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*  Histone Demethylase KDM1/LSD1 Inhibitor Assay Kit |Abcam
Histone Demethylase KDM1/LSD1 Inhibitor Assay Kit Epigenetic Kits datasheet (ab113456). Abcam offers quality products including ... Histone Demethylase (H3K4) Activity Quantification Assay Kit (ab113455) *Histone Demethylase KDM1/LSD1 Activity Quantification ... KMD1/LSD1 (Lysine Specific Histone Demethylase 1) is a histone demethylase that only acts on mono- or di-methylated lysines. ... Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator ...
http://www.abcam.com/histone-demethylase-kdm1lsd1-inhibitor-assay-kit-ab113456.html
*  The Histone Demethylase Activity of Rph1 is Not Essential for Its Role in the Transcriptional Response to Nutrient Signaling
... ... Both proteins also contain JmjC histone demethylase domains, but only Rph1 is known to be an active enzyme, demethylating ... lysine 36 of histone H3. We have studied to what extent the demethylase activity of Rph1 contributes to its role in nutrient ... Consistent with this, we find that the Rph1 mutation and a deletion of the histone H3 methylase Set2 affect the same target ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:738510
*  Histone Demethylase (Inhibitors Agonists Modulators Antagonists)-MedChemExpress.com
Histone demethylases not only target methylated sites on histone tails but also interact with methylated sites on non-histone ... KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM. ... JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50s of 230, 340, 855, 445, 435, 1100, and 290 nM for ... Histone lysine demethylases (KDMs) are of interest as drug targets due to their regulatory roles in chromatin organization and ...
http://update.medchemexpress.com/Targets/Histone%20Demethylase.html
*  Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells ...
... and α-ketoglutarate-dependent histone demethylases. Here, we investigated whether inhibition of histone demethylase JMJD1A by ... Taken together, our results suggest that histone demethylases could be targets of environmental carcinogens and their ... and α-ketoglutarate-dependent histone demethylases. Here, we investigated whether inhibition of... ... Previously, we reported that both hypoxia and nickel (an environmental carcinogen) increased global histone H3 lysine 9 ...
http://oxfordindex.oup.com/view/10.1093/carcin/bgq197
*  The JmjC domain-containing L3K4 histone demethylase jumonji AT-rich interactive domains 1B - Synthesis and Structure-activity...
The JmjC domain-containing L3K4 histone demethylase jumonji AT-rich interactive domains 1B. The JmjC domain-containing L3K4 ... histone demethylase jumonji AT-rich interactive domains 1B (JARID1C) (also known as KDM5C and PLU1) is overexpressed in breast ... In addition to its demethylase function, JARID1C can type a complicated with HDAC4 (13) and LSD1/NuRD (14) to mediate ...
http://www.conferencedequebec.org/2018/01/08/the-jmjc-domain-containing-l3k4-histone-demethylase-jumonji-at-rich-interactive-domains-1b/
*  "Histone demethylase KDM2B regulates lineage commitment in normal and m" by Jaclyn Andricovich, Yan Kai et al.
Andricovich, J., Kai, Y., Peng, W., Foudi, A., & Tzatsos, A. (2016). Histone demethylase KDM2B regulates lineage commitment in ... Jumonji Domain-Containing Histone Demethylases; Lymphoma; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins p21(ras) ...
https://hsrc.himmelfarb.gwu.edu/smhs_anatregbio_facpubs/119/
*  Gentaur Molecular :EIAab \ CLIA kit Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6,Histone arginine demethylase...
