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*  Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus
... a procedure carried out by histone or histone-related proteins, such as histone acetylase (HAT) and histone deacetylase (HDAC ... Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus. Ying ... Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer. 2006;6:38-51. ... Ng HH, Bird A. Histone deacetylases: silencers for hire. Trends Biochem Sci. 2000;25:121-126. doi: 10.1016/S0968-0004(00)01551- ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3077330/?lang=en-ca
*  Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian...
Seto E, Yoshida M. Erasers of histone acetylation: the histone deacetylase enzymes. Cold Spring Harb Perspect Biol [Review] ... The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc. J Mol Med (Berl) 2011; 89: 279-289 ... Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation. Proc Natl Acad Sci USA 2010; 107: ... Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung. Lung Cancer ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC5364039/
*  OSU-03012 enhances Ad.mda-7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial...
2003;2:623-32. [PubMed]. 30. Sarkar D, Su ZZ, Lebedeva IV, Sauane M, Gopalkrishnan RV, Valerie K, et al. mda-7 (IL-24) Mediates ... As ERK1/2 was inactivated to a greater extent in cells treated with OSU-03012 + Ad.mda-7 we determined whether maintenance of ... Figure 2. Activation of MEK and constitutive MCL-1 expression protect GBM cells from MDA-7/IL-24 and OSU-03012 toxicity. (A) ... All GBM lines were cultured at 37°C 5% (v/v CO2) in vitro using RPMI supplemented with 5% (v/v) fetal calf serum and 10% (v/v) ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2888700/
*  Design and Synthesis of Novel Histone Deacetylase Inhibitor Derived from Nuclear Localizasion Signal Peptide
a) Miller TA, Witter DJ, Belvedere S. Histone Deacetylase Inhibitors. J. Med. Chem. 2003;46:5097-5116. [PubMed] (b) Haggarty SJ ... Histone deacetylase (HDAC) inhibition has been clinically validated as a therapeutic strategy for cancer treatment with the FDA ... Isoform-selective histone deacetylase inhibitors. Chem Soc Rev. 2008;37:1402-1413. [PubMed] ... We found that these conjugates inhibited the histone deacetylase activities of HDACs 1, 2, 6, and 8 in a manner similar to ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2783919/
*  Meta-Analysis of Differential Connectivity in Gene Co-Expression Networks in Multiple Sclerosis
... the HIST2H2AB gene encoding a member of the histone H2A family and the gene histone deacetylase 2 (HDAC2). Note that almost all ... to a co-repressor complex containing histone deacetylase (HDAC) [90]. Note that many DC genes are epigenetic regulators, and ... Several DC genes are related to chromatin structural and epigenetic regulation; among them, the histone-lysine N- ... This transrepression is associated with VDIR switching from a co-activator complex containing histone acetyltransferase (HAT) ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC4926469/
*  Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon...
It is now widely recognised that histone acetyltransferases (HATs) and histone deacetylases (HDACs) have non-histone substrates ... Increased expression of histone deacetylase 2 is found in human gastric cancer. APMIS. 2005;113(4):264-8. doi: 10.1111/j.1600- ... Histone deacetylase inhibitors in cancer therapy. J Clin Oncol. 2009;27(32):5459-68. doi: 10.1200/JCO.2009.22.1291. Epub 2009 ... Histone deacetylase inhibitors: current status and overview of recent clinical trials. J Clin Oncol. 2009;27(32):5459-68. doi: ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2972244/
*  A FOXO3/IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses
A protein-protein interaction map9 predicted 8 histone deacetylases that might mediate this effect (data not shown), and direct ... Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors. Biochem J. 2008;409:581- ... and histone deacetylase 3 (HDAC3) on the Irf7 promoter (Fig. 2e and Supplementary Fig. 8). A functional role for this complex ... 7). Histone acetylation is associated with an open chromatin structure that allows access of transcription factors to the DNA8 ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3556990/?lang=en-ca
*  Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells
... as well as the global transcriptional repressor histone deacetylase 5.. The GO categories "regulation of cell cycle," "cell- ... histone deacetylase 5 (Locuslink 15184), IGF1R (Locuslink 16001), melanoma antigen, family D, 1 (Locuslink 94275), p21 ( ... Teresa A Venezia,# 1 , 2 Akil A Merchant,# 2 , 3 Carlos A Ramos, 2 , 3 Nathan L Whitehouse, 4 Andrew S Young, 4 Chad A Shaw, 4 ... We then plotted the average pattern for the P-sig and Q-sig and examined their component TOM groups (see Figure 2). The ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC520599/?lang=en-ca
