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*  Pdef Expression in Human Breast Cancer Is Correlated with Invasive Potential and Altered Gene Expression | Cancer Research
In addition, it has been shown that dephosphorylated Rb, in association with E2F, can recruit histone deacetylase to mediate ... or in combination with a histone deacetylase inhibitor (34) . A critical Ets site in the Maspin promoter has also been found to ... histone deacetylase; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Rb, retinoblastoma protein; ECM, ... Maass N., Biallek M., Rosel F., Schem C., Ohike N., Zhang M., Jonat W., Nagasaki K. Hypermethylation and histone deacetylation ...
http://cancerres.aacrjournals.org/content/63/15/4626?ijkey=b6695a1e8e832ae99774e7dd4b2221a813845946&keytype2=tf_ipsecsha
*  Abstract 2196: Novel and selective histone deacetylase (HDAC) 1 & 2 inhibitors enhance differentiation of neuroblastoma cells...
Novel and selective histone deacetylase (HDAC) 1 & 2 inhibitors enhance differentiation of neuroblastoma cells in combination ... Abstract 2196: Novel and selective histone deacetylase (HDAC) 1 & 2 inhibitors enhance differentiation of neuroblastoma cells ... Abstract 2196: Novel and selective histone deacetylase (HDAC) 1 & 2 inhibitors enhance differentiation of neuroblastoma cells ... Abstract 2196: Novel and selective histone deacetylase (HDAC) 1 & 2 inhibitors enhance differentiation of neuroblastoma cells ...
http://cancerres.aacrjournals.org/content/75/15_Supplement/2196
*  Table of Contents | Cancer Research
Statins Increase p21 through Inhibition of Histone Deacetylase Activity and Release of Promoter-Associated HDAC1/2 ... Statins Increase p21 through Inhibition of Histone Deacetylase Activity and Release of Promoter-Associated HDAC1/2 ... Mitogen- and Stress-Activated Kinase 1-Mediated Histone H3 Phosphorylation Is Crucial for Cell Transformation ... c-Jun NH2-Terminal Kinase Activating Kinase 1/Mitogen-Activated Protein Kinase Kinase 4-Mediated Inhibition of SKOV3ip.1 ...
http://cancerres.aacrjournals.org/content/68/7
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Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. Cancer Res 2003;63:7291-300. ... The histone deacetylase inhibitor entinostat is emerging as a promising antitumor agent when added to the standard-of-care ... The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist ... Phase I trial of vorinostat and doxorubicin in solid tumours: histone deacetylase 2 expression as a predictive marker. Br J ...
http://cancerres.aacrjournals.org/content/76/7/2013
*  In vivo molecular implications of the combination of the hypo-methylating agent 5-aza-2'-deoxycytidine and the histone...
Epigenetic silencing can be reversed in vitro using agents with hypomethylating or histone deacetylase inhibitory (HDI) ... deoxycytidine and the histone deacetylase inhibitor valproic acid in patients with leukemia: Results of a phase I/II study. ... deoxycytidine and the histone deacetylase inhibitor valproic acid in patients with leukemia: Results of a phase I/II study ... deoxycytidine and the histone deacetylase inhibitor valproic acid in patients with leukemia: Results of a phase I/II study ...
http://cancerres.aacrjournals.org/content/65/9_Supplement/937.2
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Inhibition of Histone Deacetylase. Melinda C. Myzak, P. Andrew Karplus, Fung-Lung Chung and Roderick H. Dashwood ... Marks PA Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc ... A balance exists in normal cells between histone acetyl transferase and histone deacetylase (HDAC) activities, and when this ... Finzer P, Kuntzen C, Soto U, zur Hausen H, Rosl F Inhibitors of histone deacetylase arrest cell cycle and induce apoptosis in ...
http://cancerres.aacrjournals.org/content/64/16/5767
*  HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+...
