北京大学医学部机构知识库(IR@PKUHSC): Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in...
histone deacetylase inhibitor ; gastric cancer ; anticancer drugs ; chemosensitivity ; apoptosis ; cell cycle ; genes ... Recently, a histone deacetylase inhibitor, trichostatin A (TSA), was proven to be a chemo-sensitizer on human erythroleukemia ... Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines[ ... Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines ...http://ir.bjmu.edu.cn/handle/400002259/55982
HKU Scholars Hub: Dual transcriptional control of claudin-11 via an overlapping GATA/NF-Y motif: Positive regulation through...
Such repression which required the recruitment and physical interactions of histone deacetylase I and its co-repressor, mSin3A ... Such repression which required the recruitment and physical interactions of histone deacetylase I and its co-repressor, mSin3A ... with Smad proteins, was abolished by treatment with Trichostatin A, thus suggesting the involvement of histone deacetylation at ... with Smad proteins, was abolished by treatment with Trichostatin A, thus suggesting the involvement of histone deacetylation at ...http://hub.hku.hk/handle/10722/84938
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity | PNAS
... more recent reports have shown that deacetylase activity of histone deacetylases is required for signal transducer and ... Longevity regulatory genes include the Forkhead transcription factor FOXO and the NAD-dependent histone deacetylase silent ... A second longevity regulatory gene is the evolutionarily conserved histone deacetylase silent information regulator (Sir2) (24 ... an inhibitor of class I and II histone deacetylases. These results indicate that Sir2 can preferentially deacetylate Foxo1 at ...http://www.pnas.org/content/101/27/10042
Dovitinib Dilactic acid - Structure of Rhomboid Protease in Complex with β-Lactam Inhibitors
Treatment of HCT116 cells with Decitabine (a DNMT inhibitor) or trichostatin A (a histone deacetylase inhibitor) up-regulated ... DNMT1-mediated suppression from the unmethylated promoter consists of methylation from the promoter whereas histone deacetylase ... DNA methylation histone adjustments and chromatin redecorating mediate epigenetic legislation of gene appearance (for review ... DNMT3B-mediated suppression from the rDNA promoter involves histone deacetylation also. ...http://rectalcancersite.com/tag/dovitinib-dilactic-acid/
HDAC inhibitors in kidney development and disease.
The discovery that histone deacetylase inhibitors (HDACis) can attenuate acute kidney injury (AKI)-mediated damage and reduce ... Inhibition of histone deacetylase activity by butyrateJ NutrYear: 20031332485S2493S12840228. 17.. Marks PA,Breslow R. Dimethyl ... HDAC histone deacetylase, RCC renal cell carcinoma, VEGF vascular endothelial growth factor, mTOR mammalian target of rapamycin ... Histone deacetylases (HDACs) play multiple roles during both kidney development  and the pathogenesis of kidney disease [2 ...http://www.biomedsearch.com/nih/HDAC-inhibitors-in-kidney-development/23052657.html
HDAC1 Antibody (NB100-56340): Novus Biologicals
Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively ... Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in ... Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 ... Change in gene activity done independently of the DNA sequence is achieved by way of histone and DNA methylation. Gene ...https://www.novusbio.com/products/hdac1-antibody_nb100-56340
Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator...
"Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator ... Histone deacetylase 3 participates in self-renewal of liver cancer stem cells through histone modification ... Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through... Lu, Xu-Feng; Cao, Xiao-Yue; ... Histone deacetylase 3 (HDAC3) plays pivotal roles in cell cycle regulation and is often aberrantly expressed in various cancers ...https://www.deepdyve.com/lp/springer_journal/histone-deacetylase-3-promotes-liver-regeneration-and-liver-cancer-0flQKpgaM5
Retinoic acid controls body axis extension by directly repressing Fgf8 transcription | Development
... as well as the associated repressive factor histone deacetylase 1 (HDAC1), near the Fgf8 RARE in WT trunk and CPZ regions. ... Histone methylation and PRC2 recruitment near Fgf8- and Hoxb1-repressive RAREs. (A) For regional ChIP assays, E8.25 embryos ... 2001). Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev. 15, ... Histone methylation near Fgf8 RARE. Gene activation through RAREs functions through RA-dependent recruitment of transcriptional ...http://dev.biologists.org/content/141/15/2972
Inflammatory | GreenMedInfo | Adverse Pharmacological Action
E-cigs cause increased oxidative/carbonyl and inflammatory responses, and DNA damage along with histone deacetylase 2 reduction ... Problem Substances : 2-chlorobenzalmalononitrile (tear gas), CS2 Riot Control Aerosol. Adverse Pharmacological Actions : ... 2-chlorobenzalmalononitrile (tear gas) exhibits a wide range of serious, unintended adverse effects including death.Mar 01, ... Brevetoxin-2 may lead to lung inflammation through an alveolar macrophage-initiated pathway.Sep 01, 2010. ...http://www.greenmedinfo.com/content/inflammatory
Prevention of Exacerbations in Chronic Obstructive Pulmonary Disease: Knowns and Unknowns<...
Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet. 2004;363(9410 ... an effect that seems to be related to a marked reduction in histone deacetylase-2, the nuclear enzyme required by ... Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med. 2005;352:1967-1976. doi: http:// ... Alvar Agustí, MD, PhD, FRCP, FERS,1 Peter M. Calverley, DSc, FMedSci,2 Marc Decramer, MD, PhD,3 Robert A. Stockley, MD, DSc, ...https://journal.copdfoundation.org/jcopdf/id/1041/Prevention-of-Exacerbations-in-Chronic-Obstructive-Pulmonary-Disease-Knowns-and-Unknowns
Experts and Doctors on tumor cell line in Houston, United States
Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2. FEBS ... Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2. FEBS ... These findings demonstrate that histone modification in the 15-LOX-1 promoter is important to 15-LOX-1 transcriptional ... AP-2 products*Sp1 products*cyclin E products*PAK1 products*MTA1 products*PELP1 products*PTEN products*GSK3beta products*HDAC1 ...http://www.labome.org/locale/united/texas/experts-and-doctors-on-tumor-cell-line-in-houston--united-states-63781.html
Top 10 Most Cited Papers Published in 2015 | MDPI Blog
Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents. ...http://blog.mdpi.com/2016/01/28/top-10-most-cited-papers-published-in-2015/
Volume 3.36 | Oct 29 - Muscle Cell News
Histone deacetylase 2 (HDAC2) knockdown enhanced the activity of NF-κBp65 and increased IL-8 and TNF-α levels in C2C12 cells. [ ... pERK1/2 downregulation was linked to downregulation of the upstream kinase MEK1/2. [Am J Respir Cell Mol Biol] Abstract ... They identified Stabilin-2 as a protein that interacted with BAI3 and stimulated its fusion promoting activity. [Nat Commun] ... Hydrogen peroxide (H2O2) treatment significantly suppressed cell viability and increased cell apoptotic rate and caspase-3 ...http://www.musclecellnews.com/issue/volume-3-36-oct-29/
Histone Deacetylase 10 Regulates the Cell Cycle G2/M Phase Transition via a Novel Let-7-HMGA2-Cyclin A2 Pathway | Molecular and...
... anti-histone H3, anti-acetyl-histone H3 (Lys9), anti-acetyl-histone H3 (Lys14), anti-acetyl-histone H3 (Lys18), anti-acetyl- ... anti-phospho-histone H3 (Ser10; 3377), anti-histone H3 (4499), anti-acetyl-histone H3 (Lys9) (9649), anti-acetyl-histone H3 ( ... Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev 24:455-469. doi:10.1101/gad.552310. ... Histone Deacetylase 10 Regulates the Cell Cycle G2/M Phase Transition via a Novel Let-7-HMGA2-Cyclin A2 Pathway. Yixuan Li, ...https://mcb.asm.org/content/35/20/3547
Vorinostat and Azacitidine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia
including: DNA methylation of specific genes (e.g. p15); histone acetylation; hematopoietic. progenitor growth and ... every 2 months thereafter.. Inclusion Criteria:. - Histologically confirmed diagnosis of 1 of the following:. - Myelodysplastic ... Life expectancy > 2 months. - ECOG performance status (PS) 0-2 OR Karnofsky PS 60-100%. - AST and ALT ≤ 2.5 times upper limit ... At least 2 weeks since prior histone deacetylase inhibitor (e.g., valproic acid). - More than 4 weeks since prior ...http://www.knowcancer.com/cancer-trials/NCT00392353/
Histone Deacetylase 1 (HDAC1) Antikörper
HD1 , histone deacetylase 1 , histone deacetylase 1-B , CG7471-PA , Rpd3 histone deacetylase , Rpd3-PA , histone Deacetylase-1 ... HISTONE DEACETYLASE, histone deacetylase 1, HISTONE DEACETYLASE 19, HISTONE DEACETYLASE19, l(3)04556, l(3)64Cc, MommeD5, mp: ... anti-Histone Deacetylase 1 (HDAC1) Antikörper. Bezeichnung:. anti-Histone Deacetylase 1 Antikörper (HDAC1). Auf www.antikoerper ... Weitere Antikörper gegen Histone Deacetylase 1 Interaktionspartner. Mouse (Murine) Histone Deacetylase 1 (HDAC1) ...http://www.antikoerper-online.de/neurotrophin-signal%C3%BCbertragung-pathway-29/hdac1-antibody-3672/
HDAC1 Antibody (monoclonal) (M14) - Mouse monoclonal antibody raised against a full length recombinant HDAC1. WB, IHC, IF, E -...
