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*  Finding epigenetic signature appears to predict inflammation risk in serious type of IBD
Histone Methylation. Histones are proteins found in the nucleus of cells. They bind with our DNA and help regulate cell ... Methylation of histones is one process by which epigenetic programs can turn genes on or off. The researchers found several ... A substantial portion of the genes exhibited levels of histone methylation associated with the severity of inflammation in IBD. ... Further analysis of cells showed that changes to histone methylation affected genes involved in immune regulation, metabolism, ...
https://www.news-medical.net/news/20180920/Finding-epigenetic-signature-appears-to-predict-inflammation-risk-in-serious-type-of-IBD.aspx
*  New system accelerates discovery of chemical compounds that inhibit enzyme implicated in cancers
NSD2 modifies histones, the proteins around which DNA is wound. For technical reasons, scientists ordinarily would study this ... Tags: Acute Lymphoblastic Leukemia, Biochemistry, Biotechnology, Compound, DNA, Enzyme, Histones, Laboratory, Leukemia, ... But NSD2 works on only whole nucleosomes: units of histone protein in combination with DNA. ... developed laboratory tests involving whole nucleosomes that could be used to see whether NSD2 was able to modify histone ...
https://www.news-medical.net/news/20180906/New-system-accelerates-discovery-of-chemical-compounds-that-inhibit-enzyme-implicated-in-cancers.aspx
*  The ketogenic diet could delay the effects of aging
This blocked the effects of an enzyme histone deacetylases, or HDACs.. HDACs work normally by inhibiting the actions of two ...
https://www.news-medical.net/news/20180202/The-ketogenic-diet-could-delay-the-effects-of-aging.aspx
*  Applications of Genome-Wide RNAi
Histone deacetylase (HDAC) inhibitors are one such class of drugs. These drugs have anticancer effects targeting tumor and non- ...
https://www.news-medical.net/life-sciences/Genome-Wide-RNAi.aspx
*  Eukaryotic and Prokaryotic Cells: Similarities and Differences
Prokaryotic DNA is circular and is neither associated with histones nor organized into chromosomes. A prokaryotic cell is ... Eukaryotic DNA is linear and complexed with packaging proteins called 'histones,' before organization into a number of ...
https://www.news-medical.net/life-sciences/Eukaryotic-and-Prokaryotic-Cells-Similarities-and-Differences.aspx
*  Epigenetics and Epigenomics
In histone modification, proteins attach chemical tags to histones, the proteins DNA is tightly wrapped around in order to ... Once the histones are marked with these tags, they are detected by other proteins, which can influence whether a DNA region ... There are at least three processes that are known to begin and sustain epigenetic modification, namely histone modification, ... DNA methylation marks the DNA directly, while histone modification marks it indirectly. In DNA methylation, methyl groups are ...
https://www.news-medical.net/life-sciences/Epigenetics-and-Epigenomics.aspx
*  Researchers track effects of epigenetic marks carried by sperm chromosomes
The particular histone mark removed in these experiments is a widely studied epigenetic mark found in animals ranging from ... In their experiments with C. elegans, researchers in Susan Strome's lab at UC Santa Cruz have focused on histone marks, ... There is debate over how much histone packaging is retained in humans, but we know it is retained in some developmentally ... With removal of the histone marks, the sperm chromosomes lost a repressive signal that normally keeps certain genes from being ...
https://www.news-medical.net/news/20190320/Researchers-track-effects-of-epigenetic-marks-carried-by-sperm-chromosomes.aspx
*  Machine Learning in Genetics
Histone modification, chromatin accessibility, and transcription factor binding along the genome can provide information ...
https://www.news-medical.net/life-sciences/Machine-Learning-in-Genetics.aspx
*  Researchers discover protein responsible for X chromosome inactivation
Tags: Cell, Chromatin, Chromosome, DNA, Embryonic Development, Gene, Gene Expression, Genes, Histones, Hospital, Inherit, ... the chromosomal structure consisting of DNA wrapped around proteins called histones - may play a role in those diseases.' ...
https://www.news-medical.net/news/20180607/Researchers-discover-protein-responsible-for-X-chromosome-inactivation.aspx
*  Potential oocyte-specific factors that can drive somatic cell reprogramming
They sort these factors into maternal histones and their chaperones, histone deacetylases and acetyltransferases, histone ... Tags: Biotechnology, Cell, Chaperones, Cloning, DNA, DNA Methylation, Histones, Induced Pluripotent Stem Cells, Medicine, ...
https://www.news-medical.net/news/20180704/Potential-oocyte-specific-factors-that-can-drive-somatic-cell-reprogramming.aspx
*  Antibodies in Flow Cytometry
... histones, lysosomes, and cytokines have been produced over the years. ...
https://www.news-medical.net/life-sciences/Antibodies-in-Flow-Cytometry.aspx
*  Study identifies RNA molecules that regulate male hormones in prostate cancer
We can't yet say whether the presence of these lncRNAs is a cause or effect of the abundance of certain activating histones and ... The same sites were also found to contain concentrations of certain histones, a family of basic proteins that modulate the ... Histones, Hormone, Immunoprecipitation, Junk DNA, Light, Machine Learning, Microarray, Nucleotides, Nucleus, Proliferation, ...
https://www.news-medical.net/news/20180719/Study-identifies-RNA-molecules-that-regulate-male-hormones-in-prostate-cancer.aspx
*  ChIP-Sequencing Analysis: Applications
Analyses of histone modifications have provided insights on how the genome is organized and the functional domains across the ...
https://www.news-medical.net/life-sciences/ChIP-Sequencing-Analysis-Applications-.aspx
*  ChIP-Seq Analysis: Histone Modifications
Histones undergo a wide range of post-translational modifications. These mainly occur in the amino-terminal tail of the histone ... Histones. Histones are small, simple proteins, usually occurring in the cell nucleus, that organize strands of DNA into ... Histone modification provides an epigenetic mechanism that enables a range of essential healthy and disease-related processes ... Histone post-translational modifications affect many chromatin-based reactions and those that influence gene expression are ...
https://www.news-medical.net/life-sciences/ChIP-Seq-Analysis-Histone-Modifications.aspx
*  DNA Methylation News, Research - Page 2
Histone Modification. *What is Methylation-Specific PCR?. *LUminometric Methylation Assay (LUMA) Pros and Cons ...
https://www.news-medical.net/?tag=/DNA-Methylation&page=2
*  Immunofluorescence Methods for IHC
Studying Histone H3 Methyltransferase and Demethylase Functions. Studying the Dynamics and Function of Microtubules to ...
https://www.news-medical.net/whitepaper/20190213/Immunofluorescence-Methods-for-IHC.aspx
*  DNA News, Research
DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person's body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA ...
https://www.news-medical.net/?tag=/DNA&
*  Inhibitors and Promoters for Actin Polymerisation Research
Highly Specific Rabbit Monoclonal Antibodies for Histone Modification Experiments * NeuN Antibodies: Fundamental Tools for ... High Quality, Purified Inhibitors to Study the Function of Histone H3 Methyltransferase and Demethylase ...
https://www.news-medical.net/whitepaper/20190205/Inhibitors-and-Promoters-for-Actin-Polymerisation-Research.aspx
*  Novel Use of Extracellular Vesicles in the Search for Biomarkers Webinars
Regulation of Bivalent Domains by Histone Modifications Webinar. Life Science Webinars by Subject Matter. *Alzheimer's Disease ...
https://www.news-medical.net/webinar/Novel-Use-of-Extracellular-Vesicles-in-the-Search-for-Biomarkers-Webinars