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*  Mao G[au] - PubMed - NCBI
Exosomal miR-95-5p regulates chondrogenesis and cartilage degradation via histone deacetylase 2/8. ... Reduced Graphene Oxide Decorated Na3V2(PO4)3 Microspheres as Cathode Material With Advanced Sodium Storage Performance. ... PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and ... 2018 May 2. doi: 10.1002/jbm.b.34146. [Epub ahead of print] ... 2.. Observation of current rectification by the new bimetallic ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Mao+G%5Bau%5D&dispmax=50
*  Thaler F[au] - PubMed - NCBI
Next generation histone deacetylase inhibitors: the answer to the search for optimized epigenetic therapies? ... Towards selective inhibition of histone deacetylase isoforms: what has been achieved, where we are and what will be next. ... Current trends in the development of histone deacetylase inhibitors: a review of recent patent applications. ... based histone deacetylase inhibitors.. Thaler F, Varasi M, Abate A, Carenzi G, Colombo A, Bigogno C, Boggio R, Zuffo RD, ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Thaler+F%5Bau%5D&dispmax=50
*  Potthoff MJ[au] - PubMed - NCBI
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice.. Montgomery RL, Potthoff MJ, Haberland M, Qi X, ... Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. ... Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. ... 2017 Feb;13(2):74-76. doi: 10.1038/nrendo.2016.206. Epub 2016 Dec 16. Review. No abstract available. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Potthoff+MJ%5Bau%5D&dispmax=50
*  Fujii S[au] - PubMed - NCBI
... a hybrid compound histone deacetylase inhibitor, regulated inflammatory response in LPS-driven human macrophages. ... Zero-Magnetic-Field Splitting in the Excited Triplet States of Octahedral Hexanuclear Molybdenum(II) Clusters: [{Mo6X8}Y6]2- (X ... 2018 Nov 2. doi: 10.2463/mrms.ci.2018-0017. [Epub ahead of print] No abstract available. ... Production of 8-nitro-cGMP in osteocytic cells and its upregulation by parathyroid hormone and prostaglandin E2. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Fujii+S%5Bau%5D&dispmax=50
*  Emerging Drugs for Duchenne Muscular Dystrophy - CADTH Issues in Emerging Health Technologies - NCBI Bookshelf
... histone deacetylase inhibition) are in early stages of development.The evidence reviewed showed that, while these drugs ... Histone Deacetylase Inhibitor Activity. Histone deacetylase inhibitor activity is upregulated in dystrophic muscles and ... Givinostat is a histone deacetylase inhibitor that may help to rebalance the repair process in muscle by increasing muscle ... Givinostat is a histone deacetylase inhibitor currently being studied for the treatment of DMD (Appendix 2). Givinostat ...
https://www.ncbi.nlm.nih.gov/books/NBK476440/
*  Lee RJ[au] - PubMed - NCBI
Neuronal Susceptibility to Beta-Amyloid Toxicity and Ischemic Injury Involves Histone Deacetylase-2 Regulation of Endophilin-B1 ... 2017 Oct 30;2(5):610-612. doi: 10.1016/j.jacbts.2017.09.007. eCollection 2017 Oct. No abstract available. ... Synergistic Inhibition of Human Carcinoma Cell Growth via Co-Delivery of p53 Plasmid DNA and bcl-2 Antisense ... 2018 May 2;98(3):547-561.e10. doi: 10.1016/j.neuron.2018.03.043. Epub 2018 Apr 19. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Lee+RJ%5Bau%5D&dispmax=50
*  Harsch A[au] - PubMed - NCBI
Design of novel histone deacetylase inhibitors.. Siliphaivanh P, Harrington P, Witter DJ, Otte K, Tempest P, Kattar S, Kral AM ... Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). ... The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors. ... Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.. Methot JL, Hoffman DM, Witter DJ, ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Harsch+A%5Bau%5D&dispmax=50
*  Fulda S[au] - PubMed - NCBI
BCL-2 selective inhibitor ABT-199 primes rhabdomyosarcoma cells to histone deacetylase inhibitor-induced apoptosis. ... 2019 Feb;20(2). pii: e46520. doi: 10.15252/embr.201846520. Epub 2019 Jan 21. Review. ... Selective BH3-mimetics targeting BCL-2, BCL-XL or MCL-1 induce severe mitochondrial perturbations. ... 2019 Jan;286(2):241-278. doi: 10.1111/febs.14608. Epub 2018 Aug 4. Review. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Fulda+S%5Bau%5D&dispmax=50
*  HDAC4 histone deacetylase 4 [Homo sapiens (human)] - Gene - NCBI
histone deacetylase 4. Names. histone deacetylase A. NP_006028.2. *EC 3.5.1.98 ... HDAC4 histone deacetylase 4 [Homo sapiens] HDAC4 histone deacetylase 4 [Homo sapiens]. Gene ID:9759 ... a Class IIa histone deacetylase. cd10006. Location:649 → 1057. HDAC4; Histone deacetylase 4. ... a Class IIa histone deacetylase. cd10006. Location:654 → 1062. HDAC4; Histone deacetylase 4. ...
