In one embodiment, the lysine methyltransferase may be administered with a histone demethylase inhibitor. The histone ...
http://www.patentsencyclopedia.com/app/20160137989
*  YEUNGNAM UNIVERSITY: dbHiMo: a web-based epigenomics platform for histone-modifying enzymes
dbHiMo: a web-based epigenomics platform for histone-modifying enzymes. Author(s). 전준현; 최재영[최재영]; 김기태[김기태]; 허아람[허아람]; 권서문[권서문] ... dbHiMo: a web-based epigenomics platform for histone-modifying enzymes. Title. ... covalent modifications such as acetylation and methylation of lysine residues on core histones emerged as a major mechanism in ... aimed at facilitating functional and comparative analysis of histone-modifying enzymes (HMEs). HMEs were identified by applying ...
http://ir.yu.ac.kr/handle/YU.REPOSITORY/31973
*  Archaeal histone elisa and antibody
Recombinant Protein and Archaeal histone Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are ... Archaeal histone A. Archaeal histone A ELISA Kit. Archaeal histone A Recombinant. Archaeal histone A Antibody. Also known as ... Archaeal histone A1. Archaeal histone A1 ELISA Kit. Archaeal histone A1 Recombinant. Archaeal histone A1 Antibody. Binds and ... Archaeal histone A2. Archaeal histone A2 ELISA Kit. Archaeal histone A2 Recombinant. Archaeal histone A2 Antibody. Binds and ...
https://www.mybiosource.com/protein_family.php?root=archaeal-histone
*  Histone Modification Associated with Initiation of DNA Replication | Center for Cancer Research - National Cancer Institute
DNA replication and packaging of DNA into chromosomes by histone proteins need to be coordinated by the cell to ensure proper ... Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per ... DNA replication and packaging of DNA into chromosomes by histone proteins need to be coordinated by the cell to ensure proper ... B) Blue peaks designate areas in which histone H3 methylation on lysine 79 was detected, as shown by the schematic cartoon ...
https://ccr.cancer.gov/news/inthejournals/MLH_H3K79Me2
*  Treatment with the histone deacetylase inhibitor Panobinostat markedly reduces chronic inflammation in HIV-infected patients
... ... Histone deacetylase inhibitors (HDACi) exert potent anti-inflammatory effects. We hypothesized that the HDACi Panobinostat ... Histone deacetylase inhibitors (HDACi) exert potent anti-inflammatory effects. We hypothesized that the HDACi Panobinostat ...
http://natap.org/2014/IAC/IAC_77.htm
*  Histone Variant Regulates DNA Repair via Chromatin Condensation | Center for Cancer Research - National Cancer Institute
Numerous alterations have been associated with DSBs, including modifications of histone tails and exchange of histone variants ... They found that dimethylation of histone H3 lysine 9 (H3K9me2) was also enriched following nuclease- and laser-induced DSBs and ... The researchers identified the repressive histone variant macroH2A1 as one of the top-five HR promoting candidates. The ... the researchers used a cell line expressing a photoactivatable green fluorescent protein fused to histone H2B. Immediately ...
https://ccr.cancer.gov/news/inthejournals/itj_khurana
*  Histone Peptide Arrays </b> <...
Histone peptide arrays are essential screening tools to evaluate the specificity and cross-reactivity of antibodies against ... histones H2A, H2B, H3, H4, and their post-translational modifications.The arrays are designed on PVDF membranes for a simple ... AbSurance™ Histone. Antibody Specificity Arrays. Learn More about AbSurance™ Histone Antibody Specificity Arrays. Start ... NEW! AbSurance™ Pro Histone Peptide Microarray. Within chromatin, the accessible regions of histones represent substrates for ...
