Clinical Studies of Histone Deacetylase Inhibitors | Clinical Cancer Research  Clinical Studies of Histone Deacetylase Inhibitors | Clinical Cancer Research
Clinical Studies of Histone Deacetylase Inhibitors. H. Miles Prince, Mark J. Bishton and Simon J. Harrison ... Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature 1999;401:188-93. PubMed doi:10.1038/ ... Clinical Studies of Histone Deacetylase Inhibitors Message Subject (Your Name) has forwarded a page to you from Clinical Cancer ... Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst 2000;92:1210- ...
more infohttp://clincancerres.aacrjournals.org/content/15/12/3958.long
Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance  Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance
Among them, histone deacetylase inhibitors are considered to be promising agents [2, 5, 6, 8]. At present, several inhibitors, ... Histone deacetylase inhibitors activate CIITA and MHC class II antigen expression in diffuse large B-cell lymphoma. Immunology ... Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives. Future Med Chem. 2012;4:1439-60 ... A model of sensitivity and resistance to histone deacetylase inhibitors in diffuse large B cell lymphoma: Role of cyclin- ...
more infohttp://www.medsci.org/v11p0994.htm
Histone Deacetylase Inhibitors and Anticancer Therapy: Ingenta Connect  Histone Deacetylase Inhibitors and Anticancer Therapy: Ingenta Connect
Recent reports have shown that pharmacological manipulation of chromatin remodeling by histone deacetylase (HDAC) inhibitors, ... Thus, HDAC inhibitors remains one of the most promising class of new anticancer agents. Further studies are needed in order to ... Alterations in histone acetylation may lead to changes in chromatin structure and transcriptional dysregulation of genes that ... In the class of HDAC inhibitors, now included a short-chain fatty acids, such as 4-phenylbutyrate and valporic acid, hydroxamic ...
more infohttps://www.ingentaconnect.com/content/ben/cmcaca/2002/00000002/00000004/art00003
Regulation of Immune Responses by Histone Deacetylase Inhibitors  Regulation of Immune Responses by Histone Deacetylase Inhibitors
C. Monneret, "Histone deacetylase inhibitors," European Journal of Medicinal Chemistry, vol. 40, no. 1, pp. 1-13, 2005. View at ... I. M. Chung, M. Y. Kim, W. H. Park, and H. I. Moon, "Histone deacetylase inhibitors from the rhizomes of Zingiber zerumbet," ... M. S. Kim, M. W. Son, W. B. Kim, Y. In Park, and A. Moon, "Apicidin, an inhibitor of histone deacetylase, prevents H-ras- ... L. Wang, R. Tao, and W. W. Hancock, "Using histone deacetylase inhibitors to enhance FOXP3+ regulatory T-cell function and ...
more infohttps://www.hindawi.com/journals/isrn/2012/690901/ref/
Dietary Histone Deacetylase Inhibitors (HDAC) - Tabular View - ClinicalTrials.gov  Dietary Histone Deacetylase Inhibitors (HDAC) - Tabular View - ClinicalTrials.gov
Dietary Histone Deacetylase Inhibitors (HDAC). The safety and scientific validity of this study is the responsibility of the ... Dietary Histone Deacetylase (HDAC) Inhibitors. Brief Summary This pilot, three-week study will help scientists understand more ... Dietary Histone Deacetylase Inhibitors (HDAC). Official Title ICMJE ... Histone Deacetylase (HDAC) Activity. Intervention ICMJE *Dietary Supplement: BSE placebo 2 pills = 0 micromoles of Sulforaphane ...
more infohttps://clinicaltrials.gov/ct2/show/record/NCT01543074
Targeting Inflammation in Heart Failure with Histone Deacetylase Inhibitors | SpringerLink  Targeting Inflammation in Heart Failure with Histone Deacetylase Inhibitors | SpringerLink
In this regard, histone deacetylase (HDAC) inhibitors represent a promising new class of compounds with broad-based ... Iyer A, et al. (2010) Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats. Br. J. ... Galli M, et al. (2010) A phase II multiple dose clinical trial of histone deacetylase inhibitor ITF2357 in patients with ... Antos CL, et al. (2003) Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors. J. Biol. Chem. ...
