Also we determine HDAC1 as a particular regulator involved with silencing of miR-200b through a Sp1-reliant system and repair ... Taken collectively the HDAC1/miR-200b/Suz-12-E-cadherin signaling might account SCH58261 for maintenance of CSCs and formation ... Also downregulation of HDAC1 or upregulation of miR-200b reduced the tumorigenicity of CSCs. Finally Suz-12 was inversely ... To the very best of our understanding there were no reviews about HDAC1/miR-200b/Suz-12/E-cadherin regulatory network in ...
It has been identified within a number of corepressor complexes together with HDAC1/2, CoREST, and BHC80 (40-42). Former ...
... represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. Proc Natl Acad Sci USA 1998. 95:10860-10865. ...
Recruitment of HDAC1/mSin3A complex by SMAR1, concomitant with alteration of histone marks results in downregulation of the ... HDAC1), to evaluate LRFs potential disturbance upon the aberrant epigenetic background and provide valuable information of the ...
Vithana, E. N., Morgan, P., Sundaresan, P., D. Ebenezer, N., Tan, D. T. H., Mohamed, M. D., Anand, S., Khine, K. O., Venkataraman, D., Yong, V. H. K., Salto-Tellez, M., Venkatraman, A., Guo, K., Hemadevi, B., Srinivasan, M., Prajna, V., Khine, M., Casey, J. R., Inglehearn, C. F. & Aung, T., Jul 2006, In: Nature Genetics. 38, 7, p. 755-757 3 p.. Research output: Contribution to journal › Article › peer-review ...
Schwabe JWR Mechanism of crosstalk between the LSD1 demethylase and HDAC1 deacetylase in the CoREST complex Cell Reports 30, (8 ... Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell ...
HDAC1 Recombinant Rabbit Monoclonal Antibody [SY12-04]. ET1612-50. HDAC2 Recombinant Rabbit Monoclonal Antibody [SD0816]. ...
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. ...
BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos ... Novelli, Flavia; ...
IL15 expression upregulated the histone deacetylases HDAC1 and HDAC6 at least in part by reducing binding of HDAC1 to the HDAC1 ... HDAC1 enhanced transcription of the oncogenic miR-21, which was overexpressed in patients with CTCL. Treatment of CTCL cells ... In vivo, HDAC6 inhibition delayed tumor progression, whereas HDAC1/2 inhibition halted tumor growth and, in some cases, induced ... IL15 overexpression can induce cutaneous T-cell lymphoma (CTCL) via induction of HDAC1/6 and miR-21. ...
This is achieved via interaction of LATS1 with the NCOR1 nuclear corepressor and recruitment of HDAC1, driving histone H3K27 ...
Inhibition of HDAC1 after 17 hrs B 6.57 pIC50 271 nM IC50 J Med Chem (2008) 51: 4370-4373 [PMID:18642892] ... Inhibition of recombinant human HDAC1 using Ac-RHKK(Ac)-ACC as substrate by fluorometric analysis B 5.45 pIC50 3567 nM IC50 ... Inhibition of recombinant human HDAC1 using Cbz-Lys(TFAc)-AMC as substrate by fluorometric analysis B 6.47 pIC50 340 nM IC50 ... Inhibition of HDAC1 (unknown origin) using carboxyfluorescein (FAM)-labeled acetylated peptide as substrate after 17 hrs by ...
Moreover, silencing HDAC1 in hepatoma cells restored TGF-β-mediated growth suppression, but this effect was attenuated if miR- ... These findings suggest that HDAC1-induced miR-195 down-regulation is an important mechanism for tumor cells to resist the ... Further investigation revealed that HDAC1, a histone deacetylase that was abnormally overexpressed in hepatocellular carcinoma ...
2017) NF-κBp50 and HDAC1 Interaction Is Implicated in the Host Tolerance to Infection Mediated by the Bacterial Quorum Sensing ... 2016) A quorum-sensing signal promotes host tolerance training through HDAC1-mediated epigenetic reprogramming. Nature ...
In addition, genes acting at the epigenetic level such as regulators of chromatin assembly and remodeling (e.g. CHAF1A, HDAC1, ... For instance, network topology analysis indicated that HDAC1/2 were the top stress genes in the PPI network. As the epigenetic ...
Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation. Chem Biol. 2013 May 23; 20(5):713-25. Frumm SM, Fan ZP, ...
2004). Histone deacetylase 1 (HDAC-1) required for normal formation of cartilage and pectoral fins of the zebrafish. ...
Beneficial effects of sulforaphane treatment in alzheimers disease may be mediated through reduced HDAC1/3 and increased ...
Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1 ...
H3K27cr is recognized by GAS41 along with the SIN3A-HDAC1 corepressive complex and is associated with a gene repression program ... and class I deacetylases HDAC1/2/3 have been shown to be capable of decrotonylation (10,11). Furthermore, crotonylation can be ...
C) Protein domain structure of the GFP-tagged HDAC1/2 (HDA-1) or mNeonGreen-tagged RBBP4/7 (LIN-53). CAF1C: histone-binding ...
HDAC-1, -2, -3, and -8) showed nuclear localization. Interestingly, HDAC-1 was predominantly detected in OL lineage cells ... Class I includes HDAC-1, -2, -3, and -8 and is composed of small proteins (377-488 aa), sharing sequence homology to the yeast ... 4, J, K, M, and P). In contrast, HDAC-1 was still expressed in the nucleus of the CC1+ cells as well as in myelinated fibers ( ... HDAC1 (1:6,000 for IHC, 1:4,000 for WB; Affinity BioReagents, Inc.); HDAC2 (1:100 for IHC, 1:1,000 for WB; Santa Cruz ...
HDAC1 (PDB ID: 4BKX); (C) JMJD1C (PDB ID: 2YPD); (D) LKB1 (PDB ID: 4ZDR); (E) AMPK (PDB ID: 4CFF); (F) DNMT1 (PDB ID: 4WXX); (G ... HDAC1; PDB ID: 4BKX), jumonji domain containing 1 C (JMJD1C; PDB ID: 2YPD), liver kinase B1 (LKB1; PDB ID: 4ZDR), ... The results of the screening suggest that these eight proteins [AKT1, AMPK1, DMNT1, HDAC1, JMJDIC, LKB1, PK3CA, and SIRT1] may ... 7A. Furthermore, Amy also showed binding energies with a variety of receptors, including HDAC1 (-5.63 kcal/mol), JMJD1C (-6.8 ...
HDAC1, HDAC2, and HDAC3), contribute to synaptic plasticity associated with learning and memory (Peixoto and Abel, 2013; ...
... as Curcumin inhibits HIV-1 Tat-mediated long terminal repeat transactivation by reversing Tat-induced dissociation of HDAC1 ...
HDAC1. HDAC2. HDAC3. HDAC4. HDAC8. HDAC9. SIRT. SIRT1. SIRT2. By biological activity: ... HDAC1 Substrate. HDAC2 Substrate. HDAC3 Substrate. HDAC4 Substrate. HDAC8 Substrate. HDAC9 Substrate. SIRT Substrate. SIRT1 ... Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems ...
ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response. ...