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for ... Histone deacetylase inhibitors (HDACi) may engage host immunity as one basis for their antitumor effects. Herein, we ... Histone deacetylase inhibitors (HDACi) are anticancer drugs that can mediate a diverse array of biological responses, including ... Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, ...
http://cancerres.aacrjournals.org/content/77/10/2594.full
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... deoxycytidine and the histone deacetylase inhibitor trichostatin A in this silencing event. The drugs were tested independently ... Finally, we tested the effect of the DNA demethylating agent 5-aza-2'- ... in tandem 2, 4 and 6 times upstream to these promoters, resulting in 7 different transgenic cassettes that were transiently and ... while the B1-containing vectors showed only 2-fold induction. In conclusion, our results are consistent with a model whereby ...
http://cancerres.aacrjournals.org/content/65/9_Supplement/643.3
*  Abstract 2022: P53-dependent thrombocytopenia induced by the histone deacetylase inhibitor S78454 | Cancer Research
Abstract 2022: P53-dependent thrombocytopenia induced by the histone deacetylase inhibitor S78454. Ashfaq Ali, Olivier Bluteau ... Abstract 2022: P53-dependent thrombocytopenia induced by the histone deacetylase inhibitor S78454 ... Abstract 2022: P53-dependent thrombocytopenia induced by the histone deacetylase inhibitor S78454 ... Abstract 2022: P53-dependent thrombocytopenia induced by the histone deacetylase inhibitor S78454 ...
http://cancerres.aacrjournals.org/content/72/8_Supplement/2022
*  Abstract 5377: Profiling of aurora kinase signaling in microdissected gastric cancer samples indicates a significant increase...
Results: We found a significant increase in histone deacetylase 4 levels (HDAC4, p,0.0001) concomitant with increased ... of aurora kinase signaling in microdissected gastric cancer samples indicates a significant increase in histone deacetylase 4 ( ... of aurora kinase signaling in microdissected gastric cancer samples indicates a significant increase in histone deacetylase 4 ( ... of aurora kinase signaling in microdissected gastric cancer samples indicates a significant increase in histone deacetylase 4 ( ...
http://cancerres.aacrjournals.org/content/73/8_Supplement/5377
*  MEK1/2 Inhibition Decreases Lactate in BRAF-Driven Human Cancer Cells | Cancer Research
Histone deacetylase inhibition increases levels of choline kinase alpha and phosphocholine facilitating non-invasive imaging in ... MEK1/2 Inhibition Decreases Lactate in BRAF-Driven Human Cancer Cells. Maria Falck Miniotis, Vaitha Arunan, Thomas R. Eykyn, ... MEK1/2 Inhibition Decreases Lactate in BRAF-Driven Human Cancer Cells. Maria Falck Miniotis, Vaitha Arunan, Thomas R. Eykyn, ... MEK1/2 Inhibition Decreases Lactate in BRAF-Driven Human Cancer Cells. Maria Falck Miniotis, Vaitha Arunan, Thomas R. Eykyn, ...
http://cancerres.aacrjournals.org/content/73/13/4039
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... in the myeloid cells through epigenetic modifications mediated by histone deacetylase 2 (HDAC2). MDSCs from patients with ... ALPPL-2 for Management of Pancreatic Adenocarcinoma. Dua P, Kang HS, Hong SM, Tsao MS, Kim S, Lee DK. Alkaline phosphatase ... In 2 Nf1-deficient murine models for MPNST, they demonstrate upregulation of Cxcr4 at the mRNA and protein levels. Using a ... Of note, ALPPL-2 expression was detectable in both the membrane and the secretome. Knockdown of ALPPL-2 from PANC-1 cells ...
http://cancerres.aacrjournals.org/content/73/7/2023
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Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated ... selectively represses IL-6 Transcription through Histone Deacetylase 1 (HDAC1)-mediated histone deacetylation in macrophages. J ... such as histone deacetylase 2 (HDAC2) and DEK (14), implicating that Daxx can function as a corepressor to repress gene ... mediated histone H4 arginine 3 dimethylation (H4R3me2; ref. 9) and SUV39H1-mediated histone H3 lysine 9 trimethylation (H3K9me3 ...
http://cancerres.aacrjournals.org/content/77/2/401
*  Histone Deacetylase Inhibitors Induce Premature Sister Chromatid Separation and Override the Mitotic Spindle Assembly...
