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*  Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance
Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma. Expert Opin Ther Targets. 2010;14 ... Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer--overexpression of HDAC2 and HDAC3 is ... Histone deacetylase inhibitors activate CIITA and MHC class II antigen expression in diffuse large B-cell lymphoma. Immunology ... Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas. Histopathology. 2009;54:688-98 ...
http://www.medsci.org/v11p0994.htm
*  Histone modification, gene regulation and epigenetic memory in embryonic stem cells - eTheses Repository
In order to explore this, the histone deacetylase inhibitor valproic acid (VPA) was used to induce hyperacetylation of histones ... Histone modifications are thought to act as a layer of epigenetic information, because of their strong association with gene ... However, although specific histone modifications correlate with transcriptional status, whether they play a causative role or ... It was concluded that histone acetylation plays an important role in transcription but additional signals are required for ...
http://etheses.bham.ac.uk/3160/
*  北京大学医学部机构知识库(IR@PKUHSC): Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in...
histone deacetylase inhibitor ; gastric cancer ; anticancer drugs ; chemosensitivity ; apoptosis ; cell cycle ; genes ... Recently, a histone deacetylase inhibitor, trichostatin A (TSA), was proven to be a chemo-sensitizer on human erythroleukemia ... Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines[ ... Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines ...
http://ir.bjmu.edu.cn/handle/400002259/55982
*  Valcote - Antimanic Agents, GABA Agents, Enzyme Inhibitors, Anticonvulsants, ATC:N03AG01
Valproic acid has also been shown to be an inhibitor of an enzyme called histone deacetylase 1 (HDAC1). HDAC1 is needed for HIV ...
http://pharmacycode.com/Valcote.html
*  New study: NAD dependent protein deacetylase sirtuin 1 - pipeline review, H1 2017 - WhaTech
NAD Dependent Protein Deacetylase Sirtuin 1 (SIR2 Like Protein 1 or Sirtuin Type 1 or Regulatory Protein SIR2 Homolog 1 or ... It modulates chromatin function through deacetylation of histones and can promote alterations in the methylation of histones ... NAD Dependent Protein Deacetylase Sirtuin 1 (SIR2 Like Protein 1 or Sirtuin Type 1 or Regulatory Protein SIR2 Homolog 1 or ... NAD Dependent Protein Deacetylase Sirtuin 1 (SIR2 Like Protein 1 or Sirtuin Type 1 or Regulatory Protein SIR2 Homolog 1 or ...
https://www.whatech.com/market-research/medical/356831-new-study-nad-dependent-protein-deacetylase-sirtuin-1-pipeline-review-h1-2017
*  Histone deacetylase 2 - Wikipedia
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein ... "An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co- ... "Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases". Nucleic Acids Res ... "A role for histone deacetylase activity in HDAC1-mediated transcriptional repression". Proc. Natl. Acad. Sci. U.S.A. 95 (7): ...
https://en.wikipedia.org/wiki/Histone_deacetylase_2
*  India Histone Deacetylase 2 Market Research Report 2018 : ReportsnReports
The global Histone Deacetylase 2 market is valued at XX... ... Check for Discount on India Histone Deacetylase 2 Market ... The global Histone Deacetylase 2 market is valued at XX million USD in 2017 and is expected to reach XX million USD by the end ... 6.1 Histone Deacetylase 2 Key Raw Materials Analysis. 6.1.1 Key Raw Materials. 6.1.2 Price Trend of Key Raw Materials. 6.1.3 ... 1.2.1 India Histone Deacetylase 2 Sales (K Pcs) Comparison by Type (2013-2025). 1.2.2 India Histone Deacetylase 2 Sales (K Pcs ...
https://www.reportsnreports.com/reports/1481778-india-histone-deacetylase-2-market-research-report-2018.html
*  Transcriptional Regulation of Endothelial Arginase 2 by Histone Deacetylase 2 | Arteriosclerosis, Thrombosis, and Vascular...