Histone arginine demethylase JMJD6,JmjC domain-containing protein 6,Jmjd6,Jumonji domain-containing protein 6,Lysyl-hydroxylase ... CLIA kit Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, ... Product name : CLIA kit Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6,Histone arginine demethylase JMJD6,JmjC ... Index / EIAab / CLIA kit Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6,Histone arginine demethylase JMJD6,JmjC ...
http://www.antibody-antibodies.com/product2765591-search-CLIA_kit__Bifunctional_arginine_demethylase_and_lysyl_hydroxylase_JMJD6,Histone_arginine_demethylase_JMJD6,JmjC_domain_containing_protein_6,Jmjd6,Jumonji_domain_containing_protein_6,Lysyl_hydroxylase_.html
*  Kdm5c - Lysine-specific demethylase 5C - Mus musculus (Mouse) - Kdm5c gene & protein
... of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36 ... Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive ... Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does ... "Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.". DiTacchio L., Le H.D., Vollmers ...
http://www.uniprot.org/uniprot/P41230
*  Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Research Products: Novus Biologicals
Browse our Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B product catalog backed by our Guarantee+. ... specific Demethylase 5B/KDM5B/JARID1B products available through Novus Biologicals. ... As histone demethylases, JARID 1 proteins function as transcriptional repressors. JARID1B expression is largely restricted to ... Histone Methylation. Cell Cycle. Cell Proliferation. Chromatin Remodeling. Cellular Senescence. Histone Modification. Cell ...
https://www.novusbio.com/common-name/lysine-
*  Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? - Oxford...
Until recently, histone methylation was considered to be irreversible, but the identification of histone demethylase enzymes ... One JmjC-domain-containing protein in budding yeast, Jhd1, has recently been identified as being a histone demethylase that ... Here, we identify a second JmjC-domain-containing histone demethylase, Rph1, which can specifically demethylate H3K36 tri- and ... In the budding yeast Saccharomyces cerevisiae, histone lysine methylation occurs on histone H3 lysines 4, 36, and 79, and its ...
https://www.neuroscience.ox.ac.uk/publications/99808
*  Probable lysine-specific demethylase elisa and antibody
Recombinant Protein and Probable lysine-specific demethylase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and ... Lysine-specific histone demethylase JMJ14) (Protein JUMONJI 14).. Encodes a histone H3K4 demethylase repressing floral ... Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a ... Probable histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a ...
https://www.mybiosource.com/protein_family.php?root=probable-lysine-specific-demethylase
*  Targeting Histone Demethylases in Cancer Therapy | Clinical Cancer Research
... histone demethylase; HDMI, histone demethylase inhibitor; HMT, histone methyltransferase; HMTI, histone methyltransferase ... histone demethylases, as well as histone methyltransferases and histone acetyltransferases, among numerous others. In addition ... A novel oligoamine analog inhibitor of histone demethylases blocks colon tumor cell growth in association with histone ... Targeting Histone Demethylases in Cancer Therapy Message Subject (Your Name) has forwarded a page to you from Clinical Cancer ...
http://clincancerres.aacrjournals.org/content/15/23/7111
*  Targeting Histone Demethylases in Cancer Therapy | Clinical Cancer Research
A novel oligoamine analog inhibitor of histone demethylases blocks colon tumor cell growth in association with histone ... Targeting Histone Demethylases in Cancer Therapy Message Subject (Your Name) has forwarded a page to you from Clinical Cancer ... It also markedly potentiates the activity of hypomethylating agents in vitro and in vivo, suggesting that histone demethylase ...
http://clincancerres.aacrjournals.org/content/early/2009/11/17/1078-0432.CCR-09-2399
*  KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells | Cancer Research
KDM4/JMJD2 proteins are demethylases that target histone H3 on lysines 9 and 36 and histone H1.4 on lysine 26. This protein ... KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells. William L. Berry and Ralf Janknecht ... KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells Message Subject (Your Name) has forwarded a page to you ... which is thought to be a consequence of the dysregulation of histone lysine methyltransferases or the opposing demethylases. ...
http://cancerres.aacrjournals.org/content/early/2013/05/03/0008-5472.CAN-12-4300
*  The emerging roles for histone demethylases in the modulation of signaling pathways : BioMolecular Concepts
The emerging roles for histone demethylases in the modulation of signaling pathways by Di Stefano, Luisa and Dyson, Nicholas J. ... Here, we summarize the different families and subfamilies of histone demethylases and the insights into the biological roles of ... Since their discovery in 2004, histone demethylases have emerged as key regulators of chromatin. Recent studies have started to ... The emerging roles for histone demethylases in the modulation of signaling pathways ...