more infohttps://link.springer.com/article/10.2119%2Fmolmed.2011.00022
Histone deacetylases: structural determinants of inhibitor selectivity.  - PubMed - NCBI  Histone deacetylases: structural determinants of inhibitor selectivity. - PubMed - NCBI
Histone deacetylases: structural determinants of inhibitor selectivity.. Micelli C1, Rastelli G2. ... Histone Deacetylase Inhibitors/chemistry. *Histone Deacetylase Inhibitors/metabolism. *Histone Deacetylase Inhibitors/ ... Histone deacetylases (HDACs) are epigenetic targets with an important role in cancer, neurodegeneration, inflammation, and ... Although clinically effective HDAC inhibitors have been developed, the design of inhibitors with the desired isoform(s) ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/25687212?dopt=Abstract
Design and synthesis of a potent histone deacetylase inhibitor.  - PubMed - NCBI  Design and synthesis of a potent histone deacetylase inhibitor. - PubMed - NCBI
Histone deacetylase (HDAC) inhibitors have potential for cancer therapy. An HDAC inhibitor based on a cyclic peptide mimic of ... Design and synthesis of a potent histone deacetylase inhibitor.. Liu T1, Kapustin G, Etzkorn FA. ... The designed inhibitor showed 4-fold selectivity for HDAC1 (57 nM) over HDAC8 (231 nM). ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/17419603
IJMS | Free Full-Text | Histone Deacetylase Inhibitors as Anticancer Drugs  IJMS | Free Full-Text | Histone Deacetylase Inhibitors as Anticancer Drugs
... and histone acetyltransferases (HAT). HDAC inhibitors induce cancer cell cycle arrest, differentiation and cell death, reduce ... HDAC inhibitors, doses, etc. HDAC inhibitors seem to be promising anti-cancer drugs particularly in the combination with other ... Modification of histones by acetylation plays a key role in epigenetic regulation of gene expression and is controlled by the ... Other HDAC inhibitors are in clinical trials for the treatment of hematological and solid malignancies. The results of such ...
more infohttps://www.mdpi.com/1422-0067/18/7/1414
Alfa Aesar Histone Deacetylase Inhibitor II 5mg:Life Sciences  Alfa Aesar Histone Deacetylase Inhibitor II 5mg:Life Sciences
Alfa Aesar Histone Deacetylase Inhibitor II 5mg Life Sciences:Cell Analysis:Cell Based Assays:Signal Transduction Reagents and ...
more infohttps://www.fishersci.com/shop/products/histone-deacetylase-inhibitor-ii-3/AAJ65479LB0
Histone Deacetylases (HDAC) Inhibitors Market, Players, trends and forecast 2016 - 2026  Histone Deacetylases (HDAC) Inhibitors Market, Players, trends and forecast 2016 - 2026
Enzymes such as histone acetyltransferases (HATs), histone methyltransferases (HMTs), histone deacetylases (HDACs) and histone ... It presents an overview of the popularity of the keywords histone deacetylase inhibitor and HDAC inhibitor on Twitter and ... Histone Deacetylases (HDAC) Inhibitors Market, Players, trends and forecast 2016 - 2026. News provided by ... phase III and phase II HDAC inhibitors.. Chapter 8 presents publication analysis of the articles published on HDAC inhibitors ...
more infohttps://www.prnewswire.com/news-releases/histone-deacetylases-hdac-inhibitors-market-players-trends-and-forecast-2016---2026-300324247.html
Dietary Histone Deacetylase Inhibitors for Cancer Prevention | Center for Research on Families  Dietary Histone Deacetylase Inhibitors for Cancer Prevention | Center for Research on Families
Tay Gavin Erickson Lecture Series-Professor Ho's research focuses on understanding the way nutrients and molecular mechanisms affect the initiation and progression of chronic disease states such as cancer. She is currentlyinvestigating the role of antioxidant nutrients such as zinc in maintaining DNA integrity and cancer development. Professor Ho is specifically concerned with the effects of zinc status on DNA damage, DNA repair, and stress-response signal pathways.
