Histone Chaperone Nap1 Is a Major Regulator of Histone H2A-H2B Dynamics at the Inducible GAL Locus Journal Article ... The Histone Chaperone Nap1 Promotes Nucleosome Assembly by Eliminating Nonnucleosomal Histone DNA Interactions Journal Article ... Chaperone Nap1 Shields Histone Surfaces Used in a Nucleosome and Can Put H2A-H2B in an Unconventional Tetrameric Form Journal ... Histone chaperone specificity in Rtt109 activation Journal Article * Homology among telomeric end-protection proteins Journal ...

Proteins assisting histone folding and assembly (histone chaperone).. *Proteins that act upon modifications of DNA or RNA in ... Proteins acting as histones, histone variants or protamines (histone).. * ... Proteins that act upon post-translational modifications of histones (histone modification read, write and erase); ... Proteins that incorporate histone variants into the nucleosomes.. Specific subgroups of proteins may be annotated as such, e.g ...

The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones. Elife. 2016 Sep 30; 5 ...

The Histone Chaperone Caf-1 Safeguards Somatic Cell Identity. Nature 528, no. 7581 (Dec 10 2015): 218-24. ... Emerging Roles of the Histone Chaperone Caf-1 in Cellular Plasticity. Curr Opin Genet Dev 46 (Oct 2017): 83-94. ... CAF-1 Histone Chaperone is a Repressor of Mixed Lineages in Myeloid Progenitors. BioRxiv [Preprint] ... Regulation of chromatin accessibility by the Histone Chaperone CAF-1 sustains lineage fidelity. Nat Commun. doi: 10.1038/s41467 ...

The histone chaperone CAF-1 safeguards somatic cell identity.. Nature 2015 Dec 10;528(7581):218-24. ...

Abstract Unlike oocytes (and all somatic cells), which package their DNA with histones, the DNA of mature sperm is bound by ... Immunoprecipitation followed by mass spectrometry has identified multiple potential chromatin remodelers/chaperones, which we ... to purify protamines from sperm to use in both in vitro DNA curtain assays and in vitro reconstitution assays of the histone-to ... poorly understood process we have developed novel genetic and biophysical tools to identify proteins implicated in the histone- ...

The H3 histone chaperone NASP(SIM3) escorts CenH3 in Arabidopsis.. Le Goff S, Keçeli BN, Jeřábková H, Heckmann S, Rutten T, ... The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ...

The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This ... In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated ... In vitro can displace histone H1 from highly bent DNA (By similarity). Can restructure the canonical nucleosome leading to ... In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in ...

The Histone Chaperones SET/TAF-1β and NPM1 Exhibit Conserved Functionality in Nucleosome Remodeling and Histone Eviction in a ... Molecular basis for the DNA damage-induced interaction between cytochrome c and the histone chaperone SET/TAF-I beta FEBS OPEN ... Structural basis for inhibition of the histone chaperone activity of SET/TAF-I beta by cytochrome c PROCEEDINGS OF THE NATIONAL ... Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c NUCLEIC ACIDS RESEARCH. ...

Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A. Z. Cell research (2014). ... Histone H2A ubiquitination inhibits the enzymatic activity of H3 Lysine 36 methyltransferases. Journal of Biological Chemistry ... Histone methyltransferase G9a contributes to H3K27 methylation in vivo. Cell research 21, 2 (2011): 365. ...

Rbbp7 chaperones chromatin remodeling proteins to their nuclear histone substrates, including histone acetylases and ... Here, we identify and focus on the histone-binding subunit of the Nucleosome Remodeling and Deacetylase (NuRD) complex: ...

The histone chaperone sNASP binds a conserved peptide motif within the globular core of histone H3 through its TPR repeats.. ... The chaperone-histone partnership: for the greater good of histone traffic and chromatin plasticity. Hondele M, Ladurner AG. ... The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A.. Mandemaker IK, ... The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states.. ...

Structural basis of histone H2A-H2B recognition by the essential chaperone FACT. Nature 499, 111-114.. Maria Hondele, Tobias ... Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site. Nat Commun 6, ... Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export. Nat. Cell Biol. 10, 707-715.. Alwin Köhler, ... Mutational Uncoupling of Sus1s role in NPC-targeting of an mRNA Export Complex and Histone H2B deubiquitination J. Biol. Chem ...

