Misregulations induced by the major Spondyloarthritis susceptibility factor HLA-B27: from Drosophila to patients' cells | ANR
The major histocompatibility complex class I antigen, HLA-B27 is the strongest genetic factor associated with disease ... ANR is the main national operator of the Investments for the Future programmes in the fields of higher education and research ... The most important part of heritability comes from the HLA-B27 allele of the Major Histocompatibility Complex (MHC). The ...
Rheumatic Fever - Pediatrics - MSD Manual Professional Edition
Genetic host risk factors include the D8/17 B-cell antigen and certain class II histocompatibility antigens. Undernutrition, ... Positive rapid GAS antigen test in a child with clinical manifestations suggestive of streptococcal pharyngitis ... Throat cultures and rapid strep antigen tests are often negative by the time ARF manifests, whereas titers of antistreptolysin ... suggesting that molecular mimicry by GAS antigens from rheumatogenic strains contributes to the arthritis, carditis, and ...
Identification of human vascular endothelial cell/monocyte antigenic system using monoclonal antibodies - Fingerprint
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Michelle H. Larsen - Publications - Albert Einstein College of Medicine
Histocompatibility Antigens Class II 75% * Major Histocompatibility Complex 70% 118 Scopus citations ... Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE-PGRS47. Saini, N. K., Baena, A., Ng, T. W., ... Stable expression of lentiviral antigens by quality-controlled recombinant mycobacterium bovis BCG vectors. Hart, B. E., ... Improving Mycobacterium bovis bacillus calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of ...
US Patent for Homologous recombination for universal donor cells and chimeric mammalian hosts Patent (Patent # 5,416,260...
Particularly, the .beta..sub.2 -microglobulin gene is inactivated for reducing or eliminating Class I MHC antigens. The ... f) breeding said offspring to produce a homozygous mouse lacking functional Class I major histocompatibility complex antigens. ... of the Class I or II MHC antigens or the .beta.-subunit(s) of the Class II MHC antigens. The human Class II MHC antigens are ... e) breeding said offspring to produce a homozygous mouse lacking functional Class I major histocompatibility complex antigens. ...
Publications | National Jewish Health
Class II major histocompatibility complex mutant mice to study the germline bias of T cell antigen receptors. Proc. Natl. Acad ... McKee, A. S. et al. Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and ... Atif, S. M. et al. Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched ... Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal ...
No. HIX Chr. location HGNC gene symbol Definition HIF Gene family/group name
... hap2 HLA class I histocompatibility antigen, B-8 alpha chain precursor (MHC class I antigen B*8). HIF0000002 Major ... hap5 HLA class I histocompatibility antigen, B-51 alpha chain; MHC class I antigen B*51; Precursor; HIF0000002 Major ... hap6 HLA-A HLA class I histocompatibility antigen, A-26 alpha chain precursor (MHC class I antigen A*26). HIF0000002 Major ... hap4 HLA-C HLA class I histocompatibility antigen, Cw-16 alpha chain precursor (MHC class I antigen Cw*16). HIF0000002 Major ...
Deakin University / All Locations
Human Class I Antigens -- See Histocompatibility Antigens Class I Membrane glycoproteins consisting of an alpha subunit and a ... Human Class II Antigens -- See HLA-D Antigens Human immune-response or Class II antigens found mainly, but not exclusively, on ... Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These ... In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in ...
Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses. - MRC Weatherall...
Selection involves B cells competing for T cell help based on the amount of antigen they capture and present on their MHC class ... complexes are periodically targeted for degradation in centroblasts to favor the presentation of recently acquired antigens, ... Animals, Antigens, CD, B-Lymphocytes, Gene Expression Regulation, Germinal Center, Histocompatibility Antigens Class II, ... Selection involves B cells competing for T cell help based on the amount of antigen they capture and present on their MHC class ...
Comparative analysis of host resistance to Sarcoptes scabiei var. cuniculi in two different rabbit breeds | Parasites & Vectors...