The goal of the current study is to determine the role of specific histone deacetylases (HDACs) in the regulation of ... Transcriptional Regulation of Endothelial Arginase 2 by Histone Deacetylase 2. Deepesh Pandey, Gautam Sikka, Yehudit Bergman, ... Objective-Arginase 2 (Arg2) is a critical target in atherosclerosis because it controls endothelial nitric oxide, proliferation ... Transcriptional Regulation of Endothelial Arginase 2 by Histone Deacetylase 2. Deepesh Pandey, Gautam Sikka, Yehudit Bergman, ...
http://atvb.ahajournals.org/content/early/2014/05/15/ATVBAHA.114.303685
*  Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers - Chemical Science (RSC Publishing)...
Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers†. F. F. Wagner a, Y.-L. Zhang a, D. M ... Here we demonstrate for the first time that the selective inhibition of histone deacetylase 2 (HDAC2) (versus all other zinc ... Neuronal histone acetylation assays. Measurements of increases in neuronal histone acetylation in mouse forebrain primary ... Cells were fixed with formaldehyde, stained with antibodies to acetyl-histone H3, lysine 9 (AcH3K9), or acetyl-histone H4, ...
http://pubs.rsc.org/En/content/articlehtml/2015/sc/c4sc02130d
*  Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus
... a procedure carried out by histone or histone-related proteins, such as histone acetylase (HAT) and histone deacetylase (HDAC ... Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus. Ying ... Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer. 2006;6:38-51. ... Ng HH, Bird A. Histone deacetylases: silencers for hire. Trends Biochem Sci. 2000;25:121-126. doi: 10.1016/S0968-0004(00)01551- ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3077330/?lang=en-ca
*  Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate-Induced Downregulation of Histone Deacetylase 2 Expression and...
Keywords: Histone deacetylase, coronary artery endothelial cells, cyclic phosphatidic acid This is an open access article ... Here, we examined whether cPA inhibited AGP-induced expression of class I histone deacetylases (HDACs, namely HDAC1, HDAC2, ... Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate-Induced Downregulation of Histone Deacetylase 2 Expression and ... Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate-Induced Downregulation of Histone Deacetylase 2 Expression and ...
http://www.medsci.org/v11p0955
*  MicroRNA-223 controls the expression of histone deacetylase 2: a novel axis in COPD - Zurich Open Repository and Archive
KEY MESSAGES: Histone deacetylase 2 is directly targeted by miR-223. Levels of miR-223 are induced by interleukin-1β and tumor ... KEY MESSAGES: Histone deacetylase 2 is directly targeted by miR-223. Levels of miR-223 are induced by interleukin-1β and tumor ... Reduced activity of histone deacetylase 2 (HDAC2) has been described in patients with chronic obstructive pulmonary disease ( ... Reduced activity of histone deacetylase 2 (HDAC2) has been described in patients with chronic obstructive pulmonary disease ( ...
http://www.zora.uzh.ch/id/eprint/123276/
*  Histone Deacetylase 2 (Transcriptional Regulator Homolog RPD3 or YY1-Associated Factor 1 or EC 3.5.1.98) - Pipeline Review, H1...
Global Markets Direct's, 'Histone Deacetylase 2 (Transcriptional Regulator Homolog... ... Check for Discount on Histone Deacetylase 2 (Transcriptional Regulator Homolog RPD3 or YY1-Associated Factor 1 or EC 3.5.1.98 ... Histone Deacetylase 2 (Transcriptional Regulator Homolog RPD3 or YY1-Associated Factor 1 or EC 3.5.1.98) - Drug Profiles 42 4SC ... Histone Deacetylase 2 (Transcriptional Regulator Homolog RPD3 or YY1-Associated Factor 1 or EC 3.5.1.98) - Pipeline Review, H1 ...
http://www.reportsnreports.com/reports/628269-histone-deacetylase-2-transcriptional-regulator-homolog-rpd3-or-yy1-associated-factor-1-or-ec-35198-pipeline-review-h1-2016.html
*  Histone Deacetylase 2 (HDAC2) Regulates Chromosome Segregation and Kinetochore Function via H4K16 Deacetylation during Oocyte...