*  Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy
Moresi V., Carrer M., Grueter C.E., Rifki O.F., Shelton J.M., Richardson J.A., Bassel-Duby R., Olson E.N. Histone deacetylases ... Histone H2B monoubiquitination (H2Bub1) is an important histone modification in gene transcriptional regulation and higher- ... Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy. Su Chen,. 1,2,3 Yuanya Jing,1 ... Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. J. Biol. Chem. 2011; 286:7190- ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC5388390/
*  Hexavalent Chromium (Cr(VI)) Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1
Cr(VI) has been shown to prevent the expression of some genes in cells by crosslinking histone deacetylase 1 to the promoters [ ... JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 ... hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Mol Cell Biol. 2005;25(15): ... The loss of acetylation at histone H4K16 has been considered to be a 'hallmark' of cancers [29]. Histone acetyltransferase MOF ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC4902237/
*  Effect of agomelatine on memory deficits and hippocampal gene expression induced by chronic social defeat stress in mice
Antidepressant actions of histone deacetylase inhibitors. J. Neurosci. 29, 11451-11460 (2009). [PMC free article] [PubMed] ... 0.7145] (Table 3). In contrast, CSDS decreased the expression of histone deacetylases HDAC2 [F(2,37). =. 4.534, p. ,. 0.05, one ... The potential use of histone deacetylase inhibitors in the treatment of depression. Prog. Neuropsychopharmacol. Biol. ... Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex. J. Biol. ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC5379201/
*  Kynurenine aminotransferase 3/glutamine transaminase L/cysteine conjugate beta-lyase 2 is a major glutamine transaminase in the...
In addition, α-Keto-γ-methylselenobutyrate and β-methylselenopyruvate are potent inhibitors of histone deacetylases and ... Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells. ... 1/2 volume saturated ammonium sulfate was added in the solution up to 33% saturation, and kept at 4 °C for at least 4 h. After ... 2.6.2. qRT-PCR analyses To confirm the RT-PCR results, six different female (3) and male (3) mice were chosen for qRT-PCR ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC5613967/
*  Propofol Inhibits SIRT2 Deacetylase through a Conformation-specific, Allosteric Site
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev. 20, 1256-1261 [PubMed] ... Finnin M. S., Donigian J. R., Pavletich N. P. (2001) Structure of the histone deacetylase SIRT2. Nat. Struct. Biol. 8, 621-625 ... 5B). The inability of other sirtuins to deacetylate α-tubulin (33), and the addition of the histone deacetylase inhibitor ... Tubulin Deacetylase Assays For each deacetylase assay, 30 μg of the soluble brain extract protein was used, and the final assay ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC4375505/
*  Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis
... histone deacetylase or mammalian target of rapamycin (mTOR)] have been investigated [11, 12]. ... 2. Subgroup analysis of progression-free survival by a local investigator review and b central review. ECOG Eastern Cooperative ... 2a). These analyses were concordant with similar subgroup analyses from data based on central review (Fig. 2b). In particular, ... The BOLERO-2 trial is the first phase 3 study to demonstrate that dual blockade of the endocrine and mTOR pathways is a ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3898123/?lang=en-ca
*  Novel Agents in Mantle Cell Lymphoma
Histone deacetylases (HDAC) control the removal of lysine residues leading to hypoacetylation of histone gene promoters and ... Histone deacetylase inhibitors have an established role in cutaneous T cell lymphoma and are now under investigation in mantle ... Histone Deacetylase. The epigenetic modulation of gene expression is a crucial component of cellular biology. In the normal ... Histone deacetylase inhibitors in cancer therapy. Journal of clinical oncology : official journal of the American Society of ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3374151/?lang=en-ca
*  HGF upregulation contributes to angiogenesis in mice with keratinocyte-specific Smad2 deletion
... which has been shown to bind histone deacetylases (HDACs) leading to gene silencing (4). TGIF binds to Smad2 and Smad3 in ... 1995;270(2):830-836. [PubMed]. 20. Cheng N, Chytil A, Shyr Y, Joly A, Moses HL. Enhanced hepatocyte growth factor signaling by ... 1995;10(2):279-289. [PubMed]. 38. Lu SL, et al. Overexpression of transforming growth factor beta1 in head and neck epithelia ... Kristina E. Hoot,1 Masako Oka,2 Gangwen Han,2 Erwin Bottinger,3 Qinghong Zhang,4 and Xiao-Jing Wang1,2 ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2947237/
*  DNA- methylation changes in a human cell model of breast cancer progression