... analyses of H3.1 and H3.3 revealed a highly conserved role for Nrp1 and Asf1 histone chaperones in nuclear influx of histones. ... whereas the expression of the putative ortholog of the H3.3-specific chaperone Hir1 is essential in Tetrahymena. Our results ... Such dynamic regulation is, in part, achieved through epigenetic modifications and selective incorporation of histone variants ... The histone chaperone sNASP binds a conserved peptide motif within the globular core of histone H3 through its TPR repeats. ...

... association with post-translationally modified canonical histones or histone variants, and positioning within the nuclear ... PML partners, such as the histone chaperones Daxx and ATRX, were also present within the structures. Because of the unusual ... association with post-translationally modified canonical histones or histone variants, and positioning within the nuclear ... during latency has been shown to match to a certain extent with their association to nucleosomes that show similar histone post ...

Chaperone Control of the Activity and Specificity of the Histone H3 Acetyltransferase Rtt109 ...

Optimal anchoring of a foldamer inhibitor of ASF1 histone chaperone through backbone plasticity. J. Mbianda, M.M. Bakail, C. ... scChIX-seq infers dynamic relationships between histone modifications in single cells. J. Yeung, M. Florescu, P. Zeller, B.A. ...

Functional analysis of the conserved histone chaperone ASF1 in the ascomycete Sordaria macrospora. Ruhr-Universität Bochum. ...

Single-cell histone chaperones patterns guide intercellular communication of tumor microenvironment that contribute to breast ... Inhibition of CAF-1 histone chaperone complex triggers cytosolic DNA and dsRNA sensing pathways and induces intrinsic immunity ...

Role of Histone Variants and Modifications in Control of Chromatin Dynamics Histone chaperones in development and disease ...

Thus, there is a division of labor among histone chaperones, as many only fulfill some of these functions (4, 8, 11, 12). ... Each nucleosome consists of histone octamer core, assembled from the histones H2A, H2B, H3 and H4 (or other histone variants in ... The histone octamer is composed of a central heterotetramer of histones H3 and H4, flanked by two heterodimers of histones H2A ... and thereby compares histone and non-histone protection,! Transcribed into RNA by RNA polymerases histones est formé en ...

In each complex, a different set of chaperones is involved, and we found specific post-translational modifications. ... Interestingly, we revealed that histones H3 and H4 are transiently poly- (ADP-ribosylated). The impact of these marks in ... histone metabolism proved to be important as we found that acetylation of lysines 5 and 12 on histone H4 stimulated its nuclear ... Much progress has been made concerning histone function in the nucleus; however, following their synthesis, how their marking ...

Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2. Mol. Cell 2018, 71:14- ... Gruszka DT, Xie S, Kimura H, Yardimci H. Single-molecule imaging reveals control of parental histone recycling by free histones ... Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3. Genes Cells 2017 ... In vivo tracking of histone H3 lysine 9 acetylation in Xenopus laevis during tail regeneration. Genes Cells 2016, 21, 358-369. ...

Design on a rational basis of high-affinity peptides inhibiting the histone chaperone ASF1. Cell Chemical Biology. 26(11), 1573 ... Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation and transposon activation ...

Cell, Stress, and Chaperones 6(1): 38-43.. J.B. Sass, C.C. Martin & P.H. Krone. (1999). Restricted expression of the zebrafish ... 2004). Histone deacetylase 1 (HDAC-1) required for normal formation of cartilage and pectoral fins of the zebrafish. ...

The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage. Piquet S, Le Parc F, Bai SK, ... The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B. Bonizec M, ... The Paramecium histone chaperone Spt16-1 is required for Pgm endonuclease function in programmed genome rearrangements. de ... Transcription recovery after DNA damage requires chromatin priming by the H3.3 histone chaperone HIRA. Adam S, Polo SE, ...

Histone H1, H2B, H2A and H3 were detected among the 9 most abundant nitrated DNA binding proteins using this proteomic approach ... One nitrated tyrosine residue (Y29) was identified in Histone H2B in the MS/MS spectrum. In addition, we observed a significant ... We have recently described a significant increase in the tyrosine nitration levels of histones H2A and H4 when trypomastigotes ... cruzi and additional evidence for modification in the nitration profile of histones upon parasite incubation with ECM. Our data ...

It can shuttle between the cytoplasm and nucleus, suggesting a task as a histone chaperone. Evaluate for пїЅRed FlagsпїЅ Ask ...

"Histone Chaperone FACT complex mediates oxidative stress response to promote liver cancer progression - Gut 2020. 69:329-342". ...