Lysine acetylation of histones is controlled by histone acetyl transferases (HATs) and histone deacetylases (HDACs). In mammals ... Changes in histone acetylation occur during oocyte development and maturation, but the role of specific histone deacetylases in ... Changes in histone acetylation occur during oocyte development and maturation, but the role of specific histone deacetylases in ... MaP, SchultzRM (2008) Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in ...
https://www.prolekare.cz/casopisy/plos-genetics/2013-3/histone-deacetylase-2-hdac2-regulates-chromosome-segregation-and-kinetochore-function-via-h4k16-deacetylation-during-oocyte-maturation-in-mouse-42835
*  Lymphocyte senescence in COPD is associated with decreased histone deacetylase 2 expression by pro-inflammatory lymphocytes |...
... and histone deacetylases (HDAC) are enzymes that upregulate and down-regulate pro-inflammatory gene transcription respectively ... Histone acetyltransferases (HAT) and histone deacetylases (HDAC) are enzymes that up-regulate and down-regulate pro- ... Histone acetyltransferases (HAT) and histone deacetylases (HDAC) are enzymes that up-regulate and down-regulate pro- ... Histone acetyltransferases (HAT) and histone deacetylases (HDAC) are enzymes that upregulate and down-regulate pro-inflammatory ...
https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-015-0287-2
*  Rat HDAC2 (Histone Deacetylase 2) ELISA Kit Manufacturers in Delhi
Histone Deacetylase 2) ELISA Kit OSCAR DIAGNOSTIC SERVICES PVT. LTD.is an India based Company in Delhi. ... Rat HDAC2 (Histone Deacetylase 2) ELISA Kit. Rat HDAC2 (Histone Deacetylase 2) ELISA Kit. ... Rat HDAC2 (Histone Deacetylase 2) ELISA Kit » Rat HDAC2 (Histone Deacetylase 2) ELISA Kit. Rat HDAC2 (Histone Deacetylase 2) ... Rat HDAC2 (Histone Deacetylase 2) ELISA Kit. Rat HDAC2 (Histone Deacetylase 2) ELISA Kit. Rat HDAC2 (Histone Deacetylase 2) ...
https://www.odspl.com/sub-product/Rat+HDAC2+%28Histone+Deacetylase+2%29+ELISA+Kit.php
*  Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2
Previous studies showed genetic knockdown of histone deacetylase (HDAC) 1 or 2 is sufficient to induce HbF. Here we show that ... by histone acetylation-induced activation of the GATA2 gene. ... These data show that chemical inhibition of HDAC1/2 induces HBG ... Chromatin immunoprecipitation and sequencing (ChIP-Seq) of primary erythroid progenitors demonstrated that HDAC1 and 2 ... HDAC1/2), elicits a dose and time dependent induction of γ-globin mRNA (HBG) and HbF in cultured primary cells derived from ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153767
*  Histone Deacetylases 1 and 2 Form a Developmental Switch That Controls Excitatory Synapse Maturation and Function | Journal of...
2008) Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development. Dev Dyn 237:2256-2267. ... 2007) Histone deacetylases-an important class of cellular regulators with a variety of functions. Appl Microbiol Biotechnol 75: ... 2003) The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. EMBO J 22:3411-3420 ... 2004) Valproic acid: an old drug newly discovered as inhibitor of histone deacetylases. Ann Hematol 83(Suppl 1):S91-S92. ...
http://www.jneurosci.org/content/29/25/8288
*  Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)amino- methyl]benzamide and m...
HDAC inhibitors induce histone hyperacetylation by a relative increase of histone acetyltransferase activity. Histone ... Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)amino- methyl]benzamide and m- ... 2004 Jun 10;110(2):301-8. Research Support, Non-U.S. Gov't ...
https://www.ncbi.nlm.nih.gov/pubmed/15069698?dopt=Abstract
*  Abstract 2196: Novel and selective histone deacetylase (HDAC) 1 & 2 inhibitors enhance differentiation of neuroblastoma cells...
