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*  The interaction of covalently bound heme with the cytochrome c maturation protein CcmE. - Radcliffe Department of Medicine
In addition, the properties of the heme resonances of the holo-protein as compared with those of a form of CcmE with non- ... covalently bound heme provide evidence for the modification of one of the heme vinyl side chains by the protein, most likely ... In the continued absence of a structure of the holoform of CcmE, identification of the heme ligands is an important step in ... In this work, we present spectroscopic data that provide insight into the ligation of the heme iron in the soluble domain of ...
https://www.rdm.ox.ac.uk/publications/100803
*  "Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in" by Kimberly K. Elbirt, Alan J. Whitmarsh et al.
We conclude that the MAP kinases ERK and p38 are involved in the induction of heme oxygenase-1, and that at least one AP-1 ... We identified a heme oxygenase-1 promoter-driven luciferase reporter construct that was highly and reproducibly expressed in ... We investigated the induction of heme oxygenase-1 by the tumor promoter arsenite in a chicken hepatoma cell line, LMH. ... This construct was used to investigate the role of mitogen-activated protein (MAP) kinases in arsenite-mediated heme oxygenase- ...
https://escholarship.umassmed.edu/oapubs/780/
*  Heme Oxygenase-1 | ALZFORUM
If you know of any papers that use this antibody, please contact us at antibodies [at] alzforum [dot] org for consideration in the References section.. ...
https://www.alzforum.org/antibodies/heme-oxygenase-1
*  HEME OXYGENASE (PS00593) | InterPro | EMBL-EBI
HEME_OXYGENASE (PS00593). Accession PS00593 Integration. Haem oxygenase conserved site (IPR018207) Member database. PROSITE ...
http://www.ebi.ac.uk/interpro/ISignatureOverview?sig=PS00593&query=P
*  Heme Peroxidases (RSC Publishing)
Heme Peroxidases serves as an essential text for those working in industry and academia in biochemistry and metallobiology. ... Chapters written and edited by worldwide experts span a range of heme peroxidases from plants, yeast, bacteria and mammals. ... This book provides a comprehensive single source of information on the various aspects of heme peroxidase structure, function ... Heme peroxidases are widely distributed in biological systems and are involved in a wide range of processes essential for life ...
http://pubs.rsc.org/en/content/ebook/978-1-84973-911-5
*  Heme | Technology Trends
Biocrystallization - Heme. ... avoid destruction by this molecule, the parasite biocrystallizes heme to form hemozoin ... Heme ... Heme. A heme (American English) or haem (British English) is a prosthetic group that consists of an iron ion contained in the ... Heme - Genes. ... The following genes are part of the chemical pathway for making heme ALAD aminolevulinic acid, delta-, ... bonding prefers a bent geometry for the heme-NO complex ... Thus nitric oxide binding ferrous heme at the distal position gives ...
http://www.primidi.com/heme
*  Bilirubin Inhibition of Heme Biosynthesis | Science
The conversion of protoporphyrin and iron to heme is catalyzed by a soluble enzyme prepared from rat liver. This reaction is ...
http://science.sciencemag.org/content/129/3365/1741
*  Heme facts, information, pictures | Encyclopedia.com articles about Heme
Make research projects and school reports about Heme easy with credible articles from our FREE, online encyclopedia and ... Hemoglobin consists of a complex of a protein plus heme. Heme consists of iron plus protoporphyrin IX. Normally, during the ... haem (heme) A metal-chelate complex in which iron is bonded to the four nitrogens of a porphyrin ring structure. The word (and ... haem (heme) An iron-containing molecule (see formula) that binds with proteins as a cofactor or prosthetic group to form the ...
http://encyclopedia.com/science-and-technology/biochemistry/biochemistry/heme
*  Heme Motions | JILA Science
What is this thing called heme? And, how does it do such amazing work inside our bodies? Scientists know that heme is a large ... In the heme molecule shown at right, the iron atom is green and the atoms in the porphyrin ring are carbon (teal), nitrogen ( ... Our lives depend on heme. As part of hemoglobin, it carries oxygen to our tissues. As part of cytochrome c, it helps transform ... Understanding how heme functions at the biomolecular level is a hot research topic for biophysicists, including Research ...