https://www.degruyter.com/view/j/bmc.2013.4.issue-1/bmc-2012-0031/bmc-2012-0031.xml
*  The Histone Demethylase KDM5 Is Essential for Larval Growth in Drosophila | Genetics
2016 The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities ... The KDM5 family of transcriptional regulators are histone H3 lysine 4 demethylases that can function through both demethylase- ... 2014 Histone demethylase KDM5B is a key regulator of genome stability. Proc. Natl. Acad. Sci. USA 111: 7096-7101. doi:10.1073/ ... 2014 Histone demethylase RBP2 is critical for breast cancer progression and metastasis. Cell Rep. 6: 868-877. doi:10.1016/j. ...
http://www.genetics.org/content/209/3/773
*  SP2509 | Histone Demethylase inhibitor | Read Reviews & Product Use Citations
SP2509 is a selective histone demethylase LSD1 inhibitor with IC50 of 13 nM, showing no activity against MAO-A, MAO-B, lactate ... SP2509 is a selective histone demethylase LSD1 inhibitor with IC50 of 13 nM, showing no activity against MAO-A, MAO-B, lactate ... dimethyl K4 peptide corresponding to the first 21 amino acids of the N-terminal tail of histone H3, and 10-acetyl-3,7- ...
http://www.selleckchem.com/products/sp2509.html
*  JIB-04 | Histone Demethylase inhibitor | Read Reviews & Product Use Citations
JIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for ... JIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for ... In two separate xenograft mouse models (H358 or A549), JIB-04 diminishes tumor growth, lowers Jumonji histone demethylase ... Jumonji demethylase/prolyl hydroxylase/LSD1 activity assays:. Active JMJD2E aa 1-350 is purified from E.coli and used in vitro ...
http://www.selleckchem.com/products/jib-04.html
*  Histone Demethylases and Their Roles in Cancer Epigenetics | Abstract
... such as DNA methylation and aberrant histone modif.. ... Histone Demethylases and Their Roles in Cancer Epigenetics. The ... The discovery of histone demethylases has provided us new insight for understanding the epigenetic landscape of the chromatin ... This review aims to summarize the current knowledge on the human histone lysine demethylases and their functions in cancers, ... and recent advances in development of small molecule inhibitors to target histone demethylases in cancer treatment. ...
http://www.alliedacademies.org/abstract/histone-demethylases-and-their-roles-in-cancer-epigenetics-5355.html
*  Histone demethylase Jmjd3 is required for the development of subsets of retinal bipolar cells | PNAS
2008) The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment. PLoS ONE 3(8):e3034. ... Histone demethylase Jmjd3 is required for the development of subsets of retinal bipolar cells. Atsumi Iida, Toshiro Iwagawa, ... 2007) The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 130 ... 2007) UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 449(7163):731-734. ...
http://www.pnas.org/content/111/10/3751
*  Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate | Science
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate ... Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate ... Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate ... Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate ...
http://science.sciencemag.org/content/363/6432/1217.full
*  The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species | Science
Ge et al. show that in the red-eared slider turtle, an epigenetic modifier, the histone demethylase KDM6B, binds to the ... The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species ... The histone demethylase KDM6B regulates temperature-dependent sex determination in a turtle species ... In this study, we show that the histone H3 lysine 27 (H3K27) demethylase KDM6B exhibits temperature-dependent sexually ...
http://science.sciencemag.org/content/360/6389/645
*  JHD2 - Histone demethylase JHD2 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) - JHD2 gene & protein
... of histone H3, thereby playing a central role in histone code. Demethylates trimethylated H3 'Lys-4'. ... Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Demethylates ... histone demethylase activity (H3-K4 specific) Source: SGD ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay ... histone demethylase activity (H3-monomethyl-K4 specific) Source: SGD ,p>Inferred from Mutant Phenotype,/p> ,p>Describes ...
http://www.uniprot.org/uniprot/P47156