Dovato may not be recommended for individuals who also have chronic, active hepatitis B unless added with another medication ... So if you have hepatitis B, you want to make sure 3TC is combined with something like tenofovir disoproxil fumarate (TDF, ... Similarly, while 3TC is known for having activity against hepatitis B, there have also been issues with resistance developing ... Additionally, guidelines recommend that clinicians ensure that patients they plan to start on Dovato are hepatitis-B negative, ...