Regulation of histone deacetylase 4 expression by the SP family of transcription factors. Mol Biol Cell. 2006;17:585-97. ... The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema. Nat Immunol. 2015;16: ... Histone deacetylase 4 (HDAC4): mechanism of regulations and biological functions. Epigenomics. 2014;6:139-50. ... histone deacetylase (HDAC) 4, MMP-9, c-Myc and SP1 (Abcam, UK), in cell lysates. Glyceraldehyde 3-phosphate dehydrogenase ( ...