Go to The IGHG3 gene shows a structural polymorphism characterized by different hinge lengths: Sequence of a new 2-exon hinge...Go to The IGHG3 gene shows a structural polymorphism characterized by different hinge lengths: Sequence of a new 2-exon hinge...

A comparison of this sequence with that of 4-exon and 3-exon hinge G3 genes suggests that the 3-exon and 2-exon hinge forms ... The IGHG3 gene shows a structural polymorphism characterized by different hinge lengths: Sequence of a new 2-exon hinge gene. ... The IGHG3 gene shows a structural polymorphism characterized by different hinge lengths: Sequence of a new 2-exon hinge gene. ... three exons. We report here the nucleotide sequence of a new 2-exon hinge G3 gene found in a Mandenka individual from Eastern ...
more infohttp://www.igmm.cnrs.fr/publication/the-ighg3-gene-shows-a-structural-polymorphism-characterized-by-different-hinge-lengths-sequence-of-a-new-2-exon-hinge-gene/

Human antibodies derived from immunized xenomice - Abgenix, Inc.Human antibodies derived from immunized xenomice - Abgenix, Inc.

Tucker, et al., "Mouse IgA heavy chain gene sequence: implications for evolution of immunoglobulin hinge exons," Proc. Natl. ...
more infohttp://www.freepatentsonline.com/6150584.html

Evolution of the porcine ( Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion | SpringerLinkEvolution of the porcine ( Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion | SpringerLink

... with an IGHG4 converted region and three hinge exons. Immunogenetics 30:250-257PubMedCrossRefGoogle Scholar ... and IGKV2-5 is missing exon 2. The nine functional IGKV genes are phylogenetically related to either the human IGKV1 or IGKV2 ...
more infohttps://link.springer.com/article/10.1007%2Fs00251-011-0589-6

List of MeSH codes (G14) - WikipediaList of MeSH codes (G14) - Wikipedia

... exons MeSH G14.340.024.340.137.232.459 --- hinge exons MeSH G14.340.024.340.137.232.920 --- vdj exons MeSH G14.340.024.340. ... hinge exons MeSH G14.340.024.340.351.300.500 --- immunoglobulin switch region MeSH G14.340.024.340.351.310 --- genes, ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(G14)

Alignment of the amino acid sequences of the nine eleph | Open-iAlignment of the amino acid sequences of the nine eleph | Open-i

... of the amino acid sequences of the nine elephant γ genes.The deduced amino acid sequences of three γ chain-coding exons and two ... The hinge exons are not included in the figure. Mentions: In addition to the eight γ genes (γ1 to γ8) in scaffold 57 (Fig. 1), ... The hinge region is usually encoded on a separate exon that could not be identified in the elephant due to the low level of ... The hinge region is usually encoded on a separate exon that could not be identified in the elephant due to the low level of ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3045440_pone.0016889.g002&req=4

Patente US5348876 - IgG3 antibodies with shortened hinge region and a complement activation test - Google PatentesPatente US5348876 - IgG3 antibodies with shortened hinge region and a complement activation test - Google Patentes

The present invention provides modified IgG3 containing human constant regions which has a shorter total-hinge region compared ... Also, one of the mutants containing three hinge exons did not hybridize with the probe. This gene has lost its large hinge exon ... Wild-type Cγ3, one mutant containing two hinge exons and three mutants containing three hinge exons hybridized with the probe, ... The plasmid containing a Cγ3 with only one hinge exon did not hybridize with the probe, as this exon is certainly h4, which ...
more infohttp://www.google.es/patents/US5348876?dq=flatulence

Patent US5959083 - Tetravalent bispecific receptors, the preparation and use thereof - Google PatentsPatent US5959083 - Tetravalent bispecific receptors, the preparation and use thereof - Google Patents

VH1 exon, CH1 exon, hinge 1 exon, hinge/linker/VH2 MAbII fusion exon and CH3 exon was isolated (FIG. 10). ... A pUC 19 plasmid which contains the CH1 exon and the first hinge exon of a human IgG3 gene (EP-A2-0404 097; FIG. 3 ibidem: IgG3 ... 7). The phasmid clone (G) which contains a fusion exon composed of a hinge exon, an oligonucleotide linker and the VH2 gene was ... 3). The phasmid clone (I) which contains the hinge/linker,/VH2 fusion exon and the CH3 exon was isolated. ...
more infohttp://www.google.com/patents/US5959083

Human IgG1, IgG3, and IgG3 Hinge-Truncated Mutants Show Different Protection Capabilities against Meningococci Depending on the...Human IgG1, IgG3, and IgG3 Hinge-Truncated Mutants Show Different Protection Capabilities against Meningococci Depending on the...