The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone ... Histone deacetylase 1, HD1, HDAC1, RPD3L1. Target/Specificity HDAC1 (AAH00301, 1 a.a. ~ 482 a.a) full-length recombinant ... PMID 20438716.Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma. Adams H, et al. ... PMID 20731616.CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1. Leone V, et al. ...http://www.abgent.com/products/AT2337a-HDAC1-Antibody-monoclonal-M14
Method and Apparatus for Acoustical Outer Ear Characterization - Patent application
Assays for Histone Deacetylase 1/2 Selective Inhibitors. 20090298045. Method For Selectively Expanding, Selecting And Enriching ... 2. A Quantization Stage Signal analysis and quantization are handled in this stage. As a result, this stage is the ... 2. The method of claim 1, characterized in that the method further comprises a step of transmitting an acoustic noise signal ( ... 2. A Reconstruction Stage An approximation of the transformed representation is reconstructed by means of the decoded ...http://www.patentsencyclopedia.com/app/20080262382
Publications/Presentations | Rhodes Sites
Identification of Molecular Interactions within Histone Deacetylase Isozymes for the Development of Potent HDAC2 Inhibitors for ... Synthesis and Computational Evaluation of Vorinostat Boron Derivatives as Potential Histone Deacetylase Inhibitors. 255th ACS ... Evaluation of panobinostat and vorinostat boron derivatives as potential histone deacetylase inhibitors. Southeastern Regional ... Design of Potent Panobinostat Histone Deacetylase Inhibitor Derivatives: Molecular Considerations for Enhanced Isozyme ...https://sites.rhodes.edu/MIRlab/publicationspresentations
US Patent # 9,987,258. Histone deacetylase as a modulator of PDL1 expression and activity - Patents.com
... comprising contacting the cell with a composition comprising a histone deacetylase (HDAC) inhibito ... Histone deacetylases (HDACs), originally described as histone modifiers, have more recently been demonstrated to modify a ... Histone deacetylases (HDACs), originally described as histone modifiers, have more recently been demonstrated to modify a ... Histone deacetylase as a modulator of PDL1 expression and activity Abstract. Disclosed herein is a method for modulating ...http://patents.com/us-9987258.html
ASMscience | Chromatin Structure and
Acetylated histones supported higher rates of RNA synthesis than did unacetylated histones, suggesting that posttranslational ... In budding yeast, transcription of the core histones is tightly regulated and is primarily restricted to the S phase of the ... Posttranslational modification of histone proteins by acetylation and methylation was first described in 1964. ... modification of the histone proteins could produce functionally distinct chromatin domains. Histone modifications can be ...http://www.asmscience.org/content/book/10.1128/9781555816636.ch09
Poly(ADP-ribosyl)ation of p53 induces gene-specific transcriptional repression of MTA1
p53 and histone deacetylases 1/2 were recruited, and acetylation of H3K9 was decreased on the promoter region including the ...https://insights.ovid.com/oncog/201231490/00006374-201231490-00006
Exploring Zebrafish Genomic, Functional and Phenotypic Data Using ZFIN - Current Protocols
287(2):237‐248. Rhee, S.Y., Wood, V., Dolinski, K., and Draghici, S. 2008. Use and misuse of gene ontology annotations. Nat. ... REREa/Atrophin‐2 interacts with histone deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish development ... Basic Protocol 2: Retrieving Information about Zebrafish Genes. *Basic Protocol 3: Finding and Viewing Comprehensive Gene ...http://www.currentprotocols.com/WileyCDA/CPUnit/refId-bi0118.html
Anti MNAR Antibody (PrecisionAb™ Polyclonal Antibody) | Bio-Rad Antibodies (formerly AbD Serotec)
... histone deacetylase 2 and MTA (metastasis-associated protein)1. Other properties of MNAR include interaction with PI3K, STAT3, ... If using DDT reconstitute the lyophilized lysate with 190μl DI H2O, add 200μl 2x Laemmli Sample Buffer and 10μl 2M DTT.. - If ... using BME reconstitute the lyophilized lysate with 180μl DI H2O, add 200μl 2x Laemmli Sample Buffer and 20μl BME.. Heat at 95°C ...https://www.bio-rad-antibodies.com/human-mnar-antibody-vpa00253.html
Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult...
... are enzymes that modulate gene expression and cellular processes by deacetylating histones and non-histone proteins. While ... Histone deacetylases (HDACs) are enzymes that modulate gene expression and cellular processes by deacetylating histones and non ... Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult ... Yamaguchi T, Cubizolles F, Zhang Y, Reichert N, Kohler H, Seiser C, Matthias P: Histone deacetylases 1 and 2 act in concert to ...https://0-bmcneurosci-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2202-12-50