Label - Free Quantitative Proteomics Analysis to Study the Effect of Triclosan on Delta-Haemolysin: A Haemolytic Factor of ... Mass spectrometric analysis of the secretome of the MRSA strain showed the presence of delta haemolysin when compared to the ... haemolysin in the untreated MRSA cultures.. On the basis of the experiments conducted, triclosan can be considered as a ... potential anti - haemolytic agent due to its deleterious effect on delta haemolysin. ...
Hemolysin and tumor necrosis factor (TNF) release assays were performed to elucidate the biological relevance of changes in α- ... However, there are no data on the effect of thymol on the production of other exotoxins (e.g., α-hemolysin and enterotoxins) by ... In addition, the influence of thymol on the transcription of hla, sea, and seb (the genes encoding α-hemolysin, SEA and SEB, ... Thymol inhibited transcription of hla, sea and seb in S. aureus, resulting in a reduction of α-hemolysin, SEA and SEB secretion ...
... and hemolysin. Gelatinase- and hemolysin-producing strains of Enterococcus faecalis have been shown to be virulent in animal ... and hemolysin. Gelatinase- and hemolysin-producing strains of Enterococcus faecalis have been shown to be virulent in animal ... We determined the presence of the esp gene and production of gelatinase and hemolysin in 219 E. faecalis isolates from a larger ... We determined the presence of the esp gene and production of gelatinase and hemolysin in 219 E. faecalis isolates from a larger ...
Emody L, Pal T, Safonova NV, Kuch B, Golutva NK (1980) The alpha haemolysin as an additive virulence factor in Escherichia coli ... Smith HW, Halls S (1967) The transmissible nature of the genetic factor in Escherichia coli that controls haemolysin production ... Hacker J, Hof H, Hughes C, Goebel W (1985 a) Salmonella typhimurium strains carrying hemolysin plasmids and cloned hemolysin ... Pellett S, Karakash T, Segal L, Welch RA (1984) Comparison of Escherichia coli hemolysins conferring differences in hemolysin ...
Bacterial hemolysins found in numerous pathogenic bacteria are often virulence factors. We describe here the nucleotide ... A multiple alignment between PhlA, these four hemolysins, and a putative hemolysin from Y. pestis was performed by using ... In order to evaluate hemolysin contribution in P. luminescens TT01 to insect virulence, we characterized a hemolysin locus ... These factors include RTX-like toxins, hemolysin and cytotoxin homologs (23). Lately, the complete genome of P. luminescens ...
Proteolysis of these factors requires host serine proteases, and paxillin degradation specifically involves the serine protease ... UPEC hemolysin: more than just for making holes. [Cell Host Microbe. 2012] ... The UPEC pore-forming toxin α-hemolysin triggers proteolysis of host proteins to disrupt cell adhesion, inflammatory, and ... The UPEC Pore Forming Toxin α-Hemolysin Triggers Proteolysis of Host Proteins to Disrupt Cell Adhesion, Inflammatory and ...
α-Haemolysin production, as a single factor, causes fulminant sepsis in a model of Escherichia coli-induced bacteraemia. Cell ... Specific host factors contribute to hemolysin cytotoxic activity. (A) (Left) PEG-precipitated HlyA was incubated at various ... coli to express a hemolytic factor, now known as hemolysin (HlyA) (3). The presence of the hlyA gene in the genome of clinical ... how hemolysin functions to enhance virulence is unknown. Our research defines the interaction of hemolysin with the β2 integrin ...
Both hemolysin determinants were about 7.5 kilobase pairs and comprised contiguous regions directing regulation, synthesis, and ... Southern hybridization of total DNA from hemolytic isolates to cloned regions of the Escherichia coli alpha-hemolysin (hly) ... Transposon mutations which eliminated secretion of the Proteus and Morganella hemolysins could be complemented specifically by ... coli alpha-hemolysin confirmed a close genetic relationship but also indicated extensive evolutionary divergence. ...
Role of the Hha/YmoA family of proteins in the thermoregulation of the expression of virulence factors.. Int. J. Med. Microbiol ... Haemolysin expression modulating, HHA (IPR007985). Short name: Hemolysn_expr_modulating_HHA Overlapping homologous ... This family consists of haemolysin expression modulating protein (Hha) from Escherichia coli and its enterobacterial homologues ... is involved in the regulation of expression of the toxin alpha-haemolysin in response to osmolarity and temperature [PMID: ...
