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*  Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance
Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma. Expert Opin Ther Targets. 2010;14 ... Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer--overexpression of HDAC2 and HDAC3 is ... Histone deacetylase inhibitors activate CIITA and MHC class II antigen expression in diffuse large B-cell lymphoma. Immunology ... Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas. Histopathology. 2009;54:688-98 ...
http://www.medsci.org/v11p0994.htm
*  Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte AutophagyCLINICAL PERSPECTIVE |...
Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte AutophagyCLINICAL PERSPECTIVE. Min ... Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte AutophagyCLINICAL PERSPECTIVE ... Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte AutophagyCLINICAL PERSPECTIVE ... Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte AutophagyCLINICAL PERSPECTIVE ...
http://circ.ahajournals.org/content/129/10/1139.short?rss=1
*  Histone deacetylase inhibition redistributes topoisomerase IIb from heterochromatin to euchromatin - Northumbria Research Link
Cowell, Ian, Papageorgiou, Nikolaos, Padget, Kay, Watters, Gary and Austin, Caroline (2011) Histone deacetylase inhibition ... While topoIIa appears to be the major target for most topoisomerase poisons, histone deacetylase-mediated potentiation of these ... HP1 proteins are concentrated in pericentric heterochromatin and histone deacetylase inhibitors such as trichostatin A (TSA) ... and it has been previously reported that histone deacetylase inhibitors can sensitise cells to these drugs. ...
http://nrl.northumbria.ac.uk/4040/
*  Histone modification, gene regulation and epigenetic memory in embryonic stem cells - eTheses Repository
In order to explore this, the histone deacetylase inhibitor valproic acid (VPA) was used to induce hyperacetylation of histones ... Histone modifications are thought to act as a layer of epigenetic information, because of their strong association with gene ... However, although specific histone modifications correlate with transcriptional status, whether they play a causative role or ... It was concluded that histone acetylation plays an important role in transcription but additional signals are required for ...
http://etheses.bham.ac.uk/3160/
*  Science and Reason: HDAC drugs for autoimmune diseases
Tags: cancer, autoimmune disease, histone deacetylase enzyme. Labels: autoimmune disease, cancer, gene expression, immune ... Hancock said drugs known as histone deacetylases inhibitors, or HDACs, which affect compounds involved in the growth and death ... because the compound is a histone deacetylase (HDAC) enzyme inhibitor. HDAC enzymes have the effect of turning off genes, so an ... 2 Comments:. Czes Kulvis said... Look: any autoimmune disease is reaction of de-regulated and overactive immune system against ...
http://scienceandreason.blogspot.com/2007/11/hdac-drugs-for-autoimmune-diseases.html
*  New study: NAD dependent protein deacetylase sirtuin 1 - pipeline review, H1 2017 - WhaTech
NAD Dependent Protein Deacetylase Sirtuin 1 (SIR2 Like Protein 1 or Sirtuin Type 1 or Regulatory Protein SIR2 Homolog 1 or ... It modulates chromatin function through deacetylation of histones and can promote alterations in the methylation of histones ... NAD Dependent Protein Deacetylase Sirtuin 1 (SIR2 Like Protein 1 or Sirtuin Type 1 or Regulatory Protein SIR2 Homolog 1 or ... NAD Dependent Protein Deacetylase Sirtuin 1 (SIR2 Like Protein 1 or Sirtuin Type 1 or Regulatory Protein SIR2 Homolog 1 or ...
https://www.whatech.com/market-research/medical/356831-new-study-nad-dependent-protein-deacetylase-sirtuin-1-pipeline-review-h1-2017
*  Preclinical evaluation of the antineoplastic action of 5-aza-2'-deoxycytidine and different histone deacetylase inhibitors on...
... in combination with an inhibitor of histone deacetylase (HDAC). Here, we used a clonogenic assay to evaluate the in vitro ... Epigenetic events, such as promoter hypermethylation and chromatin histone deacetylation, silence the expression of tumor ... These epigenetic changes can be reversed by using 5-aza-2'-deoxycytidine (5AZA-CdR), a potent inhibitor of DNA methylation, ... Jaboin J, Wild J, Hamidi H, Khanna C, Kim CJ, Robey R, Bates SE, Thiele CJ: MS-27-275, an inhibitor of histone deacetylase, has ...
https://cancerci.biomedcentral.com/articles/10.1186/1475-2867-8-16
*  Frontiers | BDNF-induced nitric oxide signals in cultured rat hippocampal neurons: time course, mechanism of generation, and...
Nott, A., Watson, P. M., Robinson, J. D., Crepaldi, L., and Riccio, A. (2008). S-Nitrosylation of histone deacetylase 2 induces ... Richard Kolarow1,2‡, Christoph R. W. Kuhlmann2‡, Thomas Munsch1, Christoph Zehendner2†, Tanja Brigadski1,2, Heiko J. Luhmann2 ... FIGURE 2. Figure 2. Activation of Trk receptors and intracellular Ca2+ elevation are required for BDNF-induced NO generation. ... BDNF-induced NO elevation can be observed in the soma, as well as in the dendrites within 1-2 min following bath application of ...
https://www.frontiersin.org/articles/10.3389/fncel.2014.00323/full
*  Histone deacetylation during brain development is essential for permanent masculinization of sexual behavior.