more infohttp://www.umass.edu/family/events/dietary-histone-deacetylase-inhibitors-cancer-prevention?type=taygavinarchives
Overview of the Classical Histone Deacetylase Enzymes and Histone Deacetylase Inhibitors  Overview of the Classical Histone Deacetylase Enzymes and Histone Deacetylase Inhibitors
... Katherine Ververis1,2 and Tom C. ... "Enhancement of xenograft tumor radiosensitivity by the histone deacetylase inhibitor MS-275 and correlation with histone ... R. W. Johnstone, "Histone-deacetylase inhibitors: novel drugs for the treatment of cancer," Nature Reviews Drug Discovery, vol ... P. A. Marks, "Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions," Biochimica et ...
more infohttps://www.hindawi.com/journals/isrn/2012/130360/ref/
Clinical Studies of Histone Deacetylase Inhibitors | Clinical Cancer Research  Clinical Studies of Histone Deacetylase Inhibitors | Clinical Cancer Research
Clinical Studies of Histone Deacetylase Inhibitors. H. Miles Prince, Mark J. Bishton and Simon J. Harrison ... Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature 1999;401:188-93. PubMed doi:10.1038/ ... Clinical Studies of Histone Deacetylase Inhibitors Message Subject (Your Name) has forwarded a page to you from Clinical Cancer ... Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst 2000;92:1210- ...
more infohttp://clincancerres.aacrjournals.org/content/15/12/3958
IJMS | Free Full-Text | Histone Deacetylase Inhibitors and Diabetic Kidney Disease  IJMS | Free Full-Text | Histone Deacetylase Inhibitors and Diabetic Kidney Disease
... including study of the histone deacetylase (HDAC) inhibitor class of agents. HDACs are a group of enzymes that remove ... Over the past decade, several HDAC inhibitors have been adopted into clinical practice, primarily for the treatment of ... Here we review the current HDAC inhibitors in the clinic and under development; the literature evidence supporting the ... functional acetyl groups from histone and non-histone proteins and they can affect cellular function through both epigenetic ...
more infohttps://www.mdpi.com/1422-0067/19/9/2630
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation | PNAS  Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation | PNAS
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Victoria M. ... Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation ... Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation ... Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation ...
more infohttps://www.pnas.org/content/97/18/10014?ijkey=bbadc7c1e8d50640bbd58d7345d80f796fa8dcdc&keytype2=tf_ipsecsha
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation | PNAS  Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation | PNAS
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Victoria M. ... Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation ... Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation ... Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation ...
more infohttps://www.pnas.org/content/97/18/10014?ijkey=58aaa81c705c7e533ca51673d666b5e5634b9529&keytype2=tf_ipsecsha
Discovery of the first histone deacetylase 6/8 dual inhibitors. | Broad Institute  Discovery of the first histone deacetylase 6/8 dual inhibitors. | Broad Institute
Antineoplastic Agents, HeLa Cells, Histone Deacetylase Inhibitors, Histone Deacetylases, Humans, Hydroxamic Acids, Molecular ... We disclose the first small molecule histone deacetylase (HDAC) inhibitor (3, BRD73954) capable of potently and selectively ...
more infohttps://www.broadinstitute.org/publications/broad5039
Active Motif » Tubastatin A (HDAC6, Histone Deacetylase Inhibitor)  Active Motif » Tubastatin A (HDAC6, Histone Deacetylase Inhibitor)
Histone Acetyltransferases (HATs) and Histone Deacetylases (HDACs). * Histone Methyltransferases (HMTs) and Histone ... Histone Acetyltransferases (HATs) and Histone Deacetylases (HDACs). *Histone Methyltransferases (HMTs) and Histone Demethylases ... Potent and selective histone deacetylase 6 (HDAC 6) inhibitor (IC50 = 15 nm; >1000-fold selective against other HDACs and 60- ... Application: Histone Acetylation (HAT & HDAC). Chemical Properties. MW = 371.9 C20H21N3O2• HCl. CAS 1310693-92-5. 99% (HPLC); ...