http://www.merckmillipore.com/FI/en/life-science-research/genomic-analysis/Epigenetics-and-Nuclear-Function/Histone-Peptide-Arrays/2AWb.qB.RKsAAAFOgu81lTAG,nav
*  The Role of NAD+ Dependent Histone Deacetylases (sirtuins) in Ageing | BenthamScience
Histone deacetylases (HDACs) are enzymes that are able to deacetylate lysine side chains in histones and certain non-histone ... Abstract: Histone deacetylases (HDACs) are enzymes that are able to deacetylate lysine side chains in histones and certain non- ... The Role of NAD+ Dependent Histone Deacetylases (sirtuins) in Ageing. Author(s): Johannes Trapp. Affiliation: ... Three classes of histone deacetylases have been recognized in humans. Class I and II are zinc-dependent amidohydrolases and ...
http://www.eurekaselect.com/58149/article
*  Acetylation of histone H4 is aberrantly increased in th | Open-i
Acetylation of histone H4 is aberrantly increased in the central kinetochore domain in mcl1 and swi7 mutants.(A) ChIP-on-chip ... We determined the acetylation status of histone H4 across the entire genome (Figure S4A). Acetylation of histone H4 was found ... We determined the acetylation status of histone H4 across the entire genome (Figure S4A). Acetylation of histone H4 was found ... Mentions: The acetylation of N-terminal tails of histone H3 and H4 is maintained at a lower level in the central core region ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2376062_pone.0002221.g005&req=4
*  Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair | JCB
histone deacetylase. IR. ionizing radiation. KO. knockout. NuRD. nucleosome remodeling and histone deacetylation. PHD. plant ... Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for ... Histone acetyltransferases, histone deacetylases (HDACs), and the acetylation reader proteins that bind acetylated marks have ... Histone demethylase KDM5B is a key regulator of genome stability. Proc. Natl. Acad. Sci. USA. 111:7096-7101. doi:10.1073/pnas. ...
http://jcb.rupress.org/content/216/7/1959
*  Histone H3 (T11) Antibody 中国教育装备采购网
P-Histone H3 (T3) Antibody. Rabbit. H,M,R. WB IHC ELISA. 25/50/100/200ug. ... Histone H3 (T11) Antibody. Rabbit. H,M,R. WB IHC ELISA. 25/50/100/200ug. ... Histone H3 (T22) Antibody. Rabbit. H,M,R. WB IHC ELISA. 25/50/100/200ug. ... P-Histone H3.1 (S10) Antibody. Rabbit. H,M. WB IHC ELISA. 25/50/100/200ug. ...
http://www.caigou.com.cn/product/201412121409.shtml
*  Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers - Chemical Science (RSC Publishing)...
Neuronal histone acetylation assays. Measurements of increases in neuronal histone acetylation in mouse forebrain primary ... Cells were fixed with formaldehyde, stained with antibodies to acetyl-histone H3, lysine 9 (AcH3K9), or acetyl-histone H4, ... Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers†. F. F. Wagner a, Y.-L. Zhang a, D. M ... While these histone acetylation increases are indicative of HDAC inhibition, it is not clear whether these changes are driven ...
http://pubs.rsc.org/En/content/articlehtml/2015/sc/c4sc02130d
*  Functional Analysis of Hif1 Histone Chaperone in Saccharomyces cerevisiae | G3: Genes | Genomes | Genetics
2015 Dissecting the Molecular Roles of Histone Chaperones in Histone Acetylation by Type B Histone Acetyltransferases (HAT-B). ... Hif1 interacts With histones H3/H4 via acidic region of TPR2. Hif1 has been shown to bind with histones H3/H4 in vitro (Ai and ... Histone over-expression analysis. A: Effect of histone over-expression in hif1Δ, hat1Δ, hat2Δ and lsm1Δ mutant strains. Note: ... 2012 Histone chaperones link histone nuclear import and chromatin assembly. Biochim. Biophys. Acta 1819: 277-289. doi:10.1016/j ...
http://www.g3journal.org/content/8/6/1993
*  "HISTONE POSTTRANSLATIONAL MODIFICATIONS AND GENE EXPRESSION IN SACCHAR" by Abhijit Shukla
Among the major modifications known so far, histone H3 acetylation at lysines 9 and 14 (H3K9/14), monoubiquitination of histone ... Here in this study, I have shown that Ubp8p, a histone deubiquitinase, is a bona fide subunit of SAGA (Spt3-Ada-Gcn5 ... Evidently a COMPASS subunit, Cps35p, is necessary for the trans-tail cross talk between histones H2B and H3. Finally, this ... Given the role of histone acetylation, ubiquitination and methylation in many human diseases, the results from this study is of ...