... with hinge regions of 15 and 17 amino acids encoded by hinge exons h2 and h1, respectively (human IgG3 has a hinge region of 62 ... 1). The IgG3m15 mutant contained a 15-amino-acid hinge region encoded by one of the identical hinge exons h2, h3, or h4, while ... For the hinge-truncated mutants, both IgG3m15, with a hinge region of 15 amino acids, and IgG3m17, with a hinge of 17 amino ... the IgG3m17 had a hinge encoded by hinge exon 1 (Fig. 1) (25). The complement-mediated bactericidal activity of both hinge- ...
more infohttps://cvi.asm.org/content/23/8/698

Immunoglobulin Switch Region | Profiles RNSImmunoglobulin Switch Region | Profiles RNS

Hinge Exons. *Immunoglobulin Switch Region. Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin ...
more infohttps://profiles.umassmed.edu/display/120566

Plus itPlus it

Similar intron/exon structural patterns were observed in the basic and hinge regions of their bZIP domains. Detailed sequence ... Pattern g was devoid of any intron in the basic or hinge region. Pattern g was found in 27 OsbZIP genes, of which only 17 were ... Pattern a had an intron in phase 2 (P2) in the basic region, whereas pattern b had an intron in phase 0 (P0) in the hinge ... P0 and P2 indicate the splicing phases of the basic and hinge regions of the bZIP domains, where P0 and P2 refer to phase 0 and ...
more infohttp://www.plantphysiol.org/content/146/2/333

Persistent androgen receptor addiction in castration-resistant prostate cancer | Journal of Hematology & Oncology | Full TextPersistent androgen receptor addiction in castration-resistant prostate cancer | Journal of Hematology & Oncology | Full Text

... exons 2 and 3), a hinge region (exons 3 and 4), and the ligand-binding domain (i.e., C-terminal) (exons 4-8) (Fig. 1). An ... the hinge region and the ligand binding domain (LBD). b. Several cryptic exons (CE) as well as exon 9 are involved in the ... The AR is a nuclear transcription factor encoded on the X chromosome at position Xq11-Xq12 [26, 27]. It contains eight exons ... It is composed of eight exons, which encode for four regions: N-terminal domain (NTD), DNA binding domain (DBD), ...
more infohttps://jhoonline.biomedcentral.com/articles/10.1186/s13045-015-0225-2

Exon Skipping - PPMD CommunityExon Skipping - PPMD Community

On the old web site there was a discussion regarding the skipping of exon 51 and the trials and dr… ... How does exon skipping work for problems with hinge areas as compared to non hinge areas. ... Skipping exon 51 for a deletion of exons 48-50 would restore the reading frame, so your son would benefit from the current exon ... I asked the same questions about hinges since my son also has a deletion of exon 50. I talked to Steve Wilton and a few other ...
more infohttp://community.parentprojectmd.org/forum/topics/1187424:Topic:6919

Exon Skipping - PPMD CommunityExon Skipping - PPMD Community

On the old web site there was a discussion regarding the skipping of exon 51 and the trials and dr… ... How does exon skipping work for problems with hinge areas as compared to non hinge areas. ... Skipping exon 51 for a deletion of exons 48-50 would restore the reading frame, so your son would benefit from the current exon ... I asked the same questions about hinges since my son also has a deletion of exon 50. I talked to Steve Wilton and a few other ...
more infohttp://community.parentprojectmd.org/forum/topics/1187424:Topic:6919?commentId=1187424%3AComment%3A19113

Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection | Science AdvancesChimeric camel/human heavy-chain antibodies protect against MERS-CoV infection | Science Advances

... containing the hinge and CH2 and CH3 exons) (Fig. 1, right). These HCAbs (HCAb-1, HCAb-4, HCAb-83, and HCAb-101) form ... Furthermore, camel/human chimeric HCAbs-composed of the camel VHH linked to a human Fc domain lacking the CH1 exon-had an ... lacking the CH1 exon as in camel HCAbs), allow them to interact with human effector cells and complement cascade factors (15). ...
more infohttp://advances.sciencemag.org/content/4/8/eaas9667.full

Familiar Familial Prionlike DisordersFamiliar Familial Prionlike Disorders

... a hinge region in the first half of exon 4, and an androgen ligand binding domain from 5 exons varying from 131 to 288 bp. As ... clustering clusers in exon 5 and in exon 7. The number of mutations in exon 1 is extremely low and no mutations have been ... exon 2 (E148Q, E167D and T267I), exon 3(P369S), and exon 5 (F479L) account for most known familial cases.. Affected individuals ... Less than 10 kb separates the CpG island identified in the X25/exon 1 from the 3-prime end of STM7/exon 16. Ataxia phenotype in ...
more infohttp://www.mad-cow.org/med_fever.html