Differential Transcription of GAS Genes Encoding Hemolysins.. Hemolysins, which are virulence factors for many pathogens (16), ... 5). In this regard, we note that transcription of the gene encoding S. aureus α-hemolysin was induced by growth at 42°C (32). ... 7). Of note, despite its role as a hemolysin, and up-regulation at 40°C (Fig. 5), spy0167 was down-regulated 7.0-fold under ... Although many environmental factors influence gene expression, our data demonstrate that GAS has the ability to alter gene ...
... the effect of sub-MIC concentrations of the ZnO nanoparticle on the expression of the alpha-hemolysin gene as a significant ... sub-MIC concentrations of the ZnO nanoparticle on the expression of the alpha-hemolysin gene as a significant virulence factor ... inhibitory concentrations of Zinc Oxide Nanoparticles Reduce the Expression of the Staphylococcus aureus Alpha-Hemolysin. ...
... β-hemolysin/cytolysin is one of the main virulence factors of GBS. It has been implicated in the pathogenesis of early- [35] ... α-hemolysin and cytolysin A from E. coli, and α-hemolysin, γ-hemolysin, and the leukocidins from S. aureus. It has long been ... 7. α-Hemolysin, γ-Hemolysin, and Leukocidins from Staphylococcus aureus. Staphylococcus aureus (S. aureus) is well recognised ... Although most clinical isolates produce the PFTs α-hemolysin, bicomponent γ-hemolysins, and bicomponent leukocidins, none of ...
Both hemolysins are thus considered to be major virulence factors of V. parahaemolyticus. Structural genes for TDH and TRH, tdh ... Detection of the thermostable direct hemolysin gene (tdh) and the thermostable direct hemolysin-related hemolysin gene (trh) of ... Analysis of the thermostable direct hemolysin (tdh) gene and the tdh-related hemolysin (trh) genes in urease-positive strains ... Soft-Agar-Coated Filter Method for Early Detection of Viable and Thermostable Direct Hemolysin (TDH)- or TDH-Related Hemolysin- ...
Extracellular virulence factors in Bacillus cereus endophthalmitis: methods and implication of involvement of hemolysin BL. ... Phenotypic assessment of B. cereus strains.Phenotypic profiles of the parental (hemolysin BL-expressing [HBL+]) and hemolysin ... cereus as a diarrheal food poisoning agent led to the characterization of a vascular permeability factor, termed hemolysin BL. ... highlighting the importance of inflammogenic and toxic factors other than hemolysin BL in intraocular virulence. ...
... and uniplex PCR assays to detect the genes encoding different cell-wall associated and extracellular virulence factors, in ... Some S. aureus strains proved the presence of CAMP-like factor, a special hemolysin, the activity of which is revealed by ... aeruginosa exhibits many virulence factors that contribute to its pathogenicity. Some of these factors help colonization, ... factors, and extracellular toxins (coagulase, hemolysins, enterotoxins, toxic-shock syndrome toxin 1, exfoliative toxins, and ...
Hemolysins have proved to be a damaging factor for vital organs, through the activity of Staphylococcus aureus. S.aureus is a ... As mentioned before, hemolysin is a potential virulence factor produced by microorganisms, which can put a humans health at ... Further findings show that the main virulence factor of S. aureus, the pore-forming toxin α-hemolysin (Hla), is the secreted ... γ-Hemolysins are pore-forming toxins in the same family as α-Hemolysin. They are unique in that they come in two components, ...
Extracellular virulence factors in Bacillus cereus endophthalmitis: Methods and implication of involvement of hemolysin BL. ... Fingerprint Dive into the research topics of Extracellular virulence factors in Bacillus cereus endophthalmitis: Methods and ... implication of involvement of hemolysin BL. Together they form a unique fingerprint. * Sort by ...
One putative virulence factor of H. ducreyi is a pore-forming hemolysin that displays toxicity against human fibroblasts and ... In order to test the role of the hemolysin in pathogenesis, an isogenic hemolysin-deficient mutant was constructed, designated ... These results indicate the hemolysin does not play a role in pustule formation. Due to the limitations of this model, the role ... Evaluation of an isogenic hemolysin-deficient mutant in the human model of Haemophilus ducreyi infection.. Palmer KL1, Thornton ...
... cytotoxic necrotizing factor; cvaC, factor facilitating colonization; dra, Dr binding adhesins; fimH, type-1 fimbriae; fyuA, ... yersiniabactin (siderophore) receptor; hlyA, α-hemolysin; hra, heat-resistant agglutinin; ibeABC, invasion of brain endothelium ... Virulence factors associated with Escherichia coli sequence type 131 clades, Calgary, Alberta, Canada, 2006, 2012, and 2016* ...
