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*  The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation
... Fajas, Lluis; Egler, Viviane ... PPARgamma and RB were shown to coimmunoprecipitate, and this PPARgamma-RB complex also contains the histone deacetylase HDAC3, ...
https://infoscience.epfl.ch/record/135337
*  Global Histone Deacetylase Inhibitors Industry 2016 Market Research Report : ReportsnReports
The Global Histone Deacetylase Inhibitors Industry 2016 Market Research Report... ... 152 Pages Report] Check for Discount on Global Histone Deacetylase Inhibitors Industry 2016 Market Research Report report by ... Global Histone Deacetylase Inhibitors Industry 2016 Market Research Report Table of Contents 1 Industry Overview of Histone ... 1.3 Applications of Histone Deacetylase Inhibitors 1.4 Industry Chain Structure of Histone Deacetylase Inhibitors 1.5 Industry ...
http://www.reportsnreports.com/reports/590469-global-histone-deacetylase-inhibitors-industry-2016-market-research-report.html
*  The Role of NAD+ Dependent Histone Deacetylases (sirtuins) in Ageing | BenthamScience
Histone deacetylases (HDACs) are enzymes that are able to deacetylate lysine side chains in histones and certain non-histone ... Abstract: Histone deacetylases (HDACs) are enzymes that are able to deacetylate lysine side chains in histones and certain non- ... The Role of NAD+ Dependent Histone Deacetylases (sirtuins) in Ageing. Author(s): Johannes Trapp. Affiliation: ... Three classes of histone deacetylases have been recognized in humans. Class I and II are zinc-dependent amidohydrolases and ...
http://www.eurekaselect.com/58149/article
*  Histone H2B monoubiquitination is required to reach maximal transcript levels of circadian clock genes in Arabidopsis
Arabidopsis, IN-SITU HYBRIDIZATION, transcriptional elongation, histone H3K4 trimethylation, histone H2B monoubiquitination, ... histone H3K4 trimethylation,histone H2B monoubiquitination,circadian clock,chromatin,RNA-POLYMERASE-II,FLOWERING-LOCUS-C,SEED ... "Histone H2B Monoubiquitination Is Required to Reach Maximal Transcript Levels of Circadian Clock Genes in Arabidopsis." Plant ... "Histone H2B Monoubiquitination Is Required to Reach Maximal Transcript Levels of Circadian Clock Genes in Arabidopsis." PLANT ...
https://biblio.ugent.be/publication/3062551
*  Histone Methyltransferase (Inhibitors Agonists Modulators Antagonists)-MedChemExpress.com
Methylation on histones H3K4, H3K36 and H3K79 is generally associated with gene activation, whereas methylation on histones ... Crucial to PRC2 activity, the histone methyltransferase enhancer of zeste homolog 2 (EZH2) tri-methylates lysine 27 of histone ... Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC50 of 0.6 μM for SU(VAR)3-9. It ... EPZ-5676 is a potent and selective aminonucleoside inhibitor of DOT1L histone methyltransferase with Ki of < 80 pM, ...
http://update.medchemexpress.com/Targets/Histone%20Methyltransferase.html
*  Histone Demethylase (Inhibitors Agonists Modulators Antagonists)-MedChemExpress.com
Histone demethylases not only target methylated sites on histone tails but also interact with methylated sites on non-histone ... KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM. ... JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50s of 230, 340, 855, 445, 435, 1100, and 290 nM for ... Histone lysine demethylases (KDMs) are of interest as drug targets due to their regulatory roles in chromatin organization and ...
http://update.medchemexpress.com/Targets/Histone%20Demethylase.html
*  METHOD OF SUPPRESSING GENE TRANSCRIPTION THROUGH HISTONE LYSINE METHYLATION - Patent application
DNA Cloning, Protein Purification, and Histone Methyltransferase Assay [0156] Full-length histone H3 DNA from Chlorella NC64A ... 0009] In non-limiting embodiments, the chromatin histone protein is the histone 3 protein (H3). In a specific non-limiting ... 6a-6f show effects of vSET histone H3-K27 methylation on transcription repression. a, Optimization of concentration of histone ... 0098] In one embodiment, the lysine methyltransferase may be administered with a histone demethylase inhibitor. The histone ...
http://www.patentsencyclopedia.com/app/20160137989
*  YEUNGNAM UNIVERSITY: dbHiMo: a web-based epigenomics platform for histone-modifying enzymes
dbHiMo: a web-based epigenomics platform for histone-modifying enzymes. Author(s). 전준현; 최재영[최재영]; 김기태[김기태]; 허아람[허아람]; 권서문[권서문] ... dbHiMo: a web-based epigenomics platform for histone-modifying enzymes. Title. ... covalent modifications such as acetylation and methylation of lysine residues on core histones emerged as a major mechanism in ... aimed at facilitating functional and comparative analysis of histone-modifying enzymes (HMEs). HMEs were identified by applying ...
http://ir.yu.ac.kr/handle/YU.REPOSITORY/31973
*  Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral...