https://www.ncbi.nlm.nih.gov/gene/9759
*  Holson E[au] - PubMed - NCBI
Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase- ... Discovery of the first histone deacetylase 6/8 dual inhibitors.. Olson DE, Wagner FF, Kaya T, Gale JP, Aidoud N, Davoine EL, ... PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule ... An unbiased approach to identify endogenous substrates of "histone" deacetylase 8.. Olson DE, Udeshi ND, Wolfson NA, Pitcairn ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Holson+E%5Bau%5D&dispmax=50
*  NCOR2 nuclear receptor corepressor 2 [Homo sapiens (human)] - Gene - NCBI
HDACs deacetylate histones, organism-specific biosystemLysine deacetylases (KDACs), historically referred to as histone ... with all the Class IIa Histone Deacetylases (HDACs 4, 5, 7, and 9). Title: Insights into the Recruitment of Class IIa Histone ... histone deacetylase binding IBA Inferred from Biological aspect of Ancestor. more info ... histone deacetylase complex IBA Inferred from Biological aspect of Ancestor. more info ...
https://www.ncbi.nlm.nih.gov/gene/9612
*  Watson P[au] - PubMed - NCBI
Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo. ... 2019 Jun 6. doi: 10.1007/s10802-019-00561-2. [Epub ahead of print] ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Watson+P%5Bau%5D&dispmax=50
*  Azab F[au] - PubMed - NCBI
microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia.. Roccaro AM, Sacco A, Jia X, Azab AK, ... Defining the role of TORC1/2 in multiple myeloma.. Maiso P, Liu Y, Morgan B, Azab AK, Ren P, Martin MB, Zhang Y, Liu Y, Sacco A ... Results of a phase 2 trial of the single-agent histone deacetylase inhibitor panobinostat in patients with relapsed/refractory ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Azab+F%5Bau%5D&dispmax=50
*  Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)amino- methyl]benzamide and m...
HDAC inhibitors induce histone hyperacetylation by a relative increase of histone acetyltransferase activity. Histone ... Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)amino- methyl]benzamide and m- ... 2004 Jun 10;110(2):301-8. Research Support, Non-U.S. Gov't ...
https://www.ncbi.nlm.nih.gov/pubmed/15069698?dopt=Abstract
*  Renoprotective effect of combined inhibition of angiotensin-converting enzyme and histone deacetylase. - PubMed - NCBI
Renoprotective effect of combined inhibition of angiotensin-converting enzyme and histone deacetylase.. Zhong Y1, Chen EY, Liu ... In summary, these data suggest that the combination of an ACE inhibitor and a histone deacetylase inhibitor could have ... Renoprotective Effect of Combined Inhibition of Angiotensin-Converting Enzyme and Histone Deacetylase ... Renoprotective Effect of Combined Inhibition of Angiotensin-Converting Enzyme and Histone Deacetylase ...