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad ... Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov 2002; 1: 287-99. ... Histone deacetylase inhibitors in cancer therapy: is transcription the primary target? Cancer Cell 2003; 4: 13-8. ... Histone deacetylase (HDAC) inhibitors (HDACI) exhibit antiproliferative activity against a variety of human cancers. They are ...
http://cancerres.aacrjournals.org/content/67/13/6360
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The p21 gene was activated only by histone deacetylase inhibitor. The p57 gene was activated by histone deacetylase inhibitors ... The level of histone acetylation depends on the activity of histone acetyl transferases and HDACs. A number of genes and ... Histone acetylation results in the separation of DNA from histones, allowing nucleosomal DNA to become more accessible to ... Inactivation by histone deacetylation seems to be broader than the methylation-mediated inactivation. The histone deacetylation ...
http://cancerres.aacrjournals.org/content/60/2/262
*  Molecular Profiling of Human Hepatocellular Carcinoma Defines Mutually Exclusive Interferon Regulation and Insulin-Like Growth...
Reversible histone deacetylase inhibitors, such as trichostatin A, were shown to modulate the IGF axis (54 , 55) , potentially ... Tsurutani J, Soda H, Oka M, et al Antiproliferative effects of the histone deacetylase inhibitor FR901228 on small-cell lung ... Butler LM, Zhou X, Xu WS, et al The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin- ... histone deacetylase 2 and replication factor C 4), apoptosis (e.g., nucleolin and desoxyribonuclease I-like 3), signal ...
http://cancerres.aacrjournals.org/content/64/17/6058?ijkey=5b066668aecd149074a0ab314229802182e6ae01&keytype2=tf_ipsecsha
*  Reversal of glucocorticoid resistance in human lymphoid malignancies with histone deacetylase inhibitors | Cancer Research
Treatment with the histone deacetylase inhibitor Vorinostat (SAHA) re-induced Bim acetylation in resistant cells; thus, we ... Reversal of glucocorticoid resistance in human lymphoid malignancies with histone deacetylase inhibitors. Rocco Piazza, Petra ... Reversal of glucocorticoid resistance in human lymphoid malignancies with histone deacetylase inhibitors ... Reversal of glucocorticoid resistance in human lymphoid malignancies with histone deacetylase inhibitors ...
http://cancerres.aacrjournals.org/content/68/9_Supplement/2464
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... and of the histone deacetylase inhibitor Trichostatin-A (TSA). Our results suggest that plakoglobin expression is inhibited by ... 2;13)(q35;q14), 2 ARMS without translocation and 3 ERMS. We found a consistent and homogeneous β-catenin expression in all of ... we assessed the effects of the DNA demethylating agent 5-Aza-2'-deoxycytidine (5AzadC) ...
http://cancerres.aacrjournals.org/content/65/9_Supplement/1111.2
*  Epigenetically Controlled Fibroblast Growth Factor Receptor 2 Signaling Imposes on the RAS/BRAF/Mitogen-Activated Protein...