Loss of function of Ezh2 removes the repressive mark of trimethylated histone H3 at lysine 27 (H3K27me3) in cortical progenitor ... We found that the histone methyltransferase of polycomb repressive complex 2 (PCR2), enhancer of Zeste homolog 2 (Ezh2), is ... Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral ... Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral ...
https://www.kennedy.ox.ac.uk/publications/482776
*  Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC...
Histone deacetylases are important targets for cancer therapeutics, but their regulation is poorly understood. Our data show ... Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC ...
http://www.mesothelioma-line.com/2015/05/18/loss-of-the-deubiquitylase-bap1-alters-class-i-histone-deacetylase-expression-and-sensitivity-of-mesothelioma-cells-to-hdac-inhibitors/
*  北京大学医学部机构知识库(IR@PKUHSC): Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase
Histone acetylation plays an important role in chromatin remodeling and gene expression. The molecular mechanisms involved in ... Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase[J]. JOURNAL OF BIOLOGICAL ... Gan, YH,et al."Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase".JOURNAL OF ... Gan, YH.,Shen, YH.,Wang, J.,Wang, XW.,Utama, B.,...&Wang, XL.(2005).Role of histone deacetylation in cell-specific expression ...
http://ir.bjmu.edu.cn/handle/400002259/59728
*  Plus it
... and they do not affect acetylation of histone H3. However, histone monoubiquitylation regulates methylation of histone H3 at ... Does histone monoubiquitylation induce transcriptional changes? (5) Does histone monoubiquitylation affect other histone ... Acetylation of histone H3 at lysines 9 and 14 (AcH3) and methylation of histone H3 at lysine 4 (methyl H3K4) are known to be ... uH2A affects methylation of histone H3 at lysine 9, whereas uH2B affects methylation of histone H3 at lysine 4. It would be ...
http://www.jneurosci.org/content/28/15/3947
*  Discovery of the first histone deacetylase 6/8 dual inhibitors. | Broad Institute
Antineoplastic Agents, HeLa Cells, Histone Deacetylase Inhibitors, Histone Deacetylases, Humans, Hydroxamic Acids, Molecular ... We disclose the first small molecule histone deacetylase (HDAC) inhibitor (3, BRD73954) capable of potently and selectively ...
https://www.broadinstitute.org/publications/broad5039
*  histone modification - oi
Epigenetic regulators and histone modification A novel, enigmatic histone modification: biotinylation of histones by ... Uncoupling histone turnover from transcription-associated histone H3 modifications Dietary Components Impact Histone ... HISTONE H3 MODIFICATIONS IN RAT HEPATIC STELLATE CELLS BY ETHANOL Alterations of histone modifications and transgene silencing ... Dynamic and distinct histone modifications of osteogenic genes during osteogenic differentiation Emerging roles for histone ...
http://oxfordindex.oup.com/view/10.1093/oi/authority.20110803095938637
*  Plus it
KDM4/JMJD2 proteins are demethylases that target histone H3 on lysines 9 and 36 and histone H1.4 on lysine 26. This protein ... KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells. William L. Berry and Ralf Janknecht ... KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells Message Subject (Your Name) has forwarded a page to you ... Changes in histone lysine methylation status have been observed during cancer formation, which is thought to be a consequence ...
http://cancerres.aacrjournals.org/content/early/2013/05/03/0008-5472.CAN-12-4300
*  THE AMINO ACID COMPOSITION AND SOME PROPERTIES OF HISTONES | JGP
In the fowl, histones are found in the somatic chromosomes and protamines are found in the sperm chromosomes. This shows that ... Some of the properties and the amino acid compositions of the histones of calf thymus, calf liver, fowl erythrocytes, and of a ... THE AMINO ACID COMPOSITION AND SOME PROPERTIES OF HISTONES. Marie M. Daly, A. E. Mirsky, Hans Ris ... The amino acid compositions of the histones were rather similar except that no methionine was found in the fowl erythrocyte ...