https://opensiuc.lib.siu.edu/dissertations/113/
*  The MLL1 Histone Methyltransferease is Essential for Development of Photoreceptor Function | IOVS | ARVO Journals
The MLL1 Histone Methyltransferease is Essential for Development of Photoreceptor Function Diana Brightman; Ray Suzuki; Shiming ... The MLL1 Histone Methyltransferease is Essential for Development of Photoreceptor Function You will receive an email whenever ... Members of the MLL family of histone H3K4 methyltransferases are expressed in mouse photoreceptors. The most prominent of these ... Diana Brightman, Ray Suzuki, Shiming Chen; The MLL1 Histone Methyltransferease is Essential for Development of Photoreceptor ...
https://iovs.arvojournals.org/article.aspx?articleid=2147327
*  Anti-Histone H3 Antibody | Rabbit anti-Human Polyclonal Biotin | LSBio
Histone H3 antibody LS-C526714 is a biotin-conjugated rabbit polyclonal antibody to Histone H3 from human and chicken. ... Histone H3 antibody LS-C526714 is a biotin-conjugated rabbit polyclonal antibody to Histone H3 from human and chicken. ... Histone H3 antibody LS-C526714 is a biotin-conjugated rabbit polyclonal antibody to Histone H3 from human and chicken. ... Histone H3 antibody was raised against kLH-conjugated, synthetic peptide corresponding to amino acids 1-12 acids (ART(dimethyl- ...
https://www.lsbio.com/antibodies/histone-h3-antibody-biotin-icc-ip-wb-western-ls-c526714/540275
*  The Drosophila G9a gene encodes a multi-catalytic histone methyltransferase required for normal development.
Mammalian G9a is a histone H3 Lys-9 (H3-K9) methyltransferase localized in euchromatin and acts as a co-regulator for specific ... We show that dG9a shares the structural organization of mammalian G9a, and that it is a multi-catalytic histone ... The Drosophila G9a gene encodes a multi-catalytic histone methyltransferase required for normal development.. Stabell, Marianne ... Histone-Lysine N-Methyltransferase/analysis/genetics/*physiology, Mice, Molecular Sequence Data, Recombinant Proteins/isolation ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:156703
*  "JMJC Domain-Containing Histone Demethylase 2 (Jhd2): Bridging the Gap " by Kayla Marie Harmeyer
Jhd2 is a homologue of the human JARID1 family of histone demethylases, which has four members: JARID1A, B, C and D. JARID1B is ... Therefore studying how these H3K4 histone demethylases function will give great insight into how JARID1 family members are ... The enzyme Jhd2 is a histone demethylase that functions to remove H3K4 methylation in S. cerevisiae. ... Gene expression has been shown to be regulated through epigenetic modifications to the N-terminal tail of histones. Among these ...
https://docs.lib.purdue.edu/open_access_dissertations/1056/
*  Plus it
Understanding the Histone DNA Repair Code: H4K20me2 Makes Its Mark. Karissa L. Paquin and Niall G. Howlett ... Understanding the Histone DNA Repair Code: H4K20me2 Makes Its Mark Message Subject (Your Name) has forwarded a page to you from ... One particularly important histone posttranslational modification process is methylation. Here, we focus on the regulation and ... In recent years, the impact of histone posttranslational modification on the DNA damage response has become increasingly well ...
http://mcr.aacrjournals.org/content/16/9/1335
*  Histone modification, gene regulation and epigenetic memory in embryonic stem cells - eTheses Repository
In order to explore this, the histone deacetylase inhibitor valproic acid (VPA) was used to induce hyperacetylation of histones ... Histone modifications are thought to act as a layer of epigenetic information, because of their strong association with gene ... However, although specific histone modifications correlate with transcriptional status, whether they play a causative role or ... It was concluded that histone acetylation plays an important role in transcription but additional signals are required for ...
http://etheses.bham.ac.uk/3160/