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*  The Role of NAD+ Dependent Histone Deacetylases (sirtuins) in Ageing | BenthamScience
Histone deacetylases (HDACs) are enzymes that are able to deacetylate lysine side chains in histones and certain non-histone ... Histone deacetylases (HDACs) are enzymes that are able to deacetylate lysine side chains in histones and certain non-histone ... Due to the homology to the yeast histone deacetylase Sir2p the NAD+-dependent deacetylases are also termed sirtuins and seven ... Due to the homology to the yeast histone deacetylase Sir2p the NAD+-dependent deacetylases are also termed sirtuins and seven ...
http://www.eurekaselect.com/58149/article
*  Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance
Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas. Histopathology. 2009;54:688-98 ... Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell ... Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma. Expert Opin Ther Targets. 2010;14 ... Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer--overexpression of HDAC2 and HDAC3 is ...
http://www.medsci.org/v11p0994.htm
*  Valproic acid, a histone deacetylase inhibitor, enhances radiosensitivity in esophageal squamous cell carcinoma
... *Authors: * ... Histone deacetylase (HDAC) inhibitors have been shown to enhance radiation response in various cancer cell lines. Valproic acid ... a histone deacetylase inhibitor, enhances radiosensitivity in esophageal squamous cell carcinoma. International Journal of ... a histone deacetylase inhibitor, enhances radiosensitivity in esophageal squamous cell carcinoma'. International Journal of ...
https://www.spandidos-publications.com/ijo/40/6/2140
*  Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10...
In contrast, histone deacetylation mediated by histone deacetylases (HDACs) leads to an inactive chromatin and gene repression ... Histone H3 (D1H2) mAb (4499), histone H4 (Lys8) polyclonal Ab (2592), acetyl-histone H3 (Lys9) polyclonal Ab (9671), and acetyl ... The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nat. Immunol. 10: 92-100. ... Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression. Curr. Opin. Genet. Dev. 13 ...
http://www.jimmunol.org/content/186/7/3986.long
*  The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo.
Histone deacetylase (HDAC) inhibitors represent a promising class of antineoplastic agents which affect tumour growth, ... 0/Histone Deacetylase Inhibitors; 99-66-1/Valproic Acid From MEDLINE®/PubMed®, a database of the U.S. National Library of ... Histone Deacetylase Inhibitors / pharmacology*. Humans. Kidney Neoplasms / pathology*. Mice. Valproic Acid / pharmacology*. ... Histone deacetylase (HDAC) inhibitors represent a promising class of antineoplastic agents which affect tumour growth, ...
http://www.biomedsearch.com/nih/Histone-deacetylase-inhibitor-valproic-acid/18657224.html
*  Depletion of histone deacetylase 3 antagonizes PI3K-mediated overgrowth of Drosophila organs through the acetylation of histone...
Depletion of histone deacetylase 3 antagonizes PI3K-mediated overgrowth of Drosophila organs through the acetylation of histone ... Depletion of histone deacetylase 3 antagonizes PI3K-mediated overgrowth of Drosophila organs through the acetylation of histone ... Depletion of histone deacetylase 3 antagonizes PI3K-mediated overgrowth of Drosophila organs through the acetylation of histone ... Depletion of histone deacetylase 3 antagonizes PI3K-mediated overgrowth of Drosophila organs through the acetylation of histone ...
http://jcs.biologists.org/content/125/22/5369
*  "Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer " by Xiaoxin S. Xu, Le Wang et al.
In this work we investigated the role of histone deacetylases (HDACs) in XPC gene silencing and bladder cancer development. The ... Xu et al.: Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer. Journal of Hematology & Oncology 2011 4:17. ... In this work we investigated the role of histone deacetylases (HDACs) in XPC gene silencing and bladder cancer development. The ...
https://digitalcommons.wayne.edu/biomedcentral/70/
*  北京大学医学部机构知识库(IR@PKUHSC): Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in...
histone deacetylase inhibitor ; gastric cancer ; anticancer drugs ; chemosensitivity ; apoptosis ; cell cycle ; genes ... Recently, a histone deacetylase inhibitor, trichostatin A (TSA), was proven to be a chemo-sensitizer on human erythroleukemia ... Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines[ ... Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines ...
http://ir.bjmu.edu.cn/handle/400002259/55982
*  Histone modification, gene regulation and epigenetic memory in embryonic stem cells - eTheses Repository
In order to explore this, the histone deacetylase inhibitor valproic acid (VPA) was used to induce hyperacetylation of histones ... Histone modifications are thought to act as a layer of epigenetic information, because of their strong association with gene ... However, although specific histone modifications correlate with transcriptional status, whether they play a causative role or ... It was concluded that histone acetylation plays an important role in transcription but additional signals are required for ...
