The histone deacetylase (HDAC) inhibitor trichostatin A (TSA) showed stronger growth suppression in H1975-OR cells than in ... Histone acetylation and deacetylation are regulated by histone deacetylase (HDAC) and histone acetyltransferase (HAT) enzymes, ... The histone deacetylase (HDAC) inhibitor trichostatin A (TSA) showed stronger growth suppression in H1975-OR cells than in ... Fu WJ, Yi SG, Qiu L, Sun JR, Tu P, Wang Y. BCL11B-mediated epigenetic repression is a crucial target for histone deacetylase ...

ChIP-qPCR assays were performed to evaluate the recruitment of different histone modifications in the core promoter region of ... this study intended to investigate the association of securin upregulation with the Rb-E2F1 circuit and epigenetic histone (H3 ... histone deacetylase 3), KDM4C (histone demethylase) and the reference gene GAPDH. Cell lysates were collected, and RNA was ... 7C). Consistent with KAT2A and KAT3B upregulation, the expression of histone deacetylase 3 (HDAC) was downregulated (Fig. 7F). ...