Histone acetylation is controlled by histone acetyltransferases and histone deacetylases (HDACs) which control gene expression ... Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov. 2002;1:287-299. [PubMed] ... Histone deacetylase inhibitors as new cancer drugs. Curr Opin Oncol. 2001;13:477-483. [PubMed] ... The treatment of these cells with the demethylating agent 5-aza-dC alone or in combination with the histone deacetylase ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2872054/?lang=en-ca
*  Atherogenic Factors and Their Epigenetic Relationships
HAT: histone acetyl transferase; HDAC: histone deacetylase; HMT: histone methyl transferase; (CH3)1−3: Lys can be mono-, ... ... Isoform-selective histone deacetylase inhibitors. Chemical Society Reviews. 2008;37(7):1402-1413. [PMC free article] [PubMed] ... Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow. ... Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2989709/
*  The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature. 2001;413(6857):739-743. ... Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's ... Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's ... histone deacetylase (HDAC) inhibition (refs. 46 and 47 and Supplemental Table 3), phosphodiesterases (PDEs; refs. 48 and 49), ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3026740/
*  Histone lysine crotonylation during acute kidney injury in mice
Regulated hyperacetylation of core histones during mouse spermatogenesis: involvement of histone-deacetylases. Eur. J. Cell ... 2011). Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 146, ... Scher M. B., Vaquero A. and Reinberg D. (2007). SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the ... Munro S. K., Mitchell M. D. and Ponnampalam A. P. (2013). Histone deacetylase inhibition by trichostatin A mitigates LPS ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC4920150/
*  E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target...
Herman D., Jenssen K., Burnett R., Soragni E., Perlman S.L., Gottesfeld J.M. Histone deacetylase inhibitors reverse gene ... Monica Benini,1,2 Silvia Fortuni,1 Ivano Condò,1 Giulia Alfedi,1 Florence Malisan,1 Nicola Toschi,3,4 Dario Serio,1,2 Damiano ... 2016;2:16019. [PubMed]. Zhang W., Sidhu S.S. Development of inhibitors in the ubiquitination cascade. FEBS Lett. 2014;588:356- ... 2006;2:551-558. [PubMed]. Igoillo-Esteve M., Gurgul-Convey E., Hu A., Romagueira Bichara Dos Santos L., Abdulkarim B., ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC5329121/
*  Coordinate to Guard: Crosstalk of Phosphorylation, Sumoylation, and Ubiquitylation in DNA Damage Response
... nucleosome remodeling deacetylase (NuRD), and histone deacetylases (HDACs) to establish a silent state of chromatin and to ... Schultz D., Friedman J., Rauscher F. J. (2001). Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD ... Schultz D. C., Ayyanathan K., Negorev D., Maul G. G., Rauscher F. J. (2002). SETDB1: a novel KAP-1-associated histone H3, ... RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 131, 901-91410.1016/j. ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3355946/?lang=en-ca
*  Ligand-Specific Dynamics of the Androgen Receptor at Its Response Element in Living Cells
... histone deacetylase inhibitors can also, in part, rescue the deficiency in transcriptional potential of AR-E897A (38). These ... Rapid exchange of histone H1.1 on chromatin in living human cells. Nature 408:873-876. [PubMed] ... A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription. EMBO ... Potentiation of androgen receptor transcriptional activity by inhibition of histone deacetylation-rescue of transcriptionally ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC1820481/?lang=en-ca
*  MafG Sumoylation Is Required for Active Transcriptional Repression
Based on reports that the differential recruitment of histone deacetylases (HDACs) serves as one of the mechanisms underlying ... Furthermore, the SUMO-dependent repression activity of MafG was sensitive to histone deacetylase inhibition. Thus, repression ... which then mediates transcriptional repression through recruitment of a repressor complex containing histone deacetylase ... Histone sumoylation is associated with transcriptional repression. Proc. Natl. Acad. Sci. USA 23:13225-13230. [PubMed] ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC1489127/?lang=en-ca
*  Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer
Histone deacetylase inhibitors, such as trichostatin A (TSA), have been associated with improved SCNT reprogramming in several ... Derivation of cloned human blastocysts by histone deacetylase inhibitor treatment after somatic cell nuclear transfer with β- ... 2011;2:488. [PMC free article] [PubMed]. *Fan Y, Jiang Y, Chen X, Ou Z, Yin Y, Huang S, Kou Z, Li Q, Long X, Liu J, et al. ... Masahito Tachibana,1 Paula Amato,2 Michelle Sparman,1 Nuria Marti Gutierrez,1 Rebecca Tippner-Hedges,1 Hong Ma,1 Eunju Kang,1 ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3772789/?lang=en-ca