http://etheses.bham.ac.uk/3160/
*  Histone deacetylase - Wikipedia
Histone acetyltransferase (HAT) Histone deacetylase inhibitor Histone methyltransferase (HMT) Histone-modifying enzymes RNA ... the histone deacetylases form an ancient protein superfamily known as the histone deacetylase superfamily. HDACs, are ... Histone deacetylases remove those acetyl groups, increasing the positive charge of histone tails and encouraging high-affinity ... These are just some examples of constantly emerging non-histone, non-chromatin roles for HDACs. Histone deacetylase inhibitors ...
https://en.wikipedia.org/wiki/Histone_deacetylase
*  Histone deacetylase inhibitor - Wikipedia
Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylase. HDIs ... Based on their homology of accessory domains to yeast histone deacetylases, the 18 currently known human histone deacetylases ... Histone deacetylase inhibition induces the accumulation of hyperacetylated nucleosome core histones in most regions of ... "Histone deacetylases: unique players in shaping the epigenetic histone code". Annals of the New York Academy of Sciences. 983: ...
https://en.wikipedia.org/wiki/Histone_deacetylase_inhibitor
*  Histone Deacetylases (HDAC) Inhibitors Market, Players, trends and forecast 2016 - 2026
Enzymes such as histone acetyltransferases (HATs), histone methyltransferases (HMTs), histone deacetylases (HDACs) and histone ... Histone Deacetylases (HDAC) Inhibitors Market, Players, trends and forecast 2016 - 2026. News provided by ... It presents an overview of the popularity of the keywords histone deacetylase inhibitor and HDAC inhibitor on Twitter and ... HATs and HDACs are the two major enzyme classes involved in post-translational modification of N-terminal tail of the histone ...
https://www.prnewswire.com/news-releases/histone-deacetylases-hdac-inhibitors-market-players-trends-and-forecast-2016---2026-300324247.html
*  Targeting Histone Deacetylases: A Novel Approach in Parkinson's Disease
Transcriptional regulation by histone acetyltransferase and histone deacetylases. HAT: histone acetyltransferase, HDAC: histone ... Histones H2A, H2B, H3, and H4 are known as the core histones, while histones H1 and H5 are known as the linker histones [5]. ... 2. Mechanism of Histone Acetylation. Histone acetylation is a chromatin modification that modulates histone-DNA interactions ... Histone deacetylases (HDACs) along with histone acetyltransferases (HATs) are the enzymes that regulate the homeostasis of ...
https://www.hindawi.com/journals/pd/2015/303294/
*  Targeting Histone Deacetylases: A Novel Approach in Parkinson's Disease
... Sorabh Sharma and Rajeev Taliyan ... The acetylation and deacetylation of histone proteins are carried out by opposing actions of histone acetyltransferases (HATs) ... and histone deacetylases (HDACs), respectively. In the recent past, studies with HDAC inhibitors result in beneficial effects ... actions of HDAC inhibitors involve transcriptional activation of neuronal survival genes and maintenance of histone acetylation ...
https://www.hindawi.com/journals/pd/2015/303294/abs/
*  RCSB PDB - Gene View - HDAC4 - histone deacetylase 4
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
http://www.rcsb.org/pdb/gene/HDAC4?chromosome=chr2&range=240033408&v=hg19
*  Histone Deacetylase Inhibitors and Anticancer Therapy: Ingenta Connect
Recent reports have shown that pharmacological manipulation of chromatin remodeling by histone deacetylase (HDAC) inhibitors, ... Alterations in histone acetylation may lead to changes in chromatin structure and transcriptional dysregulation of genes that ... First clinical studies have shown that histone hyperacetylation can be achieved safely in humans and that treatment of cancer ...
https://www.ingentaconnect.com/content/ben/cmcaca/2002/00000002/00000004/art00003
*  Histone deacetylases in RA: epigenetics and epiphenomena
... Journal. Arthritis Research & Therapy. Volume , Issue number. 12 , 5 ... Reduced synovial expression of histone deacetylases (HDACs) is proposed to contribute to pathology in rheumatoid arthritis (RA ... by enhancing histone-dependent access of transcription factors to promoters of inflammatory genes. In the previous issue of ...
http://dare.uva.nl/search?metis.record.id=340048
*  'histone deacetylases' Protocols and Video...