more infohttps://www.activemotif.com/catalog/details/14084/tubastatin-a-hydrochloride
Starch nanoparticles for delivery of the histone deacetylase inhibitor | IJN  Starch nanoparticles for delivery of the histone deacetylase inhibitor | IJN
... such as histone deacetylase inhibitors, is often diminished by poor aqueous solubility resulting in limited bioavailability and ... a histone deacetylase inhibitor in preclinical development for hard-to-treat breast cancers, which improves its bioavailability ... suggest that encapsulation of CG-1521 into starch nanoparticles can improve drug delivery of histone deacetylase inhibitors for ... Starch nanoparticles for delivery of the histone deacetylase inhibitor CG-1521 in breast cancer treatment Esma Alp,1-4 Fehmi ...
more infohttps://www.dovepress.com/starch-nanoparticles-for-delivery-of-the-histone-deacetylase-inhibitor-peer-reviewed-article-IJN
Histone deacetylase inhibitor - Wikipedia  Histone deacetylase inhibitor - Wikipedia
Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylase. HDIs ... "Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation". Proceedings of ... The histone deacetylase inhibitors are a new class of cytostatic agents that inhibit the proliferation of tumor cells in ... "S*BIO's Oral Histone Deacetylase (HDAC) Inhibitor SB939 Shows Tolerability and Safety in Phase 1 Clinical Trial in Patients ...
more infohttps://en.wikipedia.org/wiki/Histone_deacetylase_inhibitor
The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation.  - PubMed - NCBI  The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation. - PubMed - NCBI
The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation.. Karagiannis TC1, El-Osta ... Histone deacetylase inhibitors represent a new class of compounds that can modulate the effects of radiation. Research with ... Intriguingly, a report has also shown that histone deacetylase inhibitors can reduce radiation induced acute and late skin ... Hence, there is an emerging interest in potential use of histone deacetylase inhibitors as radiation sensitizers or protectors ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/16418577?dopt=Abstract
US Patent # 8,168,658. Inhibitors of histone deacetylase - Patents.com  US Patent # 8,168,658. Inhibitors of histone deacetylase - Patents.com
These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and ... inhibitors of MCAK, inhibitors of Kif14, inhibitors of Mphosph1 and inhibitors of Rab6-KIFL. Examples of "histone deacetylase ... Histone Deacetylases and Histone Deacetylase Inhibitors As demonstrated herein, the compounds of the present invention show ... inhibitors of mitotic kinesins, inhibitors of histone deacetylase, inhibitors of kinases involved in mitotic progression, ...
more infohttp://patents.com/us-8168658.html
Abstract 693: Histone deacetylase inhibitors attenuate epirubicin induced p53 expression | Cancer Research  Abstract 693: Histone deacetylase inhibitors attenuate epirubicin induced p53 expression | Cancer Research
Abstract 693: Histone deacetylase inhibitors attenuate epirubicin induced p53 expression. Kenneth T. Thurn, Scott Thomas, ... Abstract 693: Histone deacetylase inhibitors attenuate epirubicin induced p53 expression. Kenneth T. Thurn, Scott Thomas, ... Abstract 693: Histone deacetylase inhibitors attenuate epirubicin induced p53 expression. Kenneth T. Thurn, Scott Thomas, ... Abstract 693: Histone deacetylase inhibitors attenuate epirubicin induced p53 expression Message Subject (Your Name) has ...
more infohttp://cancerres.aacrjournals.org/content/70/8_Supplement/693
Asia-Pacific Histone Deacetylase Inhibitors Market Report 2017 - QY Research  Asia-Pacific Histone Deacetylase Inhibitors Market Report 2017 - QY Research
Research Report on Asia-Pacific Histone Deacetylase Inhibitors Market Report 2017. The Report includes market price, demand, ... Table 4SC AG Histone Deacetylase Inhibitors Basic Information List. Table 4SC AG Histone Deacetylase Inhibitors Sales (MT), ... Figure China Histone Deacetylase Inhibitors Sales Price (USD/Kg) Trend (2012-2017). Table China Histone Deacetylase Inhibitors ... Figure Japan Histone Deacetylase Inhibitors Sales Price (USD/Kg) Trend (2012-2017). Table Japan Histone Deacetylase Inhibitors ...
more infohttps://www.qyresearchreports.com/report/asia-pacific-histone-deacetylase-inhibitors-market-report-2017.htm