We hypothesized that alteration of histone acetylation status early in development by s ... Epigenetic histone modifications are emerging as important mechanisms for conveyance of and maintenance of effects of the ... Histone Deacetylase Inhibitors / administration & dosage, pharmacology. Histone Deacetylases / chemistry, metabolism*. Histones ... 0/DNA-Binding Proteins; 0/Estrogen Receptor alpha; 0/Histone Deacetylase Inhibitors; 0/Histones; 0/Oligodeoxyribonucleotides, ...
http://www.biomedsearch.com/nih/Histone-Deacetylation-during-Brain-Development/21586557.html
*  Mao G[au] - PubMed - NCBI
Exosomal miR-95-5p regulates chondrogenesis and cartilage degradation via histone deacetylase 2/8. ... Reduced Graphene Oxide Decorated Na3V2(PO4)3 Microspheres as Cathode Material With Advanced Sodium Storage Performance. ... PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and ... 2018 May 2. doi: 10.1002/jbm.b.34146. [Epub ahead of print] ... 2.. Observation of current rectification by the new bimetallic ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Mao+G%5Bau%5D&dispmax=50
*  IJMS | Free Full-Text | DNA Damage Due to Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) | HTML
Yao, H.; Rahman, I. Role of histone deacetylase 2 in epigenetics and cellular senescence: Implications in lung inflammaging and ... Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N. Engl. J. Med 2005, 352, 1967-1976. [Google ... NAD+-dependent protein/histone deacetylase) [50-52] expression, the decreased protection against DNA breakage and repair can be ... Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. Biochem. Biophys. Res. Commun 2011, 406, 292-298 ...
http://www.mdpi.com/1422-0067/13/12/16853/htm
*  JCI - Glucocorticoid receptors: finding the middle ground
Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression. J Exp Med. 2006;203(1):7 ... recruitment of histone deacetylase 2 by deacetylated GR to NF-κB-dependent promoters (a specific consequence of tethering) (29 ... GCs are primarily used in the clinic for their potent anti-inflammatory actions (1, 2, 13). Indications range from short-term ... Figure 2. GCs act at multiple levels in the inflammatory pathway. An inflamed cell is depicted, along with inflammatory ...
https://www.jci.org/articles/view/88886
*  TEMPLATE
The Transcriptional Repressor Sp3 Is Associated with CK2-phosphorylated Histone Deacetylase 2. The Journal of Biological ... Current Medicinal Chemistry 2: 245-250.. Hegele, R.A., H. Cao, C. Frankowski, S.T. Mathews, and T. Leff. 2002. PPARG F388L, a ... The Signaling Adapters Fibroblast Growth Factor Receptor Substrate 2 and 3 Are Activated by the Thyroid TRK Oncoproteins. ... Genes, environment and Oji-Cree type 2 diabetes. Clinical Biochemistry 36: 163-170. ...
http://www.uwo.ca/western/publications/0203/medicine/FBBC03.htm
*  IJMS | Free Full-Text | Oxidative Stress and Epigenetic Regulation in Ageing and Age-Related Diseases | HTML
Alteration of epigenetic enzyme activity, histone modifications and DNA-methylation is, in fact, typically associated with the ... the histone deacetylases (HDACs), or the histone methyltransferases (HMTases), and their opposite, the histone demethylases [17 ... deacetylase protein level [26-28]. The histone methylation pattern is also sensitive to age: methylation of histones H3 and H4 ... Jung, J.W.; Lee, S.; Seo, M.S.; Park, S.B.; Kurtz, A.; Kang, S.K.; Kang, K.S. Histone deacetylase controls adult stem cell ...
http://mdpi.com/1422-0067/14/9/17643/htm
*  Neuroepigenetic signatures of age and sex in the living human brain | Nature Communications
In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. J. Med. Chem. 57, ... Histone deacetylase 2 in the mouse hippocampus: attenuation of age-related increase by caloric restriction. Curr. Alzheimer Res ... Histone deacetylase activity is altered in brain areas from aged rats. Neurosci. Lett. 556, 152-154 (2013). ... PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. J. Clin. Invest. 129, 364-372 (2019). ...
https://www.nature.com/articles/s41467-019-11031-0?error=cookies_not_supported&code=8d09b884-83ca-4d2a-8b59-3e8c4cdd7506
*  A combination of erythromycin and dexamethasone reduces inflammatory effects of exposure to cigarette smoke extract through...