... histone deacetylases' include 'Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein- ... Histone Acetylation, and Spindle Morphology in Horse Oocytes', 'Identification of MyoD Interactome Using Tandem Affinity ... Histone Deacetylases: Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of Histones. The ... Class I and class Ii deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class Iii and ...
https://www.jove.com/keyword/histone+deacetylases
*  Dietary Histone Deacetylase Inhibitors (HDAC) - Tabular View - ClinicalTrials.gov
Dietary Histone Deacetylase Inhibitors (HDAC). The safety and scientific validity of this study is the responsibility of the ... Histone Deacetylase (HDAC) Activity. Intervention ICMJE *Dietary Supplement: BSE placebo 2 pills = 0 micromoles of Sulforaphane ... Dietary Histone Deacetylase (HDAC) Inhibitors. Brief Summary This pilot, three-week study will help scientists understand more ... Dietary Histone Deacetylase Inhibitors (HDAC). Official Title ICMJE ...
https://clinicaltrials.gov/ct2/show/record/NCT01543074
*  HDAC4 histone deacetylase 4 [Homo sapiens (human)] - Gene - NCBI
histone deacetylase 4. Names. histone deacetylase A. NP_006028.2. *EC 3.5.1.98 ... HDAC4 histone deacetylase 4 [Homo sapiens] HDAC4 histone deacetylase 4 [Homo sapiens]. Gene ID:9759 ... a Class IIa histone deacetylase. cd10006. Location:649 → 1057. HDAC4; Histone deacetylase 4. ... a Class IIa histone deacetylase. cd10006. Location:654 → 1062. HDAC4; Histone deacetylase 4. ...
https://www.ncbi.nlm.nih.gov/gene/9759
*  Targeting Inflammation in Heart Failure with Histone Deacetylase Inhibitors | SpringerLink
Regulation of lysine acetylation by histone deacetylases. Histone acetyltransferases (HATs) transfer acetyl groups from acetyl- ... Heltweg B, et al. (2004) Subtype selective substrates for histone deacetylases. J. Med. Chem. 47:5235-43.CrossRefGoogle Scholar ... 2004) Histone deacetylase is a target of valproic acid-mediated cellular differentiation. Cancer Res. 64:1079-86.CrossRefGoogle ... Bradner JE, et al. (2010) Chemical phylogenetics of histone deacetylases. Nat. Chem. Biol. 6:238-43.CrossRefGoogle Scholar ...
https://link.springer.com/article/10.2119%2Fmolmed.2011.00022
*  Histone Deacetylases with Antagonistic Roles in Saccharomyces cerevisiae Heterochromatin Formation | Genetics
Rpd3 histone deacetylase complex and is required for histone deacetylase activity. J. Biol. Chem. 275(52): 40961-40966. ... Although historically named histone deacetylases, Sir2 and Rpd3 deacetylate proteins other than histones (Lin et al. 2009; ... 2014 The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast. Mol. Cell ... 1996 The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature 384(6609): 589-591. ...
https://www.genetics.org/node/433325.full.print
*  New Endogenous Regulators of Class I Histone Deacetylases | Science Signaling
Class I histone deacetylases (HDACs) are enzymes that remove acetyl groups from histones and other nuclear proteins, thereby ... New Endogenous Regulators of Class I Histone Deacetylases Message Subject. (Your Name) has forwarded a page to you from Science ... Extracellular stimuli can elicit alterations in gene transcription through regulation of histone deacetylases by sphingosine-1- ... Extracellular stimuli can elicit alterations in gene transcription through regulation of histone deacetylases by sphingosine-1- ...
https://stke.sciencemag.org/content/3/103/pe1
*  Modulation of STAT1-Driven Transcriptional Activity by Histone Deacetylases | SpringerLink
Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE et al (1998) A role for histone deacetylase activity in HDAC1- ... Klampfer L, Huang J, Swaby LA, Augenlicht L (2004) Requirement of histone deacetylase activity for signaling by STAT1. J Biol ... Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN (1997) Histone deacetylases associated with the mSin3 corepressor ... Mounce BC, Mboko WP, Kanack AJ, Tarakanova VL (2014) Primary macrophages rely on histone deacetylase 1 and 2 expression to ...
https://link.springer.com/protocol/10.1007%2F978-1-4939-6527-4_20
*  Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. - PubMed - NCBI
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis.. Vega RB1, Matsuda K, Oh J, Barbosa AC, Yang X, ... Histone deacetylases (HDACs) modulate cell growth and differentiation by governing chromatin structure and repressing the ...
https://www.ncbi.nlm.nih.gov/pubmed/15537544?dopt=Abstract