https://jila.colorado.edu/node/5196
*  Heme oxygenase 1 is required for mammalian iron reutilization | PNAS
Mammalian heme oxygenase (Hmox, also known as HO; EC 1.14.99.3), which catabolizes cellular heme to biliverdin, carbon monoxide ... Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron ... Heme oxygenase 1 is expressed in murine erythroid cells where it controls the level of regulatory heme ... The Crystal Structures of the Ferric and Ferrous Forms of the Heme Complex of HmuO, a Heme Oxygenase of Corynebacterium ...
https://www.pnas.org/content/94/20/10919?ijkey=45b73aad056fdd275e18e8e4219f223a002b4260&keytype2=tf_ipsecsha
*  Endogenous Estrogen-Mediated Heme Oxygenase Regulation in Experimental Menopause
... Anikó Pósa,1 Renáta Szabó,1 Anett Csonka,1 ... A. M. K. Choi, "Heme oxygenase-1 protects the heart," Circulation Research, vol. 89, no. 2, pp. 105-107, 2001. View at Google ... T. M. Chen, J. Li, L. Liu et al., "Effects of heme oxygenase-1 upregulation on blood pressure and cardiac function in an animal ... Y. M. Lee, P. Y. Cheng, S. F. Hong et al., "Oxidative stress induces vascular heme oxygenase-1 expression in ovariectomized ...
https://www.hindawi.com/journals/omcl/2015/429713/ref/
*  Heme oxygenase-1: a metabolic nike. | Sigma-Aldrich
The heme oxygenases (HO) are metabolic enzymes that utilize NADPH and oxygen to break apart the heme moiety liberating ... Heme oxygenase-1: a metabolic nike.. [Barbara Wegiel, Zsuzsanna Nemeth, Matheus Correa-Costa, Andrew C Bulmer, Leo E Otterbein] ... Heme that is derived from hemoproteins can be toxic to the cells and if not removed immediately, it causes cell apoptosis and ... Further, heme is an important component of a number of metabolic enzymes, and, therefore, HO-1 plays an important role in the ...
https://www.sigmaaldrich.com/catalog/papers/24180257
*  Recombinant Human Heme Oxygenase 1 protein (ab86919)
Buy our Recombinant Human Heme Oxygenase 1 protein. Ab86919 is a protein fragment produced in Escherichia coli and has been ... Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to ... Recombinant Human Heme Oxygenase 1 protein. See all Heme Oxygenase 1 proteins and peptides. ... Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are ...
http://www.abcam.com/recombinant-human-heme-oxygenase-1-protein-ab86919.html
*  Immunoregulatory Properties of Heme Oxygenase-1 | SpringerLink
... is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the ... Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into ... Wagener F A, Eggert A, Boerman O C, et al (2001) Heme is a potent inducer of inflammation in mice and is counteracted by heme ... Wagener F A, da Silva J L, Farley T, et al (1999) Differential effects of heme oxygenase isoforms on heme mediation of ...
https://link.springer.com/protocol/10.1007/978-1-60761-869-0_18
*  Discovery and characterization of a unique mycobacterial heme acquisition system | PNAS
1 A and B), confirming that Mtb has a heme-iron uptake system, with the ability to scavenge both free heme and heme bound to ... In addition, the heme iron in two other heme-binding proteins, IsdA and IsdC, involved in Staphylococcus aureus heme uptake, ... 3A). Titration of heme into Rv0203 resulted in a 1:1 stoichiometry of heme to Rv0203 (Fig. 3B), and its heme-binding affinity ... B) Titration of heme to apo-Rv0203 (10 μM) is observed by the spectral change at 405 nm between protein plus heme and heme ...
https://www.pnas.org/content/108/12/5051?ijkey=8dad0f3104384873d37ec78fc9aeac88eaf600bc&keytype2=tf_ipsecsha
*  Heme-Egr-1 | Circulation Research
Unbound heme, is a strong oxidant, and its hydrophobic nature permits rapid entry into cells of the vascular wall. Once heme ... The importance of heme metabolism has been highlighted in clinical observations in which the lack of capacity to degrade heme ... oxidized heme) exposure and how they may contribute to the confounding actions of heme. Their findings are significant because ... HO-1 levels may be insufficient to break down increased levels of heme. Heme is an important inducer of HO-1 expression, and ...