Novel and selective histone deacetylase (HDAC) 1 & 2 inhibitors enhance differentiation of neuroblastoma cells in combination ... Abstract 2196: Novel and selective histone deacetylase (HDAC) 1 & 2 inhibitors enhance differentiation of neuroblastoma cells ... Abstract 2196: Novel and selective histone deacetylase (HDAC) 1 & 2 inhibitors enhance differentiation of neuroblastoma cells ... Abstract 2196: Novel and selective histone deacetylase (HDAC) 1 & 2 inhibitors enhance differentiation of neuroblastoma cells ...
http://cancerres.aacrjournals.org/content/75/15_Supplement/2196
*  Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma - edoc
Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma. Expert opinion on therapeutic ... Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma ...
https://edoc.unibas.ch/27566/
*  Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere,...
Histone deacetylase inhibitors induce hyperacetylation of the amino-terminal lysine residues of the core nucleosomal histones, ... "histone deacetylases" may be a misnomer, and HDIs should be appropriately called protein deacetylase inhibitors, because ... Histone acetyltransferases and histone deacetylases (HDAC) catalyze the acetylation and deacetylation of the lysine residues in ... Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc. Natl. Acad ...
http://mct.aacrjournals.org/content/2/10/971
*  Histone Deacetylase 3 (SMAP45 or RPD3 2 or HDAC3 or EC 3.5.1.98) - Pipeline Review, H2 2016
... with 80 pages available at USD 3500 ... Histone Deacetylase 3 (SMAP45 or RPD3 2 or HDAC3 or EC 3.5.1.98) - Pipeline Products Glance 12. Late Stage Products 12. Early ... Histone Deacetylase 3 (SMAP45 or RPD3 2 or HDAC3 or EC 3.5.1.98) - Drug Profiles 35. 4SC-202 - Drug Profile 35. Product ... Histone Deacetylase 3 (SMAP45 or RPD3 2 or HDAC3 or EC 3.5.1.98) - Dormant Projects 67. Histone Deacetylase 3 (SMAP45 or RPD3 2 ...
http://www.reportsweb.com/histone-deacetylase-3-smap45-or-rpd3-2-or-hdac3-or-ec-3-5-1-98-pipeline-review-h2-2016
*  In vivo molecular implications of the combination of the hypo-methylating agent 5-aza-2'-deoxycytidine and the histone...
Epigenetic silencing can be reversed in vitro using agents with hypomethylating or histone deacetylase inhibitory (HDI) ... deoxycytidine and the histone deacetylase inhibitor valproic acid in patients with leukemia: Results of a phase I/II study. ... deoxycytidine and the histone deacetylase inhibitor valproic acid in patients with leukemia: Results of a phase I/II study ... deoxycytidine and the histone deacetylase inhibitor valproic acid in patients with leukemia: Results of a phase I/II study ...
http://cancerres.aacrjournals.org/content/65/9_Supplement/937.2
*  RCSB PDB - 6G3O: Crystal structure of human HDAC2 in complex with (R)-6-[3,4-Dioxo-2-(4-trifluoromethoxy-phenylamino)-cyclobut...
4-Dioxo-2-(4-trifluoromethoxy-phenylamino)-cyclobut-1-enylamino]-heptanoic acid hydroxyamide ... Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma.. ... 6~{R})-6-[[3,4-bis(oxidanylidene)-2-[[4-(trifluoromethyloxy)phenyl]amino]cyclobuten-1-yl]amino]-~{N}-oxidanyl-heptanamide. C18 ... Crystal structure of human HDAC2 in complex with (R)-6-[3,4-Dioxo-2-(4-trifluoromethoxy-phenylamino)-cyclobut-1-enylamino]- ...
https://www.rcsb.org/structure/6G3O