... class II, DQ Alpha (MHC-DQA) gene. Compared to the IRA rabbits, the QX rabbits showed a significantly higher (P < 0.05) ... DNA extracted from the blood samples was amplified for analysis of the genetic diversity in the major histocompatibility ... Structure of the human class I histocompatibility antigen, HLA-A2. Nature. 1987;329:506-12. ... HLA class II antigens are associated with resistance or susceptibility to hepatosplenic disease in a Chinese population ...
GlyConnect
RCSB PDB Group Summary: P01889
UniProtKB description: Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 ... guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:25808313, PubMed:29531227, ... the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of ... microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T ...
Dissociation of caspase mediated events and programmed cell death induced via HLA-DR in Follicular Lymphoma<...
N2 - Human leukocyte antigens (HLA) class II antigen-mediated apoptosis has been documented in antigen-presenting cells and B ... AB - Human leukocyte antigens (HLA) class II antigen-mediated apoptosis has been documented in antigen-presenting cells and B ... Human leukocyte antigens (HLA) class II antigen-mediated apoptosis has been documented in antigen-presenting cells and B ... abstract = "Human leukocyte antigens (HLA) class II antigen-mediated apoptosis has been documented in antigen-presenting cells ...
Periodic variation in side-chain polarities of T-cell antigenic peptides correlates with their structure and activity<...
Histocompatibility Antigens Class II Medicine & Life Sciences 21% View full fingerprint Cite this. * APA ... Second, recent crystallographic determination of the structure of a peptide bound to a class II MHC molecule reveals an ... Second, recent crystallographic determination of the structure of a peptide bound to a class II MHC molecule reveals an ... Second, recent crystallographic determination of the structure of a peptide bound to a class II MHC molecule reveals an ...
Total predicted MHC-I epitope load is inversely associated with population mortality from SARS-CoV-2<...
Improved murine MHC-deficient HLA transgenic NOD mouse models for type 1 diabetes therapy development<...
Histocompatibility Antigens Class I Medicine & Life Sciences 19% * Clustered Regularly Interspaced Short Palindromic Repeats ... Hence, we used CRISPR/Cas9 to directly ablate the NOD H2-Kd and H2-Db classical class I variants either individually or in ... T1D is dependent on pathogenic CD8+ T-cell responses mediated by these human class I variants. NOD.β2m-/--A2.1 mice were ... Hence, we used CRISPR/Cas9 to directly ablate the NOD H2-Kd and H2-Db classical class I variants either individually or in ...
PeptiQuant? Plus Custom Proteomics Kits - MRM Proteomics
Morgan, A, fl1990 | University of Edinburgh Archive and Manuscript Collections
Identification of the bovine major histocompatibility complex (BoLA) class II antigens, 1990 Item ... Identification of the bovine major histocompatibility complex (BoLA) class II antigens, 1990 Item ... Identification of the bovine major histocompatibility complex (BoLA) class II antigens, 1991 Item ...
Effects of Herb-Partitioned Moxibustion on Autophagy and Immune Activity in the Colon Tissue of Rats with Crohn's Disease
... span class=irelop/,,span class=nowrap,,svg xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg ... span class=irelop/,,span class=nowrap,,svg xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg ... span class=irelop/,,span class=nowrap,,svg xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg ... span class=irelop/,,span class=nowrap,,svg xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg ...
Elucidating tumour‐associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency - Pires...
HLA class II histocompatibility antigen gamma chain; Iba1, Allograft inflammatory factor 1; MHC-II, Major histocompatibility ... class II; H2-Ab1, major histocompatibility complex, class II; H2-K1, major histocompatibility complex, class I, a; H2-T23, ... S4E). Specifically, we identified genes involved in antigen presentation via MHC class I (e.g. B2m and H2-K1) (Fig. S4C), thus ... antigen processing and presentation via MHC class I (e.g. H2-K1) and T cell-mediated cytotoxicity (e.g. H2-T23) (Fig. 5A, Fig. ...
