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*  Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2
Previous studies showed genetic knockdown of histone deacetylase (HDAC) 1 or 2 is sufficient to induce HbF. Here we show that ... by histone acetylation-induced activation of the GATA2 gene. ... These data show that chemical inhibition of HDAC1/2 induces HBG ... Chromatin immunoprecipitation and sequencing (ChIP-Seq) of primary erythroid progenitors demonstrated that HDAC1 and 2 ... HDAC1/2), elicits a dose and time dependent induction of γ-globin mRNA (HBG) and HbF in cultured primary cells derived from ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153767
*  The Cardiac Acetyl-Lysine Proteome
Nuclear targets included histones and the transcriptional regulators E1A(p300) and CREB binding protein. Comparison of our ... Work by Gupta and coworkers identified the acetyltransferase, PCAF [14], and both class I and class II histone deacetylases ( ... In the years since, families of histone acetyltransferases and deacetylases have been discovered, and nuclear protein ... Among the core histones that comprise the nucleosome, acetylation sites were found in isoforms of H2A, H2B, H3, H4, including, ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067513
*  Spinal SIRT1 Activation Attenuates Neuropathic Pain in Mice
These data indicate that the reduction in SIRT1 deacetylase activity may be a factor contributing to the development of ... plays complex systemic roles in a variety of processes through deacetylating acetylated histone and other specific substrates. ... It was found that spinal SIRT1 expression, deacetylase activity and NAD/NAM decreased significantly 1, 3, 7, 14 and 21 days ... Silent information regulator 1 (sir2 or SIRT1), a NAD-dependent deacetylase, ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100938
*  MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the...
... and it affects about 2-3 people in every 100. Obesity is defined as having a body mass index of over 30 in adults or over the ... Myt1 family recruits histone deacetylase to regulate neural transcription. J Neurochem. 2005; 93 (6): 1444-1453. pmid:15935060 ... Fig 2. Structural effects of MYT1L missense variants.. (A)Schematic diagram of MYT1L protein, the yellow boxes indicate zinc ... 2. Van der Klaauw AA, Farooqi IS. The hunger genes: pathways to obesity. Cell. 2015;161(1): 119-132. pmid:25815990 * View ...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006957
*  4-Phenylbutyrate Inhibits Tunicamycin-Induced Acute Kidney Injury via CHOP/GADD153 Repression
4-PBA has 3 main biologic effects: it is an ammonia scavenger [16], a weak histone deacetylase (HDAC) inhibitor [17], and an ER ... Miller AC, Cohen S, Stewart M, Rivas R, Lison P (2011) Radioprotection by the histone deacetylase inhibitor phenylbutyrate. ... acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor ... Its effects on protein acetylation may extend beyond those affecting histones. HDAC inhibitors are known to prevent ...
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084663
*  Genetic Variations in Plasma Circulating DNA of HBV-Related Hepatocellular Carcinoma Patients Predict Recurrence after Liver...
Multivariate analyses demonstrated that the co-index of the 2 SNPs was an independent prognostic factor for recurrence (P = . ... Wu et al [38] found Histone Deacetylase 3 could serve as a biomarker for tumor recurrence following LT in HBV-Associated HCC. ... 2010) Identification of Histone Deacetylase 3 as a Biomarker for Tumor Recurrence Following Liver Transplantation in HBV- ... Table 2. Kaplan-Meier survival estimates and log-rank tests of factors associated with TTR and OS in patients exceeding Milan ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026003
*  De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects
The key histone deacetylase HDAC1 is directly activated by NR1D2 binding and indirectly activated by NR2F2 via PROX1 [33-35]. ... Histone Modifier Genes Alter Conotruncal Heart Phenotypes in 22q11.2 Deletion Syndrome. Am J Hum Genet. Elsevier; 2015;97: 869- ... De novo mutations in histone-modifying genes in congenital heart disease. Nature. 2013;498: 220-3. pmid:23665959 * View Article ... 2. Pradat P, Francannet C, Harris Ja, Robert E. The epidemiology of cardiovascular defects, part I: a study based on data from ...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005963
*  Comparative Genomic and Transcriptomic Characterization of the Toxigenic Marine Dinoflagellate Alexandrium ostenfeldii
... is directly correlated to the exceptionally genome organization of dinoflagellates with a low amount of histones and histone- ... 15] discovered all four core nucleosomal histones (H2A.X, H2B, H3, and H4), along with histone deacetylase and nucleosome ... Alternatively, these histones may be involved in the regulation of gene expression. It is likely that in earlier studies ... The low amounts of histones and the presence of peripheral DNA loops are probably due to a secondary loss and gain of the ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028012
*  NEDD9 Is a Positive Regulator of Epithelial-Mesenchymal Transition and Promotes Invasion in Aggressive Breast Cancer
Moreover, our ChIP assays revealed that overexpression of NEDD9 enhanced the recruitment of histone deacetylase HDAC1/HDAC2 ... Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol Cell Biol ... 2, 3). These data suggested that NEDD9 was a regulator of the migration, invasion and proliferation in breast cancer cells. In ... 2. Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, et al. (2001) Gene expression patterns of breast carcinomas distinguish ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022666
*  EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers
... the histone methyltransferase of the Polycomb Repressive complex 2 catalyzing histone H3 lysine 27 tri-methylation (H3K27me3), ... Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase ... Cameron EE, Bachman KE, Myöhänen S, Herman JG, Baylin SB (1999) Synergy of demethylation and histone deacetylase inhibition in ... EZH2 is a histone methyltransferase that specifically catalyzes histone H3 lysine 27 tri-methylation (H3K27me3), which in turn ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068226
*  Nucleosome Assembly Proteins Get SET to Defeat the Guardian of Chromosome Cohesion
... and histone deacetylases (Nap1), and SET is a component of INHAT, an inhibitor of histone acetyltransferases [10]-[12]. It is ... Histones Is the Subject Area "Histones" applicable to this article? Yes. No. ... 2009) Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during ... Das C, Tyler JK, Churchill ME (2010) The histone shuffle: histone chaperones in an energetic dance. Trends Biochem Sci 35: 476- ...
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003829
*  Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1
Thus, our results highlight complex interactions between histone demethylase, deacetylase and chromatin remodelling activities ... the histone deacetylase Clr6, and the chromatin remodeller Hrp1. The data presented here demonstrate that in fission yeast the ... However, we find that this complex specifically demethylates lysine 9 in histone H3 (H3K9) and both up- and down-regulates ... we have studied genome-wide changes in patterns of histone methylation, and their correlation with gene expression, upon ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000386
*  PLOS ONE: HDAC6 Regulates Epidermal Growth Factor Receptor (EGFR) Endocytic Trafficking and Degradation in Renal Epithelial...
We present for the first time that histone deacetylase 6 (HDAC6) regulates EGFR degradation and trafficking along microtubules ... HDAC6, the microtubule-associated α-tubulin deacetylase, demonstrates increased expression and activity in Pkd1 mutant mouse ... In addition, inhibition of HDAC activity decreased the phosphorylation of ERK1/2, the downstream target of EGFR axis, and ...
http://journals.plos.org/plosone/article/related?id=10.1371/journal.pone.0049418