... reduces inflammatory effects of exposure to cigarette smoke extract through modulation of Akt and histone deacetylase 2. ... reduces inflammatory effects of exposure to cigarette smoke extract through modulation of Akt and histone deacetylase 2 ... reduces inflammatory effects of exposure to cigarette smoke extract through modulation of Akt and histone deacetylase 2 ... reduces inflammatory effects of exposure to cigarette smoke extract through modulation of Akt and histone deacetylase 2 ...
http://erj.ersjournals.com/content/44/Suppl_58/P3654
*  Herpes Simplex Virus 1 Serine/Threonine Kinase US3 Hyperphosphorylates IRF3 and Inhibits Beta Interferon Production | Journal...
... blocking of histone deacetylation by phosphorylation of histone deacetylase 1 and 2 (HDAC1/2) (19-21), disruption of ... Hyperphosphorylation of histone deacetylase 2 by alphaherpesvirus US3 kinases. J. Virol. 84:9666-9676. ... ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression. ... Fig 2 US3 targets IRF3 to inhibit IFN-β production. HEK 293T cells were cotransfected with (pRDIII-I)4-Luc reporter, PRL-TK, ...
https://jvi.asm.org/content/87/23/12814?ijkey=ee37ff358216a1befceb1f14523f5c345922f1ea&keytype2=tf_ipsecsha
*  Publications - Colorectal Cancer Translational Research Program | MD Anderson Cancer Center
Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res ... Identification of an histone H3 acetylated/K4-methylated-bound intragenic enhancer regulatory for urokinase receptor expression ... Gene silencing in cancer by histone H3 lysine 27 tri-methylation independent of promoter DNA methylation. Nature Genetics 40(6 ... e-Pub 2/2010. PMCID: PMC2822883.. *Chen J, Etzel CJ, Amos CI, Zhang Q, Viscofsky N, Lindor NM, Lynch PM, Frazier ML. Genetic ...
https://www.mdanderson.org/research/departments-labs-institutes/programs-centers/colorectal-cancer-translational-research-program/publications.html
*  Frontiers | Resolving Viral-Induced Secondary Bacterial Infection in COPD: A Concise Review | Immunology
SAA is a functional agonist for formyl peptide receptor 2 (FPR2/ALX), where it promotes chemotaxis and survival of neutrophils ... SAA is a functional agonist for formyl peptide receptor 2 (FPR2/ALX), where it promotes chemotaxis and survival of neutrophils ... Oxidative and nitrosative stress and histone deacetylase-2 activity in exacerbations of COPD. Chest (2016) 149:62-73. doi: ... Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy. Nat Commun. (2017) 8:69. doi: ...
https://www.frontiersin.org/articles/10.3389/fimmu.2018.02345/full
*  Table of Contents - January 23, 2006, 203 (1) | JEM
Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression Kazuhiro Ito, Satoshi ... AID-dependent histone acetylation is detected in immunoglobulin S regions Lili Wang, Naree Whang, Robert Wuerffel, Amy L. ...
http://jem.rupress.org/content/203/1
*  2015 ȯ ?? ???? ?? ??????? ?ȸ
Posttranslational Modification of Histone Deacetylase 2 in Cardiac Hypertrophy. ??/?? ?? 16:25-16:45. Role of Formyl Peptide ... Special Debate Session: "A Patient with Type 2 Diabetes without Any History of Cardiovascular Disease and Already on Statin ... Receptor 2 in Therapeutic Angiogenesis. ???ȣ/ λ??? 16:45-17:05. ROS Signaling in Atherosclerosis via Impaired Autophagy. ...
http://www.circulation.or.kr/workshop/2015spring/program_02.html
*  Compound Report Card
Histone deacetylase 1 inhibitor Histone deacetylase 1 PubMed PubMed Histone deacetylase 11 inhibitor Histone deacetylase 11 ... Histone deacetylase 3 inhibitor Histone deacetylase 3 PubMed PubMed Histone deacetylase 8 inhibitor Histone deacetylase 8 ... Histone deacetylase 2 inhibitor Histone deacetylase 2 PubMed PubMed ... Vascular endothelial growth factor receptor 2 Homo sapiens 0.765 CHEMBL2007 Platelet-derived growth factor receptor alpha Homo ...
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/ChEMBL272980
*  Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of IκB kinases in mice:...
Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. Am J Respir Cell Mol Biol 40: 464-473 ... of histone H3, and acetylation of histone H4 (Lys12) in lung by immunoblotting using acid-extracted nuclear histone fraction (i ... histone H3 (#9715), acetylated histone H4 (Lys12) (#2591), and histone H4 (#2592) were purchased from Cell Signaling Technology ... Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis 27: 811- ...
http://ajplung.physiology.org/content/299/2/L192
*  Table of Contents - April 03, 2013, 33 (14) | Journal of Neuroscience
Histone Deacetylase 2 Cell Autonomously Suppresses Excitatory and Enhances Inhibitory Synaptic Function in CA1 Pyramidal ...
http://www.jneurosci.org/content/33/14