http://circres.ahajournals.org/content/102/1/6
*  Biology of Heme in Mammalian Erythroid Cells and Related Disorders
This review will focus on the biology of heme in mammalian erythroid cells, including the heme biosynthetic pathway as well as ... Biology of Heme in Mammalian Erythroid Cells and Related Disorders. Tohru Fujiwara1,2 and Hideo Harigae1,2 ... Heme is a prosthetic group comprising ferrous iron (Fe2+) and protoporphyrin IX and is an essential cofactor in various ... Heme biosynthesis is induced during erythroid differentiation and is coordinated with the expression of genes involved in ...
https://www.hindawi.com/journals/bmri/2015/278536/abs/
*  Myoglobin Human heme free | ProSpec
The Myoglobin heme free contains N-terminal T7 tag and purified by proprietary chromatographic techniques. ... Recombinant Human Myoglobin heme free produced in E.Coli is a non-glycosylated polypeptide chain having a molecular mass of ... Myoglobin heme free although stable at 15°C for 2 weeks, should be stored at 4°C. For long term storage it is recommended to ... Myoglobin heme free Human Recombinant produced in E.Coli is a non-glycosylated polypeptide chain having a molecular mass of ...
https://www.prospecbio.com/Myoglobin_Human_heme_free
*  JCI - Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation
Heme oxygenase-1 (HO-1, encoded by HMOX1) dampens inflammatory reactions via the catabolism of heme into CO, Fe, and biliverdin ...
https://www.jci.org/articles/view/28844/figure/1
*  Oxide Design Co. | Projects | Heme Perfusion
Heme Perfusion. Logo design for a perfusion partner, providing personnel, capital equipment, and disposables to hospitals and ...
https://oxidedesign.com/project/heme-perfusion/
*  HMOX1 - Heme oxygenase 1 - Homo sapiens (Human) - HMOX1 gene & protein
Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are ... Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. ... Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to ... Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, ...
https://www.uniprot.org/uniprot/P09601
*  RCSB PDB - Protein Feature View - Heme oxygenase 1 - P06762 (HMOX1 RAT)
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to ... Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are ... Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. UniProt ...
http://www.rcsb.org/pdb/protein/P06762
*  Heme Oxygenase-1 Detection: ELISAs and Antibodies
Heme Oxygenase-1 Detection. Heme oxygenase-1 (HO-1) is a microsomal enzyme that degrades heme, a prosthetic group of the heme ... Heme oxygenase exists in at least two isozyme forms: heme oxygenase-1 and heme oxygenase-2, each of which differs in tissue ... Antibodies for Heme Oxygenase-1 Detection. Anti-Heme Oxygenase-1 Antibody, Monoclonal (Clone GTS-1) and Anti-Heme Oxygenase-1 ... Heme oxygenase‑1. M174. IHC. WB. Heme oxygenase‑1 inhibition assay. Rat. (GTS-1). Mouse IgG1 MoAb. Cross-reacts with human and ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Cell_Proliferation_and_Viability/Heme_Oxygenase-1?sitex=10020:22372:US&PEBCL1=zjSgfwItVwkgPgXTDIiLgJk7fa&PEBCL1_pses=ZGDA5926A0884E3B659A91BD6C03C75314F0DD912290C026E1776337865235E3BD84DE34A7C7A118006B622F01CF6C93ED3F262CD98CCD9AFD
*  Uridine affects liver protein glycosylation, insulin signaling, and heme biosynthesis. - PubMed - NCBI
Uridine affects liver protein glycosylation, insulin signaling, and heme biosynthesis.. Urasaki Y1, Pizzorno G1, Le TT1. ... A) Western blots of proteins participating in the regulation of heme biosynthesis and catabolism. (B) Quantitative analysis of ... A) Western blot analyses of protein participating in the heme-deficiency response pathway. (B) Quantitative analysis of Western ... UPase1-/- mice exhibit activation of the liver HRI-eIF-2α-ATF4 heme-deficiency stress response pathway. UPase1-/- mice also ...
https://www.ncbi.nlm.nih.gov/pubmed/24918436