https://www.ncbi.nlm.nih.gov/pubmed/23559582
*  Gao Y[au] - PubMed - NCBI
Histone deacetylase 2 is involved in DNA damage-mediated cell death of human osteosarcoma cells through stimulation of the ATM/ ... 2.. New Insights into the Combination of Permanganate and Bisulfite as a Novel Advanced Oxidation Process: Importance of High ... A Novel Berberine - Metformin Hybrid Compound Exerts Therapeutic Effects on Obese Type 2 Diabetic Rats. ... on the risks of major adverse cardiovascular outcomes and hypoglycemia in patients with different glycemic control and type 2 ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Gao+Y%5Bau%5D&dispmax=50
*  Mayor F[au] - PubMed - NCBI
... and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility. ... 2.. Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis ... G protein-coupled receptor kinase 2 (GRK2) in migration and inflammation.. Penela P, Murga C, Ribas C, Salcedo A, Jurado-Pueyo ... 2013 Apr;36(2):175-84; discussion 184-5. doi: 10.1007/s10143-012-0432-z. Epub 2012 Oct 25. Review. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Mayor+F%5Bau%5D&dispmax=50
*  Boxer LM[au] - PubMed - NCBI
Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. ... Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factor. ... Role of the cyclic AMP response element in the bcl-2 promoter in the regulation of endogenous Bcl-2 expression and apoptosis in ... Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Boxer+LM%5Bau%5D&dispmax=50
*  Merkler D[au] - PubMed - NCBI
Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context- ... 2018 Feb 20;48(2):380-395.e6. doi: 10.1016/j.immuni.2018.01.011. Epub 2018 Feb 6. Erratum in: Immunity. 2018 Mar 20;48(3):599. ... 2018 Oct 4;175(2):458-471.e19. doi: 10.1016/j.cell.2018.07.049. Epub 2018 Aug 30. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Merkler+D%5Bau%5D&dispmax=50
*  RERE arginine-glutamic acid dipeptide repeats [Homo sapiens (human)] - Gene - NCBI
A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor ... Conserved Domains (2) summary. TIGR04420. Location:58 → 146. Sec_Non_Glob; Sec region non-globular protein. pfam03154. Location ... Variants 1 and 2 encode the same isoform (a).. Source sequence(s). AB036737, AL356072, AL357552, BC062342, CD679363, DA868444 ... Title: Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse ...
https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=DetailsSearch&Term=473
*  Hao W[au] - PubMed - NCBI
Histone deacetylase 2 is involved in DNA damage-mediated cell death of human osteosarcoma cells through stimulation of the ATM/ ... 2.. Intrinsic Mitochondrial Nutrient Utilization May Underlie the Association of Metabolite Levels with BMIz and Insulin ... Bimetal-Catalyzed Cascade Reaction for Efficient Synthesis of N-Isopropenyl 1,2,3-Triazoles via In-Situ Generated 2- ... Cafestol Activates Nuclear Factor Erythroid-2 Related Factor 2 and Inhibits Urotensin II-Induced Cardiomyocyte Hypertrophy. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Hao+W%5Bau%5D&dispmax=50
*  Hdac5 histone deacetylase 5 [Rattus norvegicus (Norway rat)] - Gene - NCBI
Hdac5 histone deacetylase 5 [Rattus norvegicus] Hdac5 histone deacetylase 5 [Rattus norvegicus]. Gene ID:84580 ... histone deacetylase 5provided by RGD. Primary source. RGD:619980 See related. Ensembl:ENSRNOG00000020905 Gene type. protein ... Intracellular translocation of histone deacetylase 5 regulates neuronal cell apoptosis. Wei JY, et al. Brain Res, 2015 Apr 16. ... NAD-dependent histone deacetylase activity (H3-K14 specific) IEA Inferred from Electronic Annotation. more info ...
https://www.ncbi.nlm.nih.gov/gene?amp=&cmd=Retrieve&dopt=Graphics&list_uids=84580
*  An epigenetic blockade of cognitive functions in the neurodegenerating brain. - PubMed - NCBI
Histone deacetylase 2 associates with and reduces the histone acetylation of genes important for learning and memory, which ... Importantly, reversing the build-up of histone deacetylase 2 by short-hairpin-RNA-mediated knockdown unlocks the repression of ... This blockade is mediated by histone deacetylase 2, which is increased by Alzheimer's-disease-related neurotoxic insults in ... These findings advocate for the development of selective inhibitors of histone deacetylase 2 and suggest that cognitive ...
https://www.ncbi.nlm.nih.gov/pubmed/22388814
*  Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and...
Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and ... Feingold PL1, Surman DR1, Brown K1, Xu Y1, McDuffie LA1, Shukla V1, Reardon ES1, Crooks DR2, Trepel JB3, Lee S3, Lee MJ3, Gao S ... 2. Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.. 3. Developmental ... 1, Xi S1, McLoughlin KC1, Diggs LP1, Beer DG4, Nancarrow DJ4, Neckers LM2, Davis JL1, Hoang CD1, Hernandez JM1, Schrump DS1, ...
https://www.ncbi.nlm.nih.gov/pubmed/29934340
*  Similar articles for PubMed (Select 14976264) - PubMed - NCBI
Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting ... Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 ( ... Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.. Brunet A, Sweeney LB, Sturgill JF, Chua KF ... FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress. ...
https://www.ncbi.nlm.nih.gov/pubmed?LinkName=pubmed_pubmed&from_uid=14976264