Yueh-hsiu Chien | Stanford Medicine ProfilesYueh-hsiu Chien | Stanford Medicine Profiles

Each C region comprises four exons encoding an external globular domain, a small hinge-like region, a transmembrane region and ... The C delta is divided into four exons, three of which encode amino acids of TcR delta polypeptide, and the fourth comprises ...
more infohttps://med.stanford.edu/profiles/yueh-hsiu-chien

Glucocorticoid Receptor (GR) | SpringerLinkGlucocorticoid Receptor (GR) | SpringerLink

The structural organization of the GR arises from exons 2 to 9 and includes a DNA-binding domain and hinge region between the N ... Exon 2 codes the N-terminal domain. Exons 3 and 4 encode the DNA-binding domain consisting of two zinc fingers. The GR consists ... 2012). It counts 2201 bp and contains 15 exons. The five prime untranslated region consists of exon 1 while the protein- ... encoding region involves exons 2-9. Homologs are conserved in chimpanzees, dogs, rats, zebra fish, and frogs. ...
more infohttps://link.springer.com/referenceworkentry/10.1007/978-3-319-67199-4_101536

NOVEL RECEPTOR TREM (TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS) AND     USES THEREOF - Patent applicationNOVEL RECEPTOR TREM (TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS) AND USES THEREOF - Patent application

The ˜600-bp PCR product was cut with EcoRI and HindIII, and ligated into an expression vector containing the exons for hinge, ... containing the exons for hinge, CH2, CH3 and CH4 regions of human IgM, the guanosine phosphotransferase gene conferring ... expression vector containing the exons for hinge, CH2, and CH3 region of human IgG1. Transfection of the chimeric gene into the ... into an expression vector containing the exons for hinge, CH2 and CH3 regions of human IgG1, the guanosine phosphotransferase ...
more infohttp://www.patentsencyclopedia.com/app/20130028901

Indian Patents. 257815:METHOD FOR SCREENING A COMPOSITE ANTIBODY VARIABLE REGIONIndian Patents. 257815:'METHOD FOR SCREENING A COMPOSITE ANTIBODY VARIABLE REGION'

This fragment includes the CHI, hinge, CH2 and CHS introns and exons of human IgGl. This vector also included a gene for ... within the hinge regions) or cause some other deleterious effect such as lack of expression. Alternatively, for one or both of ...
more infohttp://www.allindianpatents.com/patents/257815-method-for-screening-a-composite-antibody-variable-region

TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations | Molecular Cancer TherapeuticsTAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations | Molecular Cancer Therapeutics

... inhibitor designed to be fit to the ATP binding site of the EGFR hinge region and to exhibit inhibitory activity against exon ... Rare EGFR exon 18 and exon 20 mutations in non-small-cell lung cancer on 10 117 patients: a multicentre observational study by ... Among a wide variety of somatic mutations in EGFR, exon 19 deletion mutations and L858R substitution mutation in exon 21 are ... However, in contrast to exon 19 deletions and L858R mutation, exon 20 insertions do not sensitize the kinase domain to EGFR- ...
more infohttp://mct.aacrjournals.org/content/17/8/1648?utm_source=aug18&utm_medium=carousel3&utm_campaign=171206

Androgen insensitivity syndromeAndrogen insensitivity syndrome

... portion of exon 4 encodes the hinge region.[3] The remainder of exon 4 through exon 8 encodes the ligand binding domain.[3] ... The transactivation domain is encoded by exon 1, and makes up more than half of the AR protein.[3] Exons 2 and 3 encode the DNA ... a b Gottlieb B, Vasiliou DM, Lumbroso R, Beitel LK, Pinsky L, Trifiro MA (1999). "Analysis of exon 1 mutations in the androgen ... publishes its intron-exon boundaries.[109]. *1994: The androgen receptor gene mutations database is created to provide a ...
more infohttp://enacademic.com/dic.nsf/enwiki/33673/7949

GenetherapyGenetherapy

Exons 2 and 3 encode the DNA-binding domain, while the 5 portion of exon 4 encodes the hinge region.[3] The remainder of exons ... The AR gene contains two polymorphic trinucleotide microsatellites in exon 1.[2] The first microsatellite (nearest the 5 end) ... spanning eight exons, designated 1-8 or A-H.[1][3] Introns vary in size between 0.7 and 26 kb.[3] Like other nuclear receptors ... mutations in the hinge region have been known to affect nuclear translocation, mutations in the DNA-binding domain have been ...
more infohttp://www.genetherapy.me