Virulence factors in Serratia marcescens: cell-bound hemolysin and aerobactin Virulence factors in Serratia marcescens: cell- ... These results indicate that cell-bound hemolysin is not a main factor of virulence for mice in Serratia marcescens ... No aerobactin-producing strains were found, and the incidence of cell-bound hemolysin was 97%. Hemolysin-positive (58 strains) ... and hemolysin-negative (2 strains) Serratia marcescens showed the same LD50 (3 x 107) bacteria) in a test of virulence for mice ...
Antivirulence agents inhibit the production of disease-causing virulence factors but are neither bacteriostatic nor ... which acts as a transcription factor for the expression of several of the most prominent S. aureus toxins and virulence factors ... The small-molecule compounds discovered inhibit the production of the toxins alpha-hemolysin and phenol-soluble modulin α in a ... Antivirulence agents inhibit the production of disease-causing virulence factors but are neither bacteriostatic nor ...
To assess the contributions of agr-dependent factors to the fate of organis … ... has fueled interest in the contributions of specific staphylococcal virulence factors to clinical disease. ... required α-hemolysin (hla) as USA300 (LAC agr KO) and USA300 (LAC hla KO) promoted PMN lysis only at high MOIs. Taken together ... To assess the contributions of agr-dependent factors to the fate of organisms in polymorphonuclear neutrophils (PMN), we ...
... such as α-hemolysin (26, 34, 84), clumping factor (58, 60), coagulase (55, 60) fibronectin-binding protein A (58), lipases (44 ... 12 alternative σ factors) (12), and Pseudomonas aeruginosa (23 alternative σ factors) (76). Two alternative σ factors, σB and σ ... General stress transcription factor σB and sporulation transcription factor σH each contribute to survival of Bacillus subtilis ... aur, zinc metalloprotease aureolysin; hla, α-hemolysin; hlgBC, γ-hemolysin components B and C; lip, lipase; lrgAB, holin-like ...
YmoA modulates the expression of various virulence factors, such as Yop proteins and YadA adhesin, in response to temperature. ... In molecular biology, the haemolysin expression modulating protein family is a family of proteins. This family consists of ... "Role of the Hha/YmoA family of proteins in the thermoregulation of the expression of virulence factors". Int. J. Med. Microbiol ... is involved in the regulation of expression of the toxin alpha-haemolysin in response to osmolarity and temperature. ...
... from red deer produced heat-stable enterotoxin and another strain produced both hemolysin and cytotoxic necrotizing factor. A ... were examined for antimicrobial resistance and production of toxic factors. Direct plating of specimens on media containing ... marmot isolate produced hemolysin alone. No strains were found to produce heat-labile enterotoxin or verotoxins. ...
Hemolysin (α-toxin, Hla); 8.2 β-Hemolysin (Sphingomyelinase C, Hlb); 8.3 γ-Hemolysin (Hlg); 8.4 Î-́Hemolysin; References ... 7.3 Von Willebrand Factor-Binding Protein; 7.4 Differences in Coagulation Time of Human and Animal Plasmas; 7.5 Role of ... Coagulases in Staphylococcal Infections; 7.6 Conclusion; Acknowledgments; References; Chapter 8 The Staphylococcal Hemolysins; ...
... hemolysin production. Enzymatic activity was highest for organisms in biotypes 1, followed by biotypes 3, 4, and 2 in ... Virulence factors of biotypes of Staphylococcus epidermidis from clinical sources.. B M Males, W A Rogers, Jr, J T Parisi ... Virulence factors of biotypes of Staphylococcus epidermidis from clinical sources. Message Subject (Your Name) has forwarded a ... The production of virulence factors was based on the results of three groups of tests: (i) deoxyribonuclease, urease, ...
What are the virulence factors associated with MRSA? a-Hemolysin. Panton-Valentine Leukocidin (PVL). Phenol-Soluble Modulins ( ...
virulence factors: similar to TB (wax D, etc.). 2 disease types: a) Tuberculoid (delayed hypersensitivity). b) Lepromatous ( ... pore-forming cytotoxin, hemolysins. Dissemination (3): LPS, Exoenzyme S, Exotoxin A 60 ... specific virulence factors: pili for attachment, cytolysin (RTX). also: - cystitis (bladder infection 2nd to UTI -- poly/ ... 1. O antigen (LPS) flagella, K Ag capsule; variable but not VIRULENT factors) ...