6C). Moreover, histone deacetylase inhibition by trichostatin A failed to alter FGFR1 or FGFR2 expression in these cells. These ... Histone deacetylase inhibition by trichostatin A treatment failed to significantly alter FGFR1 or FGFR2 expression. ... For histone deacetylase inhibition, trichostatin A (0.3 μmol/L, Sigma) was applied for 24 h. The equivalent volume of vehicle ( ... 2D].. Restoration of FGFR2-IIIb attenuates RAS/BRAF/MAPK phosphorylation. Given the recognized importance of the BRAF/MAPK ...
http://cancerres.aacrjournals.org/content/67/11/5461
*  Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules | Cancer Research
Novel intracellular targets of S1P include histone deacetylase (HDAC; ref. 12), TRAF2 (13), p21-activated protein kinase 1 ( ... Regulation of histone acetylation in the nucleus by sphingosine 1-phosphate. Science 2009;325:1254-7. ... S1P inhibition of HDACs increases histone acetylation, thereby promoting expression of p21 and c-fos (12). The identification ... 2, 3). Moreover, S1P promotes migration of ER+ MCF-7 breast cells via an SK1-dependent mechanism, and this might suggest a role ...
http://cancerres.aacrjournals.org/content/71/21/6576.full
*  Histone deacetylase inhibitor activation of p21 involves changes in promoter associated proteins, including HDAC1 | Cancer...
Histone deacetylase inhibitor activation of p21 involves changes in promoter associated proteins, including HDAC1. Chang-Yun ... Histone Deacetylase Inhibitors (HDACi) cause cancer cell growth arrest and/or apoptosis, in vivo and in vitro. HDACi, ... Histone deacetylase inhibitor activation of p21 involves changes in promoter associated proteins, including HDAC1 ... Histone deacetylase inhibitor activation of p21 involves changes in promoter associated proteins, including HDAC1 ...
http://cancerres.aacrjournals.org/content/64/7_Supplement/222.1
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Just recently, the use of inhibitors of histone deacetylase in the drug treatment of neoplasm such as breast, bladder, and ... Iguchi H., Imura G., Toh Y., Ogata Y. Expression of MTA1, a metastasis-associated gene with histone deacetylase activity in ... Munster P. N., Troso-Sandoval T., Rosen N., Rifkind R., Marks P. A., Richon V. M. The histone deacetylase inhibitor ... a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol. Cell, 2: 851-861, 1998. ...
http://cancerres.aacrjournals.org/content/64/3/825
*  5-AZA-2′-Deoxycytidine in Cancer Immunotherapy: A Mouse to Man Story | Cancer Research
... with optimized dose/schedules of decitabine alone or in conjunction with other types of agents such as histone deacetylase ... 5-AZA-2′-Deoxycytidine in Cancer Immunotherapy: A Mouse to Man Story. Z. Sheng Guo, Nicholas P. Restifo and David S. Schrump ... De novo induction of a cancer/testis antigen by 5-aza-2′-deoxycytidine augments adoptive immunotherapy in a murine tumor model ... Phase I trial of sequential low-dose 5-aza-2′-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with ...
http://cancerres.aacrjournals.org/content/67/6/2901
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Mei S, Ho AD, Mahlknecht U. Role of histone deacetylase inhibitors in the treatment of cancer [review]. Int J Oncol 2004;25: ... Histone deacetylase inhibitors, such as tributyrin, have been considered as potential differentiation therapy drugs (26) and as ... Dai Y, Rahmani M, Grant S. An intact NF-κB pathway is required for histone deacetylase inhibitor-induced G1 arrest and ... Tributyrin induces replication arrest, cell cycle block, and differentiation in PC-3 cells. Tributyrin, a histone deacetylase ...
http://cancerres.aacrjournals.org/content/65/24/11588
*  Sixteenth Annual Pezcoller Symposium | Cancer Research
Paul Marks discussed the therapeutic use of histone deacetylase (HDAC) inhibitors. There are three classes of human HDAC ... Histone chaperones have been isolated from cell extracts that stimulate early steps in chromatin assembly in vitro and ... Methylation of lysine 9 of histone H3 (me-K9-H3) may be a critical signal that helps to recruit DNA methylation to the ... Manel Esteller discussed cancer as an epigenetic disease with focus on a disruption of DNA methylation and histone codes. DNA ...
http://cancerres.aacrjournals.org/content/64/22/8474.full