Transplant - Legal, Ethical, Problems | Britannica
HLA antigens are divided into two groups: class I antigens, which are the target of an effector rejection response; and class ... The main human transplantation antigens-called the major histocompatibility complex, or the HLA (human leukocyte antigens) ... Class II antigens are not found in all tissues, although class I antigens are. Certain macrophagelike tissue cells-called ... The factors that provoke graft rejection are called transplantation, or histocompatibility, antigens. If donor and recipient ...
Immunovirological and environmental screening reveals actionable risk factors for fatal COVID-19 during post-vaccination...
On the other hand, a generalized downregulation of major histocompatibility complex (MHC) class I-mediated antigen presentation ... SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis. Nat. Commun. 12, 6602 (2021). ... in agreement with previous reports demonstrating loss of MHC class I activity at the transcriptomic, epigenomic and functional ...
Publications | Molecular Virology
Dynamics of major histocompatibility complex class I association with the human peptide-loading complex.Panter MS, Jain A, ... A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation.Paul P, van den Hoorn ... C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients. ... Regulation of MHC class I assembly and peptide binding.Peaper DR, Cresswell P. Annu Rev Cell Dev Biol. 2008. PMID: 18729726. ...
Olivia Martinez's Profile | Stanford Profiles
The percentage of Leu-M3+ monocytes bearing the HLA Class II antigens and the density of antigen on the monocytes, however, was ... Stem cells and immature neural progenitor cells (NPC) do not express major histocompatibility complex (MHC) antigens and can ... Monocytes that bear HLA Class II antigens, such as HLA-DR, HLA-DQ, or HLA-DP, are obligatory for many cell-mediated ... To determine whether an alteration in expression of HLA Class II antigens is involved in the defect, monocytes from the ...
Centre for Integrated Research in Life and Health Sciences - Research output - University of Roehampton Research Explorer
Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum. ... Recognition of the HLA class II-peptide complex by T-cell receptor: reversal of major histocompatibility complex restriction of ... Poor loading of major histocompatibility complex class II molecules with endogenously synthesized short peptides in the absence ... Structural analysis of a peptide-HLA class II complex. Rothbard, J. B., Busch, R., Hill, C. M. & Lamb, J. R., 1989, In: Cold ...
Renal tubular cell expression of MHC class II (I-Eb) is insufficient to initiate immune injury in a transgenic kidney...
Histocompatibility Antigens Class II. *Genes, MHC Class II. *Crosses, Genetic. Citation. APA ... Renal tubular cell expression of MHC class II (I-Eb) is insufficient to initiate immune injury in a transgenic kidney ... "Renal tubular cell expression of MHC class II (I-Eb) is insufficient to initiate immune injury in a transgenic kidney ... Renal tubular cell expression of MHC class II (I-Eb) is insufficient to initiate immune injury in a transgenic kidney ...
Graft rejection. Medical search
CDHistocompatibility Antigens Class IIMycophenolic AcidAntigens, CD4Antibodies, BlockingCreatinineCTLA-4 AntigenReceptors, ... HLAHistocompatibility AntigensMinor Histocompatibility AntigensAntibodies, MonoclonalH-2 AntigensCD40 LigandHLA-DR6 Antigen ... Histocompatibility Antigens. A group of antigens that includes both the major and minor histocompatibility antigens. The former ... HeterologousHistocompatibility AntigensCadaverMinor Histocompatibility AntigensEndothelium, CornealMice, Inbred C3HRats, Inbred ...
HLA-DR3 Antigen | Palmetto Profiles
Histocompatibility Antigens [D23.050.301.500]. *Histocompatibility Antigens Class II [D23.050.301.500.400]. *HLA-D Antigens [ ... "HLA-DR3 Antigen" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "HLA-DR3 Antigen" by people in this website by year, and ... An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles. ...
Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and...
Genes, MHC Class II. Histocompatibility Antigens Class I. Chronic Idiopathic Urticaria Appare nelle tipologie: ... Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/ ... We observed an association between some HLA class-I antigens and AICU. To the best of our knowledge this is the first ... We observed an association between some HLA class-I antigens and AICU. To the best of our knowledge this is the first ...