http://jgp.rupress.org/content/34/4/439
*  Starch nanoparticles for delivery of the histone deacetylase inhibitor | IJN
... such as histone deacetylase inhibitors, is often diminished by poor aqueous solubility resulting in limited bioavailability and ... a histone deacetylase inhibitor in preclinical development for hard-to-treat breast cancers, which improves its bioavailability ... The findings suggest that encapsulation of CG-1521 into starch nanoparticles can improve drug delivery of histone deacetylase ... Starch nanoparticles for delivery of the histone deacetylase inhibitor CG-1521 in breast cancer treatment Esma Alp,1-4 Fehmi ...
https://www.dovepress.com/starch-nanoparticles-for-delivery-of-the-histone-deacetylase-inhibitor-peer-reviewed-article-IJN
*  Frontiers | Histone Ubiquitination and Deubiquitination in Transcription, DNA Damage Response, and Cancer | Oncology
Among them, histone ubiquitination has been discovered for more than three decades. However, its functions are still less well ... Among them, histone ubiquitination has been discovered for more than three decades. However, its functions are still less well ... In particular, we will focus on how they are regulated by histone ubiquitin ligases and deubiquitinating enzymes. We will then ... In particular, we will focus on how they are regulated by histone ubiquitin ligases and deubiquitinating enzymes. We will then ...
https://www.frontiersin.org/articles/10.3389/fonc.2012.00026/full
*  A Global View of DNA-Packing Proteins Cracks the Histone Code
Why might histone tails exhibit so many modifications if they form only two independent categories? It's possible that histone- ... These tasks are mediated in part by chemical modifications to histone proteins most commonly to histone tails, long, ... these results suggest that histone modifications are facilitators rather than activators and that the histone code is more a ... Histones package DNA into repetitive coils, which not only provide genomic structure but also help regulate gene expression. ...
http://www.rxpgnews.com/research/biotechnology/printer_2196.shtml
*  Histone modifications and prospects for an epigenetic code | HSTalks
Bryan Turner on Histone modifications and prospects for an epigenetic code, part of a collection of online lectures. ... Histone modifications and prospects for an epigenetic code. This talk will give an overview of the wide range of histone ... Histone modifications and prospects for an epigenetic code. *Prof. Bryan Turner - University of Birmingham Medical School, UK ... histone modifications may constitute a heritable epigenetic code that acts in concert with the genetic code as a long-term ...
https://hstalks.com/t/116/histone-modifications-and-prospects-for-an-epigene/?biosci
*  India Histone Deacetylase 2 Market Research Report 2018 : ReportsnReports
The global Histone Deacetylase 2 market is valued at XX... ... 113 Pages Report] Check for Discount on India Histone ... 1 Histone Deacetylase 2 Overview. 1.1 Product Overview and Scope of Histone Deacetylase 2. 1.2 Classification of Histone ... 1.2.1 India Histone Deacetylase 2 Sales (K Pcs) Comparison by Type (2013-2025). 1.2.2 India Histone Deacetylase 2 Sales (K Pcs ... 2.4.1 India Histone Deacetylase 2 Market Concentration Rate. 2.4.2 India Histone Deacetylase 2 Market Share of Top 3 and Top 5 ...
https://www.reportsnreports.com/reports/1481778-india-histone-deacetylase-2-market-research-report-2018.html
*  Histone acetyltransferase-dependent chromatin remodeling and the vascular clock
... Domenii publicaţii > Ştiinţe medicale + Tipuri ... In addition, a rhythm in core histone H3 acetylation on the mPer1 promoter in vivo correlates with the cyclical expression of ... Here we show the transcriptional coactivators and histone acetyltransferases, p300/CBP, PCAF, and ACTR associate with the bHLH- ...
http://ad-astra.ro/2006/05/22/histone-acetyltransferase-dependent-chromatin-remodeling-and-the-vascular-clock/
*  Histone lysine-crotonylation in acute kidney injury | Disease Models & Mechanisms
Histone lysine-crotonylation was observed in tubular cells from healthy murine and human kidney tissue. Kidney tissue histone ... We hypothesized that histone crotonylation may modulate kidney injury. Histone crotonylation was studied in cultured murine ... Post-translational histone modifications modulate gene expression and kidney injury. Histone crotonylation is a recently ... Histone lysine-crotonylation in acute kidney injury. Olga Ruiz-Andres, Maria Dolores Sanchez-Niño, Pablo Cannata-Ortiz, Marta ...
http://dmm.biologists.org/content/early/2016/04/26/dmm.024455