The current presence of cancer stem-like cells (CSCs) is one of - Stem cell application on skin cancer research
Also we determine HDAC1 as a particular regulator involved with silencing of miR-200b through a Sp1-reliant system and repair ... Taken collectively the HDAC1/miR-200b/Suz-12-E-cadherin signaling might account SCH58261 for maintenance of CSCs and formation ... Also downregulation of HDAC1 or upregulation of miR-200b reduced the tumorigenicity of CSCs. Finally Suz-12 was inversely ... To the very best of our understanding there were no reviews about HDAC1/miR-200b/Suz-12/E-cadherin regulatory network in ...
Frontiers | Tranylcypromine Causes Neurotoxicity and Represses BHC110/LSD1 in Human-Induced Pluripotent Stem Cell-Derived...
JCI - Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia
PDF) Mapping of scaffold/matrix attachment regions in human genome: a data mining exercise
Manuel Salto-Tellez - Research output - Queen's University Belfast
Vithana, E. N., Morgan, P., Sundaresan, P., D. Ebenezer, N., Tan, D. T. H., Mohamed, M. D., Anand, S., Khine, K. O., Venkataraman, D., Yong, V. H. K., Salto-Tellez, M., Venkatraman, A., Guo, K., Hemadevi, B., Srinivasan, M., Prajna, V., Khine, M., Casey, J. R., Inglehearn, C. F. & Aung, T., Jul 2006, In: Nature Genetics. 38, 7, p. 755-757 3 p.. Research output: Contribution to journal › Article › peer-review ...
Publications | Institute for Structural and Chemical Biology | University of Leicester
Schwabe JWR Mechanism of crosstalk between the LSD1 demethylase and HDAC1 deacetylase in the CoREST complex Cell Reports 30, (8 ... Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell ...
Huabio - Stratech
Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β...
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. ...
Who We Fund: Publications associated with Basic Cellular And Molecular Research - Human Genetics / Gene X Environment...
In This Issue | Cancer Discovery | American Association for Cancer Research
IL15 expression upregulated the histone deacetylases HDAC1 and HDAC6 at least in part by reducing binding of HDAC1 to the HDAC1 ... HDAC1 enhanced transcription of the oncogenic miR-21, which was overexpressed in patients with CTCL. Treatment of CTCL cells ... In vivo, HDAC6 inhibition delayed tumor progression, whereas HDAC1/2 inhibition halted tumor growth and, in some cases, induced ... IL15 overexpression can induce cutaneous T-cell lymphoma (CTCL) via induction of HDAC1/6 and miR-21. ...
Home | Efrat Shema's Lab
BML-281 | Ligand Activity Charts | IUPHAR/BPS Guide to PHARMACOLOGY
Inhibition of HDAC1 after 17 hrs B 6.57 pIC50 271 nM IC50 J Med Chem (2008) 51: 4370-4373 [PMID:18642892] ... Inhibition of recombinant human HDAC1 using Ac-RHKK(Ac)-ACC as substrate by fluorometric analysis B 5.45 pIC50 3567 nM IC50 ... Inhibition of recombinant human HDAC1 using Cbz-Lys(TFAc)-AMC as substrate by fluorometric analysis B 6.47 pIC50 340 nM IC50 ... Inhibition of HDAC1 (unknown origin) using carboxyfluorescein (FAM)-labeled acetylated peptide as substrate after 17 hrs by ...
SMAD7 | Cancer Genetics Web
Moreover, silencing HDAC1 in hepatoma cells restored TGF-β-mediated growth suppression, but this effect was attenuated if miR- ... These findings suggest that HDAC1-induced miR-195 down-regulation is an important mechanism for tumor cells to resist the ... Further investigation revealed that HDAC1, a histone deacetylase that was abnormally overexpressed in hepatocellular carcinoma ...
ID Tree - Arunava Bandyopadhaya
Discovering master regulators in hepatocellular carcinoma: one novel MR, SEC14L2 inhibits cancer cells | Aging
In addition, genes acting at the epigenetic level such as regulators of chromatin assembly and remodeling (e.g. CHAF1A, HDAC1, ... For instance, network topology analysis indicated that HDAC1/2 were the top stress genes in the PPI network. As the epigenetic ...
William Smith | UCSF Profiles
Cristofre Martin, PhD <span class='post-format-icon minor-meta'>...
2004). Histone deacetylase 1 (HDAC-1) required for normal formation of cartilage and pectoral fins of the zebrafish. ...
Perioperative Heart-Brain Axis Protection in Obese Surgical Patients: The Nutrigenomic Approach | Bentham Science
Structural Biology @ UniPV - publications
Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1 ...
Butyryl/Crotonyl-Histone H3 (Lys9) (E9N8C) Rabbit mAb | Cell Signaling Technology
Vacuolar H+-ATPase Determines Daughter Cell Fates through Asymmetric Segregation of the Nucleosome Remodeling and Deacetylase...
Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain | Journal of...
HDAC-1, -2, -3, and -8) showed nuclear localization. Interestingly, HDAC-1 was predominantly detected in OL lineage cells ... Class I includes HDAC-1, -2, -3, and -8 and is composed of small proteins (377-488 aa), sharing sequence homology to the yeast ... 4, J, K, M, and P). In contrast, HDAC-1 was still expressed in the nucleus of the CC1+ cells as well as in myelinated fibers ( ... HDAC1 (1:6,000 for IHC, 1:4,000 for WB; Affinity BioReagents, Inc.); HDAC2 (1:100 for IHC, 1:1,000 for WB; Santa Cruz ...
Hepatocellular Carcinoma cells: activity of Amygdalin and Sorafenib in Targeting AMPK /mTOR and BCL-2 for anti-angiogenesis and...
HDAC1 (PDB ID: 4BKX); (C) JMJD1C (PDB ID: 2YPD); (D) LKB1 (PDB ID: 4ZDR); (E) AMPK (PDB ID: 4CFF); (F) DNMT1 (PDB ID: 4WXX); (G ... HDAC1; PDB ID: 4BKX), jumonji domain containing 1 C (JMJD1C; PDB ID: 2YPD), liver kinase B1 (LKB1; PDB ID: 4ZDR), ... The results of the screening suggest that these eight proteins [AKT1, AMPK1, DMNT1, HDAC1, JMJDIC, LKB1, PK3CA, and SIRT1] may ... 7A. Furthermore, Amy also showed binding energies with a variety of receptors, including HDAC1 (-5.63 kcal/mol), JMJD1C (-6.8 ...
Plus it
RELA RELA proto-oncogene, NF-kB subunit [Homo sapiens (human)] - Gene - NCBI
FLUOR DE LYS® deacetylase substrate - BML-KI104 - Enzo Life Sciences
HDAC1. HDAC2. HDAC3. HDAC4. HDAC8. HDAC9. SIRT. SIRT1. SIRT2. By biological activity: ... HDAC1 Substrate. HDAC2 Substrate. HDAC3 Substrate. HDAC4 Substrate. HDAC8 Substrate. HDAC9 Substrate. SIRT Substrate. SIRT1 ... Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems ...